1. Adverse Effects of Atropine on the Sinus Node in Familial Amyloid Polyneuropathy
- Author
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Yoichi Hokamura, Toru Okajima, Yoshiaki Matsumoto, Haruhiko Tokuomi, Tadahiro Ono, and Yutaka Horio
- Subjects
Adult ,Atropine ,Male ,Pulmonary and Respiratory Medicine ,Bradycardia ,Critical Care and Intensive Care Medicine ,medicine ,Humans ,Paresthesia ,Adverse effect ,Cycle length ,Sinus (anatomy) ,Sinoatrial Node ,business.industry ,Sinoatrial node ,Amyloidosis ,Syndrome ,medicine.disease ,medicine.anatomical_structure ,Anesthesia ,Heart Function Tests ,Amyloid polyneuropathy ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
Electrophysiologic studies were performed in a 33-year-old man with familial amyloid polyneuropathy (FAP) before and after administration of atropine, 1 mg intravenously. Atropine induced prolongation of the sinus node cycle length, sinoatrial conduction time, and sinus nodal recovery time. These findings indicate that the therapeutic doses of atropine may be useless or potentially detrimental for bradyarrhythmias or sinoatrial conduction disturbances in some patients with FAP.
- Published
- 1982
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