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3. Faricimab Treat-and-Extend for Diabetic Macular Edema

Author

Wong, Tien Y., primary, Haskova, Zdenka, additional, Asik, Kemal, additional, Baumal, Caroline R., additional, Csaky, Karl G., additional, Eter, Nicole, additional, Ives, Jane A., additional, Jaffe, Glenn J., additional, Korobelnik, Jean-François, additional, Lin, Hugh, additional, Murata, Toshinori, additional, Ruamviboonsuk, Paisan, additional, Schlottmann, Patricio G., additional, Seres, András I., additional, Silverman, David, additional, Sun, Xiaodong, additional, Tang, Yannan, additional, Wells, John A., additional, Yoon, Young Hee, additional, Wykoff, Charles C., additional, Aaberg, Thomas, additional, Abbey, Ashkan, additional, Abdulaeva, Elmira, additional, Abengoechea, Santiago, additional, Abraham, Prema, additional, Ach, Thomas, additional, Adams, Serrhel, additional, Adan Civera, Alfredo, additional, Adrean, Sean, additional, Agostini, Hansjurgen, additional, Alam, Suhail, additional, Alezzandrini, Arturo, additional, Alfaro, Virgil, additional, Aliseda, Daniel, additional, Almony, Arghavan, additional, Amat, Pedro, additional, Amini, Payam, additional, Antoszyk, Andrew, additional, Arias, Luis, additional, Asaria, Riaz, additional, Avila, Marcos, additional, Awh, Carl C., additional, Bafalluy, Joaquin, additional, Baker, Carl, additional, Bandello, Francesco, additional, Barakat, Mark, additional, Barraza, Karen, additional, Bator, Gyorgy, additional, Baumal, Caroline, additional, Belfort, Rubens, additional, Bergstrom, Chris, additional, Bertolucci, George, additional, Bochow, Thomas, additional, Bolz, Matthias, additional, Borcz, Emilia, additional, Bordon, Arnaldo, additional, Boyer, David, additional, Bratko, Galina, additional, Brent, Michael, additional, Brown, Jamin, additional, Brown, David M., additional, Budzinskaya, Maria, additional, Buffet, Sylvia, additional, Burgess, Stuart, additional, Burton, Ben, additional, Busquets, Miguel, additional, Cabrera, Francisco, additional, Cagini, Carlo, additional, Calzada, Jorge, additional, Campochiaro, Peter, additional, Carlson, John, additional, Castellarin, Alessandro, additional, Cava, Carlos, additional, Chaikitmongkol, Voraporn, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chang, Jonathan, additional, Chang, Andrew, additional, Charles, Steve, additional, Chaudhry, Nauman, additional, Chee, Caroline, additional, Chen, Judy, additional, Chen, Fred, additional, Chen, Shih-Jen, additional, Cheong-Leen, Richard, additional, Chiang, Allen, additional, Chittum, Mark, additional, Chow, David, additional, Connolly, Brian, additional, Cornut, Pierre Loic, additional, Csaky, Karl, additional, Danzig, Carl, additional, Das, Arup, additional, Daskalov, Vesselin, additional, Desco, Carmen, additional, Dessouki, Amr, additional, Dickinson, John, additional, Do, Brian, additional, Dollin, Michael, additional, Dugel, Pravin, additional, Dusova, Jaroslava, additional, Eichenbaum, David, additional, Eldem, Bora, additional, Engstrom, Robert, additional, Ernest, Jan, additional, Escobar, Joan Josep, additional, Esposti, Simona, additional, Falk, Naomi, additional, Farkas, Andrej, additional, Feiner, Leonard, additional, Feltgen, Nicolas, additional, Fernandez, Carlos, additional, Fernandez Vega, Alvaro, additional, Ferrone, Philip, additional, Figueira, Joao, additional, Figueroa, Marta, additional, Findl, Oliver, additional, Fine, Howard, additional, Fortun, Jorge, additional, Fox, Gregory M., additional, Foxman, Scott, additional, Framme, Carsten, additional, Fraser-Bell, Samantha, additional, Fu, Arthur, additional, Fukutomi, Akira, additional, Fung, Nicholas, additional, Furno Sola, Federico, additional, Gallego-Pinazo, Roberto, additional, Garcia, Renata, additional, Garcia-Layana, Alfredo, additional, Gawecki, Maciej, additional, George, Sheen, additional, Ghanchi, Faruque, additional, Ghorayeb, Ghassan, additional, Goldberg, Roger, additional, Goldstein, Michaella, additional, Gomes, Nuno, additional, Ulla, Francisco Gomez, additional, Gonzalez, Victor, additional, Greven, Craig, additional, Gupta, Sunil, additional, Guzman, Miguel, additional, Harris, Martin, additional, Hatz, Katja, additional, Hau, Vivienne, additional, Hau, Vincent, additional, Hayashi, Ken, additional, Heier, Jeffrey, additional, Herba, Ewa, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Hirakata, Akito, additional, Ho, Allen, additional, Holekamp, Nancy, additional, Honda, Shigeru, additional, Hsu, Jason, additional, Hu, Allen, additional, Hurcikova, Maria, additional, Ikeda, Yasuhiro, additional, Isernhagen, Ricky, additional, Ito, Yasuki, additional, Jackson, Tim, additional, Jacoby, Rachael, additional, Jafree, Afsar, additional, Javey, Golnaz, additional, Javid, Cameron, additional, Jhaveri, Chirag, additional, Johnson, Mark, additional, Kacerík, Marek, additional, Kaluzny, Jakub, additional, Kampik, Daniel, additional, Kang, Se Woong, additional, Kapoor, Kapil, additional, Karabas, Levent, additional, Kawasaki, Tsutomu, additional, Kerenyi, Agnes, additional, Khanani, Arshad, additional, Khurana, Rahul, additional, Kim, Brian, additional, Kimura, Kazuhiro, additional, Kishino, Genichiro, additional, Kitano, Shigehiko, additional, Klein-Mascia, Kendra, additional, Kokame, Gregg, additional, Korobelnik, Jean Francois, additional, Kulikov, Alexey, additional, Kuriyan, Ajay, additional, Kwong, Henry, additional, Kwun, Robert, additional, Lai, Timothy, additional, Lai, Chi-Chun, additional, Laird, Philip, additional, Lalonde, Laurent, additional, Lanzetta, Paolo, additional, Larsen, Michael, additional, Laugesen, Caroline, additional, Lavinsky, Daniel, additional, Lebreton, Olivier, additional, Lee, Seong, additional, Levy, Jaime, additional, Lipkova, Blandina, additional, Liu, Mimi, additional, Liu, Judy, additional, Lohmann, Chris P., additional, London, Nikolas, additional, Lorenz, Katrin, additional, Lotery, Andrew, additional, Lozano Rechy, David, additional, Lujan, Silvio, additional, Ma, Patrick, additional, Maeno, Takatoshi, additional, Mahmood, Sajjad, additional, Makkouk, Fuad, additional, Malik, Khurram, additional, Marcus, Dennis, additional, Margherio, Alan, additional, Mastropasqua, Leonardo, additional, Maturi, Raj, additional, McCabe, Frank, additional, McKibbin, Martin, additional, Mehta, Hemal, additional, Menon, Geeta, additional, Mentes, Jale, additional, Michalska-Malecka, Katarzyna, additional, Misheva, Aneta, additional, Mitamura, Yoshinori, additional, Mitchell, Paul, additional, Modi, Yasha, additional, Mohamed, Quresh, additional, Montero, Javier, additional, Moore, Jeffrey, additional, Morales Canton, Virgilio, additional, Morori-Katz, Haia, additional, Morugova, Tatiana, additional, Murakami, Tomoaki, additional, Muzyka-Wozniak, Maria, additional, Nardi, Marco, additional, Nemcansky, Jan, additional, Nester-Ostrowska, Kamila, additional, Neto, Julio, additional, Newell, Charles, additional, Nicolo, Massimo, additional, Nielsen, Jared, additional, Noda, Kousuke, additional, Obana, Akira, additional, Ogata, Nahoko, additional, Oh, Hideyasu, additional, Oh, Kean, additional, Ohr, Matthew, additional, Oleksy, Piotr, additional, Oliver, Scott, additional, Olivier, Sebastien, additional, Osher, James, additional, Ozcalışkan, Sehnaz, additional, Ozturk, Banu, additional, Papp, Andras, additional, Park, Kyu Hyung, additional, Parke, D. Wilkin, additional, Parravano, Maria Cristina, additional, Patel, Sugat, additional, Patel, Sunil, additional, Pearce, Ian, additional, Pearlman, Joel, additional, Penha, Fernando, additional, Perente, Irfan, additional, Perkins, Stephen, additional, Pertile, Grazia, additional, Petkova, Iva, additional, Peto, Tunde, additional, Pieramici, Dante, additional, Pollreisz, Andreas, additional, Pongsachareonnont, Pear, additional, Pozdeyeva, Nadezhda, additional, Priglinger, Siegfried, additional, Qureshi, Jawad, additional, Raczynska, Dorota, additional, Rajagopalan, Rajesh, additional, Ramirez Estudillo, Juan, additional, Raskauskas, Paul, additional, Rathod, Rajiv, additional, Razavi, Hessam, additional, Regillo, Carl, additional, Ricci, Federico, additional, Rofagha, Soraya, additional, Romanczak, Dominika, additional, Romanowska-Dixon, Bożena, additional, Rosberger, Daniel, additional, Rosenblatt, Irit, additional, Rosenblatt, Brett, additional, Ross, Adam, additional, Ruiz Moreno, Jose Maria, additional, Salomão, Gustavo, additional, Sandhu, Sukhpal, additional, Sandner, Dirk, additional, Sararols, Laura, additional, Sawada, Osamu, additional, Schadlu, Ramin, additional, Schlottmann, Patricio, additional, Schuart, Claudia, additional, Seitz, Berthold, additional, Seres, András, additional, Sermet, Figen, additional, Shah, Sandeep, additional, Shah, Ankur, additional, Shah, Rohan, additional, Sharma, Sumit, additional, Sheidow, Thomas, additional, Sheth, Veeral, additional, Shimouchi, Akito, additional, Shimura, Masahiko, additional, Sikorski, Bartosz, additional, Silva, Rufino, additional, Singer, Michael, additional, Singerman, Lawrence, additional, Singh, Rishi, additional, Souied, Eric, additional, Spinak, David J., additional, Spital, Georg, additional, Steinle, Nathan, additional, Stern, Jeffrey, additional, Stoller, Glenn, additional, Stoltz, Robert, additional, Stone, Cameron, additional, Stone, Amy, additional, Suan, Eric, additional, Sugimoto, Masahiko, additional, Sugita, Iichiro, additional, Sun, Jennifer, additional, Suner, Ivan, additional, Szalczer, Lajos, additional, Szecsko, Timea, additional, Tabassian, Ali, additional, Tadayoni, Ramin, additional, Takagi, Hitoshi, additional, Takayama, Kei, additional, Taleb, Alexandre, additional, Talks, James, additional, Tan, Gavin, additional, Tanabe, Teruyo, additional, Taylor, Stanford, additional, Thach, Allen, additional, Thompson, John, additional, Tlucek, Paul, additional, Torti, Robert, additional, Tosheva Guneva, Daniela, additional, Toth-Molnar, Edit, additional, Uchiyama, Eduardo, additional, Vajas, Attila, additional, Varma, Deepali, additional, Varsanyi, Balazs, additional, Vassileva, Petja, additional, Vaz-Pereira, Sara, additional, Veith, Miroslav, additional, Vela, Jose Ignacio, additional, Viola, Francesco, additional, Virgili, Gianni, additional, Vogt, Gábor, additional, Vorum, Henrik, additional, Weber, Pamela, additional, Wecke, Thoalf, additional, Wee, Raymond, additional, Weger, Martin, additional, Weishaar, Paul, additional, Wickremasinghe, Sanjeewa, additional, Williams, Thomas Reginald, additional, Williams, Thomas, additional, Williams, Geoff, additional, Wolf, Armin, additional, Wolfe, Jeremy, additional, Wong, James, additional, Wong, David, additional, Wong, Ian, additional, Wong, Robert, additional, Wowra, Bogumil, additional, Wylęgała, Edward, additional, Yang, Chang-Hao, additional, Yasukawa, Tsutomu, additional, Yates, Paul, additional, Yilmaz, Gursel, additional, Yiu, Glenn, additional, Yoreh, Barak, additional, Yoshida, Shigeo, additional, Yu, Hyeong Gon, additional, Yu, Seung Young, additional, Yurieva, Tatiana, additional, Zacharias, Leandro, additional, Zaczek Zakrzewska, Karolina, additional, Zambrano, Alberto, additional, Zatorska, Barbara, additional, Zeolite, Carlos, additional, and Zheutlin, Jeffrey, additional

