34 results on '"Hang Yao"'
Search Results
2. Process optimization and thermal hazard analysis of the preparation of diphenyl sulfoxide using hydrogen peroxide as oxidant
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Qingwei Song, Lei Ni, Juncheng Jiang, Zhiquan Chen, Gang Fu, Hang Yao, and Zhen Cheng
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Environmental Engineering ,General Chemical Engineering ,Environmental Chemistry ,Safety, Risk, Reliability and Quality - Published
- 2022
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Catalog
3. A microenvironment sensitive pillar[5]arene-based fluorescent probe for cell imaging and drug delivery
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Qing Wang, Hang Yao, Chao-Guo Yan, Xiaohui Yuan, Xiaoyan Bian, Jingwen Fan, and Ying Han
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Fluorescent nanoparticles ,biology ,Chemistry ,Cell ,Pillar ,Serum albumin ,Nanoparticle ,General Chemistry ,Fluorescence ,medicine.anatomical_structure ,Drug delivery ,medicine ,biology.protein ,Biophysics ,Drug carrier - Abstract
Dansylamide (DNSA) is a typical ICT probe that has a favorable serum albumin sensitivity. Inspired by this, we designed a microenvironment sensitive fluorescent probe 4C-G through introducing DNSA into pillar[5]arene. Unlike DNSA, 4C-G displayed differentiated sensitivity to multiple proteins, which was benefit from pillar[5]arene assisted the probe to form complexes with proteins. 4C-G could not only be applied in imaging of HepG2, but also act as a favorable drug carrier for regorafenib (REG) encapsulation. The 4C-G-REG complex would aggregate into high drug-loading fluorescent nanoparticles in a physiological environment (pH 7.4). Such nanoparticles exhibited pH-triggered enrichment ability, which rapidly enriched REG in the acidic environment (pH 6.0). Furthermore, the complexation between 4C-G and REG maintained the imaging property of the probe and the excellent anticancer activity of the drug on HepG2. more...
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- 2022
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4. Investigation of pyrolysis kinetics, mechanism and thermal stability of tert-butyl peroxy-2-ethyl hexanoate
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Hang Yao, Juncheng Jiang, Bocun Li, Lei Ni, Yuqing Ni, and Xinyu Yao
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Environmental Engineering ,General Chemical Engineering ,Environmental Chemistry ,Safety, Risk, Reliability and Quality - Published
- 2022
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5. GSDMD in peripheral myeloid cells regulates microglial immune training and neuroinflammation in Parkinson's disease
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Bingwei Wang, Yan Ma, Sheng Li, Hang Yao, Mingna Gu, Ying Liu, You Xue, Jianhua Ding, Chunmei Ma, Shuo Yang, and Gang Hu
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General Pharmacology, Toxicology and Pharmaceutics - Published
- 2023
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6. Repair of Large-Scale Osteochondral Defects Under an Induced Condition of Osteoarthritis in Rat Knee Joint with Decellularized Tissue-Engineered Hyaline Cartilage Graft
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Xu Hu, Min Jin, Kang Sun, Zhen Zhang, Peilai Liu, Hang Yao, and Dong-an Wang
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- 2023
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7. Thermal hazard characteristics and essential mechanism study of 1-hydroxybenzotriazole: Thermodynamic study combined DFT simulation
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Zhang, Han, primary, Jiang, Juncheng, additional, Fei, Miao, additional, Ni, Lei, additional, and Hang, Yao, additional
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- 2022
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8. Recent advances in cardiovascular stent for treatment of in-stent restenosis: Mechanisms and strategies
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Nan Huang, Jinrong Ma, Lang Jiang, Jingan Li, Hang Yao, Jin Wang, and Yuwei He
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medicine.medical_specialty ,Environmental Engineering ,business.industry ,General Chemical Engineering ,medicine.medical_treatment ,Stent ,General Chemistry ,equipment and supplies ,medicine.disease ,Biochemistry ,Practical guideline ,Vascular stent ,surgical procedures, operative ,Restenosis ,Polymeric drug ,Medicine ,cardiovascular diseases ,In stent restenosis ,business ,Intensive care medicine ,Cardiovascular stent ,Medical costs - Abstract
Treatments of atherogenesis, one of the most common cardiovascular diseases (CVD), are continuously being made thanks to innovation and an increasingly in-depth knowledge of percutaneous transluminal coronary angioplasty (PTCA), the most revolutionary medical procedure used for vascular restoration. Combined with an expanding balloon, vascular stents used at stricture sites enable the long-time restoration of vascular permeability. However, complication after stenting, in-stent restenosis (ISR), hinders the advancement of vascular stents and are associated with high medical costs for patients for decades years. Thus, the development of a high biocompatibility stent with improved safety and efficiency is urgently needed. This review provides an overview of current advances and potential technologies for the modification of stents for better treatment and prevention of ISR. In particular, the mechanisms of in-stent restenosis are investigated and summarized with the aim to comprehensively understanding the pathogenesis of stent complications. Then, according to different therapeutic functions, the current stent modification strategies are reviewed, including polymeric drug eluting stents, biological friendly stents, pro-healing stents, and gene stents. Finally, the review provides an outlook of the challenges in the design of stents with optimal properties. Therefore, this review is a valuable and practical guideline for the development of cardiovascular stents. more...
