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This paper reports a numerical study of the sensitivity and applicability of the Nonlinear Coda Wave Interferometry (NCWI) method in a heterogeneous material with a localized microcracked zone. We model the influence of a strong pump wave on the localized microcracked zone as a small average increase in the length of each crack. Further probing of this microcracked zone with a multiply scattered ultrasonic wave induces small changes to the coda-type signal, which are quantified with coda wave interferometry. A parametric sensitivity study of the CWI observables with respect to the changes in crack length is established via numerical simulations of the problem using a 2D spectral element method (SEM2D). The stretching of the signal, proportional to the relative variation in effective velocity, is found to be linearly proportional to the global change in crack length, while the other CWI parameter, the remnant decorrelation coefficient, is found to be quadratically proportional to the crack length change. The NCWI method is shown to be relevant for the detection of different damaged material states in complex solids. The reported numerical results are especially significant in the context of quantitative nondestructive evaluation of micro-damage level of a heterogeneous materials using nonlinear ultrasound signals.

Data regarding the efficacy and safety of zero or near-zero fluoroscopic ablation of cardiac arrhythmias are limited. A literature search was conducted using PubMed and Embase for relevant studies through January 2016. Ten studies involving 2,261 patients were identified. Compared with conventional radiofrequency ablation method, zero or near-zero fluoroscopy ablation significantly showed reduced fluoroscopic time (standard mean difference [SMD] -1.62, 95% CI -2.20 to -1.05; p0.00001), ablation time (SMD -0.16, 95% CI -0.29 to -0.04; p = 0.01), and radiation dose (SMD -1.94, 95% CI -3.37 to -0.51; p = 0.008). In contrast, procedure duration was not significantly different from that of conventional radiofrequency ablation (SMD -0.03, 95% CI -0.16 to 0.09; p = 0.58). There were no significant differences between both groups in immediate success rate (odds ratio [OR] 0.99, 95% CI 0.49 to 2.01; p = 0.99), long-term success rate (OR 1.13, 95% CI 0.42 to 3.02; p = 0.81), complication rates (OR 0.98, 95% CI 0.49 to 1.96; p = 0.95), and recurrence rates (OR 1.29, 95% CI 0.74 to 2.24; p = 0.37). In conclusion, radiation was significantly reduced in the zero or near-zero fluoroscopy ablation groups without compromising efficacy and safety.

Metabolic diseases are associated with an increased risk of developing cardiovascular disease. The features comprising metabolic diseases include obesity, insulin resistance, hyperglycemia, hyperlipidemia, and hypertension. Recent evidence has emerged showcasing a role for cytochrome P450 epoxygenases, soluble epoxide hydrolase, and epoxyeicosatrienoic acids (EETs) in the development and progression of metabolic diseases. This review discusses the current knowledge related to the modulation of cytochrome P450 epoxygenases and soluble epoxide hydrolase to alter concentrations of biologically active EETs, resulting in effects on insulin resistance, lipid metabolism, obesity, and diabetes. Future areas of research to address current deficiencies in the understanding of these enzymes and their eicosanoid metabolites in various aspects of metabolic diseases are also discussed.

Nanostructured tin dioxide (SnO 2 ) powders were prepared by a sol-gel dialytic process and and the doping of CuO on it was completed by a deposition-precipitation method. The thick film sensors were fabricated from the CuO/SnO 2 polycrystalline powders. Sensing behavior of the sensor was investigated with various gases including CO, H 2 , NH 3 , hexane, acetone, ethanol, methanol and H 2 S in air. The as-synthesized gas sensor had much better response to H 2 S than to other gases. At the same time, the CuO/SnO 2 sensor had enough sensitivity, together with fast response and recovery, to distinguish H 2 S from those gases at 160 and 210 °C. Therefore, it might have promising applications in the future.