Published
2023
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6. TCT-592 Transcatheter Aortic Valve Replacement With Balloon- Versus Self-Expandable Bioprostheses for the Treatment of Bicuspid Aortic Valve Stenosis

Author

Giacoppo, Daniele, primary, Covarrubias, Hector Alvarez, additional, Xhepa, Erion, additional, Matsuda, Yuji, additional, Cangemi, Stefano, additional, Michel, Jonathan, additional, Sannino, Anna, additional, Ziegelmueller, Johannes, additional, Criscione, Enrico, additional, Fukutomi, Motoki, additional, Hein, Manuel, additional, Didier, Romain, additional, Meier, David, additional, Okuno, Taishi, additional, Ludwig, Sebastian, additional, Ancona, Marco, additional, Schewel, Dimitry, additional, Fabris, Tommaso, additional, Vincent, Flavien, additional, Voigtländer, Lisa, additional, Ziviello, Francesca, additional, Tanner, Richard, additional, Tamburino, Claudia, additional, Ruge, Hendrik, additional, Lunardi, Mattia, additional, Codner, Pablo, additional, Barbanti, Marco, additional, Nietlispach, Fabian, additional, Nef, Holger, additional, Casserly, Ivan, additional, Babaliaros, Vasilis, additional, Tchetche, Didier, additional, Lange, Ruediger, additional, Gilard, Martine, additional, Montorfano, Matteo, additional, Landt, Martin, additional, Grayburn, Paul, additional, Ruile, Philipp, additional, Van Mieghem, Nicolas, additional, Bedogni, Francesco, additional, Dangas, George, additional, Tamburino, Corrado, additional, Schofer, Niklas, additional, Burzotta, Francesco, additional, Van Belle, Eric, additional, Neumann, Franz-Josef, additional, Kornowski, Ran, additional, Ribichini, Flavio, additional, Mylotte, Darren, additional, Windecker, Stephan, additional, Richardt, Gert, additional, Sondergaard, Lars, additional, Webb, John, additional, Tarantini, Giuseppe, additional, Pilgrim, Thomas, additional, Mehran, Roxana, additional, Capodanno, Davide, additional, Kastrati, Adnan, additional, Joner, Michael, additional, Spence, Mark, additional, and Kasel, Markus, additional