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- 2021
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9. Process hazard evaluation and exothermic mechanism for the synthesis of n-butylmagnesium bromide Grignard reagent in different solvents
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Hang Yao, Shuliang Ye, Qiang Chen, Wei Jiang, Junjie Wang, Fusheng Cui, Juncheng Jiang, Lei Ni, and Zhen Cheng
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Exothermic reaction ,021110 strategic, defence & security studies ,Environmental Engineering ,Materials science ,Thermal runaway ,General Chemical Engineering ,Inorganic chemistry ,0211 other engineering and technologies ,Ether ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Isothermal process ,chemistry.chemical_compound ,chemistry ,Bromide ,Reagent ,Environmental Chemistry ,Diethyl ether ,Safety, Risk, Reliability and Quality ,Tetrahydrofuran ,0105 earth and related environmental sciences - Abstract
The synthesis of Grignard reagents, which are formed by the reaction of magnesium and organic halides (RX), is hazardous because of the highly exothermic nature of this reaction. In this work, calorimetry and infrared (IR) spectroscopy were used to identify the exothermic mechanism and process hazards for the synthesis of n-butylmagnesium bromide Grignard reagent (n-BuMgBr) in diethyl ether (DE), tetrahydrofuran (THF), 2-methyltetrahydrofuran (2-MeTHF), cyclopentylmethyl ether (CPME), and diethylene glycol butyl ether (DGBE). The latter three solvents were chosen by the substitution principle of the “inherent safety” design concept, which aims to reduce the risk of the target reaction in a fundamental manner. An EasyMax102 calorimeter was used to characterize the exothermic behavior of the reactions using isothermal and isoperibolic experiments carried out in a semi-batch glass reactor coupled with an IR probe to monitor changes in the species and concentrations during the reaction process. An adiabatic TAC-500A calorimeter was also used to understand the adiabatic decomposition behavior of the products obtained in the isothermal experiments under the worst-case (cooling failure and thermal runaway) scenario. Meanwhile, density functional theory calculations were performed to understand the reaction pathway and associated energies based on the experimental data. Further, the risk assessment of thermal runaway was analyzed using a risk matrix and a Stoessel criticality diagram. The results indicate that the risk of the reactions when using 2-MeTHF, CPME, and DGBE are all class 1, making reactions in these solvents inherently safer than those using DE or THF, which were both class-3 risks. These findings provide further evidence that 2-MeTHF, CPME, and DGBE are safer than the typical solvents used for the industrial production of Grignard reagents. more...
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- 2021
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10. MoS2/graphene composites: Fabrication and electrochemical energy storage
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Yang Bai, Hang Yao, Yan Zhao, Chunli Liu, and Huan Pang
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Supercapacitor ,Fabrication ,Materials science ,Renewable Energy, Sustainability and the Environment ,Graphene ,Energy Engineering and Power Technology ,Heterojunction ,02 engineering and technology ,Electrolyte ,Conductivity ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,law.invention ,chemistry.chemical_compound ,chemistry ,law ,General Materials Science ,Composite material ,0210 nano-technology ,Molybdenum disulfide ,Electrochemical energy storage - Abstract
Numerous studies have focused on the development of energy-storage devices, such as batteries and supercapacitors (SCs). As molybdenum disulfide (MoS2) and graphene have complementary physical properties and similar layered structures, they can be combined in specific ways to create heterostructures. This capability alleviates the weaknesses of the individual counterparts and optimizes their performance. Recent advances have revealed that the unique structure and morphology, as well as the continuous conductive channels of MoS2/graphene (MoS2/G) composites, provide more active sites, improve the conductivity, and accelerate the charge transport and electrolyte diffusion of the material. Thus, MoS2/G composites could provide new opportunities for energy-storage technologies. In this review, we summarize and discuss recent advances and potential applications of MoS2/G composites in energy-storage devices. More importantly, we expound the improvement in the electrochemical performance of composites with functional materials and via heteroatom-doping. Furthermore, we discuss the challenges and opportunities for the future direction of MoS2/G composites. more...
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- 2020
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11. Drd2 biased agonist prevents neurodegeneration against NLRP3 inflammasome in Parkinson’s disease model via a β-arrestin2-biased mechanism
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Jing Zhang, Gang Hu, Jian-Hua Ding, Jialei Zhu, Hang Yao, Hong Zhu, Dongshuo Wang, Yang Liu, Ting Sun, and Ming Lu
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0301 basic medicine ,Agonist ,Inflammasomes ,medicine.drug_class ,Immunology ,Substantia nigra ,Neuroprotection ,Mice ,03 medical and health sciences ,Behavioral Neuroscience ,chemistry.chemical_compound ,0302 clinical medicine ,NLR Family, Pyrin Domain-Containing 3 Protein ,medicine ,Animals ,Neuroinflammation ,Receptors, Dopamine D2 ,Endocrine and Autonomic Systems ,Chemistry ,Dopaminergic Neurons ,MPTP ,Neurodegeneration ,MPTP Poisoning ,Parkinson Disease ,Inflammasome ,medicine.disease ,Cell biology ,Mice, Inbred C57BL ,Disease Models, Animal ,beta-Arrestin 1 ,030104 developmental biology ,medicine.anatomical_structure ,Neuron ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Activated astrocytes secrete inflammatory cytokines such as interleukin-1β (IL-1β) into the extracellular milieu, damaging surrounding neurons and involving in the pathogenesis of neurodegenerative diseases, such as Parkinson's disease (PD). Dopamine receptor D2 (Drd2) expresses both in neurons and astrocytes, and neuronal Drd2 is a significant target in therapy of PD. Our previous study reveals that astrocytic Drd2 exerts anti-inflammatory effect via non-classical β-arrestin2 signaling in PD model. Therefore, seeking new biased ligands of Drd2 with better efficacy and fewer side effects to treat PD is desirable and meaningful. In the present study, we evaluated the effects of UNC9995, a novel biased Drd2 agonist on astrocyte-derived neuroinflammation and dopaminergic (DA) neuron degenerationin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. We showed that UNC9995 rescued the TH+ neurons loss and inhibited glial cells activation in mouse substantia nigra in a Drd2 dependent manner. Focusing on astrocytes, we found UNC9995 shows a relatively safe concentration range and significantly suppresses astrocytic NLRP3 inflammasome activation induced by lipopolysaccharide plus ATP. Further study revealed that the anti-inflammatory effect of UNC9995 is independent of Drd2 / Gαi protein pathway. It activates β-arrestin2 by recruiting it to cell membrane. Critically, UNC9995 enhances β-arrestin2 interacting with NLRP3 to interfere inflammasome assembly, which consequently reduces IL-1β production. On the other hand, UNC9995 inhibits IL-1β-induced inflammatory pathway activation in DA neurons and rescues subsequent apoptosis via β-arrestin2 interacting with protein kinases, such as JNK and suppressing their phosphorylation. Furthermore, β-arrestin2 knockout abolishes the anti-inflammatory and neuroprotective effects of UNC9995 in PD mouse model, supporting that UNC9995 is a β-arrestin2-biased Drd2 agonist and revealing its novel function in PD treatment. Collectively, this work illustrates that Drd2 agonist UNC9995 prevents DA neuron degeneration in PD and provides a new strategy for developing the β-arrestin2-biased ligands in the therapy of NDDs. more...
