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2. How to Prevent Atopic Dermatitis (Eczema) in 2024: Theory and Evidence.

Author

Chu, DK, Koplin, JJ, Ahmed, T, Islam, N, Chang, C-L, Lowe, AJ, Chu, DK, Koplin, JJ, Ahmed, T, Islam, N, Chang, C-L, and Lowe, AJ

Abstract

Atopic dermatitis (AD) or eczema is a chronic inflammatory skin disease characterized by dry, itchy, and inflamed skin. We review emerging concepts and clinical evidence addressing the pathogenesis and prevention of AD. We examine several interventions ranging from skin barrier enhancement strategies to probiotics, prebiotics, and synbiotics; and conversely, from antimicrobial exposure to vitamin D and omega fatty acid supplementation; breastfeeding and hydrolyzed formula; and house dust mite avoidance and immunotherapy. We appraise the available evidence base within the context of the Grades of Recommendation, Assessment, Development, and Evaluation approach. We also contextualize our findings in relation to concepts relating AD and individual-patient allergic life trajectories versus a linear concept of the atopic march and provide insights into future knowledge gaps and clinical trial design considerations that must be addressed in forthcoming research. Finally, we provide implementation considerations to detect population-level differences in AD risk. Major international efforts are required to provide definitive evidence regarding what works and what does not for preventing AD.

Published
2024

5. 1446 RNase L acts as a regeneration suppressor

Author

Kirby, C., primary, Islam, N., additional, Wier, E., additional, Alphonse, M.P., additional, Sweren, E., additional, Wang, G., additional, Liu, H., additional, Kim, D., additional, Li, A., additional, Lee, S., additional, Xue, Y., additional, Reddy, S., additional, Miller, L., additional, Yu, J., additional, Huang, W., additional, Jones, J.W., additional, Kim, S., additional, Kane, M., additional, Silverman, R.H., additional, and Garza, L.A., additional

Published
2023
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12. Factors Influencing the Choice of Entreprenurship in Bangladesh: A Case Study of Dhaka City

Author

Islam N

Subjects
Economic freedom, Entrepreneurship, Human migration, business.industry, media_common.quotation_subject, Unemployment, Respondent, Sample (statistics), Personal knowledge base, Business, Marketing, Affect (psychology), media_common
Abstract

In Bangladesh, the development of entrepreneurship is especially significant for its intrinsic role of creating new employment opportunities, income generation, and ultimately poverty reduction. This research has put substantial effort to identify what factors affect an individual to be an entrepreneur. The underlying factors are categorized as push associated with some negative forces and pull linked with some positive forces. Primary data were collected from 57 respondents picked up purposively from among the individuals engaged in various entrepreneurial activities. The ownership style, nature of enterprise, Experience, educational qualifications, push and pull factors of the sample enterprises were considered as the main sources of primary data. Due to Covid's 19 pandemic situation, primary data were collected through the construction of structured google based survey questionnaire containing 12 pull factors and 7 push factors, finalized by reviewing several national and international literature. The data analysis has been performed in two ways: Average Response of the Respondent on a statement, Principle Component Analysis (PCA) using STATA tool. Based on a comparison between the outcome of “Average Response of the Respondent on a statement” and “Principle Component Analysis (PCA) of the Responses”, “Curse of Unemployment” has been identified as a push factor that compelled the respondents to become an entrepreneur. On the other hand, “Strong will power to do something by own”, “Self-Employment and Economic Freedom”, “Use of Personal Knowledge and Previous Experience” and “Career Advancement” have been found to be leading pull factors that encourage respondents to become an entrepreneur.

Published
2021

13. Association Between Accelerometer-Assessed Physical Activity and Severity of COVID-19 in UK Biobank.

Author

Rowlands, AV, Dempsey, PC, Gillies, C, Kloecker, DE, Razieh, C, Chudasama, Y, Islam, N, Zaccardi, F, Lawson, C, Norris, T, Davies, MJ, Khunti, K, Yates, T, Rowlands, AV, Dempsey, PC, Gillies, C, Kloecker, DE, Razieh, C, Chudasama, Y, Islam, N, Zaccardi, F, Lawson, C, Norris, T, Davies, MJ, Khunti, K, and Yates, T

