1. Biosilica-enveloped ferritin cage for more efficient drug deliveries
- Author
-
Hyun Sik Jun, Seung Pil Pack, Thi Khoa My Nguyen, and Mi-Ran Ki
- Subjects
Drug ,chemistry.chemical_classification ,biology ,media_common.quotation_subject ,Bioengineering ,Peptide ,02 engineering and technology ,Matrix (biology) ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Biocompatible material ,01 natural sciences ,Applied Microbiology and Biotechnology ,Biochemistry ,Small molecule ,0104 chemical sciences ,Ferritin ,chemistry ,Chemical engineering ,biology.protein ,0210 nano-technology ,Cage ,Drug carrier ,media_common - Abstract
Ferritin (FT), a cage-protein composed of 24 subunits, may carry small molecules inside the core of cage. To enhance the potential of FT as a more functional drug carrier, FT genetically-fused with silaffin R5 peptide at N-terminus (R5FT) and silica-enveloped cage protein (SiO2/R5FT) were developed. Doxorubicin (Dox) can be loaded into cage interior by re-assembly of R5FT. The release of Dox loaded in internal cages was retarded by the silica-coated matrix and showed the pH-controlled behavior, in which the release amount is larger in acidic environments than neutral. R5FT provides a biocompatible and eco-friendly manufacturing process for the drug-laden silica nanoparticles over conventional production methods.
- Published
- 2018