132 results on '"Goldstein, Joseph L."'
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2. The surprise element: A hallmark of creativity in scientists, artists, and comedians
3. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing
4. The Spanish 1918 Flu and the COVID-19 Disease: The Art of Remembering and Foreshadowing Pandemics
5. Seurat’s Dots: A Shot Heard ’Round the Art World—Fired by an Artist, Inspired by a Scientist
6. What Makes a Piece of Art or Science a Masterpiece?
7. Artists Create Puzzles, Scientists Solve Them
8. Cholesterol-induced conformational changes in the sterol-sensing domain of the Scap protein suggest feedback mechanism to control cholesterol synthesis
9. The Rule of Three for Prizes in Science and the Bold Triptychs of Francis Bacon
10. Direct Demonstration That Loop1 of Scap Binds to Loop7
11. A Well-Hung Horse: Sired by Knowledge and Imagination
12. A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
13. Induced Ablation of Ghrelin Cells in Adult Mice Does Not Decrease Food Intake, Body Weight, or Response to High-Fat Diet
14. Point Mutation in Luminal Loop 7 of Scap Protein Blocks Interaction with Loop 1 and Abolishes Movement to Golgi
15. Scientific Side Trips: Six Excursions from the Beaten Path
16. Profound Hypoglycemia in Starved, Ghrelin-deficient Mice Is Caused by Decreased Gluconeogenesis and Reversed by Lactate or Fatty Acids
17. The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals
18. Identification of Luminal Loop 1 of Scap Protein as the Sterol Sensor That Maintains Cholesterol Homeostasis
19. Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
20. Hair Growth Defects in Insig-Deficient Mice Caused by Cholesterol Precursor Accumulation and Reversed by Simvastatin
21. LXR-SREBP-1c-Phospholipid Transfer Protein Axis Controls Very Low Density Lipoprotein (VLDL) Particle Size
22. Regulated Endoplasmic Reticulum-associated Degradation of a Polytopic Protein
23. Accelerated Fatty Acid Oxidation in Muscle Averts Fasting-induced Hepatic Steatosis in SJL/J Mice
24. Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
25. Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
26. Switch-like Control of SREBP-2 Transport Triggered by Small Changes in ER Cholesterol: A Delicate Balance
27. Identification of the Acyltransferase that Octanoylates Ghrelin, an Appetite-Stimulating Peptide Hormone
28. Selective versus Total Insulin Resistance: A Pathogenic Paradox
29. Purified NPC1 Protein
30. Purified NPC1 Protein
31. Protein Sensors for Membrane Sterols
32. Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
33. Insig Required for Sterol-mediated Inhibition of Scap/SREBP Binding to COPII Proteins in Vitro*♦
34. Identification of FBL2 As a Geranylgeranylated Cellular Protein Required for Hepatitis C Virus RNA Replication
35. Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver
36. Cholesterol and 25-Hydroxycholesterol Inhibit Activation of SREBPs by Different Mechanisms, Both Involving SCAP and Insigs
37. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes
38. LOWERING PLASMA CHOLESTEROL BY RAISING LDL RECEPTORS
39. A tribute to Akira Endo, discoverer of a “Penicillin” for cholesterol
40. Direct Binding of Cholesterol to the Purified Membrane Region of SCAP
41. Membrane Topology of Human Insig-1, a Protein Regulator of Lipid Synthesis
42. Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and Geranylgeraniol
43. Reconstitution of Sterol-regulated Endoplasmic Reticulum-to-Golgi Transport of SREBP-2 in Insect Cells by Co-expression of Mammalian SCAP and Insigs
44. Characterization of Mouse Short-chain Aldehyde Reductase (SCALD), an Enzyme Regulated by Sterol Regulatory Element-binding Proteins
45. Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to Its Sterol-Sensing Domain
46. Cholesterol Addition to ER Membranes Alters Conformation of SCAP, the SREBP Escort Protein that Regulates Cholesterol Metabolism
47. Crucial Step in Cholesterol Homeostasis
48. Diminished Hepatic Response to Fasting/Refeeding and Liver X Receptor Agonists in Mice with Selective Deficiency of Sterol Regulatory Element-binding Protein-1c
49. The SREBP Pathway in Drosophila
50. Mutant Mammalian Cells as Tools to Delineate the Sterol Regulatory Element-Binding Protein Pathway for Feedback Regulation of Lipid Synthesis
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