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- 2020
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12. Process safety evaluation and reaction mechanism of two step synthesis of tert-butyl hydrogen peroxide
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Miao Fei, Lei Ni, Tianyi Yan, Juncheng Jiang, Hang Yao, Han Zhang, and Chenwei Dai
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General Chemical Engineering ,General Chemistry - Published
- 2023
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13. Reaction mechanism and process safety assessment of acid-catalyzed synthesis of tert-butyl peracetate
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Yuying Zhang, Lei Ni, Hang Yao, Qiang Chen, Juncheng Jiang, Chi-Min Shu, Zhiquan Chen, Chenghao Li, and Wen Zhu
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Control and Systems Engineering ,General Chemical Engineering ,Energy Engineering and Power Technology ,Management Science and Operations Research ,Safety, Risk, Reliability and Quality ,Industrial and Manufacturing Engineering ,Food Science - Published
- 2023
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14. Mixed solvent exchange enabled high-performance polymeric gels
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Yongchuan Wu, Wenqian Xing, Jing Wen, Zhonglian Wu, Ya Zhang, Hechuan Zhang, Haidi Wu, Hang Yao, Huaiguo Xue, and Jiefeng Gao
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Polymers and Plastics ,Organic Chemistry ,Materials Chemistry - Published
- 2023
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15. Thermal Hazard and Pyrolysis Mechanism Investigation Using Thermal Analysis Coupled with Quantum-Chemical Dft Simulation for 1-Hydroxy-7-Azabenzotriazole
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Han Zhang, Juncheng Jiang, Lei Ni, Chi-Min Shu, and Hang Yao
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History ,Polymers and Plastics ,Business and International Management ,Industrial and Manufacturing Engineering - Published
- 2022
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16. Superhydrophobic hierarchical fiber/bead composite membranes for efficient treatment of burns
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Paul D. Topham, Hang Yao, Weichang Li, Linge Wang, Li Ren, Zhu Yue, Kan Yue, and Qianqian Yu
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Staphylococcus aureus ,Biocompatibility ,Cell Survival ,Polyesters ,0206 medical engineering ,Composite number ,Biomedical Engineering ,Microbial Sensitivity Tests ,02 engineering and technology ,Biochemistry ,Rats, Sprague-Dawley ,Biomaterials ,Mice ,Elastic Modulus ,Tensile Strength ,Escherichia coli ,Animals ,Lotus effect ,Molecular Biology ,Wound Healing ,integumentary system ,Chemistry ,Povidone ,Water ,Membranes, Artificial ,General Medicine ,Adhesion ,021001 nanoscience & nanotechnology ,Bandages ,020601 biomedical engineering ,Controlled release ,Microspheres ,Electrospinning ,Anti-Bacterial Agents ,Nanostructures ,Drug Liberation ,Membrane ,NIH 3T3 Cells ,Female ,Stress, Mechanical ,Burns ,0210 nano-technology ,Wound healing ,Hydrophobic and Hydrophilic Interactions ,Biotechnology ,Biomedical engineering - Abstract
One of the current challenges in burn wound care is the development of multifunctional dressings that can protect the wound from bacteria or organisms and promote skin regeneration and tissue reconstitution. To this end, we report the design and fabrication of a composite electrospun membrane, comprised of electrospun polylactide: poly(vinyl pyrrolidone)/polylactide: poly(ethylene glycol) (PLA:PVP/PLA:PEG) core/shell fibers loaded with bioactive agents, as a functionally integrated wound dressing for efficient burns treatment. Different mass ratios of PLA:PVP in the shell were screened to optimize mechanical, physicochemical, and biological properties, in addition to controlled release profiles of loaded antimicrobial peptides (AMPs) from the fibers for desirable antibacterial activity. Fibroblasts were shown to readily adhere and proliferate when cultured on the membrane, indicating good in vitro cytocompatibility. The introduction of PLA beads by electrospraying on one side of the membrane resulted in biomimetic micro-nanostructures similar to those of lotus leaves. This designer structure rendered the composite membranes with superhydrophobic property to inhibit the adhesion/spreading of exogenous bacteria and other microbes. The administration of the resulting composite fibrous membrane on burnt skin in an infected rat model led to faster healing than a conventional product (sterile silicone membrane) and control detailed herein. These composite fibrous membranes loaded with bioactive drugs provide an integrated strategy for promoting burn wound healing and skin regeneration. STATEMENT OF SIGNIFICANCE: To address an urgent need in complex clinical requirements on developing a new generation of wound dressings with integrated functionalities. This article reports research work on a hierarchical fiber/bead composite membranes design, which combines a lotus-leaf-like superhydrophobic surface with drugs preloaded in the core and shell of fibers for effective burn treatment. This demonstrates a balance between simplified preparation processes and increased multifunctionality of the wound dressings. The creation of hierarchically structured surfaces can be readily achieved by electrospinning, and the composite dressings possessed a considerable mechanical strength, effective wound exudate absorption and permeability, good biocompatibility, broad antibacterial ability and promoting wound healing etc. Thus, our work unveils a promising strategy for the development of functionally integrated wound dressings for burn wound care. more...