Abstract

OBJECTIVE: To quantify the association between accelerometer-assessed physical activity and coronavirus disease 2019 (COVID-19) outcomes. METHODS: Data from 82,253 UK Biobank participants with accelerometer data (measured 2013-2015), complete covariate data, and linked COVID-19 data from March 16, 2020, to March 16, 2021, were included. Two outcomes were investigated: severe COVID-19 (positive test result from in-hospital setting or COVID-19 as primary cause of death) and nonsevere COVID-19 (positive test result from community setting). Logistic regressions were used to assess associations with moderate to vigorous physical activity (MVPA), total activity, and intensity gradient. A higher intensity gradient indicates a higher proportion of vigorous activity. RESULTS: Average MVPA was 48.1 (32.7) min/d. Physical activity was associated with lower odds of severe COVID-19 (adjusted odds ratio per standard deviation increase: MVPA, 0.75 [95% CI, 0.67 to 0.85]; total, 0.83 [0.74 to 0.92]; intensity, 0.77 [0.70 to 0.86]), with stronger associations in women (MVPA, 0.63 [0.52 to 0.77]; total, 0.76 [0.64 to 0.90]; intensity, 0.63 [0.53 to 0.74]) than in men (MVPA, 0.84 [0.73 to 0.97]; total, 0.88 [0.77 to 1.01]; intensity, 0.88 [0.77 to 1.00]). In contrast, when mutually adjusted, total activity was associated with higher odds of a nonsevere infection (1.10 [1.04 to 1.16]), whereas the intensity gradient was associated with lower odds (0.91 [0.86 to 0.97]). CONCLUSION: Odds of severe COVID-19 were approximately 25% lower per standard deviation (∼30 min/d) MVPA. A greater proportion of vigorous activity was associated with lower odds of severe and nonsevere infections. The association between total activity and higher odds of a nonsevere infection may be through greater community engagement and thus more exposure to the virus. Results support calls for public health messaging highlighting the potential of MVPA for reducing the odds of severe COVID-19.

Published
2021

15. Comparing X-ray color selection in separating X-ray binary classes using color-color-intensity diagrams

Author

Islam, N., primary, Vrtilek, S.D., additional, Boroson, Bram, additional, Kim, D.-W., additional, O’Sullivan, E., additional, McCollough, M.L., additional, Fabbiano, G., additional, Anderson, C., additional, Burke, D.J., additional, D’Abrusco, R., additional, Fruscione, A., additional, Lauer, J.L., additional, Morgan, D., additional, Mossman, A., additional, Paggi, A., additional, and Trinchieri, G., additional

Published
2021
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16. 620 RNase L is a regeneration repressor gene

Author

Wier, E., primary, Alphonse, M.P., additional, Wang, G., additional, Islam, N., additional, Sweren, E., additional, Liu, H., additional, Li, A., additional, Reddy, S., additional, Miller, L., additional, Lee, S.(., additional, Kane, M., additional, Silverman, R., additional, and Garza, L.A., additional

Published
2021
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17. Deletion of Thioredoxin-interacting protein ameliorates high fat diet-induced non-alcoholic steatohepatitis through modulation of Toll-like receptor 2-NLRP3-inflammasome axis: Histological and immunohistochemical study

Author

Nahla Reda Sarhan, Mohamed Ahmed Eladl, Mohamed El-Sherbiny, Islam N. Mohamed, and Azza B. El-Remessy

Subjects
0301 basic medicine, medicine.medical_specialty, Histology, Thioredoxin-Interacting Protein, Normal diet, Inflammasomes, Blotting, Western, Diet, High-Fat, 03 medical and health sciences, Drug Delivery Systems, Non-alcoholic Fatty Liver Disease, Fibrosis, Internal medicine, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Mice, Knockout, business.industry, food and beverages, nutritional and metabolic diseases, Inflammasome, Cell Biology, General Medicine, Reference Standards, medicine.disease, Immunohistochemistry, Toll-Like Receptor 2, 030104 developmental biology, Endocrinology, Liver, Steatohepatitis, Steatosis, Macrovesicular hepatic steatosis, Carrier Proteins, business, Gene Deletion, TXNIP, medicine.drug
Abstract

