1. Cytotoxic cuparene sesquiterpenes from Laurencia microcladia
- Author
-
Giovanni Furnari, Christos Roussakis, Dimitri Moreau, Maria Kladi, Constantinos Vagias, and Vassilios Roussis
- Subjects
biology ,Stereochemistry ,Metabolite ,Organic Chemistry ,Laurencia ,biology.organism_classification ,Biochemistry ,chemistry.chemical_compound ,Lung cancer cell ,chemistry ,Drug Discovery ,Cytotoxic T cell ,Spectral data ,Microcladia ,Methyl group - Abstract
Three new cuparene sesquiterpenes 1 – 3 were isolated from the organic extract of the red alga Laurencia microcladia , collected at Chios island in the North Aegean Sea, Greece. The structures and the relative stereochemistry of the compounds are proposed on the basis of their spectral data. Metabolite 2 shows an unprecedented (for the cuparene class of sesquiterpenes) migration of the C-1 methyl group. All metabolites 1 – 3 were found to exhibit significant cytotoxic activity against two lung cancer cell lines.
- Published
- 2005