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Start Over Author "Ili-Yun Jeong" Publisher elsevier bv
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1. Novel heterocyclic ring-expansion and/or dehydration-hydration reactions of propargylic and allenylic hydroxy γ-lactams in the presence of strong base or Lewis acid

Author

Ili-Yun Jeong, Yoshimitsu Nagao, Motoo Shiro, Woo Song Lee, Satoru Goto, and Shigeki Sano

Subjects
Benzazepines, Chemistry, Organic Chemistry, Drug Discovery, medicine, Organic chemistry, Dehydration, Lewis acids and bases, medicine.disease, Ring (chemistry), Biochemistry, Medicinal chemistry
Abstract

Dehydration-hydration products were obtained in good yields by the treatment of propargylic hydroxy γ-lactams with some Lewis acids. Several propargylic and allenylic hydroxy γ-lactams were successfully converted to the corresponding ring-expanded benzazepines in various yields via a tandem decyclization-cyclization process in the presence of (TMS)2NLi, (TMS)2NNa, or n-BuLi under reflux conditions in THF.

Published
1998
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