Published
2023
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12. Longitudinal changes in the prevalence of adult asthma: An epidemiological survey among Japanese salaried employees and their dependents using healthcare insurance claim from 1999 to 2019

Author

Kisako Nagayama, Yuma Fukutomi, Eiji Nakatani, Yuto Hamada, Mari Irie, Kazuhiro Azekawa, Yasuhiro Tomita, Kentaro Watai, Yosuke Kamide, Kiyoshi Sekiya, Yoichi Nakamura, Chiharu Okada, Terufumi Shimoda, Mizuho Nagao, Takao Fujisawa, and Masami Taniguchi

Subjects
Immunology and Allergy, General Medicine
Abstract

Information on changes in asthma prevalence and the treatment status for asthma is used as basic information for taking medical and administrative measures against asthma. However, this information among adults is relatively limited.To elucidate changes in the prevalence of asthma and treatment status over time among Japanese adults, health insurance claim data from some health insurance societies covering salaried employees and their dependents were studied longitudinally. Claim data from FY1999 to 2007 were obtained from two health insurance societies, and data from FY 2011 to 2019 were obtained from three different health insurance societies, and changes in standardized asthma prevalence among subjects aged 20-59 years, proportion of asthma patients prescribed ICS, leukotriene receptor antagonist (LTRA), and LABA, and the mean number of acute asthma exacerbations per year were analyzed.The prevalence of asthma increased from 1.6% in 1999 to 3.0% in 2007 and 2.9% in 2011 to 4.6% in 2019. Increased trends in asthma prevalence from 2011 to 2019 were more noticeable in subjects in their 50s than those in their 20s for both sexes. The number of emergency visits related to asthma was 1.5 per year in 1999, which decreased to 0.8 per year in 2019. The proportion of people prescribed all anti-asthma medications (ICS, LTRA, and LABA) increased over time.The prevalence of adult asthma among Japanese salaried employees and their dependents has increased over the last 20 years, suggesting more attention should be paid to the prevention of this disease in adults.

Published
2023

13. Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure

Author

Kai Ryu, Yuma Fukutomi, Eiji Nakatani, Maki Iwata, Kisako Nagayama, Koichi Yano, Yuto Nakamura, Yuto Hamada, Kentaro Watai, Yosuke Kamide, Kiyoshi Sekiya, Jun Araya, Kazuyoshi Kuwano, and Masami Taniguchi

Subjects
Immunology and Allergy, General Medicine
Abstract

Frailty is a geriatric syndrome of age-related physiological decline, which is associated with higher mortality and decreased healthy life expectancy, and muscle weakness is one of the presentations of frailty. We investigated an association between lifetime oral corticosteroid (OCS) exposure with frailty and muscle weakness among elderly patients with asthma.We studied 203 consecutive elderly outpatients with asthma aged ≥60 years old. They were classified into three groups according to their cumulative lifetime OCS dose (lifetime non-users, lower-dose users, and higher-dose users), which was retrospectively estimated from the response to a structured questionnaire. The prevalence of frailty determined by the Kihon Checklist was compared between the three groups. Hand-grip strength, and lean mass index were also measured as markers of muscle strength.Thirty-seven percent of the patients studied were considered frail. Higher cumulative lifetime OCS exposure was associated with a significantly higher prevalence of frailty (33% in lifetime non-users, 59% in lower-dose users, and 68% in higher-dose users; P for trend0.005). This was also associated with lower hand-grip strength in both sexes (P for trend; 0.012 in men, and 0.020 in women), and lower lean mass index in men (P for trend 0.002). However, current doses of OCS were not significantly associated with these outcomes.Cumulative lifetime OCS exposure was associated with a higher prevalence of frailty and muscle weakness. These findings emphasize the importance of minimizing lifetime OCS exposure for the prolongation of healthy life expectancy in patients with asthma.

Published
2023

16. Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)

Author

Maho Suzukawa, Ken Ohta, Yuma Fukutomi, Hiroya Hashimoto, Takeo Endo, Masahiro Abe, Yosuke Kamide, Makoto Yoshida, Yoshihiro Kikuchi, Toshiyuki Kita, Kenji Chibana, Yasushi Tanimoto, Kentaro Hyodo, Shohei Takata, Toshiya Inui, Masahide Yasui, Yoshinori Harada, Toshio Sato, Yumi Sakakibara, Yoshiaki Minakata, Yoshikazu Inoue, Shinji Tamaki, Tsutomu Shinohara, Kazutaka Takami, Motofumi Tsubakihara, Masahide Oki, Kentaro Wakamatsu, Masahide Horiba, Gen Ideura, Koko Hidaka, Akiko M. Saito, Nobuyuki Kobayashi, and Masami Taniguchi

Subjects
Immunology and Allergy, General Medicine
Abstract

Asthma is a heterogeneous disease, and phenotyping can facilitate understanding of disease pathogenesis and direct appropriate asthma treatment. This nationwide cohort study aimed to phenotype asthma patients in Japan and identify potential biomarkers to classify the phenotypes.Adult asthma patients (n = 1925) from 27 national hospitals in Japan were enrolled and divided into Global Initiative for Asthma (GINA) steps 4 or 5 (GINA 4, 5) and GINA Steps 1, 2, or 3 (GINA 1-3) for therapy. Clinical data and questionnaires were collected. Biomarker levels among GINA 4, 5 patients were measured. Ward's minimum variance hierarchical clustering method and tree analysis were performed for phenotyping. Analysis of variance, the Kruskal-Wallis, and chi-square tests were used to compare cluster differences.The following five clusters were identified: 1) late-onset, old, less-atopic; 2) late-onset, old, eosinophilic, low FEVFive distinct phenotypes were identified for moderate to severe asthma and may be classified using clinical and molecular variables (Registered in UMIN-CTR; UMIN000027776.).

Published
2023

20. Computed tomography findings of paranasal sinuses in patients with eosinophilic granulomatosis with polyangiitis: Comparison with other eosinophilic sinus diseases and clinical relevance of their severity

Author

Iwata, Maki, primary, Fukutomi, Yuma, additional, Hamada, Yuto, additional, Nakamura, Yuto, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Ishii, Toyota, additional, Taniguchi, Masami, additional, and Sekiya, Kiyoshi, additional

Published
2023
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21. Omalizumab ameliorates extrarespiratory symptoms in patients with aspirin-exacerbated respiratory disease

Author

Hayashi, Hiroaki, primary, Fukutomi, Yuma, additional, Mitsui, Chihiro, additional, Kajiwara, Keiichi, additional, Watai, Kentaro, additional, Tomita, Yasuhiro, additional, Kamide, Yosuke, additional, Tsuburai, Takahiro, additional, Sekiya, Kiyoshi, additional, Ishii, Makoto, additional, Hasegawa, Yoshinori, additional, and Taniguchi, Masami, additional

Published
2023
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28. Classifications of moderate to severe asthma phenotypes in Japan and analysis of serum biomarkers: A Nationwide Cohort Study in Japan (NHOM Asthma Study)

