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Your search keyword '"Gentilomi, Giovanna Angela"' showing total 12 results
Start Over Author "Gentilomi, Giovanna Angela" Publisher elsevier bv
12 results on '"Gentilomi, Giovanna Angela"'

5. A radiopaque calcium phosphate bone cement with long-lasting antibacterial effect: From paste to injectable formulation

Author

Di Filippo, Maria Francesca, primary, Dolci, Luisa Stella, additional, Albertini, Beatrice, additional, Passerini, Nadia, additional, Torricelli, Paola, additional, Parrilli, Annapaola, additional, Fini, Milena, additional, Bonvicini, Francesca, additional, Gentilomi, Giovanna Angela, additional, Panzavolta, Silvia, additional, and Bigi, Adriana, additional

Published
2020
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12. Biomimetic fabrication of antibacterial calcium phosphates mediated by polydopamine

Author

Gigliola Lusvardi, Lucia Forte, Milena Fini, Elisa Boanini, Elena Della Bella, Giovanna Angela Gentilomi, Francesca Bonvicini, Adriana Bigi, Paola Torricelli, Edoardo Vecchio Nepita, Forte, Lucia, Torricelli, Paola, Bonvicini, Francesca, Boanini, Elisa, Gentilomi, Giovanna Angela, Lusvardi, Gigliola, Della Bella, Elena, Fini, Milena, Vecchio Nepita, Edoardo, and Bigi, Adriana

Subjects
Biocompatible, Calcium Phosphates, Polydopamine, Indoles, Silver, Tricalcium phosphate, Cell Survival, Polymers, Surface Properties, Silver nanoparticle, Inorganic chemistry, Nanoparticle, chemistry.chemical_element, Octacalcium phosphate, Multi-drug resistant bacteria, 02 engineering and technology, Calcium, 010402 general chemistry, Polymerase Chain Reaction, 01 natural sciences, Biochemistry, Cell Line, Inorganic Chemistry, chemistry.chemical_compound, Coated Materials, Biocompatible, Biomimetics, Humans, Osteoblasts, Osteoblast, Silver nanoparticles, α-Tricalcium phosphate, Anti-Bacterial Agents, Nanoparticles, Coated Materials, Substrate (chemistry), 021001 nanoscience & nanotechnology, Phosphate, 0104 chemical sciences, Silver nitrate, chemistry, Surface modification, 0210 nano-technology, Nuclear chemistry
Abstract

In this work we developed new antibacterial composite materials using polydopamine (PDA) to trigger the deposition of silver nanoparticles (AgNPs) onto calcium phosphates, namely octacalcium phosphate (OCP) and Alpha-tricalcium phosphate (TCP). Functionalization of OCP and TCP with a self-polymerized polydopamine layer was obtained by soaking the calcium phosphates in dopamine solution. The PDA surface of functionalized calcium phosphates (OCPd and TCPd) promoted the deposition of AgNPs by reducing silver ions when soaked in a silver nitrate solution. The amount of deposited AgNPs can be modulated by varying the concentration of silver nitrate solution and the type of substrate. The results of in vitro tests carried out with osteoblast-like MG63 cells indicate that the combination of AgNPs with OCP provides more biocompatible materials than those obtained using TCP as substrate. In particular, the study of osteoblast activity and differentiation was focused on the samples OCPdAg5 (silver content = 8.2 wt%) and TCPdAg5 (silver content = 4.7 wt%), which did not show any cytotoxicity, and compared with those obtained on pure OCP and TCP. The results demonstrate that the AgNPs loaded materials support osteoblast viability and differentiation, whereas they significantly inhibit the growth of relevant antibiotic-resistant pathogenic bacteria.

Published
2018

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