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Start Over Author "Garcia-Lopez, M. T." Publisher elsevier bv
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1. A facile synthesis of 8-amino-3-oxoindolizidine derivatives as conformationally restricted ornithyl pseudodipeptides

Author

I. Gomez‐Monterrey, J. R. Harto, Rosario González-Muñiz, M. T. Garcia‐Lopez, Maria Dominguez, GOMEZ MONTERREY, ISABEL MARIA, Dominguez, M. J., GONZALEZ MUNIZ, R., Harto, J. R., and GARCIA LOPEZ, M. T.

Subjects
Dipeptide, Intramolecular reaction, Bicyclic molecule, Chemistry, Stereochemistry, medicine.drug_class, Organic Chemistry, Carboxamide, Biochemistry, Reductive amination, chemistry.chemical_compound, Hydrogenolysis, One pot reaction, Intramolecular force, Drug Discovery, medicine
Abstract

One pot procedure for the synthesis of 8-amino-3-oxoindolizidines from Zδ-protected ornithyl ketomethylene pseudodipeptide derivatives is described. This procedure, involving hydrogenolysis of the Z-group, intramolecular reductive amination and γ-lactamization, provides readily access to a variety of 3-oxoindolizidines of defined stereochemistry at C-8 and C-8a.

Published
1991

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