1. Vitamin D levels and chronic hepatitis C
- Author
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Annamaria Colao, Francesco Auriemma, G. Mazzone, R. Granata, Federica Cariati, Vincenzo Lembo, Carolina Di Somma, Ilaria Loperto, Filomena Morisco, Manila Rubino, Maria Guarino, L. Donnarumma, Claudia Pivonello, Nicola Caporaso, Anna Mariniello, Morisco, Filomena, Annamaria, Colao, Guarino, Maria, Vincenzo, Lembo, Rocco, Granata, Laura, Donnarumma, Francesco, Auriemma, Anna, Mariniello, Giovanna, Mazzone, Carolina Di Somma, Manila, Rubino, Federica, Cariati, Pivonello, Claudia, Ilaria, Loperto, and Caporaso, Nicola
- Subjects
medicine.medical_specialty ,education.field_of_study ,Nutrition and Dietetics ,Cirrhosis ,medicine.diagnostic_test ,business.industry ,Endocrinology, Diabetes and Metabolism ,Population ,Parathyroid hormone ,chemistry.chemical_element ,Calcium ,medicine.disease ,vitamin D deficiency ,Endocrinology ,chemistry ,Internal medicine ,Immunoassay ,Vitamin D and neurology ,Medicine ,business ,education ,Homeostasis - Abstract
summary Background and purpose: Vitamin D (VitD) is involved in homeostasis of calcium and interacts with parathyroid hormone (PTH). Low levels of VitD in chronic liver diseases, in particular in chronic hepatitis C (CHC) was reported. We aimed to determine the levels of VitD and PTH in patients with CHC without cirrhosis to evaluate the disturbance of VitD-PTH axis. Methods: We conduced a caseecontrol studyenrolling59patients with CHCand 59 controls. We determined serum concentration of VitD, PTH, calcium and phosphate. VitD was quantified by chemiluminescence immunoassay. PTH was measured by 2-site chemiluminescent enzyme-labeled immunoassay. Results: The mean value of VitD was 26.28 and 28.43 ng/ml in HCV patients and controls respectively (p < 0.31). The distribution of the severity of VitD deficit in HCV population was the following: 5% had a deficiency, 64% had an insufficiency and 31% had normal levels. No difference was observed in the control group (p < 0.9). The mean value of PTH was 17.04 and 26.7 pg/ml in HCV patients and controls respectively (p < 0.0004). Calcium and phosphate were in the range of normality in both. Conclusions: The VitD deficit is similar in HCV-patients and general population of the same geographic area. Therefore we can state that this is a public health problem.
- Published
- 2013