7 results on '"Jin Feng Shi"'
Search Results
2. Effects of the deposition temperature on the microwave-absorption performance of Fe/CNT composites
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Yuan Liu, Jin-feng Shi, and Jie Lai
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Nanocomposite ,Materials science ,Materials Science (miscellaneous) ,Nanoparticle ,02 engineering and technology ,Chemical vapor deposition ,Carbon nanotube ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,0104 chemical sciences ,law.invention ,Carbonyl iron ,law ,General Materials Science ,Composite material ,0210 nano-technology ,Absorption (electromagnetic radiation) ,Microwave - Abstract
Iron coated carbon nanotube (CNT) nanocomposite absorbents were prepared by a metal organic chemical vapor deposition method using carbonyl iron as the Fe precursor. The microstructures and electromagnetic properties of the composites were characterized by XRD, FESEM, TEM, and a vector network analyzer. Results show that the morphology and microwave absorption properties of these core-shell composites are controlled by changing the deposition temperature. The number of iron nanoparticles deposited on the surface of the CNTs gradually increases with increasing deposition temperature in the range 210–240 oC. Too high a temperature (270 oC) causes agglomeration of the Fe nanoparticles on the surface of the CNTs. When the thickness of the electromagnetic coating is 2.9 mm, the composite prepared at 240 oC has the best microwave absorption, with a maximum absorption bandwidth of 6.1 GHz (10.2-16.3 GHz), a minimum reflectivity of −28.3 dB and an absorption intensity less than −10 dB at 6.1 GHz.
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- 2020
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3. pH-sensitive nano-polyelectrolyte complexes with arthritic macrophage-targeting delivery of triptolide
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Jia, Xin Li, Meng, Jiao Zhang, Jin, Feng Shi, Sheng, Peng Wang, Xue, Mei Zhong, Yi, Han Wu, Yan, Qu, Hui, Le Gao, and Jin, Ming Zhang
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Pharmaceutical Science - Abstract
Since pro-inflammatory macrophages take on a critical significance in the pathophysiology of rheumatoid arthritis (RA), the therapeutics to affect macrophages may receive distinct anti-RA effects. However, the therapeutic outcomes are still significantly impeded, which is primarily due to the insufficient drug delivery at the arthritic site. In this study, the macrophage-targeting and pH stimuli-responsive nano-polyelectrolyte complexes were designed for the efficient targeted delivery of triptolide (TP/PNPs) on the arthritic site. The anionic and cationic amphiphilic copolymers, i.e., hyaluronic acid-g-vitamin E succinate (HA-VE) and the quaternized poly (β-amino ester) (QPBAE-C
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- 2023
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4. Calcium pectinate and hyaluronic acid modified lactoferrin nanoparticles loaded rhein with dual-targeting for ulcerative colitis treatment
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Arlene McDowell, Jinming Zhang, Qiyan Chen, Fu Shu, Chen Zhang, Haiting Xu, Naijing Ye, Bin Deng, Ruifeng Luo, Xiulan Pu, Chaomei Fu, Meisi Lin, Fei Gao, Jiayi Sun, Jin-Feng Shi, Linlin Dong, and Dasheng Lin
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Polymers and Plastics ,Nanoparticle ,Anthraquinones ,02 engineering and technology ,Pharmacology ,01 natural sciences ,Mice ,chemistry.chemical_compound ,Hyaluronic acid ,Materials Chemistry ,Tissue Distribution ,Enzyme Inhibitors ,Hyaluronic Acid ,Drug Carriers ,biology ,Lactoferrin ,Chemistry ,Dextran Sulfate ,NF-kappa B ,021001 nanoscience & nanotechnology ,Ulcerative colitis ,Hyaluronan Receptors ,Cytokines ,Pectins ,Signal transduction ,medicine.symptom ,0210 nano-technology ,Receptors, Cell Surface ,Inflammation ,010402 general chemistry ,Cell Line ,In vivo ,medicine ,Animals ,Humans ,Tight Junction Proteins ,Macrophages ,Organic Chemistry ,technology, industry, and agriculture ,Biological Transport ,Epithelial Cells ,medicine.disease ,0104 chemical sciences ,Toll-Like Receptor 4 ,Disease Models, Animal ,Drug Liberation ,TLR4 ,biology.protein ,Nanoparticles ,Colitis, Ulcerative - Abstract
Herein, dual-bioresponsive of Rhein (RH) in promoting colonic mucous damage repair and controlling inflammatory reactions were combined by the dual-targeting (intestinal epithelial cells and macrophages) oral nano delivery strategy for effective therapy of ulcerative colitis (UC). Briefly, two carbohydrates, calcium pectinate (CP) and hyaluronic acid (HA) were used to modify lactoferrin (LF) nanoparticles (NPs) to encapsulate RH (CP/HA/RH-NPs). CP layer make CP/HA/RH-NPs more stable and protect against the destructive effects of the gastrointestinal environment and then release HA/RH-NPs to colon lesion site. Cellular uptake evaluation confirmed that NPs could specifically target and enhance the uptake rate via LF and HA ligands. in vivo experiments revealed that CP/HA/RH-NPs significantly alleviated inflammation by inhibiting the TLR4/MyD88/NF-κB signaling pathway and accelerated colonic healing. Importantly, with the help of CP, this study was the first to attempt for LF as a targeting nanomaterial in UC treatment and offers a promising food-based nanodrug in anti-UC.