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- 2019
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17. Comparison of RFE-DL and stacking ensemble learning algorithms for classifying mangrove species on UAV multispectral images
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Bolin Fu, Xu He, Hang Yao, Yiyin Liang, Tengfang Deng, Hongchang He, Donglin Fan, Guiwen Lan, and Wen He
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Global and Planetary Change ,Management, Monitoring, Policy and Law ,Computers in Earth Sciences ,Earth-Surface Processes - Published
- 2022
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18. Utilization of pillar[5]arene-based ICT probes embedded into proteins for live-cell imaging and traceable drug delivery
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Qing, Wang, Xiaoyan, Bian, Hang, Yao, Xiaohui, Yuan, Ying, Han, and Chaoguo, Yan
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Quaternary Ammonium Compounds ,Biomaterials ,Drug Delivery Systems ,Biomedical Engineering ,Nanoparticles ,Bioengineering ,Calixarenes ,Fluorescent Dyes - Abstract
Three protein microenvironment-sensitive pillar[5]arene-based fluorescent probes (3/4/5C-B) were designed and synthesized based on intramolecular charge transfer (ICT) mechanism. Unlike the majority of micromolecular ICT probes, the aforementioned probes displayed differentiated sensitivity to multiple proteins. The 7-(diethylamino)coumarin-3-formic acid (DCCA) group in the probes was essential for their sensitivity. The presence of a pillar[5]arene group was also crucial as they benefit 3/4/5C-B form complexes with the proteins, although it changed the electron density distribution of the DCCA group. 3/4/5C-B exhibited favorable carrier ability for regorafenib (REG). 4C-B had the best spatial structure for complexation. The 3/4/5C-B-REG complexes would assemble into high drug-loading fluorescent nanoparticles in a physiological environment (pH = 7.4). Such nanoparticles exhibited pH-triggered enrichment ability, which rapidly enriched REG in the acidic environment (pH = 6.0). Moreover, the complexation between 3/4/5C-B and REG maintained the live-cell membrane imaging property of the probes and the excellent targeted anticancer activity of the drug. more...
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- 2022
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19. Magnetic nanoparticles combining teamed boronate affinity and surface imprinting for efficient selective recognition of glycoproteins under physiological pH
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Xiulian Yin, Jianming Pan, Hang Yao, Hengjia Zhu, Xia Kexu, Jinxin Liu, and Wenli Zhang
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chemistry.chemical_classification ,Glycidyl methacrylate ,Chemistry ,General Chemical Engineering ,Molecularly imprinted polymer ,Nanoparticle ,02 engineering and technology ,General Chemistry ,Polymer ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Combinatorial chemistry ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,chemistry.chemical_compound ,Polymerization ,Environmental Chemistry ,Magnetic nanoparticles ,0210 nano-technology ,Molecular imprinting ,Superparamagnetism - Abstract
Boronate-functionalized surface imprinted nanoparticles that function under physiological pH would be highly desirable for specific enrichment of target glycoproteins. In this work, magnetic molecularly imprinted polymers integrated with low pKa teamed boronate affinity (Fe3O4@PGMA-TBA/MIPs) were fabricated for selective separation of glycoprotein at pH = 7.4. The teamed boronate affinity (TBA) was formed by boron-nitrogen (B-N) coordination between 1,6-hexamethylenediamine and 3-aminophenylboronic acid, and then was fixed on the surface of magnetic poly(glycidyl methacrylate) (Fe3O4@PGMA) through ring-opening reaction. After immobilizing the template glycoproteins (ovalbumin, OVA), surface imprinting layer was deposited onto Fe3O4@PGMA-TBA surface via redox polymerization of aniline, and Fe3O4@PGMA-TBA/MIPs with obvious core–shell-shell structure were prepared by removing template. Fe3O4@PGMA-TBA/MIPs were demonstrated with an imprinted polymer film (10–20 nm) and exhibited superparamagnetic property (Ms = 32 emu g−1) and magnetic stability after multiple regenerations. Besides, the results of 11B MAS NMR spectrum and zeta potentials confirmed the presence of TBA resulting from B-N coordination. Additionally, taking advantage of surface imprinting and TBA, as-prepared Fe3O4@PGMA-TBA/MIPs posed high binding capacity (190.7 mg g−1) and fast capture kinetics (50 min) toward OVA under physiological pH. More importantly, because of the TBA was electroneutral at pH = 7.4, Fe3O4@PGMA-TBA/MIPs not only exhibited superior specific recognition toward OVA (imprinting factor IF = 7.51), but also maintained the activity of OVA from practical samples analysis. Therefore, this work opened up a universal route for developing intelligent controllability molecular imprinting materials for the specific separation of glycoproteins in biomedical filed under physiological pH. more...