Endemic prevalence of obesity is associated with alarming increases in non-alcoholic steatohepatitis (NASH) with limited available therapeutics. Toll-like receptor2 (TLR2) and Nod-like receptor protein 3 (NLRP3) Inflammasome are implicated in hepatic steatosis, inflammation and fibrosis; the histological landmark stages of NASH. TXNIP, a member of α-arrestin family activates NLRP3 in response to various danger stimuli. The aim of current work was to investigate the effect of TXNIP genetic deletion on histological manifestations of high fat diet-induced steatohepatitis and activation of TLR2-NLRP3-inflammasome axis. Wild-type mice (WT) and TXNIP knock out (TKO) littermates were randomized to normal diet (WT-ND and TKO-ND) or high fat diet (HFD, 60% fat) (WT-HFD and TKO-HFD). After 8-weeks, liver samples from all groups were evaluated by histological, immunohistochemical and western blot analysis. HFD resulted in significant induction of micro and macrovesicular hepatic steatosis, that was associated with increased inflammatory immune cell infiltration in WT-HFD compared with WT-ND and TKO-ND controls, but not in TKO-HFD group. In parallel, WT-HFD group showed significant fibrosis and α-SMA expression; a marker of pro-fibrotic stellate-cell activation, in areas surrounding the central vein and portal circulation, versus all other groups. Western blot revealed increased activation of TLR2-NLRP3 inflammasome pathway and downstream IL-1β and TNFα in WT-HFD group, but not in TKO-HFD group. IL-1β expression coincided within the same areas of steatosis, inflammatory cell infiltration, collagen deposition and α-SMA expression in WT-HFD mice, that was significantly reduced in TKO-HFD mice. In conclusion, TXNIP deletion ameliorates the HFD-induced steatosis, inflammatory and fibrotic response via modulation of TLR2-NLRP3 inflammasome axis. Targeting TXNIP-TLR2-NLRP3 pathway may provide potential therapeutic modalities for NASH treatment.

Published
2018

20. 794 RNase L is a regeneration repressor gene

Author

Islam, N., primary, Wier, E.M., additional, Alphonse, M., additional, Liu, H., additional, Kim, D., additional, Li, A., additional, Reddy, S., additional, Miller, L.S., additional, Weiliang, H., additional, Lee, S., additional, Kim, S., additional, Wang, G., additional, Kane, M., additional, Silverman, R., additional, and Garza, L., additional

Published
2020
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21. 795 Bacteria induce skin regeneration

Author

Wang, G., primary, Liu, H., additional, Wier, E.M., additional, Ortines, R., additional, Islam, N., additional, Li, A., additional, Xue, Y., additional, Wang, Y., additional, Archer, N., additional, Miller, L.S., additional, and Garza, L., additional

Published
2020
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22. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study

