1. Light and electron microscopic evaluation of antileukotriene therapy on human endometriosis
- Author
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Ichiro Uchiide, Tomomi Ihara, and Masao Sugamata
- Subjects
Pathology ,medicine.medical_specialty ,business.industry ,Leukotriene receptor ,medicine.medical_treatment ,Antagonist ,Endometriosis ,General Medicine ,medicine.disease ,Treatment period ,law.invention ,Antileukotriene ,Apoptosis ,law ,Medicine ,Electron microscope ,business ,Electron microscopic - Abstract
To evaluate the effect of leukotriene receptor antagonist (LTR-A) on human endometriosis, we examined morphological alterations under light and electron microscope, clinical symptoms, and formation of fibrous adhesion using the revised American Fertility Society classification (r-AFS score) in endometriosis cases with and without LTR-A treatment. Morphologically, the lesions of LTR-A-treated cases showed not only decrease of activated mast cells but also numerous apoptotic fibroblasts. Collagen fibers around these apoptotic fibroblasts were filamentous and thin compared with those of nontreated cases, partially condensed or disappeared completely. In LTR-A-treated cases, a significant decrease of r-AFS score was observed (p
- Published
- 2004
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