1. Acute Cardiovascular Manifestations in 286 Children with Multisystem Inflammatory Syndrome Associated with COVID-19 Infection in Europe
- Author
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Andreia Francisco, Phuoc Duong, Shalan Uaid Fadl, Karl Viktor Perminow, Owen Miller, Vladislav Vukomanovic, Marisa Vieira, Gabriela Doros, Savina Mannarino, Israel Valverde, Francisco Gonzalez Barlatay, Maria Ilina, Ornella Milanesi, Beata Kucińska, Irene M. Kuipers, Antigoni Deri, Fernando Centeno, Susana Maria Rey-García, Zdenka Reinhardt, Victoria C. Ziesenitz, Simona Anna Marcora, Ana R. Sousa, Begoña Manso, Moises Rodriguez-Gonzalez, Jussi Niemelä, Jelena Hubrechts, Cecilia Lazea, Gernot Grangl, Joan Sanchez-de-Toledo, Almudena Ortiz-Garrido, Ferran Gran, Daniël De Wolf, Giulia Bordin, Abigail Sharpe, Francesca Cairello, Bernadette Brent, Gauri Nepali, Isabelle Loeckx, Paraskevi Theocharis, Sylvie Di Filippo, Colin J. McMahon, Ashish Chikermane, Emanuela Valsangiacomo-Buchel, Giridhar Soda, Marie-Christine Seghaye, Fatima Pinto, Paolo Ciliberti, Xavier Iriart, Giulia Tuo, Yogen Singh, Wendy Dewals, Constancio Medrano-Lopez, Amalia Tamariz-Martel, Carlo Pace Napoleone, Andrea Donti, Federico Gutierrez-Larraya, and Kristof Vandekerckhove
- Subjects
medicine.medical_specialty ,Ejection fraction ,biology ,business.industry ,030204 cardiovascular system & hematology ,medicine.disease ,Pericardial effusion ,Procalcitonin ,3. Good health ,Ferritin ,03 medical and health sciences ,0302 clinical medicine ,Troponin complex ,Intensive care ,Internal medicine ,Shock (circulatory) ,biology.protein ,medicine ,030212 general & internal medicine ,medicine.symptom ,10. No inequality ,business ,Cardiac imaging - Abstract
Background: The aim of the study was to document cardiovascular clinical findings, cardiac imaging and laboratory markers in children presenting with the novel multisystemic inflammatory syndrome associated with COVID-19. Methods: A real-time internet based survey was sent via the member mailing database for Association for European Paediatric and Congenital Cardiologists (AEPC) working groups for Cardiac Imaging and Cardiovascular Intensive Care member. Inclusion criteria was children 0-18 years admitted to hospital between March 1 and June 6, 2020 with diagnosis of an inflammatory syndrome and acute cardiovascular complications. Findings: A total of 286 children from 55 centres from 17 European countries were included. The median age was 8·4 years (IQR 3·8-12·4 years) and 67% were males. Most common cardiovascular complications were shock (40%), cardiac arrhythmias (35%), pericardial effusion (28%) and coronary artery dilatation (24%). Reduced left ventricular ejection fraction was present in 52% of patients and 93% had raised cardiac troponin (cTnT). The biochemical markers of inflammation were raised in majority of patients on admission: elevated CRP (99%), ferritin (79%), procalcitonin (96%), NT-proBNP (93%), IL-6 level (88%) and D-dimers (90%). There was a statistically significant correlation between degree of elevation in cardiac and biochemical parameters and need of intensive care support (p
- Published
- 2020