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Cell adhesion molecules (CADMs) comprise a protein family whose functions include maintenance of cell polarity and tumor suppression. In this report, we show that the CADM2 gene is repressed in human clear renal cell carcinoma by DNA promoter hypermethylation and/or loss of heterozygosity. Moreover, the loss of CADM2 expression is associated with a higher tumor pathology stage (p

Significant public investments in rural broadband internet service authorized by the American Recovery and Reinvestment Act raise new questions regarding the impacts of broadband on rural residents and communities. The results of a natural field experiment involving broadband internet projects funded by the Community Connect program of the Rural Utilities Service are reviewed here to provide a context for future evaluations of the effects of broadband infrastructure deployment and efforts to stimulate sustainable broadband use in rural areas. Based on pre–post surveys conducted in four communities in 2005 and 2008, the implementation of broadband infrastructure grants increased broadband adoption, although penetration also increased where a grant was awarded but later terminated. Public education efforts in a community participating in the ConnectKentucky initiative had an incremental effect on broadband adoption by positively affecting residents' perceptions of broadband service. Impacts on individual economic development activities and community satisfaction were not found. Implications for rural broadband initiatives and future evaluations of their effects are drawn.

Even as geographic disparities in high speed Internet access narrow, an urban-rural broadband gap persists, pointing to the importance of individual differences in motivations to adopt broadband as the key to closing the gap. Diffusion of innovation is reconceptualized through contemporary perspectives of the digital divide and social cognitive theory and tested on a survey sample drawn from four rural communities. Path analysis was used to examine the factors that cause broadband Internet service adoption in rural communities. Prior experience with the Internet, the expected outcomes of broadband usage, direct personal experience with broadband, and self-efficacy had direct effects on broadband intentions. Age and income, but not education or ethnicity, also had direct impacts. Efforts that promote the personal benefits of broadband and advanced ICT literacy skills among Internet users are recommended.

Purpose This article describes testing of a prototype Web site for adolescent mothers with postpartum depression; providing proof of concept. Methods Participants ( N =138) were recruited from a public school-based program for adolescent parents and completed the Mental Health Acceptability Scale, Stigma Scale for Receiving Psychological Help, and Attitudes Towards Seeking Professional Psychological Help Scale before, and after, the Web site intervention. They also provided feedback on the usability of the Web site. Results Attitudes related to depression and treatment (ATSPPH) improved after viewing the Web site ( p =.023). Feedback on the Web site indicated that it was easy to use (77%), reflecting highly acceptable score for product usability. Conclusions The data provide the foundation for the launch of the Web site from prototype to product and more comprehensive testing. The creation and testing of informational text messages will be added to the Web site to increase the interactivity and dose of the intervention.