Search

Your search keyword '"Howells, Lynne"' showing total 7 results
Start Over Author "Howells, Lynne" Publisher elsevier bv
7 results on '"Howells, Lynne"'

3. Curcumin Combined with FOLFOX Chemotherapy Is Safe and Tolerable in Patients with Metastatic Colorectal Cancer in a Randomized Phase IIa Trial

Author

Howells, Lynne M, primary, Iwuji, Chinenye O O, additional, Irving, Glen R B, additional, Barber, Shaun, additional, Walter, Harriet, additional, Sidat, Zahirah, additional, Griffin-Teall, Nicola, additional, Singh, Rajinder, additional, Foreman, Nalini, additional, Patel, Samita R, additional, Morgan, Bruno, additional, Steward, William P, additional, Gescher, Andreas, additional, Thomas, Anne L, additional, and Brown, Karen, additional

Published
2019
Full Text
View/download PDF

4. Curcumin inhibits cancer stem cell phenotypes in ex vivo models of colorectal liver metastases, and is clinically safe and tolerable in combination with FOLFOX chemotherapy

Author

James, Mark I., Iwuji, Chinenye, Irving, Glen, Karmokar, Ankur, Higgins, Jennifer A., Griffin-Teal, Nicola, Thomas, Anne, Greaves, Peter, Cai, Hong, Patel, Samita R., Morgan, Bruno, Dennison, Ashley, Metcalfe, Matthew, Garcea, Giuseppe, Lloyd, David M., Berry, David P., Steward, William P., Howells, Lynne M., and Brown, Karen

Subjects
Colorectal liver metastases, Cancer Research, Curcumin, Oncology, Cancer stem cells, Combination therapy, digestive system diseases
Abstract

In vitro and pre-clinical studies have suggested that addition of the diet-derived agent curcumin may provide a suitable adjunct to enhance efficacy of chemotherapy in models of colorectal cancer. However, the majority of evidence for this currently derives from established cell lines.Here, we utilised patient-derived colorectal liver metastases (CRLM) to assess whether curcumin may provide added benefit over 5-fluorouracil (5-FU) and oxaliplatin (FOLFOX) in cancer stem cell (CSC) models. Combination of curcumin with FOLFOX chemotherapy was then assessed clinically in a phase I dose escalation study. Curcumin alone and in combination significantly reduced spheroid number in CRLM CSC models, and decreased the number of cells with high aldehyde dehydrogenase activity (ALDHhigh/CD133−). Addition of curcumin to oxaliplatin/5-FU enhanced anti-proliferative and pro-apoptotic effects in a proportion of patient-derived explants, whilst reducing expression of stem cell-associated markers ALDH and CD133. The phase I dose escalation study revealed curcumin to be a safe and tolerable adjunct to FOLFOX chemotherapy in patients with CRLM (n = 12) at doses up to 2 grams daily.Curcumin may provide added benefit in subsets of patients when administered with FOLFOX, and is a well-tolerated chemotherapy adjunct.

Published
2015
Full Text
View/download PDF

7. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells

Author

Squires, Matthew S., primary, Hudson, E.Ann, additional, Howells, Lynne, additional, Sale, Stewart, additional, Houghton, Catherine E., additional, Jones, J.Louise, additional, Fox, Louise H., additional, Dickens, Martin, additional, Prigent, Sally A., additional, and Manson, Margaret M., additional

Published
2003
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results