Author

Nepogodiev, Dmitri, primary, Wilkin, Richard JW, additional, Bradshaw, Catherine J, additional, Skerritt, Clare, additional, Ball, Alasdair, additional, Moni-Nwinia, Waaka, additional, Blanco-Colino, Ruth, additional, Chauhan, Priyesh, additional, Drake, Thomas M, additional, Frasson, Matteo, additional, Gee, Oliver, additional, Glasbey, James C, additional, Matthews, Jacob H, additional, Morley, Gabriella L, additional, Naumann, David N, additional, Pata, Francesco, additional, Soares, Antonio S, additional, Bhangu, Aneel, additional, Abbas, SH, additional, Abdelgadir, AM, additional, Abdelrahman, A, additional, Abdelrahman, M, additional, Abdelwahed, A, additional, Abou El Ella, Y, additional, Abulafi, M, additional, Acharya, A, additional, Adam, ME, additional, Adams, RE, additional, Adegbola, SO, additional, Adimonye, A, additional, Adnan, M, additional, Afshar, S, additional, Ahad, A, additional, Ahel, J, additional, Ahern, DP, additional, Ahmad Asmadi, A, additional, Ahmed, B, additional, Ahmed, G, additional, Ahmed, OS, additional, Ahmed, S, additional, Akbari, K, additional, Akinsola, O, additional, Al-Khyatt, W, additional, Al-Sarireh, B, additional, Al-Sheikh, M, additional, Alani, M, additional, Alexander, R, additional, Alhammali, T, additional, Ali, M, additional, Aljorfi, A, additional, Allen, M, additional, Allington, J, additional, Alshafei, A, additional, Amarasinghe, R, additional, Amayo, A, additional, Amin, V, additional, Amuthalingam, Thuva, additional, Anandan, L, additional, Anderson, O, additional, Andreani, SM, additional, Andrews, B, additional, Ang, A, additional, Aravind, B, additional, Archer, JE, additional, Aremu, MA, additional, Arunachalam, S, additional, Aruparayil, N, additional, Ashmore, DL, additional, Ashour, O, additional, Ashraf, N, additional, Assaf, N, additional, Avalapati, H, additional, Awokoya, OO, additional, Ayube-Brown, J, additional, Badenoch, T, additional, Bagga, R, additional, Baginski, A, additional, Bailey, S, additional, Bailey, STR, additional, Baird, C, additional, Baker, B, additional, Balai, EJ, additional, Balasubramaniam, A, additional, Bandyopadhyay, SK, additional, Banks, A, additional, Bansal, H, additional, Barnieh, W, additional, Barrie, A, additional, Barter, CA, additional, Bastianpillai, J, additional, Beasley, WD, additional, Bell, CR, additional, Bell, J, additional, Beral, D, additional, Berry, BJM, additional, Bevan, KE, additional, Bevan, V, additional, Bhanderi, Shiv, additional, Bhargava, A, additional, Bilku, D, additional, Birindelli, A, additional, Blackford, OD, additional, Blackwell, JEM, additional, Blake, L, additional, Blencowe, Natalie S, additional, Boam, TD, additional, Boereboom, C, additional, Bogdan, M, additional, Bohra, P, additional, Bolger, JC, additional, Bolton, W, additional, Bond, S, additional, Borg, CM, additional, Borghol, K, additional, Boshier, PR, additional, Bouhadiba, N, additional, Bowen, J, additional, Bowerman, H, additional, Bowman, CR, additional, Boyd-Carson, H, additional, Bradshaw, CJ, additional, Branagan, G, additional, Brennan, P, additional, Brett, M, additional, Brewer, HK, additional, Brewer, H, additional, Bronder, C, additional, Brown, A, additional, Brown, AG, additional, Brown, CE, additional, Brown, M, additional, Brown, R, additional, Buckley-Jones, S, additional, Budzanowski, A, additional, Bukhari, W, additional, Bull, C, additional, Bullivant, JK, additional, Burns, KM, additional, Burnside, D, additional, Busuttil, A, additional, Byrne, BE, additional, Byrnes, CK, additional, Caldwell, M, additional, Callan, R, additional, Cameron, FC, additional, Campbell, U, additional, Campbell, UM, additional, Campbell, W, additional, Carden, CA, additional, Carder, CFW, additional, Carney, K, additional, Cartwright, H, additional, Cay, P, additional, Chalk, A, additional, Chambers, B, additional, Champsi, A, additional, Chan, D, additional, Chan, TCW, additional, Chandler, SB, additional, Chapman, J, additional, Charalabopoulos, A, additional, Chasty, B