1. Too rapid increase and too much breathlessness are distinct indices of exertional dyspnea in COPD
- Author
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Bruno Mahut, Brigitte Chevalier-Bidaud, Etienne Callens, Judith Valcke-Brossollet, Karine Gillet-Juvin, Christophe Delclaux, Semia Graba, and Mohamed Essalhi
- Subjects
Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Physiology ,Physical Exertion ,Hyperinflation ,Physical exercise ,Incremental exercise ,Pulmonary function testing ,Pulmonary Disease, Chronic Obstructive ,Internal medicine ,medicine ,Humans ,Exercise physiology ,Exercise ,Aged ,COPD ,business.industry ,General Neuroscience ,Respiratory disease ,Middle Aged ,medicine.disease ,Respiratory Function Tests ,respiratory tract diseases ,Cross-Sectional Studies ,Dyspnea ,Exercise Test ,Breathing ,Cardiology ,Physical therapy ,Female ,business - Abstract
To assess whether different indices of dyspnea can be obtained from cardiopulmonary exercise test and whether these indices correlate with distinct physiological parameters in COPD. Forty-two COPD patients (12 females, median [IQ] age 66 [56-70] years; FEV(1)% predicted: 51 [38-65]) underwent pulmonary function and incremental exercise tests. A power law function described the oxygen consumption (V(O₂)-Dyspnea relationship from which two indices correlated with MRC score: dyspnea score measured at 50% of predicted V(O₂) (too much breathless for that effort) and tangent measured at 50% of peak dyspnea (too rapid increase in dyspnea at this time point). The former independently correlated with ventilation on exercise, while the latter independently correlated with baseline hyperinflation. An upward shift of both (iso)-V(O₂) and -ventilation was evidenced in patients with higher levels of dyspnea (MRC score ≥ 3) and their tangents were significantly different. In conclusion, baseline hyperinflation is associated with the perception of a too rapid increase in dyspnea on exercise in COPD.
- Published
- 2011
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