Author

Suzukawa, Maho, primary, Ohta, Ken, additional, Fukutomi, Yuma, additional, Hashimoto, Hiroya, additional, Endo, Takeo, additional, Abe, Masahiro, additional, Kamide, Yosuke, additional, Yoshida, Makoto, additional, Kikuchi, Yoshihiro, additional, Kita, Toshiyuki, additional, Chibana, Kenji, additional, Tanimoto, Yasushi, additional, Hyodo, Kentaro, additional, Takata, Shohei, additional, Inui, Toshiya, additional, Yasui, Masahide, additional, Harada, Yoshinori, additional, Sato, Toshio, additional, Sakakibara, Yumi, additional, Minakata, Yoshiaki, additional, Inoue, Yoshikazu, additional, Tamaki, Shinji, additional, Shinohara, Tsutomu, additional, Takami, Kazutaka, additional, Tsubakihara, Motofumi, additional, Oki, Masahide, additional, Wakamatsu, Kentaro, additional, Horiba, Masahide, additional, Ideura, Gen, additional, Hidaka, Koko, additional, Saito, Akiko M., additional, Kobayashi, Nobuyuki, additional, and Taniguchi, Masami, additional

Published
2023
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31. Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

Author

Charles C Wykoff, Francis Abreu, Anthony P Adamis, Karen Basu, David A Eichenbaum, Zdenka Haskova, Hugh Lin, Anat Loewenstein, Shaun Mohan, Ian A Pearce, Taiji Sakamoto, Patricio G Schlottmann, David Silverman, Jennifer K Sun, John A Wells, Jeffrey R Willis, Ramin Tadayoni, Thomas Aaberg, Ashkan Abbey, Elmira Abdulaeva, Santiago Abengoechea, Prema Abraham, Thomas Ach, Serrhel Adams, Alfredo Adan Civera, Sean Adrean, Hansjurgen Agostini, Suhail Alam, Arturo Alezzandrini, Virgil Alfaro, Daniel Aliseda, Arghavan Almony, Pedro Amat, Payam Amini, Andrew Antoszyk, Luis Arias, Riaz Asaria, Marcos Avila, Carl C Awh, Joaquin Bafalluy, Carl Baker, Francesco Bandello, Mark Barakat, Karen Barraza, Gyorgy Bator, Caroline Baumal, Rubens Belfort Jr, Chris Bergstrom, George Bertolucci, Thomas Bochow, Matthias Bolz, Emilia Borcz, Arnaldo Bordon, David Boyer, Galina Bratko, Michael Brent, Jamin Brown, David M Brown, Maria Budzinskaya, Sylvia Buffet, Stuart Burgess, Ben Burton, Miguel Busquets, Francisco Cabrera, Carlo Cagini, Jorge Calzada, Peter Campochiaro, John Carlson, Alessandro Castellarin, Carlos Cava, Voraporn Chaikitmongkol, Clement Chan, Emmanuel Chang, Jonathan Chang, Andrew Chang, Steve Charles, Nauman Chaudhry, Caroline Chee, Judy Chen, Fred Chen, Shih-Jen Chen, Richard Cheong-Leen, Allen Chiang, Mark Chittum, David Chow, Brian Connolly, Pierre Loic Cornut, Karl Csaky, Carl Danzig, Arup Das, Vesselin Daskalov, Carmen Desco, Amr Dessouki, John Dickinson, Brian Do, Michael Dollin, Pravin Dugel, Jaroslava Dusova, David Eichenbaum, Bora Eldem, Robert Engstrom, Jan Ernest, Joan Josep Escobar, Simona Esposti, Nicole Eter, Naomi Falk, Andrej Farkas, Leonard Feiner, Nicolas Feltgen, Carlos Fernandez, Alvaro Fernandez Vega, Philip Ferrone, Joao Figueira, Marta Figueroa, Oliver Findl, Howard Fine, Jorge Fortun, Gregory M Fox, Scott Foxman, Carsten Framme, Samantha Fraser-Bell, Arthur Fu, Akira Fukutomi, Nicholas Fung, Federico Furno Sola, Roberto Gallego-Pinazo, Renata Garcia, Alfredo Garcia-Layana, Maciej Gawecki, Sheen George, Faruque Ghanchi, Ghassan Ghorayeb, Roger Goldberg, Michaella Goldstein, Nuno Gomes, Francisco Gomez Ulla, Victor Gonzalez, Craig Greven, Sunil Gupta, Miguel Guzman, Martin Harris, Katja Hatz, Vivienne Hau, Vincent Hau, Ken Hayashi, Jeffrey Heier, Ewa Herba, Vrinda Hershberger, Patrick Higgins, Akito Hirakata, Allen Ho, Nancy Holekamp, Shigeru Honda, Jason Hsu, Allen Hu, Maria Hurcikova, Yasuhiro Ikeda, Ricky Isernhagen, Yasuki Ito, Tim Jackson, Rachael Jacoby, Afsar Jafree, Golnaz Javey, Cameron Javid, Chirag Jhaveri, Mark Johnson, Marek Kacerík, Jakub Kaluzny, Daniel Kampik, Se Woong Kang, Kapil Kapoor, Levent Karabas, Tsutomu Kawasaki, Agnes Kerenyi, Arshad Khanani, Rahul Khurana, Brian Kim, Kazuhiro Kimura, Genichiro Kishino, Shigehiko Kitano, Kendra Klein-Mascia, Gregg Kokame, Jean Francois Korobelnik, Alexey Kulikov, Ajay Kuriyan, Henry Kwong, Robert Kwun, Timothy Lai, Chi-Chun Lai, Philip Laird, Laurent Lalonde, Paolo Lanzetta, Michael Larsen, Caroline Laugesen, Daniel Lavinsky, Olivier Lebreton, Seong Lee, Jaime Levy, Blandina Lipkova, Mimi Liu, Judy Liu, Chris P Lohmann, Nikolas London, Katrin Lorenz, Andrew Lotery, David Lozano Rechy, Silvio Lujan, Patrick Ma, Takatoshi Maeno, Sajjad Mahmood, Fuad Makkouk, Khurram Malik, Dennis Marcus, Alan Margherio, Leonardo Mastropasqua, Raj Maturi, Frank McCabe, Martin McKibbin, Hemal Mehta, Geeta Menon, Jale Mentes, Katarzyna Michalska-Malecka, Aneta Misheva, Yoshinori Mitamura, Paul Mitchell, Yasha Modi, Quresh Mohamed, Javier Montero, Jeffrey Moore, Virgilio Morales Canton, Haia Morori-Katz, Tatiana Morugova, Tomoaki Murakami, Maria Muzyka-Wozniak, Marco Nardi, Jan Nemcansky, Kamila Nester-Ostrowska, Julio Neto, Charles Newell, Massimo Nicolo, Jared Nielsen, Kousuke Noda, Akira Obana, Nahoko Ogata, Hideyasu Oh, Kean Oh, Matthew Ohr, Piotr Oleksy, Scott Oliver, Sebastien Olivier, James Osher, Sehnaz Ozcalişkan, Banu Ozturk, Andras Papp, Kyu Hyung Park, D Wilkin Parke, Maria Cristina Parravano, Sugat Patel, Sunil Patel, Ian Pearce, Joel Pearlman, Fernando Penha, Irfan Perente, Stephen Perkins, Grazia Pertile, Iva Petkova, Tunde Peto, Dante Pieramici, Andreas Pollreisz, Pear Pongsachareonnont, Nadezhda Pozdeyeva, Siegfried Priglinger, Jawad Qureshi, Dorota Raczynska, Rajesh Rajagopalan, Juan Ramirez Estudillo, Paul Raskauskas, Rajiv Rathod, Hessam Razavi, Carl Regillo, Federico Ricci, Soraya Rofagha, Dominika Romanczak, Bożena Romanowska-Dixon, Daniel Rosberger, Irit Rosenblatt, Brett Rosenblatt, Adam Ross, Paisan Ruamviboonsuk, Jose Maria Ruiz Moreno, Gustavo Salomão, Sukhpal Sandhu, Dirk Sandner, Laura Sararols, Osamu Sawada, Ramin Schadlu, Patricio Schlottmann, Claudia Schuart, Berthold Seitz, András Seres, Figen Sermet, Sandeep Shah, Ankur Shah, Rohan Shah, Sumit Sharma, Thomas Sheidow, Veeral Sheth, Akito Shimouchi, Masahiko Shimura, Bartosz Sikorski, Rufino Silva, Michael Singer, Lawrence Singerman, Rishi Singh, Eric Souied, David J Spinak, Georg Spital, Nathan Steinle, Jeffrey Stern, Glenn Stoller, Robert Stoltz, Cameron Stone, Amy Stone, Eric Suan, Masahiko Sugimoto, Iichiro Sugita, Jennifer Sun, Xiaodong Sun, Ivan Suner, Lajos Szalczer, Timea Szecsko, Ali Tabassian, Hitoshi Takagi, Kei Takayama, Alexandre Taleb, James Talks, Gavin Tan, Teruyo Tanabe, Stanford Taylor, Allen Thach, John Thompson, Paul Tlucek, Robert Torti, Daniela Tosheva Guneva, Edit Toth-Molnar, Eduardo Uchiyama, Attila Vajas, Deepali Varma, Balazs Varsanyi, Petja Vassileva, Sara Vaz-Pereira, Miroslav Veith, Jose Ignacio Vela, Francesco Viola, Gianni Virgili, Gábor Vogt, Henrik Vorum, Pamela Weber, Thoalf Wecke, Raymond Wee, Martin Weger, Paul Weishaar, Sanjeewa Wickremasinghe, Thomas Reginald Williams, Thomas Williams, Geoff Williams, Armin Wolf, Jeremy Wolfe, James Wong, David Wong, Ian Wong, Robert Wong, Bogumil Wowra, Edward Wylęgała, Chang-Hao Yang, Tsutomu Yasukawa, Paul Yates, Gursel Yilmaz, Glenn Yiu, Young Hee Yoon, Barak Yoreh, Shigeo Yoshida, Hyeong Gon Yu, Seung Young Yu, Tatiana Yurieva, Leandro Zacharias, Karolina Zaczek Zakrzewska, Alberto Zambrano, Barbara Zatorska, Carlos Zeolite, and Jeffrey Zheutlin

