1. Performance of the CoreValve Evolut R and PRO in Severely Calcified Anatomy: A Propensity Score Matched Analysis
- Author
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Katharina Hellhammer, Maryam Al Juburi, Gerald Antoch, Malte Kelm, Shazia Afzal, Houtan Heidari, Verena Veulemans, Kerstin Piayda, Anna Christina Wimmer, and Tobias Zeus
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Aortic valve ,Time Factors ,medicine.medical_treatment ,Hemodynamics ,030204 cardiovascular system & hematology ,Prosthesis Design ,Severity of Illness Index ,Transcatheter Aortic Valve Replacement ,03 medical and health sciences ,0302 clinical medicine ,Valve replacement ,Risk Factors ,Humans ,Medicine ,In patient ,030212 general & internal medicine ,Propensity Score ,Retrospective Studies ,Aged, 80 and over ,Bioprosthesis ,business.industry ,Calcinosis ,Aortic Valve Stenosis ,Anatomy ,medicine.disease ,Treatment Outcome ,medicine.anatomical_structure ,Aortic Valve ,Heart Valve Prosthesis ,Aortic valve stenosis ,Propensity score matching ,Clinical safety ,Female ,Aortic valve calcification ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Background The CoreValve Evolut R and PRO (Medtronic, Minneapolis, MN, USA) are among the newest-generation of self-expandable transcatheter aortic valve replacement (TAVR) devices and show excellent results. Treating patients with severely calcified (SC) native aortic valve anatomy may be challenging because of the increased risk of periprocedural complications. This study investigated the performance of Evolut R and PRO in this special patient subset. Methods Patients who underwent TAVR with the CoreValve Evolut R or PRO (n=381) from September 2015 to March 2018 were divided by aortic valve calcification extent. Patients with SC aortic valve anatomy (n=98; men, >2,062 and women, >1,377 Agatston units) were compared with those with non-severely calcified (NCS) aortic valve anatomy after 1:2 propensity score matching. Outcomes were evaluated according to the updated valve academic research consortium criteria. Results Patients with SC anatomy were older (83 years vs 80 years, p Conclusion The CoreValve Evolut R and PRO showed good clinical safety profiles and excellent haemodynamic results in patients with SC anatomy and who more often required permanent pacemaker implantation.
- Published
- 2020
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