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- 2018
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20. Down-regulation of Inwardly Rectifying K+ Currents in Astrocytes Derived from Patients with Monge’s Disease
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Hang Yao, Gabriel G. Haddad, Juan Wang, Wei Wu, and Helen Zhao
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0301 basic medicine ,Membrane potential ,medicine.medical_specialty ,Chemistry ,General Neuroscience ,Sodium channel ,Gating ,Neuropathology ,medicine.disease ,03 medical and health sciences ,Electrophysiology ,030104 developmental biology ,0302 clinical medicine ,Endocrinology ,Chronic mountain sickness ,Downregulation and upregulation ,health services administration ,Internal medicine ,medicine ,Patch clamp ,health care economics and organizations ,030217 neurology & neurosurgery - Abstract
Chronic mountain sickness (CMS) or Monge's disease is a disease in highlanders. These patients have a variety of neurologic symptoms such as migraine, mental fatigue, confusion, dizziness, loss of appetite, memory loss and neuronal degeneration. The cellular and molecular mechanisms underlying CMS neuropathology is not understood. In the previous study, we demonstrated that neurons derived from CMS patients' fibroblasts have a decreased expression and altered gating properties of voltage-gated sodium channel. In this study, we further characterize the electrophysiological properties of iPSC-derived astrocytes from CMS patients. We found that the current densities of the inwardly rectifying potassium (Kir) channels in CMS astrocytes (-5.7 ± 2.2 pA/pF at -140 mV) were significantly decreased as compared to non-CMS (-28.4 ± 3.4 pA/pF at -140 mV) and sea level subjects (-28.3 ± 5.3 pA/pF at -140 mV). We further demonstrated that the reduced Kir current densities in CMS astrocytes were caused by their decreased protein expression of Kir4.1 and Kir2.3 channels, while single channel properties (i.e., Po, conductance) of Kir channel in CMS astrocytes were not altered. In addition, we found no significant differences of outward potassium currents between CMS and non-CMS astrocytes. As compared to non-CMS and sea level subjects, the K+ uptake ability in CMS astrocytes was significantly decreased. Taken together, our results suggest that down-regulation of Kir channels and the resulting decreased K+ uptake ability in astrocytes could be one of the major molecular mechanisms underlying the neurologic manifestations in CMS patients. more...
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- 2018
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21. Thermal hazard and pyrolysis mechanism of tetrazolo[1,5-a]pyridine by TG, DSC, ARC, TG-MS and DFT methods
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Yuqing Ni, Hang Yao, Peihong Wu, Lei Ni, Xinyu Yao, and Juncheng Jiang
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Thermogravimetric analysis ,Materials science ,Activation energy ,Decomposition ,Analytical Chemistry ,Calorimeter ,chemistry.chemical_compound ,Fuel Technology ,Differential scanning calorimetry ,chemistry ,Pyridine ,Physical chemistry ,Density functional theory ,Pyrolysis - Abstract
The pyrolysis characteristics of tetrazolo[1,5-a]pyridine were investigated by thermogravimetric analysis (TG) and differential scanning calorimetry (DSC). The apparent activation energy (Eα) was estimated with DSC and various kinetic analysis methods, and it was determined that the decomposition of tetrazolo[1,5-a]pyridine follows the Avarami-Erofeve (A2) reaction pattern. The thermal safety and thermodynamic parameters were calculated. In addition, the thermal runaway behavior and kinetic parameters under adiabatic conditions were studied by employing an adiabatic accelerating calorimeter (ARC). Thermogravimetric-photoionization mass spectrometry (TG-MS) was used to identify the vapor phase products of the pyrolysis process. The different decomposition pathways were analyzed by density functional theory (DFT). The main decomposition products were N2, C2H2 and HCN according to TG-MS experiments and theoretical calculations. The most likely proposed decomposition mechanism proceeded through the opening of the tetrazole ring to dissociate N2 and the rupturing of the pyridine ring to release C2H2 and HCN. The findings of these experiments and theoretical calculations can contribute to the determination of safety precautions for possible heat hazard accidents during the handling, transportation, use and storage of tetrazolo[1,5-a]pyridine. more...
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- 2021
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22. Preparation and characterization of PVA-PEEK/PVA-β-TCP bilayered hydrogels for articular cartilage tissue repair
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Kang Junpei, Weichang Li, Jianxi Lu, Yingjun Wang, Yulin Yuan, Fengcai Xiao, Li Ren, Sa Liu, Hang Yao, and Wang Zhen
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Vinyl alcohol ,Materials science ,integumentary system ,Biocompatibility ,Scanning electron microscope ,technology, industry, and agriculture ,General Engineering ,macromolecular substances ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Microstructure ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Permeability (electromagnetism) ,Self-healing hydrogels ,Ceramics and Composites ,Articular cartilage repair ,Peek ,Composite material ,0210 nano-technology - Abstract
The poly(vinyl alcohol) (PVA) hydrogel is regarded as a potential articular cartilage replacement for its good biocompatibility, high permeability to fluid and load-bearing properties. This work investigated a novel Poly(vinyl alcohol)-polyetheretherketone/Poly(vinyl alcohol)-β-tricalcium phosphate (PVA-PEEK/PVA-β-TCP) bilayered hydrogels by freezing-thawing with biomimetic properties for articular cartilage and subchondral bone is developed. The bilayered hydrogels microarchitecture consists of a highly porous and dense structure, and the internal structure were analyzed by micro-CT. The morphology of the resulting hydrogels was analyzed by scanning electron microscopy (SEM), the enhancement of the mechanical properties of the PVA-PEEK/PVA-β-TCP bilayered hydrogels were demonstrated by mechanical testing. The bilayered structure indicate that a good bonding exist between the two layers, which is known to be a requisite necessary to assure a good integrity and functionality of the osteochondral construct. In addition, in vitro cell culture studies revealed that the hydrogels has no negative effect on the cell viability and proliferation and possess good biocompatibility. Then, the bilayered hydrogels were implanted into the knee joint defect of rabbits and hematoxylin and eosin and immunohistochemical staining. The PVA-PEEK/PVA-β-TCP bilayered hydrogels show good potential for use in the field of articular cartilage repair. more...
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- 2016
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23. Hydrolysis of urea induces the formation of bismuth-rich Bi4O5I2 nanosheets with promoted visible-light photoreduction of Cr (VI)
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Zhaohui Wu, Feng Hu, Deshou Zhang, Ziliang Zheng, Shiying Zhang, Hang Yao, Zhongfu Li, Min Wu, Kaiqiang Xu, and Shumin Zhang
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Materials science ,Mechanical Engineering ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,0104 chemical sciences ,Bismuth ,law.invention ,Solvent ,Hydrolysis ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,law ,Urea ,General Materials Science ,Calcination ,Charge carrier ,0210 nano-technology ,Ethylene glycol ,Nuclear chemistry ,Visible spectrum - Abstract
Bismuth-rich Bi4O5I2 nanosheets were prepared through progressive hydrolysis of urea in a facile solvothermal route, which is different from the conventional strategies of pH adjusting or calcination. To promote the hydrolysis of urea for the formation of Bi4O5I2 nanosheets, the type of solvents and urea concentration were the distinctive roles. Especially, urea concentration over 1.0 g but less than 3.0 g in the solvent of ethylene glycol could boost the formation of Bi4O5I2 nanosheets. Furthermore, the resulted Bi4O5I2 nanosheets possessing more negative conductive band level of −1.02 eV showed superior visible-light photoreduction activity of Cr (VI) due to the efficient separation of charge carriers. more...