Subjects
Male, Vascular Endothelial Growth Factor A, Diabetic Retinopathy, Recombinant Fusion Proteins, Visual Acuity, Angiogenesis Inhibitors, General Medicine, Middle Aged, Drug Administration Schedule, Angiopoietin-2, Receptors, Vascular Endothelial Growth Factor, Treatment Outcome, Double-Blind Method, Antibodies, Bispecific, Intravitreal Injections, Edema, Humans, Female, Macula Lutea, Aged
Abstract

To reduce treatment burden and optimise patient outcomes in diabetic macular oedema, we present 1-year results from two phase 3 trials of faricimab, a novel angiopoietin-2 and vascular endothelial growth factor-A bispecific antibody.YOSEMITE and RHINE were randomised, double-masked, non-inferiority trials across 353 sites worldwide. Adults with vision loss due to centre-involving diabetic macular oedema were randomly assigned (1:1:1) to intravitreal faricimab 6·0 mg every 8 weeks, faricimab 6·0 mg per personalised treatment interval (PTI), or aflibercept 2·0 mg every 8 weeks up to week 100. PTI dosing intervals were extended, maintained, or reduced (every 4 weeks up to every 16 weeks) based on disease activity at active dosing visits. The primary endpoint was mean change in best-corrected visual acuity at 1 year, averaged over weeks 48, 52, and 56. Efficacy analyses included the intention-to-treat population (non-inferiority margin 4 Early Treatment Diabetic Retinopathy Study [ETDRS] letters); safety analyses included patients with at least one dose of study treatment. These trials are registered with ClinicalTrials.gov (YOSEMITE NCT03622580 and RHINE NCT03622593).3247 patients were screened for eligibility in YOSEMITE (n=1532) and RHINE (n=1715). After exclusions, 940 patients were enrolled into YOSEMITE between Sept 5, 2018, and Sept 19, 2019, and 951 patients were enrolled into RHINE between Oct 9, 2018, and Sept 20, 2019. These 1891 patients were randomly assigned to faricimab every 8 weeks (YOSEMITE n=315, RHINE n=317), faricimab PTI (n=313, n=319), or aflibercept every 8 weeks (n=312, n=315). Non-inferiority for the primary endpoint was achieved with faricimab every 8 weeks (adjusted mean vs aflibercept every 8 weeks in YOSEMITE 10·7 ETDRS letters [97·52% CI 9·4 to 12·0] vs 10·9 ETDRS letters [9·6 to 12·2], difference -0·2 ETDRS letters [-2·0 to 1·6]; RHINE 11·8 ETDRS letters [10·6 to 13·0] vs 10·3 ETDRS letters [9·1 to 11·4] letters, difference 1·5 ETDRS letters [-0·1 to 3·2]) and faricimab PTI (YOSEMITE 11·6 ETDRS letters [10·3 to 12·9], difference 0·7 ETDRS letters [-1·1 to 2·5]; RHINE 10·8 ETDRS letters [9·6 to 11·9], difference 0·5 ETDRS letters [-1·1 to 2·1]). Incidence of ocular adverse events was comparable between faricimab every 8 weeks (YOSEMITE n=98 [31%], RHINE n=137 [43%]), faricimab PTI (n=106 [34%], n=119 [37%]), and aflibercept every 8 weeks (n=102 [33%], n=113 [36%]).Robust vision gains and anatomical improvements with faricimab were achieved with adjustable dosing up to every 16 weeks, demonstrating the potential for faricimab to extend the durability of treatment for patients with diabetic macular oedema.F Hoffmann-La Roche.