, additional, Chatzikonstantinou, M, additional, Cheah, WL, additional, Chean, CS, additional, Cheng, S, additional, Cheng, SA, additional, Cheruvu, M, additional, Chin, MY, additional, Chishti, IA, additional, Choi, S, additional, Chok, SM, additional, Chong, B, additional, Choong, JH, additional, Chowdhary, M, additional, Chowdhury, F, additional, Choy, CH, additional, Christian, L, additional, Christopoulos, P, additional, Chui, K, additional, Cipparrone, M, additional, Clark, GL, additional, Clarke, SA, additional, Cleeve, SJ, additional, Clement, KD, additional, Clements, B, additional, Clements, C, additional, Clements, JD, additional, Clements, JM, additional, Clements, JS, additional, Clements, JA, additional, Clingan, R, additional, Cloney, L, additional, Clough, ECS, additional, Coe, PO, additional, Collier-Wakefield, O, additional, Colliver, DW, additional, Colvin, DA, additional, Connelly, TM, additional, Connor, MJ, additional, Cook, V, additional, Cooke, F, additional, Cooper, F, additional, Cotton, AE, additional, Couch, DG, additional, Cousins, L, additional, Coyle, D, additional, Creasy, W, additional, Cresner, RL, additional, Crone, A, additional, Cross, K, additional, Crozier, J, additional, Cunha, P, additional, Curtis, NJ, additional, D'Souza, N, additional, Dagash, H, additional, Dalmia, S, additional, Daniels, I, additional, Danquah-Boateng, D, additional, Dar, FA, additional, Dart, K, additional, Das, A, additional, Daureeawoo, R, additional, Davidson, S, additional, Davidson, JR, additional, Davies, PL, additional, Davis, S, additional, Daya Shetty, V, additional, De-Manzoni-Garberini, A, additional, De-Marchi, JA, additional, Dean, EA, additional, Dean, S, additional, Delimpalta, C, additional, Denley, S, additional, Dennison, G, additional, Devine, AA, additional, Dharamavaram, S, additional, Dhari, AA, additional, Di Franco, F, additional, Di Saverio, S, additional, Dobson, C, additional, Docherty, JA, additional, Doherty, C, additional, Donaldson, G, additional, Donohoe, NO, additional, Donohoe, O, additional, Douka, E, additional, Doulias, T, additional, Downey, M, additional, Doyle, C, additional, Drye, N, additional, Du, DT, additional, Dudek, JG, additional, Dunning, PG, additional, Dyal, ARS, additional, Eardley, NJ, additional, Earnshaw, L, additional, Easdon, S, additional, Edwards, SE, additional, Egan, RJ, additional, El-Masry, S, additional, El-Tayar, O, additional, Elbourne, CR, additional, Elgaddal, S, additional, Elseedawy, M, additional, Elshaer, M, additional, Elsharnoby, OH, additional, Elzeneini, WMA, additional, Emslie, KM, additional, Engall, NFT, additional, Ertansel, B, additional, Esmail, HD, additional, Ettles, C, additional, Evans, J, additional, Evans, JD, additional, Everden, A, additional, Fadel, M, additional, Fahmy, SE, additional, Fairfield, CJ, additional, Fanibi, BF, additional, Farina, Valeria, additional, Farrell, SM, additional, Farrow, EZ, additional, Fasuyi, JA, additional, Faulkner, G, additional, Fawkner-Corbett, D, additional, Fawzi, F, additional, Fehervari, M, additional, Ferguson, N, additional, Finch, JG, additional, Finlayson, H, additional, Flack, T, additional, Foers, W, additional, Foley, NM, additional, Ford, K, additional, Forgie, A, additional, Foster, A, additional, Foster, JD, additional, Fox, AMW, additional, Francis, N, additional, Franklin, D, additional, Froud, H, additional, Fuller, HL, additional, Gaines, E, additional, Galea, J, additional, Gammeri, E, additional, Garnham, J, additional, Garvin, J, additional, Gates, Z, additional, Gentry, R, additional, Ghaffari, I, additional, Ghatorae, S, additional, Gidwani, AL, additional, Gilbert, TG, additional, Gilbert, TM, additional, Gill, S, additional, Gillespie, M, additional, Gillick, J, additional, Giorga, A, additional, Gopalakrishnan, K, additional, Gopalswamy, S, additional, Gopinath, S, additional, Gormely, R, additional, Govind, G, additional, Grant, C, additional, Graveston, J, additional, Gray, J, additional, Gray, RT, additional, Griffith, D, additional, Griffith, JP, additional, Griffiths, Ewen