1. Transcriptome profiling in adult attention-deficit hyperactivity disorder
- Author
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Montse Corrales, Paula Rovira, Klaus-Peter Lesch, Vanesa Richarte, Marta Ribasés, María Soler Artigas, Miguel Casas, Olga Rivero, Christian Fadeuilhe, Cristina Sánchez-Mora, Laura Vilar-Ribó, Niall Mortimer, Josep Antoni Ramos-Quiroga, Psychiatrie & Neuropsychologie, and RS: MHeNs - R3 - Neuroscience
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Adult ,Male ,Candidate gene ,Attention-deficit/hyperactivity disorder (ADHD) ,Genome-wide association study ,Transcriptomic assays ,Biology ,behavioral disciplines and activities ,Peripheral blood mononuclear cell ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Neurodevelopmental disorder ,mental disorders ,Gene expression ,medicine ,Humans ,Attention deficit hyperactivity disorder ,Genetic Predisposition to Disease ,Pharmacology (medical) ,Gene ,Biological Psychiatry ,Pharmacology ,Genetics ,Gene Expression Profiling ,Gene-expression signatures ,Middle Aged ,Heritability ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Neurology ,Attention Deficit Disorder with Hyperactivity ,Case-Control Studies ,Female ,Neurology (clinical) ,030217 neurology & neurosurgery ,Genome-Wide Association Study - Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD. (c) 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
- Published
- 2020
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