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The effect of Helicobacter pylori treatment on the potential reversal of atrophic body gastritis (ABG) is controversial. Body atrophy reversal was evaluated in a cohort of H. pylori-negative and treated H. pylori-positive ABG patients.Observational long-term follow-up cohort study including 300 ABG patients with at least one follow-up gastroscopy with three biopsies from the antrum and three from the body performed no earlier than 1 year after diagnosis was included. H. pylori was diagnosed by Giemsa-stain and serology. H. pylori-positive patients (n = 192) were treated with bismuth-based triple regimen.After a mean follow-up of 5.2 years, body atrophy reversal was observed in 42/300 patients (14%). Body atrophy reversal occurred more frequently in patients treated for H. pylori than in H. pylori-negative ones (21.3% vs 0.9%, p0.00001) and was observed between 2 and 8 years after treatment in 52% of cases. Predictive factors for body atrophy reversal at Cox-regression analysis were mild atrophy (HR 2.14; 95% CI 1.12-4.1), moderate-severe inflammation (HR 5.3; 95% CI 1.64-17.3), and absence of intestinal metaplasia (HR 2.4; 95% CI 1.2-4.8).Body atrophy reversal was observed in about 20% of ABG patients treated for H. pylori infection, and about 50% of reversals occurred during long-term follow-up.

A linker has been developed for use in solid-phase peptide synthesis which allows a protected peptide to be cleaved from the resin under neutral conditions (nBu3P, DMF, imidazole buffer pH 7) whilst retaining tBuO-, Boc- and Fmoc-protecting groups. The linker comprises a 2-azidomethyl-4-hydroxy-6,N-dimethylbenzamide moiety, which is coupled to polystyrene resin as a phenol ether and to the peptide via a N-hydroxymethyl group. The protected peptide fragments so produced may be useful, for example, in subsequent fragment condensations using the Fmoc-chemistry.

Sections of the torsioned side revealed a marked hyperplasia and hypertrophy of all the several coats of the uterus, i.e., endometrial, muscular and serous. There was a marked increase in the number and of the blood vessels. There was also an actual increase in the elastic tissue ratio of the blood vessels while the connective tissue ratio of the entire organ was grossly increased.

To conclude, I may summarize the trend of gynecology today, as follows: 1. (1) It is in the direction of a better understanding of the basic pathology. 2. (2) All of our therapy is based upon this underlying principle. 3. (3) The trained surgeon has a greater respect for the physiological processes known as nature's defensive barriers. 4. (4) Fewer operations are being done for the correction of obstetric errors. 5. (5) All operations are being preceded by intelligent preoperative preparation. 6. (6) Operation for cancer is done only in selected cases.

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