A, additional, Griffiths, SN, additional, Griggs, EJ, additional, Grosvenor, S, additional, Grove, T, additional, Gulamhussein, M, additional, Guliani, J, additional, Gummaraju, A, additional, Gunning, S, additional, Gurjar, SV, additional, Guru-Naidu, S, additional, Gurung, S, additional, Habib, H, additional, Hackney, L, additional, Haddow, James B, additional, Hajibandeh, S, additional, Halkias, C, additional, Hall, NJ, additional, Hamelmann, RN, additional, Haneef, M, additional, Haneef, MS, additional, Hanif, Z, additional, Hanley, C, additional, Hann, AJ, additional, Hanna, T, additional, Hardy, E, additional, Harlinska, A, additional, Harper, F, additional, Harries, RL, additional, Harris, A, additional, Harris, Grant, additional, Harris, MP, additional, Hasan, R, additional, Hassane, A, additional, Hatt, JR, additional, Haveliwala, Z, additional, Hawkins, W, additional, Hayat, Z, additional, Hayes, C, additional, Hebbar, KRM, additional, Henderson, L, additional, Henderson, LT, additional, Herrod, PJJ, additional, Hever, P, additional, Hickey, LM, additional, Hicks, G, additional, Hodgson, JM, additional, Hoff, M, additional, Hollingsworth, A, additional, Hook, A, additional, Hornby, ST, additional, Horsfield, E, additional, Howie, EE, additional, Huang, L, additional, Hudson-Peacock, NJ, additional, Hughes, DL, additional, Hureibi, KA, additional, Hussain, A, additional, Hussain, N, additional, Hussaini, SA, additional, Hussein, A, additional, Hutchinson, B, additional, Ibrahim, YMS, additional, Ikram, S, additional, Ilozue, T, additional, Iosif, E, additional, Iqbal, MR, additional, Irukulla, S, additional, Irwin, R, additional, Islam, N, additional, Ivey, P, additional, Jackson, CR, additional, Jackson, A, additional, Jah, SMH, additional, Jain, A, additional, Jain, S, additional, Jain, Sarus, additional, Jama, GM, additional, Jamieson, NB, additional, Janardanan, S, additional, Jasinski, B, additional, Jenner, D, additional, Jerome, E, additional, Johnson, B, additional, Johnstone, A, additional, Jokhan, S, additional, Jones, A, additional, Jones, CE, additional, Jones, CS, additional, Jones, E, additional, Jones, L, additional, Kabir, U, additional, Kabwama, S, additional, Kamal, M, additional, Kamande, IW, additional, Kanakala, V, additional, Kannegieser-Bailey, M, additional, Kaptanis, S, additional, Karim, MJ, additional, Karwal, RS, additional, Kaur, G, additional, Keegan, R, additional, Kelay, A, additional, Kennedy, ND, additional, Kent, DA, additional, Khair, A, additional, Khan, K, additional, Khan, S, additional, Khasria, A, additional, Kho, H, additional, Kilkenny, J, additional, King, R, additional, Kinross, J, additional, Kirkham, EN, additional, Knight, B, additional, Kochupapy, R, additional, Koh, C, additional, Kouli, O, additional, Krishnamoorthy, A, additional, Krivan, S, additional, Kumar, K, additional, Kumar, S, additional, Kung, VWS, additional, Kuo, R, additional, Lafaurie, G, additional, Lai, CW, additional, Lal, N, additional, Lawday, S, additional, Layman, S, additional, Layton, GR, additional, Lazzaro, A, additional, Lecky-Thompson, L, additional, Lee, KA, additional, Lee, KJ, additional, Lee, M, additional, Lee, SL, additional, Leighton, PA, additional, Leitch, RP, additional, Lennox-Warburton, HC, additional, Leung, EL, additional, Li, CH, additional, Lim, JM, additional, Limb, C, additional, Ljungqvist, G, additional, Lloyd, G, additional, Lodhia, S, additional, Logan, PC, additional, Long, M, additional, Long, P, additional, Long, RH, additional, Longshaw, A, additional, Louw, C, additional, Lund, JN, additional, Ly, C, additional, Lynch