247 results on '"Hannun, Yusuf A."'
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2. Neutral ceramidase-active site inhibitor chemotypes and binding modes
3. A Novel HSPB1S139F Mouse Model of Charcot-Marie-Tooth Disease
4. ACSL1 is a key regulator of inflammatory and macrophage foaming induced by short-term palmitate exposure or acute high-fat feeding
5. A simple, highly sensitive, and facile method to quantify ceramide at the plasma membrane
6. Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury
7. Short-Term Palmitate Exposure or Acute High Fat Feeding Promotes a Foamy and Inflammatory Macrophage Phenotype Which Involves ACSL1-Associated Signaling via the CD36/FABP4/P38/PPARδ Axis
8. 1-Deoxysphinganine initiates adaptive responses to serine and glycine starvation in cancer cells via proteolysis of sphingosine kinase
9. ACSL1 Is a Key Regulator of Inflammatory and Macrophage Foaming Induced by Short-Term Palmitate Exposure or Acute High-Fat Feeding
10. Bioactive sphingolipids: Advancements and contributions from the laboratory of Dr. Lina M. Obeid
11. Synthesis of erythro- B13 enantiomers and stereospecific action of full set of B13-isomers in MCF7 breast carcinoma cells: Cellular metabolism and effects on sphingolipids
12. Erratum: Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis
13. Identification of Small-Molecule Inhibitors of Neutral Ceramidase (nCDase) via Target-Based High-Throughput Screening
14. Inhibition of acid ceramidase regulates MHC class II antigen presentation and suppression of autoimmune arthritis
15. Probing compartment-specific sphingolipids with targeted bacterial sphingomyelinases and ceramidases
16. Approaches for probing and evaluating mammalian sphingolipid metabolism
17. The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme
18. Multiple actions of doxorubicin on the sphingolipid network revealed by flux analysis
19. Quantifying 1-deoxydihydroceramides and 1-deoxyceramides in mouse nervous system tissue
20. Emergence of membrane sphingolipids as a potential therapeutic target
21. Neutral ceramidase: Advances in mechanisms, cell regulation, and roles in cancer
22. Dose dependent actions of LCL521 on acid ceramidase and key sphingolipid metabolites
23. Functions of neutral ceramidase in the Golgi apparatus
24. Visualizing bioactive ceramides
25. Tsc3 regulates SPT amino acid choice in Saccharomyces cerevisiae by promoting alanine in the sphingolipid pathway
26. Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria
27. An intrinsic lipid-binding interface controls sphingosine kinase 1 function
28. Quantification of 3-ketodihydrosphingosine using HPLC-ESI-MS/MS to study SPT activity in yeast Saccharomyces cerevisiae
29. Probing de novo sphingolipid metabolism in mammalian cells utilizing mass spectrometry
30. The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1
31. Identification of an acid sphingomyelinase ceramide kinase pathway in the regulation of the chemokine CCL5 [S]
32. Sphingosine 1-phosphate activation of ERM contributes to vascular calcification
33. Alkaline Ceramidase 1 Protects Mice from Premature Hair Loss by Maintaining the Homeostasis of Hair Follicle Stem Cells
34. Contributions of the Intrinsic Mutation Process to Cancer Mutation and Risk Burdens
35. Inhibiting glucosylceramide synthase exacerbates cisplatin-induced acute kidney injury
36. Novel sphingosine kinase-1 inhibitor, LCL351, reduces immune responses in murine DSS-induced colitis
37. Ceramide Is Metabolized to Acylceramide and Stored in Lipid Droplets
38. Ceramidases, roles in sphingolipid metabolism and in health and disease
39. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation
40. Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols
41. Tumor Necrosis Factor-α (TNFα)-induced Ceramide Generation via Ceramide Synthases Regulates Loss of Focal Adhesion Kinase (FAK) and Programmed Cell Death
42. Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase
43. GPR40/FFA1 and neutral sphingomyelinase are involved in palmitate-boosted inflammatory response of microvascular endothelial cells to LPS
44. Endoplasmic reticulum heat shock protein gp96 maintains liver homeostasis and promotes hepatocellular carcinogenesis
45. Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization
46. Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes
47. Targeting (cellular) lysosomal acid ceramidase by B13: Design, synthesis and evaluation of novel DMG-B13 ester prodrugs
48. Sphingolipids and mitochondrial function in budding yeast
49. Defining a Role for Acid Sphingomyelinase in the p38/Interleukin-6 Pathway
50. Evolving concepts in cancer therapy through targeting sphingolipid metabolism
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