1. Rest tremor in Parkinson's disease: Body distribution and time of appearance
- Author
-
Paolo Livrea, G. Iliceto, Angelo Fabio Gigante, Roberta Pellicciari, Giovanni Defazio, Daniele Liuzzi, Marco Guido, Paola Vincenza Mancino, and Giacomo Emanuele Custodero
- Subjects
Adult ,Male ,030506 rehabilitation ,medicine.medical_specialty ,Time Factors ,Parkinson's disease ,Databases, Factual ,Population ,Kaplan-Meier Estimate ,upper limb ,Disease ,Severity of Illness Index ,Motor symptoms ,Rest tremor ,rest tremor ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Tremor ,medicine ,Humans ,In patient ,education ,Aged ,Aged, 80 and over ,Human Body ,education.field_of_study ,business.industry ,Parkinson Disease ,Middle Aged ,medicine.disease ,body distribution ,time of appearance ,lower limb ,nervous system diseases ,Increased risk ,medicine.anatomical_structure ,Neurology ,Disease Progression ,Upper limb ,Female ,Neurology (clinical) ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Objective To assess body distribution and timing of appearance of rest tremor in Parkinson's disease. Methods Information was obtained by a computerized database containing historical information collected at the first visit and data collected during the subsequent follow-up visits. Information on rest tremor developed during the follow-up could be therefore obtained by our own observation in a proportion of patients. Results Among 289 patients, rest tremor was reported at disease onset in 65.4% of cases and detected at last follow-up examination in 74.4% of patients. Analysis of patients who did not report rest tremor at disease onset indicated that 26% of such patients (9% in the overall population) manifested rest tremor over the disease course. Rest tremor spread to new sites in 39% of patients who manifested rest tremor at disease onset. Regardless of tremor presentation at disease onset or during the follow-up, upper limb was the most frequent tremor localization. Over the follow-up, rest tremor developed faster in the upper limb than in other body sites. The risk of developing rest tremor during the follow-up was not affected by sex, side of motor symptom onset and site of tremor presentation. However, age of disease onset > 63 years was associated with an increased risk of rest tremor spread. Conclusions This study provides new information about body distribution and timing of rest tremor appearance during the course of early stages of Parkinson's disease that may help clinicians in patients' counselling.
- Published
- 2017