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Though limited success through chemotherapy, radiotherapy and surgery has been obtained for efficient cancer therapy for modern decades, cancers are still considered high burden to human health worldwide to date. Recently repurposing drugs are attractive with lower cost and shorter time compared to classical drug discovery, just as Metformin from Galega officinalis, originally approved for treating Type 2 diabetes by FDA, is globally valued at millions of US dollars for cancer therapy. As most previous reviews focused on FDA approved drugs and synthetic agents, current review discussed the anticancer potential of phytochemicals originally approved for treatment of cardiovascular diseases, diabetes, infectious diarrhea, depression and malaria with their molecular mechanisms and efficacies and suggested future research perspectives.

Galbanic acid (GBA) is known a sesquiterpene coumarin to have apoptotic, anti-hypoxic, anti-proliferative, anti-hepatitis, anti-angiogenic, anti-bacteria and anti-thrombotic effects. Also, antitumor effect of GBA was reported in prostate, ovary, breast and lung cancers. Nevertheless, the underlying molecular mechanism of GBA was not fully understood to overcome chemoresistance in resistant lung cancer so far. Thus, synergistic antitumor mechanism of GBA and TNF-related apoptosis-inducing ligand (TRAIL) was elucidated in H460 and resistant H460/R non-small cell lung cancer cells (NSCLCs). Combination of GBA and TRAIL significantly exerted cytotoxicity in a dose dependent manner compared to GBA or TRAIL alone in H460/R cells. Also, GBA and TRAIL significantly increased the number of terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positive cells and sub-G1 population in a dose dependent manner in H460/R cells. Consistently, GBA and TRAIL induced cleavages of poly (ADP-ribose) polymerase (PARP), caspase-9 and caspase-8 along with upregulation of death receptor 5 (DR5) and also attenuated the expression of B-cell lymphoma-extra-large (Bcl-xL), B-cell lymphoma 2 (Bcl-2), X-linked inhibitor of apoptosis protein (XIAP) in H460/R cells. Furthermore, combination of GBA and TRAIL remarkably inhibited the expression of decoy receptor 1 (DcR1) and multidrug resistance 1(MDR1) in H460/R cells. Consistently, GBA and TRAIL effectively maintained Rhodamine 123 accumulation in H460/R cells compared to GBA or TRAIL alone by blocking multidrug efflux pump from the cells. Overall, our findings suggest that galbanic acid enhances TRAIL induced apoptosis via inhibition of MDR1 and activation of caspases and DR5 in H460/R cells as a potent TRAIL sensitizer.

In this study, we executed optical simulations to compute the optimum power conversion efficiency (PCE) of a-Si:H/organic photovoltaic (OPV) hybrid tandem solar cell. The maximum ideal short circuit current density (Jsc,max) of the tandem solar cell is initially obtained by optimizing the thickness of the active layer of the OPV subcell for varying thickness of the a-Si:H bottom subcell. To investigate the effect of Haze parameter on the ideal short-circuit current density (Jsc,ideal) of the solar cells, we have varied the haze ratio for the TCO electrode of the a-Si:H subcell in the tandem structure. The haze ratio was obtained for various root mean square (RMS) roughness of the TCO of the front cell. The effect of haze ratio on the Jsc,ideal on the tandem structured solar cell was studied, and the highest Jsc,ideal was obtained at a haze of 55.5% when the thickness of the OPV subcell was 150 nm and that of the a-Si:H subcell was 500 nm.

Chronic alcohol consumption is a major risk factor for alcoholic liver disease. In this study, we examined the effect of an extract of Pinus koraiensis leaves, Lycium chinense fruit, and Saururus chinensis (Lour.) Baill. leaves (PLC) on liver function in Korean. A randomized, double-blind, placebo-controlled study was performed in 50 excessive drinkers. The subjects were randomly assigned to PLC (n = 25, 2,000 mg/day) or placebo (n = 25) groups. Blood liver enzymes, lipid profiles, and antioxidant enzymes were assessed at baseline and 12 weeks. GGT level significantly decreased in women in the test group compared with the placebo group (-2.50 ± 3.54 U/L vs. 3.80 ± 11.23 U/L, P = 0.006). TC (-13.04 ± 25.65 mg/dL, P = 0.020) and LDL-C (-10.33 ± 24.15 mg/dL, P = 0.047) levels reduced in the test group after 12 weeks. Although PLC, appears the possibility of improving liver function in excessive drinkers, however, a larger scale and long-term intervention study should be performed.

We developed a facile technique, termed as dual-targeted hydrophobic adhesion (DHA) to improve on- and off-current features simultaneously in solution-processed organic thin-film transistors (OTFTs). Simple DHA process not only modifies the interface between source-drain electrodes and organic semiconductor (OSC), but also acts as passivation in OSC fabrication process. The modified interface induces shift of the Fermi energy level and decreases the contact resistance. Moreover, the passivation function of DHA suppresses water permeation and prevents the increase of trap-induced conductivity at off-state. As a result, DHA-treated OTFTs exhibit a field-effect mobility with a threefold increase and on/off current ratio (by two orders of magnitude), as compared to non-treated transistors.

Thermoplastic composites are rapidly emerging as alternative materials for auto parts owing to recyclability as well as excellent stiffness- and strength-to weight ratios. In this study, an optimal stacking sequence using twill-weave carbon fiber-reinforced polypropylene (CF/PP) prepregs and random fiber-reinforced polypropylene (RFP) sheets were investigated for the fabrication of an automobile fender. The lamination consisting of CF/PP only incurred imperfect resin impregnation. RFP insertion between CF/PP layers improved the resin impregnation. The hybrid stacking sequence not only reduced internal void contents but also increased the flexural and impact strength of the composite laminate. Using the optimal stacking sequence, a real-scale composite fender was fabricated and impact tests were performed. The test results were compared with the ones from an existing steel fender. In case of the steel fender, permanent deformation was observed even in one attempt, while no visible damage was found from the composite fender even after five consecutive impact tests.