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- 2021
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5. Synergistic breast cancer suppression efficacy of doxorubicin by combination with glycyrrhetinic acid as an angiogenesis inhibitor
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Liang Zou, Jin-Feng Shi, Winston Wing Shum Mak, George P.H. Leung, Jiaxin Li, Fei Gao, Chaomei Fu, Jinming Zhang, Xiaoping Wu, Jingjing Li, and Renkai Li
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Combination therapy ,Pharmaceutical Science ,Angiogenesis Inhibitors ,Apoptosis ,Breast Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Antineoplastic Combined Chemotherapy Protocols ,Drug Discovery ,Human Umbilical Vein Endothelial Cells ,medicine ,Animals ,Humans ,MTT assay ,Doxorubicin ,Viability assay ,Cytotoxicity ,030304 developmental biology ,Membrane Potential, Mitochondrial ,Pharmacology ,Tube formation ,Mice, Inbred BALB C ,0303 health sciences ,Chemistry ,Vascular Endothelial Growth Factor Receptor-2 ,Xenograft Model Antitumor Assays ,Cardiotoxicity ,Angiogenesis inhibitor ,Complementary and alternative medicine ,030220 oncology & carcinogenesis ,MCF-7 Cells ,Cancer research ,Glycyrrhetinic Acid ,Molecular Medicine ,Female ,medicine.drug - Abstract
Background Therapeutic regimens of breast cancer treatment are increasingly inclined to adopt combination strategy based on the broad spectrum antitumor effect of doxorubicin (Dox). Currently, combination therapy comprises of conventional anti-cancer drugs and angiogenesis inhibitors have been corroborated as an effective approach in cancer treatment. Purpose We explored the ability of a natural anti-angiogenic compound glycyrrhetinic acid (GA), derived from an edible-medicinal herb licorice, to enhance the breast cancer suppression effect of Dox. Study design The drug ratio of GA and Dox with synergistic anticancer effect against MCF-7 cells was optimized by combination index (CI) value in vitro, followed by evaluation of the improved anticancer effects and reduced side-effects of this combination in vitro and in vivo. Methods Cell viability was measured by MTT assay. Analyses of mitochondrial membrane potential and cell apoptosis on MCF-7 cells were performed by JC-1 dye and Annexin V-FITC/PI assays. The cellular accumulation of Dox when combined with GA was evaluated. Levels of apoptosis-related proteins in MCF-7 cells were measured by Western blot analysis. Synergistic anti-angiogenic effects on HUVECs were evaluated. A breast cancer mouse model was established to investigate the anti-tumor effects in vivo. Results Based on the optimization by CI value, Dox and GA at 1:20 molar ratio was chosen as the optimal combination drug ratio that exhibited synergistic effect against MCF-7 breast cancer cells. In addition, the combination of GA and Dox exhibited significantly enhanced cytotoxicity, apoptosis, and loss of mitochondrial membrane potential via the upregulation of a mitochondrial-dependent apoptosis pathway against MCF-7 cells. Interestingly, the addition of GA increased the intracellular accumulation of Dox in MCF-7 cells. Moreover, VEGF-induced HUVECs proliferation, migration, and tube formation were strongly inhibited by Dox when used with GA via the significant down-regulation of VEGFR2-mediated pathway, indicating that the combination of Dox and GA could exhibit ideal synergistic anti-angiogenesis effect. Expectedly, the enhanced anti-tumor efficacy of Dox and reduced Dox-induced cardiotoxicity when used in combination with GA were evident in a mouse breast tumor model. Conclusions These findings support that the combination of Dox with GA is a novel and promising therapeutic strategy for the treatment of breast cancer.