Published
2022

34. Longitudinal changes in the prevalence of adult asthma: An epidemiological survey among Japanese salaried employees and their dependents using healthcare insurance claim from 1999 to 2019

Author

Nagayama, Kisako, primary, Fukutomi, Yuma, additional, Nakatani, Eiji, additional, Hamada, Yuto, additional, Irie, Mari, additional, Azekawa, Kazuhiro, additional, Tomita, Yasuhiro, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Nakamura, Yoichi, additional, Okada, Chiharu, additional, Shimoda, Terufumi, additional, Nagao, Mizuho, additional, Fujisawa, Takao, additional, and Taniguchi, Masami, additional

Published
2022
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35. Frailty and muscle weakness in elderly patients with asthma and their association with cumulative lifetime oral corticosteroid exposure

Author

Ryu, Kai, primary, Fukutomi, Yuma, additional, Nakatani, Eiji, additional, Iwata, Maki, additional, Nagayama, Kisako, additional, Yano, Koichi, additional, Nakamura, Yuto, additional, Hamada, Yuto, additional, Watai, Kentaro, additional, Kamide, Yosuke, additional, Sekiya, Kiyoshi, additional, Araya, Jun, additional, Kuwano, Kazuyoshi, additional, and Taniguchi, Masami, additional

Published
2022
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37. Genome-wide association study reveals an association between the HLA-DPB1∗02:01:02 allele and wheat-dependent exercise-induced anaphylaxis

Author

Yukinobu Nakagawa, Naoe Harada, Yoshiko Oda, Masashi Nakamura, Yuko Chinuki, Akiko Yagami, Hiroo Yokozeki, Koya Fukunaga, Kayoko Matsunaga, Michihiro Hide, Yuma Fukutomi, Yuto Hamada, Eishin Morita, Reiko Kishikawa, Atsushi Fukunaga, Tsukasa Ugajin, Taisei Mushiroda, Masataka Suehiro, Emiko Noguchi, and Akiko Sugiyama

Subjects
HLA-DPB1, business.industry, Locus (genetics), Genome-wide association study, Human leukocyte antigen, medicine.disease, Food allergy, Genetic model, Immunology, Genetics, medicine, Allele, business, Genetics (clinical), Wheat allergy
Abstract

Summary Wheat-dependent exercise-induced anaphylaxis (WDEIA) is a life-threatening food allergy triggered by wheat in combination with the second factor such as exercise. The identification of potential genetic risk factors for this allergy might help high-risk individuals before consuming wheat-containing food. We aimed to identify genetic variants associated with WDEIA. A genome-wide association study was conducted in a discovery set of 77 individuals with WDEIA and 924 control subjects via three genetic models. The associations were confirmed in a replication set of 91 affected individuals and 435 control individuals. Summary statistics from the combined set were analyzed by meta-analysis with a random-effect model. In the discovery set, a locus on chromosome 6, rs9277630, was associated with WDEIA in the dominant model (OR = 3.95 [95% CI, 2.31−6.73], p = 7.87 × 10−8). The HLA-DPB1∗02:01:02 allele displayed the most significant association with WDEIA (OR = 4.51 [95% CI, 2.66−7.63], p = 2.28 × 10−9), as determined via HLA imputation following targeted sequencing. The association of the allele with WDEIA was confirmed in replication samples (OR = 3.82 [95% CI, 2.33−6.26], p = 3.03 × 10−8). A meta-analysis performed in the combined set revealed that the HLA-DPB1∗02:01:02 allele was significantly associated with an increased risk of WDEIA (OR = 4.13 [95% CI, 2.89−5.93], p = 1.06 × 10−14). Individuals carrying the HLA-DPB1∗02:01:02 allele have a significantly increased risk of WDEIA. Further validation of these findings in independent multiethnic cohorts is needed.

Published
2021

38. Respiratory sensitization to insect allergens: Species, components and clinical symptoms

Author

Yuji Kawakami and Yuma Fukutomi

Subjects
0301 basic medicine, Allergy, Insecta, Occupational allergy, Exacerbation, media_common.quotation_subject, Cockroaches, Insect, Moths, medicine.disease_cause, Sensitization, Chironomidae, 03 medical and health sciences, 0302 clinical medicine, Allergen, immune system diseases, biology.animal, Respiratory Hypersensitivity, medicine, Animals, Humans, Immunology and Allergy, media_common, Asthma, Larva, Cockroach, biology, business.industry, fungi, General Medicine, RC581-607, Allergens, medicine.disease, Rhinitis, Allergic, respiratory tract diseases, Occupational Diseases, 030104 developmental biology, medicine.anatomical_structure, 030228 respiratory system, Immunology, Insect Proteins, Immunologic diseases. Allergy, business
Abstract

Airborne insect particles have been identified as an important cause of respiratory allergies, including allergic asthma and rhinitis. In the literature, the significance of respiratory exposure to insect particles as a cause of occupational allergy has been well-documented. Indeed, many cases of occupational allergy have been reported including allergy to the larvae of flies and moths in anglers and occupationally exposed workers, to grain pests in bakers or other workers handling grains, and to crickets and/or locusts in researchers and workers in aquaculture companies. Furthermore, the prevalence of sensitization to insect allergens is considerably high among patients with asthma and/or rhinitis who are not occupationally exposed to insects, suggesting the clinical relevance of exposure to insects in indoor and outdoor environmental non-occupational settings. Exposure to cockroaches, a well-studied indoor insect, is associated with cockroach sensitization and the development and exacerbation of asthma. Booklice, another common indoor insect, were recently identified as a significant sensitizer of asthmatic patients in Japan and India, and potentially of asthma patients living in warm and humid climates around the world. Lip b 1 was identified as an allergenic protein contributing to the species-specific sensitization to booklice. Moths are considered a significant seasonal outdoor allergen and their allergens are considered to have the highest sensitization rate among Japanese patients. However, other than cockroaches, allergenic insect proteins contributing to sensitization have not been fully characterized to date.

Published
2021

39. USP40 deubiquitinates HINT1 and stabilizes p53 in podocyte damage

Author

Takahashi, Shohei, primary, Fukuhara, Daisuke, additional, Kimura, Toru, additional, Fukutomi, Toshiyuki, additional, Tanaka, Eriko, additional, Mikami, Naoaki, additional, Hada, Ichiro, additional, Takematsu, Hiromu, additional, Nishibori, Yukino, additional, Akimoto, Yoshihiro, additional, Kiyonari, Hiroshi, additional, Abe, Takaya, additional, Huber, Otmar, additional, and Yan, Kunimasa, additional

Published
2022
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42. Optimal Aspergillus fumigatus and Asp f 1 serum IgG cut-offs for the diagnosis of allergic bronchopulmonary aspergillosis

Author

Tadashi Nagai, Eiji Nakatani, Akemi Saito, Yoshiki Shiraishi, Koichiro Asano, Yuto Hamada, Masami Taniguchi, Kiyoshi Sekiya, Tsuyoshi Oguma, Kazuki Harada, Yosuke Kamide, Yuma Fukutomi, and Kentaro Watai

Subjects
Adult, lcsh:Immunologic diseases. Allergy, 0301 basic medicine, Antigens, Fungal, IgG, Aspergillus fumigatus, law.invention, Precipitin, 03 medical and health sciences, 0302 clinical medicine, Reference Values, law, Allergic bronchopulmonary aspergillosis, medicine, Humans, Immunology and Allergy, Aged, Asthma, biology, medicine.diagnostic_test, business.industry, Aspergillosis, Allergic Bronchopulmonary, Serine Endopeptidases, Cut-off, General Medicine, Allergens, Immunoglobulin E, Middle Aged, biology.organism_classification, medicine.disease, Asp f 1, 030104 developmental biology, ROC Curve, 030228 respiratory system, IgG binding, Case-Control Studies, Immunoglobulin G, Immunoassay, Immunology, Recombinant DNA, biology.protein, Antibody, lcsh:RC581-607, business, Biomarkers
Abstract

