1. Obesogenic Alterations in Adrenal Function and Neurotransmitter Balance Improved with Dietary Supplementation (P21-008-19)
- Author
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Ingrid Kohlstadt, Jeffrey Firewalker Schmitt, and Roy Watkins
- Subjects
medicine.medical_specialty ,Nutrition and Dietetics ,business.industry ,Medicine (miscellaneous) ,Dehydroepiandrosterone ,chemistry.chemical_compound ,Norepinephrine ,Endocrinology ,medicine.anatomical_structure ,chemistry ,Internal medicine ,medicine ,Adrenal function ,Obesity ,Serotonin ,Neurotransmitter ,business ,Hypothalamic–pituitary–adrenal axis ,Food Science ,Balance (ability) ,Hydrocortisone ,medicine.drug - Abstract
OBJECTIVES: Dysfunction of the HPA axis, as evidenced by alterations in the diurnal salivary cortisol rhythm, has been shown to contribute to the pathophysiology of obesity both directly by skewing body composition and indirectly by altering appetite and microbiome. The aim of this study was to assess the impact of a laboratory and clinical-guided dietary supplemental protocol on HPA axis dysfunction. METHODS: This study examines a cohort of 703 patients utilizing a clinical analysis of 1. Hypothalamic-pituitary-adrenal axis tests which were 4 point salivary cotisol, 2 point salivary DHEA, and 6 urinary neurotransmitters. 2. Self-reported Quality of Life questionnaire 3. Personalized dietary supplementation with neurotransmitter amino acid precursors and/or adrenal support monitored for 8 months. RESULTS: Pre and post test demonstrated improved sleep quality (47%, P
- Published
- 2019
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