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Your search keyword '"Gervois, Pascal"' showing total 7 results
Start Over Author "Gervois, Pascal" Publisher elsevier bv
7 results on '"Gervois, Pascal"'

1. Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis

Author

Schepers, Melissa, primary, Paes, Dean, additional, Tiane, Assia, additional, Rombaut, Ben, additional, Piccart, Elisabeth, additional, van Veggel, Lieve, additional, Gervois, Pascal, additional, Wolfs, Esther, additional, Lambrichts, Ivo, additional, Brullo, Chiara, additional, Bruno, Olga, additional, Fedele, Ernesto, additional, Ricciarelli, Roberta, additional, ffrench-Constant, Charles, additional, Bechler, Marie E., additional, van Schaik, Pauline, additional, Baron, Wia, additional, Lefevere, Evy, additional, Wasner, Kobi, additional, Grünewald, Anne, additional, Verfaillie, Catherine, additional, Baeten, Paulien, additional, Broux, Bieke, additional, Wieringa, Paul, additional, Hellings, Niels, additional, Prickaerts, Jos, additional, and Vanmierlo, Tim, additional

Published
2023
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2. The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Author

Vanherle, Sam, primary, Jorissen, Winde, additional, Dierckx, Tess, additional, Loix, Melanie, additional, Grajchen, Elien, additional, Mingneau, Fleur, additional, Guns, Jeroen, additional, Gervois, Pascal, additional, Lambrichts, Ivo, additional, Dehairs, Jonas, additional, Swinnen, Johannes V., additional, Mulder, Monique T., additional, Remaley, Alan T., additional, Haidar, Mansour, additional, Hendriks, Jerome J.A., additional, and Bogie, Jeroen J.F., additional

Published
2022
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7. The ApoA-I mimetic peptide 5A enhances remyelination by promoting clearance and degradation of myelin debris

Author

Sam Vanherle, Winde Jorissen, Tess Dierckx, Melanie Loix, Elien Grajchen, Fleur Mingneau, Jeroen Guns, Pascal Gervois, Ivo Lambrichts, Jonas Dehairs, Johannes V. Swinnen, Monique T. Mulder, Alan T. Remaley, Mansour Haidar, Jerome J.A. Hendriks, Jeroen J.F. Bogie, Guns, Jeroen/0000-0003-0464-2601, VANHERLE, Sam, JORISSEN, Winde, DIERCKX, Tess, LOIX, Melanie, GRAJCHEN, Elien, MINGNEAU, Fleur, GUNS, Jeroen, GERVOIS, Pascal, LAMBRICHTS, Ivo, Dehairs, Jonas, Swinnen, Johannes, V, Mulder, Monique T., Remaley, Alan T., HAIDAR, Mansour, HENDRIKS, Jerome, BOGIE, Jeroen, and Internal Medicine

Subjects
Apolipoprotein A-I, Neuroscience [CP], phagocyte, lipid droplet degradation, myelin debris clearance, General Biochemistry, Genetics and Molecular Biology, remyelination, Remyelination, ApoA-I mimetic peptide 5A, Humans, Peptides, Myelin Sheath, Demyelinating Diseases
Abstract

The progressive nature of demyelinating diseases lies in the inability of the central nervous system (CNS) to induce proper remyelination. Recently, we and others demonstrated that a dysregulated innate immune response partially underlies failure of CNS remyelination. Extensive accumulation of myelin-derived lipids and an inability to process these lipids was found to induce a disease-promoting phagocyte phenotype. Hence, restoring the ability of these phagocytes to metabolize and efflux myelin-derived lipids represents a promising strategy to promote remyelination. Here, we show that ApoA-I mimetic peptide 5A, a molecule well known to promote activity of the lipid efflux transporter ABCA1, markedly enhances remyelination. Mechanistically, we find that the repair-inducing properties of 5A are attributable to increased clearance and metabolism of remyelination-inhibiting myelin debris via the fatty acid translocase protein CD36, which is transcriptionally controlled by the ABCA1-JAK2-STAT3 signaling pathway. Altogether, our findings indi-cate that 5A promotes remyelination by stimulating clearance and degradation of myelin debris. We thank M.P. Tulleners for excellent technical assistance. The work was financially supported by the Research Foundation of Flanders (FWO Vlaanderen; 1S15519N, G099618FWO, and 12J9119N) and the Interreg V-A EMR program (EURLIPIDS, EMR23). The funding agencies had no role in the design, analysis, or writing of the article.

Published
2022

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