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Start Over Author "Henrik K. Munch" Publisher elsevier bv
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1. A new efficient synthesis of isothiocyanates from amines using di-tert-butyl dicarbonate

Author

Jon S. Hansen, Henrik K. Munch, Ulrik Boas, Michael Pittelkow, and Jørn B. Christensen

Subjects
chemistry.chemical_classification, Aryl, Organic Chemistry, DABCO, Biochemistry, Di-tert-butyl dicarbonate, Catalysis, chemistry.chemical_compound, chemistry, Thiourea, Drug Discovery, Organic chemistry, Amine gas treating, Dicarbonate, Alkyl
Abstract

Alkyl and aryl amines are converted smoothly to the corresponding isothiocyanates via the dithiocarbamates in good to excellent yields using di- tert -butyl dicarbonate (Boc 2 O) and 1–3 mol % of DMAP or DABCO as catalyst. As most of the byproducts are volatile, the work-up involves simple evaporation of the reaction mixture.

Published
2008
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