Background: The presence of IgG antibodies (Abs) to Aspergillus fumigatus (Af) is a crucial diagnostic criterion for allergic bronchopulmonary aspergillosis (ABPA). Although precipitation is traditionally used to document IgG Abs, anti-Af serum IgG levels can also be measured by enzyme immunoassay (EIA). However, there are insufficient data on the optimal cut-offs to assess diagnostic performance of the EIA method. This study aimed to determine cut-off levels of IgG binding crude Af extracts or recombinant Asp f 1 (by ImmunoCAP®) and to compare their efficacy for ABPA diagnosis with Af-precipitating Abs. Methods: The age distribution of levels of IgG to crude extracts of Af (Af-IgG) and recombinant Asp f 1 (Asp f 1-IgG) was established using sera from 694 healthy controls (HC). Receiver operating characteristic analysis for Af-IgG and Asp f 1-IgG levels for the purpose of ABPA diagnosis was performed in 306 Af-sensitized asthma patients (including 49 ABPA), and cut-offs were determined. Results: An age-dependent decline in the levels of Af-IgG was observed in HC. Thus, cut-offs for Af-IgG levels were determined separately by age as 60 mg/L for patients aged

Published
2021

43. Percutaneous Transaxillary versus Surgically-Assisted Transsubclavian TAVR: A Single Center Experience

Author

Lars Søndergaard, Ben Wilkins, Giulia Costa, Ole De Backer, Motoki Fukutomi, and Gintautas Bielauskas

Subjects
TAVR, alternative access, transaxillary, percutaneous, next-day discharge, medicine.medical_specialty, Percutaneous, Transcatheter aortic, business.industry, medicine.medical_treatment, Single Center, Surgery, Valve replacement, medicine, Cardiology and Cardiovascular Medicine, business
Abstract

Background: Transfemoral access is the standard approach for transcatheter aortic valve replacement (TAVR). However, an important proportion of TAVR patients may not be considered for transfemoral ...

Published
2021

44. Prophylactic Permanent Pacemaker Implantation in Patients With Right Bundle Branch Block Undergoing TAVR

Author

Lars Søndergaard, Gintautas Bieliauskas, Ole De Backer, Thijmen Hokken, Motoki Fukutomi, Nicolas M. Van Mieghem, Ivan Wong, Joost Daemen, and Peter de Jaegere

Subjects
Pacemaker, Artificial, medicine.medical_specialty, business.industry, Bundle-Branch Block, Cardiac Pacing, Artificial, MEDLINE, Aortic Valve Stenosis, Right bundle branch block, medicine.disease, Surgery, Transcatheter Aortic Valve Replacement, Electrocardiography, Treatment Outcome, Text mining, Risk Factors, medicine, Humans, In patient, Permanent pacemaker, Cardiology and Cardiovascular Medicine, business
Published
2021

46. Comparison of Morphological Patterns Between In-Stent Restenosis Lesions of Overlapping and Non-Overlapping Second- and Third-Generation Stents Using Optical Frequency Domain Imaging

Author

Motoki Fukutomi, Masao Takahashi, Seigo Arima, Kazuomi Kario, Hiroshi Funayama, Yukako Ogoyama, and Yusuke Oba

Subjects
Male, medicine.medical_treatment, 030204 cardiovascular system & hematology, Coronary Angiography, Coronary Restenosis, 03 medical and health sciences, Percutaneous Coronary Intervention, 0302 clinical medicine, Restenosis, Optical frequencies, Interquartile range, Humans, Medicine, 030212 general & internal medicine, Aged, Retrospective Studies, business.industry, Stent, Drug-Eluting Stents, General Medicine, Middle Aged, medicine.disease, Domain imaging, Third generation, Treatment Outcome, Homogeneous, Female, Stents, In stent restenosis, Cardiology and Cardiovascular Medicine, business, Nuclear medicine
Abstract

Purpose To analyze the difference in morphological patterns between in-stent restenosis (ISR) lesions of overlapping segments and ISR lesions of non-overlapping segments with second- and third-generation drug-eluting stents (DESs) using optical frequency domain imaging (OFDI). Methods We analyzed 23 consecutive ISR lesions after second- or third-generation DES implantation using OFDI. Results A total of 18 men and 5 women (median age, 68.0 years; interquartile range, 51.0–74.0 years) were included in the analysis. Fourteen and nine patients underwent second- and third-generation DES implantation, respectively. The median ISR detection timepoint was 10.0 months after implantation (interquartile range, 9.0–34.0 months). In 9 out of 23 lesions, ISR was found in the stent overlap area (overlapping segment group); the remaining 14 cases were categorized as the non-overlapping segment group. In OFDI analysis, homogeneous, layered, and heterogeneous patterns were found in 22%, 55%, and 22%, respectively, of lesions in the overlapping segment group and 14%, 50%, and 35%, respectively, of lesions in the non-overlapping segment group. There was no difference in the distribution of restenotic tissue structure patterns between the groups (p = .756). Conclusions Morphological assessments of ISR tissue using OFDI showed no difference between the overlapping and non-overlapping segment groups with second and third-generation DESs in this hypothesis generating study.

Published
2020

47. SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy

Author

Takahiro Kodama, Tasuku Nakabori, Tomohide Tatsumi, Keisuke Fukutomi, Takuo Yamai, Kazuhiro Murai, Ryotaro Sakamori, Ryoko Yamada, Hayato Hikita, Kei Miyakawa, Akihide Ryo, Makoto Fukuoka, Tetsuo Takehara, and Kohei Watashi

Subjects
Transcriptional Activation, 0301 basic medicine, Hepatitis B virus, endocrine system diseases, Biophysics, Resveratrol, Virus Replication, medicine.disease_cause, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sirtuin 1, Downregulation and upregulation, Transcription (biology), Autophagy, medicine, Humans, Molecular Biology, Gene knockdown, Chemistry, food and beverages, virus diseases, Hep G2 Cells, Cell Biology, Autophagy-related protein 13, Hepatitis B, digestive system diseases, Up-Regulation, Cell biology, 030104 developmental biology, 030220 oncology & carcinogenesis, Host-Pathogen Interactions, RNA, Viral, RNA Interference, hormones, hormone substitutes, and hormone antagonists, Intracellular
Abstract

Autophagy is an intracellular process that can lead to the degradation of malfunctioned proteins and damaged organelles to maintain homeostasis during cellular stress. Here, we evaluated the change in hepatitis B virus (HBV) production by regulating hepatic autophagy in HBV-producing cells. We examined focusing on a relation with a positive autophagy regulator, sirtuin1 (SIRT1). Starvation and rapamycin treatment induced autophagy with increasing SIRT1 protein, HBc protein and pregenomic RNA (pgRNA) levels in HBV- producing cells. Knockdown of Atg7 or Atg13 suppressed hepatic autophagy, and it did not change SIRT1 protein, HBc protein or pgRNA levels in HBV- producing cells. Resveratrol, which increases SIRT1 expression and activity, promoted autophagy and increased HBc protein and pgRNA levels. siRNA-mediated knockdown of SIRT1 inhibited autophagy and decreased HBc protein and pgRNA levels. In SIRT1-knockdown cells, starvation promoted autophagy but did not increase HBc protein and pgRNA levels. In conclusion, HBc protein and pgRNA levels are upregulated not by the autophagic process itself but by the SIRT1 expression level.

