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All over the world there is serious concern about the shortage of organs available for transplantation. In an effort to address this, transplantation with grafts, which was previously considered a contraindication, are now performed. In some cases, this practice has contributed to increasing the organ pool. Fibromuscular dysplasia (FMD) is the second-most-common cause of renovascular hypertension and is observed in 2%-6.6% of potential live kidney donors. Kidney with FMD is generally considered to be a contraindication for renal transplantation because renal artery stenosis may progress after transplantation and cause graft loss. Here, we report on a successful case of kidney transplantation using a graft with FMD of a deceased donor who had multiple aneurysms in the renal artery.

To evaluate the potential of anthocyanin as a supplement for the treatment of Peyronie disease (PD) by examining the anti-inflammatory and antifibrosis activities of anthocyanin in a PD animal model.We performed the preliminary experiment to confirm the plaque formation of tunica albuginea (TA). Six animals received fibrin (TISSEEL VH Sealer; Baxter, Glendale, CA; 30 μL each of human fibrin and thrombin solutions) injections into the TA. After 2 weeks, PD-like plaque formation was confirmed by Masson trichrome staining in preliminary experimental animal group. A PD rat model was made by intratunical injection of fibrin. Experimental animals were divided into 3 groups as follows: control group (n = 8), PD group (n = 8), and anthocyanin-treated group (n = 8) that received anthocyanin at 50 mg/kg twice a day for 4 weeks using orogastric tubes. After 4 weeks, penile tissue was collected to perform Masson trichrome and transforming growth factor (TGF)-β1 staining.We confirmed PD-like plaque formation by Masson trichrome stain 2 weeks after fibrin injection. The ratio of smooth muscle cells in the corpus cavernosum in the PD group was significantly lower than that of the control group (P.05). The PD group showed strong TGF-β1 immunoreactivity with increased expression in the collagenous connective tissues and fibroblasts around the TA.We confirmed PD-like plaque formation after 2 weeks of fibrin injections into the TA. This is the first study to suggest that anthocyanin extracted from black soybean may have anti-inflammatory and antifibrotic effects for penile plaque formation in rat PD models.

Background The need for liver retransplantation (re-LT) has been increasing. Here we describe the outcome and technical aspects of re-LT during 25 years in a single major center. Methods We retrospectively reviewed patients who underwent LT from March 1988 to February 2013. Among 1,312 LTs during 25 years, 38 (2.9%) were re-LTs, including 28 adults (mean age 52.0 y) and 10 children (mean age 5.7 y). Results The most common indication was primary nonfunction in early re-LT and biliary complication in late re-LT. Preoperative major comorbidity was very common (81.6%). Among them, infection was the most frequent (52.6%). Living-donor re-LT constituted 21.1%. In operative technique, nonconventional methods were substantially performed, including high hilar dissection for hepatectomy (>50%), arterial anastomosis with the use of right gastroepiploic or jump graft (23.7%), and hepaticoenterostomy (60.5%). Several reanastomoses were needed in 10.5% for artery and 5.3% for duct. In adults and children, mean estimated blood losses were 9,541 mL and 977 mL, respectively. Mean operative times for adults and children were 508 and 432 minutes, respectively. In-hospital mortality was 35.7% in adults and 40.0% in children. The main cause of death was sepsis for both adults and children. Survival rates at 1 month and 1, 3, and 5 years were, respectively, 89.4%, 56.5%, 50.3%, and 50.3% in adults, and 70.0%, 60.0%, 60.0%, and 60.0% in children. Conclusions Outcome of re-LT is poorer than primary LT regardless of the cause of graft failure. Therefore, more technical concerns need to be considered. We also need more efforts to control perioperative infections to improve survival after re-LT.