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- 2021
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6. Genipin-crosslinked human serum albumin coating using a tannic acid layer for enhanced oral administration of curcumin in the treatment of ulcerative colitis
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Qiyan Chen, Jinming Zhang, Minyue Zhang, Siyuan Zhang, Ruifeng Luo, Chen Zhang, Yichen Hu, Jin-Feng Shi, Meisi Lin, and Fei Gao
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Male ,Curcumin ,Administration, Oral ,Serum Albumin, Human ,Pharmacology ,01 natural sciences ,Analytical Chemistry ,Mice ,chemistry.chemical_compound ,Drug Delivery Systems ,0404 agricultural biotechnology ,Oral administration ,Tannic acid ,medicine ,Animals ,Humans ,Iridoids ,Colitis ,Mice, Inbred BALB C ,010401 analytical chemistry ,technology, industry, and agriculture ,04 agricultural and veterinary sciences ,General Medicine ,medicine.disease ,Human serum albumin ,040401 food science ,Ulcerative colitis ,0104 chemical sciences ,chemistry ,Genipin ,Nanoparticles ,Colitis, Ulcerative ,Caco-2 Cells ,Nanocarriers ,Tannins ,Food Science ,medicine.drug - Abstract
Curcumin (CUR) is a promising edible phytochemical compound with ideal ulcerative colitis (UC) treatment activity; however, it is characteristically instable in the digestive tract and has a short retention time in colon. Therefore, we designed and fabricated an oral food-grade nanocarrier composed of tannic acid (TA)-coated, Genipin (Gnp)-crosslinked human serum albumin (HSA) to encapsulate CUR (TA/CUR-NPs). The resulting CUR nanoparticles (NPs) were about 220 nm and −28.8 mV. With the assistance of TA layer and Gnp-crosslinking, the entire nano-scaled system effectively delayed CUR release in simulated gastric fluid, prolonged its colon adhesion and increased its uptake in Caco-2 cells. As expected, TA/CUR-NPs oral administration significantly alleviated colitis symptoms in DSS-treated mice when compared with controls by inhibiting the TLR4-linked NF-κB signaling pathway. Collectively, this study indicates that we have developed a convenient, eco-friendly, nano-scaled vehicle for oral delivery of CUR with anti-UC benefit.
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- 2020
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7. Energy efficiency analysis on Chinese industrial sectors: an improved Super-SBM model with undesirable outputs
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Jin-feng Shi and Hong Li
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Engineering ,Renewable Energy, Sustainability and the Environment ,business.industry ,Strategy and Management ,Scale (chemistry) ,Welfare economics ,Light industry ,Convergence (economics) ,Building and Construction ,Heavy industry ,Environmental economics ,Industrial and Manufacturing Engineering ,Energy accounting ,Secondary sector of the economy ,business ,Energy (signal processing) ,General Environmental Science ,Efficient energy use - Abstract
In this article we proposed an improved Super-SBM model dealing with undesirable outputs under the weak disposability assumption of undesirable outputs. Energy efficiencies of various industrial sectors in China from 2001 to 2010 are measured based on this model, and the influencing factors for energy efficiency are explored by Tobit regression model. Empirical results show that, during “The Eleventh Five-year Plan”, energy efficiency of each industrial sector and category has been improved to various extents, but overall efficiency variations among industries have not taken on a convergence trend. Light industry has achieved the highest energy efficiency, followed by heavy industry; while the energy efficiency of the latter has a faster growth rate compared with that of light industry; the gap between these two industries' energy efficiency has been reduced. Energy efficiency variation presents an obvious feature of industrial economy transformation. The analysis of influencing factors show that enterprise scale, industry concentration, industrial property rights structure, and government regulation all affect energy efficiency apparently, but their effects vary across industries. Lastly, based on research results, this paper gives some policy recommendations on improving energy efficiency of the industrial sectors in China.
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- 2014
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