Wong, MJ, additional, Ma, JKY, additional, Macdonald, A, additional, Macinnes, EGE, additional, Magro, T, additional, Mahapatra, R, additional, Mahendran, B, additional, Mahmood, F, additional, Mahmoud, A, additional, Mahon, D, additional, Mai, D, additional, Maina, A, additional, Major, CP, additional, Makhija, R, additional, Malam, Y, additional, Malik, A, additional, Malik, K, additional, Malik, SN, additional, Manda, VM, additional, Manektella, KM, additional, Mann, C, additional, Manoharan, P, additional, Manson, R, additional, Mansoor, S, additional, Mansour, MM, additional, Mansour, S, additional, Maqboul, F, additional, Maragouthakis, D, additional, Marangoni, G, additional, Mardhiah, S, additional, Maripi, H, additional, Marriott, P, additional, Marsh, L, additional, Marshall, G, additional, Martin, A, additional, Martin, LM, additional, Martinou, E, additional, Mashar, R, additional, Mason, John, additional, Masood, M, additional, Mathew, G, additional, Maude, K, additional, Mazumdar, E, additional, Mc-Dermott, A, additional, Mcarthur, D, additional, Mccain, RS, additional, McCain, S, additional, Mccann, C, additional, Mccaughey, P, additional, Mccluney, SJ, additional, Mccullough, J, additional, Mcdonnell, D, additional, Mcdowall, NA, additional, McEntee, JE, additional, McGlynn, K, additional, Mcgrath, D, additional, Mcgucken, O, additional, Mcilwaine, S, additional, Mcilwrath, AC, additional, Mckay, SC, additional, McKelvie, MA, additional, Mckenna, M, additional, Mckeon, J, additional, Mckevitt, KL, additional, Mckinley, NC, additional, McLaughlin, D, additional, McMahon, SV, additional, Mcmorran, D, additional, McNally, L, additional, Mcquaid, M, additional, Mcwhirter, DM, additional, Mealy, K, additional, Mears, A, additional, Menzies, D, additional, Merai, H, additional, Mersh, RJ, additional, Miguras, M, additional, Milgrom, D, additional, Miller, K, additional, Milward, J, additional, Mirza, S, additional, Misky, AT, additional, Mistry, D, additional, Mitchard, MJ, additional, Mitru, RM, additional, Mohamed, IM, additional, Mohamed, Imran, additional, Mohamed, TM, additional, Mohamed, WO, additional, Mohd, N, additional, Moore, C, additional, Moradzadeh, J, additional, Morrison, TEM, additional, Morrison-Jones, V, additional, Morton, Dion G, additional, Mothe, BS, additional, Motiwala, Fh, additional, Motter, D, additional, Mowbray, NG, additional, Mughal, Z, additional, Mulsow, J, additional, Mundkur, N, additional, Muntean, A, additional, Murphy, C, additional, Murphy, R, additional, Murray, MP, additional, Muzaffar, M, additional, Myatt, A, additional, Nadeem, A, additional, Nagarajan, D, additional, Nagendram, S, additional, Nair, A, additional, Nair, MK, additional, Nair, MS, additional, Naismith, KN, additional, Nambiar, K, additional, Nana, GR, additional, Nash, Z, additional, Nastro, P, additional, Nazarian, S, additional, Neagle, G, additional, Neale, A, additional, Neary, PM, additional, Newton, RC, additional, Ng, M, additional, Ng, S, additional, Niaz, O, additional, Nickson, S, additional, Nicol, D, additional, Nimako, E, additional, Noor Mohamed, MS, additional, Nyeko-Lacek, M, additional, O'Connor, BR, additional, O'Neill, E, additional, O'Neill, N, additional, O'Sullivan, D, additional, O'Brien, J, additional, Oakey, M, additional, Obeid, N, additional, Odeh, A, additional, Ogboru, S, additional, Ogbuokiri, C, additional, Okekunle, B, additional, Okorocha, E, additional, Olagbaiye, O, additional, Olivier, JB, additional, Ooi, R, additional, Orawiec, P, additional, Orizu, M, additional, Orme, N, additional, Ormiston, R, additional, Paget, C, additional, Pal, A, additional, Palani-Velu, LK, additional, Pan, Y, additional, Panda, N, additional, Pandey, V, additional, Pandya, R, additional, Pandya, D, additional, Paramasevon, KR, additional, Pardy, C, additional, Parkola, MJ, additional, Pasquali, Sandro, additional, Patel, AS, additional, Patel, BY, additional, Patel, C, additional, Patel, H, additional, Patel, N, additional, Patel, RT, additional, Patel, S, additional, Patel, Y, additional, Patel, MM, additional, Patil, SD, additional, Payne, 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Published
2020
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30. Contribution of machining to the fatigue behaviour of metal matrix composites (MMCs) of varying reinforcement size