Despite the recent advances in augmented reality (AR), which has shown the potential to significantly impact on our daily lives by offering a new way to manipulate and interact with virtual information, minimizing visual discomfort due to the vergence–accommodation conflict remains a challenge. Emerging AR technologies often exploit focus-tunable optics to address this problem. Although they demonstrated improved depth perception by enabling proper focus cues, a bulky form factor of focus–tunable optics prevents their use in the form of a pair of eyeglasses. Here, we propose a novel optical configuration for a compact vari-focal AR display which deliberately utilizes the zeroth and first diffraction orders of the LC lens to produce two foci: one for a real object and the other for a virtual object with addressable focal planes. The prototype AR glasses can adjust the accommodation distance of the virtual image, mitigating the vergence–accommodation conflict without substantially compromising the form factor or image quality. In addition, we describe the design, fabrication, and characterization of an ultrathin, polarization-insensitive focus-tunable liquid crystal (LC) diffractive lens with a large aperture, a low weight, and a low operating voltage. We show that the polarization dependence of the lens, which is an inherent optical property of LC lenses, can be insensitive using the trilayer birefringent materials and by aligning the optical axes of each birefringent material at a specific angle. The polarization insensitivity eliminates the need for a polarizer, thus further reducing the form factor of the optical system. This novel approach offers significantly reduced complexity for designing AR glasses with addressable focal planes. These technologies for ultrathin lens and AR display show promising potential for developing compact optical systems in various applications.

Although 1,2,3,4,6-penta-O-galloyl-beta-d-glucose (PGG) was well known to have antitumor activities in breast, prostate, kidney, liver cancers and HL-60 leukemia via regulation of caspase 3, p53, S-phase kinase-associated protein 2 (Skp2) and insulin receptor signaling, the underlying mechanism of PGG-induced apoptosis linked with reactive oxygen species (ROS) mediated c-Jun N-terminal kinase (JNK) and DAXX was never elucidated in chronic myeloid leukemia (CML) K562 cells until now. Herein PGG significantly decreased the viability of CML cell lines such as K562 and KBM-5 without hurting normal peripheral blood lymphocytes (PBLs). PGG increased the number of TUNEL-positive cells and the sub-G1 cell population as well as activated caspase cascades including caspase-8, -9 and -3 in K562 cells. Interestingly, a significant activation of JNK by PGG was observed by MULTIPLEX assay and Western blotting. Conversely, JNK inhibitor D-JNKi suppressed the cleavages of caspase 3 and PARP induced by PGG in K562 cells. Also, PGG dramatically enhanced generation of ROS and reduced the expression of death-domain-associated protein (DAXX). Of note, ROS inhibitor acetyl-L-cysteine (NAC) reversed JNK-dependent apoptosis and DAXX inhibition induced by PGG. Overall, these findings suggest that ROS-dependent JNK activation and DAXX downregulation are critically involved in PGG-induced apoptosis in K562 cells.

We, authors report a study on the junction leakage current of CMOS image sensor adopting p-epi/n-sub structure. High leakage current (more than 100 μA) through the junction between p-epi and n-sub (at reverse bias) were observed with non-uniformed or jagged test patterns (dislodged slivers) of the chip sidewalls such as the metal burrs causing defective trap induced field or fringing field, playing as a role of the additional electrical path in our devices. In order to minimize the junction leakage current, we controlled the penetration (or cutting) depth of the sawing blade to remove the remaining test patterns through the wafer sawing process and treated our devices with n-type guard ring fabrication along the chip boundary to isolate the area including the defective sidewalls of the sawn wafer, thereby decreasing the leakage current dramatically. Thus, we could obtain our devices with the excellent low junction leakage to be more reliable products for the low power consumption.

This experimental study is carried out to investigate reliability and effectiveness of a new method of using photo-coupler for detecting frost formation in an air source heat pump, and further to determine the most efficient initiation point of the defrost cycle. This new method of using photo-coupler as a frost sensing device is evaluated by comparing its performance with conventional time control defrost system in which defrost cycle is set to start at predetermined interval, e.g. about at every 1–1.5 h. Results indicate that overall heating capacity of photo-coupler detection method (case IV) is 5.5% higher than that of time control method. It is also shown that for maximum efficiency the defrost cycle must be initiated before the frost build-up area exceeds 45% of total front surface of the outdoor coil.

candidates referring to training in endoscopic mucosal resection (EMR). The median number of formative colonoscopy assessments was 3 (range 0-16). In the year since DOPyS was introduced there were 150 applications for certification. The median number of procedures per candidate was 206. All of these candidates had evidence of polypectomy assessment with a median number of DOPyS of 7 (range 3-27). 89 per cent of applicants had evidence of assessed EMR. The median number of formative colonoscopy assessments in this cohort was 32 (range 9-199). There was a significant increase in the number of logged polypectomy assessments (p 0.001), experience of EMR (p 0.001) and formative colonoscopy assessments (p 0.001). There was no significant difference in the total number of colonoscopy procedures performed. Conclusions: These data the largest in the literature to date show that structured polypectomy assessment improves trainees’ documented exposure to therapeutic endoscopy as well as providing formal evidence of skills acquisition. As polypectomy plays an increasing role globally in colorectal cancer prevention, the DOPyS provides an effective means of assessing and certifying polypectomy in order to minimize the well-recognized risks associated with this technique. Reference: 1. Gupta S et al. Development and validation of a novel method for assessing competency in polypectomy: direct observation of polypectomy skills. Gastrointest Endosc. 2011 Jun ;73(6):1232-9.e2.