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- 2021
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24. Synthesis of carbon nitride quantum dots and biocompatibility evaluation using C. elegans as a model organism
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Hualing Li, Jun Wang, Zhangyue Chen, Hui Chong, Chengyin Wang, Chengxin Fei, Di Yang, Hang Yao, Chuan Tan, Guoxiu Wang, and Hongying Fan
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Materials science ,Biocompatibility ,Pharyngeal pumping ,Quantum yield ,Nanoparticle ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Quantum dot ,Materials Chemistry ,Fluorescence microscope ,General Materials Science ,0210 nano-technology ,Carbon nitride - Abstract
Carbon nitride quantum dots (CNQDs) were synthesized by the solid-phase method. The obtained CNQDs were characterized by XPS, TEM, FTIR and XRD. The results suggested that the CNQDs were ball-like nanoparticles (average diameter of 5 nm) with carboxyl and hydroxyl groups on the surface. The fluorescent emissions of the CNQDs were centered at 478 nm upon excitation with 365 nm UV light. The corresponding fluorescent quantum yield was measured as 32 %. The biocompatibility of the CNQDs with the model organism Caenorhabditiselegans (C. elegans) was systematically evaluated. The synthesized CNQDs enhanced the pharyngeal pumping rate, body length and life span of nematodes in a concentration-dependent manner after 24 h of exposure. Thus, the CNQDs affected the growth of the nematodes. The reproduction and motion capability indicators, including the egg laying rate and head thrash and body bend frequencies, were not influenced by the CNQDs. Therefore, the CNQDs did not show obvious toxicity to the C. elegans nematode model organism. The CNQDs could be taken up by nematodes, as characterized by fluorescence microscopy, proving that this material could be applied as a promising in vivo fluorescent imaging reagent. more...
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- 2020
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25. Hollow cobalt-iron prussian blue analogue nanocubes for high-performance supercapacitors
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Huan Pang, Xiaxia Li, Hang Yao, and Peiyao Zhu
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Supercapacitor ,Prussian blue ,Materials science ,Renewable Energy, Sustainability and the Environment ,020209 energy ,Energy Engineering and Power Technology ,chemistry.chemical_element ,02 engineering and technology ,Electrolyte ,021001 nanoscience & nanotechnology ,Electrochemistry ,Capacitance ,Nanomaterials ,chemistry.chemical_compound ,chemistry ,Transition metal ,Chemical engineering ,0202 electrical engineering, electronic engineering, information engineering ,Electrical and Electronic Engineering ,0210 nano-technology ,Cobalt - Abstract
The hollow cobalt-iron Prussian blue analogue (Co2HCFe) is fabricated via simple co-precipitation at room temperature through a way of dominating the molar mass of transition metal cobalt. The hollow structure nanomaterials have more active sites, larger area in contact with electrolyte, and good electrical conductivity. These advantages make Co2HCFe exhibit excellent electrochemical performance as the electrode material of supercapacitor. At the current density of 0.5 A g−1, the specific capacitance of Co2HCFe even reaches 2526 F g−1 under alkaline conditions, while remaining a capacity retention rate of 90.25% after 2000 cycles. more...
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- 2020
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26. Copper-mediated synergistic catalytic titanium dioxide nanofilm with nitric oxide generation and anti-protein fouling for enhanced hemocompatibility and inflammatory modulation
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Nan Huang, Dan Zou, Lang Jiang, Jiang Chen, Chenjue Tang, Yuwei He, Congzhen Han, Hang Yao, Xiao Luo, Ansha Zhao, and Ping Yang
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Anatase ,Fouling ,Doping ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Nitric oxide ,Catalysis ,Metal ,chemistry.chemical_compound ,chemistry ,Chemical engineering ,visual_art ,Titanium dioxide ,visual_art.visual_art_medium ,Surface modification ,General Materials Science ,0210 nano-technology - Abstract
Nitric oxide (NO) has become a highly compelling therapeutic gas for treating vascular diseases due to its versatile functions to vascular responses. Currently, NO biomimetic materials are successfully established through loading catalyst (i.e., Se, Cu) with the vehicle to decompose endogenous NO donors in blood continuously. However, current NO biomimetic materials are susceptible to the non-specific protein fouling, resulting in undesired therapeutic inefficiency with the observation of attenuated or even blocked NO catalytic activities. Herein, we produced a multifunctional nanofilm with dual catalysis based on the vascular stent platform via simply doping one kind of metal (Cu) as cocatalyst into anatase TiO2 crystal. Beneficial synergistic interactions between two kinds of catalysis are reported in this work. The nanofilm surface is endowed with photoinduced super hydrophilic conversion and controlled NO catalytic release simultaneously. The super hydrophilic surface shows the excellent self-cleaning ability to resist protein fouling. Importantly, the maintenance of the protein-resistant surface can effectively improve the NO catalytic release and reduce inflammatory stimuli, contributing to enhanced hemocompatibility. The optimum doping amount of Cu (TiO2@Cu1, 0.77 wt.%) is determined through the characterization of adjustable photoinduced hydrophilic conversion and appropriate NO catalytic generation within the effective physiological concentration. After vascular implantation in rats, the TiO2@Cu1 nanofilms achieved elevated performances on antithrombosis, reducing the intima hyperplasia area and promoting rapid reendothelialization at 4 weeks. This study provides a valuable guideline for NO-biomimetic materials used for blood contact devices and paves the way for the surface modification for vascular implants. more...
