Search

A direct and efficient approach for the trifluoromethylation and pentafluoroethylation of 1,1-diaryl-2,2-difluoroethenes with TMSCF3 and TMSCF2CF3 in the presence of TBAF was developed. The reactions proceeded smoothly under mild reaction conditions to give the corresponding monotrifluoromethylated, bistrifluoromethylated, monopentafluoroethylated and bispentafluoroethylated products in fair to good yields, respectively, without the addition of metal catalyst.

A mild and convenient method for the stereoselective synthesis of a series of conjugated β-fluoroenynes by the reaction of gem-difluoroalkenes with terminal alkynes with the assistance of n-butyllithium and K3PO4 is described.

A series of 1-aryl-5-trifluoromethyl (or difluoromethyl)–1,4,5-trisubstituted 1,2,3-triazoles were synthesized in high yield by a novel one-pot three-component reaction of arylboronic acids, sodium azide, and active methylene ketones, such as ethyl 4,4-difluoroacetoacetate or ethyl 4,4,4-trifluoroacetoacetate in the presence of Cu(OAc)2 and piperidine using a DMSO/H2O (10/1) mixture as solvent.