1. Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity
- Author
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Ryan S. Gray, Isabelle Roszko, and Lilianna Solnica-Krezel
- Subjects
Frizzled ,Polarity (physics) ,Mammalian embryology ,Biology ,Article ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,0302 clinical medicine ,Cell polarity ,Animals ,Humans ,Cilia ,Molecular Biology ,Body Patterning ,030304 developmental biology ,chemistry.chemical_classification ,0303 health sciences ,Cilium ,Cell Polarity ,Cell Biology ,Embryo, Mammalian ,Embryonic stem cell ,Frizzled Receptors ,Cell biology ,Dishevelled ,chemistry ,Microtubule-Organizing Center ,030217 neurology & neurosurgery ,Intracellular ,Signal Transduction ,Developmental Biology - Abstract
Planar cell polarization entails establishment of cellular asymmetries within the tissue plane. An evolutionarily conserved planar cell polarity (PCP) signaling system employs intra- and intercellular feedback interactions between its core components, including Frizzled, Van Gogh, Flamingo, Prickle, and Dishevelled, to establish their characteristic asymmetric intracellular distributions and coordinate planar polarity of cell populations. By translating global patterning information into asymmetries of cell membranes and intracellular organelles, PCP signaling coordinates morphogenetic behaviors of individual cells and cell populations with the embryonic polarity. In vertebrates, by polarizing cilia in the node/Kupffer's vesicle, PCP signaling links the anteroposterior to left-right embryonic polarity.
- Published
- 2011
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