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- 2020
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27. Transparent nano hydroxyapatite coated platform for bone cell imaging
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An Qin, Gang Chen, Peizhi Zhu, Jinyu Wang, Guanxiong Liu, Hang Yao, and Gu Jin
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010302 applied physics ,Materials science ,Biocompatibility ,Biomaterial ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Bone tissue ,01 natural sciences ,Bone resorption ,medicine.anatomical_structure ,Nano hydroxyapatite ,Osteoclast ,0103 physical sciences ,Bone cell ,medicine ,General Materials Science ,Bone biology ,0210 nano-technology ,Biomedical engineering - Abstract
Hydroxyapatite is an essential inorganic component of bone tissue which is important for bone cell biology. In laboratory, bone cells are routinely cultured on glass or plastic plates with lacking HA. Some commercial plates coated with HA are now available for investigating osteoclast bone resorption. However, the opaque nature of these plates limits further application to investigating bone cell biology. It is impossible to observe real-time interactions between hydroxyapatite and bone cells under microscope. In this study, glasses with HA nano-coating were prepared by the hydrothermal process. This nano-coating platform (HCP) offers a stage to image real-time interactions between hydroxyapatite and bone cells directly. The ease of fabrication and the repeatability of this platform approach could open a host of biomedical imaging applications in bone biology research as well as bone drug development. Different osteocytes were used to detect the biocompatibility and imaging advantages of the platform. The results showed that the platform could simulate the native bone environment and reflect the state of the bone cells accurately. more...
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- 2020
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28. Thermal hazard analysis and initial decomposition mechanism of 5-(4-pyridyl)tetrazolate-methylene tetrazole
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Xinyu Yao, Juncheng Jiang, Chi-Min Shu, Yong Pan, Lei Ni, Zhirong Wang, and Hang Yao
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Materials science ,Exothermic process ,020209 energy ,General Chemical Engineering ,Organic Chemistry ,Thermal decomposition ,Chemical process of decomposition ,Energy Engineering and Power Technology ,02 engineering and technology ,Activation energy ,Dissociation (chemistry) ,chemistry.chemical_compound ,Fuel Technology ,Differential scanning calorimetry ,020401 chemical engineering ,chemistry ,0202 electrical engineering, electronic engineering, information engineering ,Physical chemistry ,Tetrazole ,0204 chemical engineering ,Mulliken population analysis - Abstract
5-(4-Pyridyl)tetrazolate-methylene tetrazole (H4-PTZ-methylene tetrazole) was prepared. Thermokinetic characteristics of H4-PTZ-methylene tetrazole were described through differential scanning calorimetry (DSC). Ozawa method, Kissinger method, and isoconversional approach were used to calculate the kinetic parameters. Thermal safety parameters, such as self-accelerated decomposition temperature (SADT) and thermal ignition temperature (TTIT), were evaluated from experimental results. The initial decomposition process was investigated using experimental and theoretical calculations. Geometric optimisation, Mulliken charges, electrostatic potentials, and decomposition pathways were explored using Gaussian 16. The simultaneous dissociation of C7–N8 and N9–N10 bonds (DM1) and of C13–N17 and N15–N16 bonds (DM2) had lower energy barriers. The theoretical apparent activation energy was higher than the experimental one. As a novel finding, the exothermic process observed through DSC was primarily because of the reaction that opened the tetrazole ring, which released nitrogen. more...
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- 2020
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29. Polydopamine Modified Copper-Doped Titanium Dioxide Nanotube Arrays for Long-Term Controlled Nitric Oxide Release and Improved Re-Endothelialization
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Lang Jiang, Hang Yao, Xiao Luo, Dan Zou, Sheng Dai, Luying Liu, Ping Yang, Ansha Zhao, and Nan Huang
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- 2019
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30. Precise control and prediction of the greenhouse growth environment of Dendrobium candidum
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Ding, Jin-Ting, primary, Tu, Hang-Yao, additional, Zang, Ze-Lin, additional, Huang, Min, additional, and Zhou, Sheng-Jun, additional
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- 2018
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31. Collagen films with suitable physical properties and biocompatibility for corneal tissue engineering prepared by ion leaching technique
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Yang Liu, Li Ren, Hang Yao, and Yingjun Wang
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Materials science ,Biocompatibility ,Mechanical Engineering ,Condensed Matter Physics ,Thermal diffusivity ,Ion ,medicine.anatomical_structure ,Corneal edema ,Mechanics of Materials ,Cornea ,medicine ,General Materials Science ,Leaching (metallurgy) ,Thin film ,Composite material ,Porosity ,Biomedical engineering - Abstract
Porous collagen films were fabricated by ion leaching technique using NaCl as a porogen. In proper preparing condition (the mass ratio of Collagen:NaCl was 100:2.5(CNa2.5)/100:5.0(CNa5.0)), the films show appropriate optical performance and mechanical properties. Besides, CNa2.5 and CNa5.0 have similar diffusivity as the human cornea. In addition, human corneal epithelial cells were cultured on the collagen films. CNa2.5 and CNa5.0 show high biocompatibility in vitro, which could be covered by 2–3 layers of corneal epithelial cells within a week. Our results indicate that these films have potential use to address the current problems of collagen materials that used for corneal repair. more...
