1. The role of two-component regulatory system in β-lactam antibiotics resistance
- Author
-
Zheng Chengkun, Li Lingzhi, Jia Mengdie, Zhou Xiaohui, Ge Haojie, Meng Hongmei, Li Yang, and Gu Dan
- Subjects
0301 basic medicine ,Histidine Kinase ,medicine.drug_class ,030106 microbiology ,Antibiotics ,Drug resistance ,Biology ,beta-Lactams ,Microbiology ,beta-Lactam Resistance ,beta-Lactamases ,03 medical and health sciences ,Antibiotic resistance ,Bacterial Proteins ,polycyclic compounds ,medicine ,Bacteria ,Histidine kinase ,Membrane Proteins ,Agriculture ,Gene Expression Regulation, Bacterial ,Two-component regulatory system ,Anti-Bacterial Agents ,Multiple drug resistance ,Response regulator ,030104 developmental biology ,Efflux - Abstract
The irrational use of antibiotics in agriculture and in the medical field has led to a variety of pathogenic microorganisms that produce drug resistance and even multidrug resistance. B-lactam is one of the most widely used antibiotics to treat infectious diseases. Resistance to β-lactam resistance can be primarily due to the presence β-lactamase, mutation of β-lactam targets and overexpression of efflux pumps. Two-component regulatory systems are composed of histidine kinase and response regulator that regulate gene expression under different environmental conditions. In this review, we summarized the mechanisms by which β-lactam resistance is developed and the role of the two-component regulatory system in β-lactam resistance.
- Published
- 2018