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Start Over Author "Hiroyasu Watanabe" Publisher elsevier bv
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1. Enantioselective addition of dialkylzinc to aldehydes catalyzed by (S)-2-(N,N-disubstituted aminomethyl)indoline

Author

Kiyoshi Honda, Masatoshi Asami, Hiroyasu Watanabe, and Seiichi Inoue

Subjects
Inorganic Chemistry, chemistry.chemical_compound, chemistry, Organic Chemistry, Indoline, Enantioselective synthesis, Physical and Theoretical Chemistry, Medicinal chemistry, Catalysis
Abstract

Chiral di- or triamines, ( S )-2-( N , N -disubstituted aminomethyl)indoline 1a – d , derived from ( S )-indoline-2-carboxylic acid were efficient chiral catalysts for the enantioselective addition of dialkylzincs to aldehydes. The best results were obtained by employing 15 mol% of ( S )-2-(4-methylpiperazin-1-ylmethyl)indoline 1c , and chiral secondary alcohols were obtained in up to 97% ee.

Published
1998
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