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Start Over Author "Jo-Hsin Chen" Publisher elsevier bv
2 results on '"Jo-Hsin Chen"'

2. miR-137 is a tumor suppressor in endometrial cancer and is repressed by DNA hypermethylation

Author

Yi-Wen Huang, Tim H M Huang, Li-Shu Wang, Tianjiao Shan, Xiugui Sheng, Jo-Hsin Chen, Wei Zhang, Irene Aguilera-Barrantes, and Janet S. Rader

Subjects
0301 basic medicine, Mice, Nude, Adenocarcinoma, Biology, Article, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, microRNA, medicine, Animals, Humans, Gene silencing, Enhancer of Zeste Homolog 2 Protein, Gene Silencing, Molecular Biology, Histone Demethylases, Endometrial cancer, EZH2, Cell Biology, DNA Methylation, medicine.disease, Endometrial Neoplasms, 3. Good health, MicroRNAs, mir-137, 030104 developmental biology, Differentially methylated regions, 030220 oncology & carcinogenesis, DNA methylation, Cancer cell, Cancer research, Female
Abstract

Endometrial cancer is the most common gynecological cancer in the United States. We wanted to identify epigenetic aberrations involving microRNAs (miRNAs), whose genes become hypermethylated in endometrial primary tumors. By integrating known miRNA sequences from the miRNA database (miRBase) with DNA methylation data from methyl-CpG-capture sequencing, we identified 111 differentially methylated regions (DMRs) associated with CpG islands (CGIs) and miRNAs. Among them, 22 DMRs related to 29 miRNAs and within 8 kb of CGIs were hypermethylated in endometrial tumors but not in normal endometrium. miR-137 was further validated in additional endometrial primary tumors. Hypermethylation of miR-137 was found in both endometrioid and serous endometrial cancer (P

Published
2018

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