Author

Pramanik, A., Islam, N., Davies, I., Boswell, B., Dong, Yu, Basak, A., Uddin, M., Dixit, A., Pramanik, A., Islam, N., Davies, I., Boswell, B., Dong, Yu, Basak, A., Uddin, M., and Dixit, A.

Abstract

The high cycle constant stress amplitude fatigue performance of metal matrix composite (MMC) components machined by a milling process was investigated in this study as a function of machining speed, feed rate and reinforcement particle size. The presence of reinforcement and particle size were found to be the most influential factors that affected the fatigue life. In contrast to this, the effect of feed and speed on tool-particle interaction, strain hardening and heat generation during milling of MMCs were balanced in such a way that the contributions of feed and speed on fatigue life were negligible. The interactions of different parameters contributed significantly to the fatigue life which indicated that the modelling of fatigue life based on these three parameters was relatively complex. The fatigue life of the machined MMC samples increased with decreasing particle size and increasing feed. However, the fatigue life was not influenced by speed variation. The presence of smaller or no particles induced a complete separation of failed samples, in contrast to that of specimens containing larger reinforcing particles where crack growth was arrested or deflected by the reinforcing particles.

Published
2017

38. Deletion of TXNIP Mitigates High Fat Diet-Impaired Blood Flow and Inflammation in a Model of Critical Limb Ischemia

Author

Wael Eldahshan, Renee Lorys, M. Nusrul Hoda, Sally L. Elshaer, Maha Coucha, Sara Altantawi, Islam N. Mohamed, and Azza B. El-Remessy

Subjects
medicine.medical_specialty, medicine.diagnostic_test, digestive, oral, and skin physiology, Ischemia, food and beverages, Skeletal muscle, Inflammation, Biology, medicine.disease, Biochemistry, Endocrinology, Insulin resistance, medicine.anatomical_structure, Western blot, Physiology (medical), Internal medicine, Diabetes mellitus, Knockout mouse, medicine, medicine.symptom, TXNIP
Abstract

Introduction Previous work demonstrated that silencing thioredoxin-interacting protein (TXNIP) prevents diabetes-impaired vascular recovery in diabetic model. Here, we examine the impact of high fat diet (HFD) on impaired vascular recovery and possible protective roles of deleting TXNIP. We hypothesize that deletion of TXNIP prevents HFD-mediated nitrative stress, inflammation and preserves vascular recovery. Methods Wild type mice (WT, C57Bl/6) and TXNIP knockout mice (TKO) were fed either normal chow (WT-ND and TKO-ND) or 60% fat diet (WT-HFD and TKO-HFD). After 4 weeks of HFD, unilateral hind limb ischemia was performed and blood flow was measured using Laser doppler scanner at baseline and then weekly for additional 3 weeks. Vascular density, nitrative stress, infiltration of CD68-macrophages, and expression of inflammasome, VEGF, VEGF receptor-2 were examined by slot blot, Western blot and immunohistochemistry. Results HFD increased total body weight and induced insulin resistance in both WT and TKO mice. HFD significantly impaired blood flow and vascular density (CD31 labeled) in skeletal muscle of WT mice compared to ND but not in TKO. HFD and ischemia induced tyrosine nitration, cleaved caspase-1 and IL-1 and infiltration of CD68 in skeletal muscle from WT but not from TKO. HFD or ischemia had no effect on VEGF or VEGFR2 levels in all groups. Under ND, ischemia induced phosphorylation of VEGFR2 in both WT and TKO. HFD impaired VEGFR2 activation in WT but not in TKO. Conclusion Similar to diabetes, HFD-induced obesity can compromise vascular recovery in response to ischemic insult. The mechanism involves increased nitrative stress and impaired VEGFR2 activation. Deletion of TXNIP reduced nitrative stress and restored VEGFR2 signaling and blood flow in HFD. Targeting TXNIP can provide potential therapeutic target in obesity-induced vascular complication.

Published
2016

46. Corrections to “A multicenter phase II study incorporating high-dose rituximab and liposomal doxorubicin into the CODOX-M/IVAC regimen for untreated Burkitt's lymphoma”

Author

Evens, A.M., primary, Carson, K.R., additional, Kolesar, J., additional, Nabhan, C., additional, Helenowski, I., additional, Islam, N., additional, Jovanovic, B., additional, Barr, P.M., additional, Caimi, P.F., additional, Gregory, S.A., additional, and Gordon, L.I., additional

Published
2014
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