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- 2012
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32. Selective adsorption of 2,6-dichlorophenol by surface imprinted polymers using polyaniline/silica gel composites as functional support: Equilibrium, kinetics, thermodynamics modeling
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Hongxiang Ou, Xiaohua Zou, Chunxiang Li, Jianming Pan, Pengwei Huo, Wei Guan, Hang Yao, and Xue Wang
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Materials science ,Silica gel ,General Chemical Engineering ,Diffusion ,Analytical chemistry ,Langmuir adsorption model ,Thermodynamics ,General Chemistry ,Endothermic process ,Industrial and Manufacturing Engineering ,symbols.namesake ,chemistry.chemical_compound ,Adsorption ,chemistry ,Diffusion process ,Selective adsorption ,Polyaniline ,symbols ,Environmental Chemistry ,Composite material - Abstract
Based on polyaniline/silica gel composites (PAS) as support and functional monomer, the surface imprinted polymers (MIP–PAS) were synthesized for the selective adsorption of 2,6-dichlorophenol (2,6-DCP) from aquatic environment. The MIP–PAS was characterized by FTIR spectroscopy, scanning electron microscopy, nitrogen adsorption–desorption analysis, particle-size and EDX analysis. The effects of pH, initial analyte concentration, contact time and temperature of medium on the adsorption were studied. Equilibrium data, at various temperatures, can be described well by the Langmuir isotherm model. Kinetic can be described by the pseudo-first-order model, pseudo-second-order model, and by an intraparticle diffusion equation. A diffusion-controlled process as the essential adsorption rate-controlling step was also obtained. Moreover, intraparticle diffusion coefficient ( k i ) and pore diffusion coefficient ( D 2 ) for MIP–PAS elevated with the increased of 2,6-DCP concentration and temperature of medium, while increase in 2,6-DCP concentration was found to reduce film diffusion. Furthermore, the values of film diffusion coefficient ( D 1 ) were lower than those of D 2 , indicating the diffusion process was controlled by film diffusion. Thermodynamics parameters (positive values for delta H ° and delta S °, negative values of delta G °) indicated that the process is endothermic and spontaneous. The selectivity of the imprint also demonstrates high affinity for 2,6-DCP over related phenolic compounds and over non-imprinted polymers (NIP). more...
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- 2011
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33. Synthesis of chitosan/γ-Fe2O3/fly-ash-cenospheres composites for the fast removal of bisphenol A and 2,4,6-trichlorophenol from aqueous solutions
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Bing Wang, Xiuxiu Li, Hongxiang Ou, Pengwei Huo, Jianming Pan, Wanzhen Xu, Yongsheng Yan, and Hang Yao
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Bisphenol A ,Environmental Engineering ,Materials science ,Health, Toxicology and Mutagenesis ,Coal Ash ,Ferric Compounds ,Water Purification ,Chitosan ,chemistry.chemical_compound ,symbols.namesake ,Adsorption ,Phenols ,Environmental Chemistry ,Microemulsion ,Thermal stability ,Benzhydryl Compounds ,Composite material ,Waste Management and Disposal ,Aqueous solution ,Langmuir adsorption model ,Pollution ,Carbon ,Solutions ,chemistry ,2,4,6-Trichlorophenol ,symbols ,Emulsions ,Particulate Matter ,Water Pollutants, Chemical ,Chlorophenols ,Mutagens - Abstract
The chitosan/fly-ash-cenospheres/γ-Fe(2)O(3) (CTS/γ-Fe(2)O(3)/FACs) magnetic composites were prepared by microemulsion process. The resulting composites were characterized by XRD, FT-IR, SEM, TGA, DTG and VSM, and the results indicated that CTS/γ-Fe(2)O(3)/FACs exhibited magnetic property (M(s)=6.553 emu g(-1)) and thermal stability, and composed of chitosan wrapping magnetic γ-Fe(2)O(3) and fly-ash-cenospheres (thickness of the cross-linked chitosan was about 5.2 μm). Then the CTS/γ-Fe(2)O(3)/FACs were employed as adsorbents for the fast removal of bisphenol A (BPA) and 2,4,6-trichlorophenol (TCP) from aqueous solutions. The adsorption performances of CTS/γ-Fe(2)O(3)/FACs were investigated by batch mode experiments with respect to pH, temperature, initial concentration, contact time and binary solution system. The Langmuir isotherm model was fitted to the equilibrium data better than the Freundlich model, and the kinetic properties were well described by the pseudo-second-order equation. The effects of binary solution systems also demonstrated that BPA adsorption onto CTS/γ-Fe(2)O(3)/FACs was more affected by the simultaneous presence of competitive phenolic compound than that of TCP. In addition, the resulting composite reusability without obviously deterioration in performance was demonstrated by at least three repeated cycles. more...
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- 2011
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34. Hematopoietic stem cell transplantation protects mice from lethal stroke
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Alysson R. Muotri, Hady Felfly, Hang Yao, and Gabriel G. Haddad
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Pathology ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Hematopoietic Stem Cell Transplantation ,Hematopoietic stem cell transplantation ,medicine.disease ,Immunohistochemistry ,Neuroprotection ,Article ,Stroke ,Transplantation ,Mice ,Haematopoiesis ,medicine.anatomical_structure ,Developmental Neuroscience ,Neurology ,medicine ,Paralysis ,Animals ,Bone marrow ,medicine.symptom ,Stem cell ,business - Abstract
Stroke is a major cause of mortality and morbidity in the United States. The ideal therapeutic approach would minimize cell death and regenerate brain tissue. In order to investigate some questions that are related to such an approach, we have generated a mouse model in which we induce a stroke using the middle cerebral artery occlusion method. After 2 h occlusion followed by reperfusion, 99% of mice died within 8 days of stroke. Total bone marrow cell transplantation by intravenous injection revealed an optimal timing of cell transfer in two doses on days 1 (same day of surgery) and 2 after surgery. Moreover, intravenous injection of Sca1+ bone marrow cells (enriched in hematopoietic stem cells) showed a dose–response effect on survival. Surviving mice also had no signs of apparent paralysis or weakness. Tracking analysis using donor stem cells expressing LacZ revealed only few donor cells in the brain. We conclude that hematopoietic stem cell-rich Sca1+ bone marrow cell transplantation after stroke protects the brain of a sizeable portion of mice subjected to stroke and alleviate remarkably the resulting neurological morbidity in surviving mice. more...
- Published
- 2010
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