Published
2020

48. Left Atrial Appendage Closure

Author

Lars Søndergaard, Motoki Fukutomi, Ole De Backer, and Ben Wilkins

Subjects
Leak, medicine.medical_specialty, business.industry, Vascular access, 030204 cardiovascular system & hematology, medicine.disease, Pericardial effusion, Surgery, Stroke risk, 03 medical and health sciences, 0302 clinical medicine, Left atrial, Physiology (medical), Device Embolization, medicine, cardiovascular diseases, 030212 general & internal medicine, Thrombus, Cardiology and Cardiovascular Medicine, business, Stroke
Abstract

Left atrial appendage closure (LAAC) is noninferior to oral vitamin K antagonist therapy for the reduction of nonvalvular atrial fibrillation-related stroke risk. Currently, the procedure is most widely accepted in patients who cannot tolerate oral anticoagulants. This patient population is generally comorbid, making any reduction in procedural complications paramount. LAAC has important complications described in the periprocedural and postprocedural periods. The prevention and management of complications regarding vascular access, transseptal puncture, pericardial effusion, device embolization, stroke, air embolusperidevice leak, device-related thrombus and device erosion/ late pericardial effusion are discussed.

Published
2020

49. Combination gemcitabine plus S-1 versus gemcitabine plus cisplatin for advanced/recurrent biliary tract cancer: the FUGA-BT (JCOG1113) randomized phase III clinical trial

Author

Ken Kamata, R. Sugimoto, Hiroki Hara, Tatsuya Yamashita, Naohiro Okano, Hiroaki Yanagimoto, Masataka Ikeda, Masato Ozaka, Chigusa Morizane, Junji Furuse, Hiroyuki Miyakawa, Kazuhiko Shioji, Junki Mizusawa, Kazuya Sugimori, Keita Wada, Naoya Kato, Ayumu Hosokawa, Shoji Nakamori, Ken Kawabe, Tomohisa Iwai, Tatsuya Ioka, Toshio Nakagohri, Kazutoshi Tobimatsu, Hiroshi Ishii, Makoto Ueno, Hironori Yamaguchi, Seigo Yukisawa, Yasuyuki Kawamoto, T. Okusaka, Y. Kojima, K. Yane, Nobumasa Mizuno, Hiroshi Katayama, Kenji Nakamura, Ken Shimizu, Akira Fukutomi, and Akinori Asagi

Subjects
Adult, Male, 0301 basic medicine, medicine.medical_specialty, Vomiting, Nausea, Deoxycytidine, Gastroenterology, Disease-Free Survival, law.invention, 03 medical and health sciences, 0302 clinical medicine, Japan, Randomized controlled trial, law, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Clinical endpoint, medicine, Mucositis, Humans, Aged, Tegafur, business.industry, Standard treatment, Hazard ratio, Hematology, Middle Aged, medicine.disease, Gemcitabine, Drug Combinations, Oxonic Acid, Biliary Tract Neoplasms, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Female, Cisplatin, medicine.symptom, business, medicine.drug
Abstract

Background Gemcitabine plus cisplatin (GC) is the standard treatment of advanced biliary tract cancer (BTC); however, it causes nausea, vomiting, and anorexia, and requires hydration. Gemcitabine plus S-1 (GS) reportedly has equal to, or better, efficacy and an acceptable toxicity profile. We aimed to confirm the non-inferiority of GS to GC for patients with advanced/recurrent BTC in terms of overall survival (OS). Patients and methods We undertook a phase III randomized trial in 33 institutions in Japan. Eligibility criteria included chemotherapy-naive patients with recurrent or unresectable BTC, an Eastern Cooperative Oncology Group Performance Status of 0−1, and adequate organ function. The calculated sample size was 350 with a one-sided α of 5%, a power of 80%, and non-inferiority margin hazard ratio (HR) of 1.155. The primary end point was OS, while the secondary end points included progression-free survival (PFS), response rate (RR), adverse events (AEs), and clinically significant AEs defined as grade ≥2 fatigue, anorexia, nausea, vomiting, oral mucositis, or diarrhea. Results Between May 2013 and March 2016, 354 patients were enrolled. GS was found to be non-inferior to GC [median OS: 13.4months with GC and 15.1months with GS, HR, 0.945; 90% confidence interval (CI), 0.78–1.15; P=0.046 for non-inferiority]. The median PFS was 5.8months with GC and 6.8months with GS (HR 0.86; 95% CI 0.70–1.07). The RR was 32.4% with GC and 29.8% with GS. Both treatments were generally well-tolerated. Clinically significant AEs were observed in 35.1% of patients in the GC arm and 29.9% in the GS arm. Conclusions GS, which does not require hydration, should be considered a new, convenient standard of care option for patients with advanced/recurrent BTC. Clinical Trial number This trial has been registered with the UMIN Clinical Trials Registry (http://www.umin.ac.jp/ctr/index.htm), number UMIN000010667.

Published
2019

50. Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomised, double-masked, phase 3 trials

Author

Wykoff, Charles C, primary, Abreu, Francis, additional, Adamis, Anthony P, additional, Basu, Karen, additional, Eichenbaum, David A, additional, Haskova, Zdenka, additional, Lin, Hugh, additional, Loewenstein, Anat, additional, Mohan, Shaun, additional, Pearce, Ian A, additional, Sakamoto, Taiji, additional, Schlottmann, Patricio G, additional, Silverman, David, additional, Sun, Jennifer K, additional, Wells, John A, additional, Willis, Jeffrey R, additional, Tadayoni, Ramin, additional, Aaberg, Thomas, additional, Abbey, Ashkan, additional, Abdulaeva, Elmira, additional, Abengoechea, Santiago, additional, Abraham, Prema, additional, Ach, Thomas, additional, Adams, Serrhel, additional, Adan Civera, Alfredo, additional, Adrean, Sean, additional, Agostini, Hansjurgen, additional, Alam, Suhail, additional, Alezzandrini, Arturo, additional, Alfaro, Virgil, additional, Aliseda, Daniel, additional, Almony, Arghavan, additional, Amat, Pedro, additional, Amini, Payam, additional, Antoszyk, Andrew, additional, Arias, Luis, additional, Asaria, Riaz, additional, Avila, Marcos, additional, Awh, Carl C, additional, Bafalluy, Joaquin, additional, Baker, Carl, additional, Bandello, Francesco, additional, Barakat, Mark, additional, Barraza, Karen, additional, Bator, Gyorgy, additional, Baumal, Caroline, additional, Belfort Jr, Rubens, additional, Bergstrom, Chris, additional, Bertolucci, George, additional, Bochow, Thomas, additional, Bolz, Matthias, additional, Borcz, Emilia, additional, Bordon, Arnaldo, additional, Boyer, David, additional, Bratko, Galina, additional, Brent, Michael, additional, Brown, Jamin, additional, Brown, David M, additional, Budzinskaya, Maria, additional, Buffet, Sylvia, additional, Burgess, Stuart, additional, Burton, Ben, additional, Busquets, Miguel, additional, Cabrera, Francisco, additional, Cagini, Carlo, additional, Calzada, Jorge, additional, Campochiaro, Peter, additional, Carlson, John, additional, Castellarin, Alessandro, additional, Cava, Carlos, additional, Chaikitmongkol, Voraporn, additional, Chan, Clement, additional, Chang, Emmanuel, additional, Chang, Jonathan, additional, Chang, Andrew, additional, Charles, Steve, additional, Chaudhry, Nauman, additional, Chee, Caroline, additional, Chen, Judy, additional, Chen, Fred, additional, Chen, Shih-Jen, additional, Cheong-Leen, Richard, additional, Chiang, Allen, additional, Chittum, Mark, additional, Chow, David, additional, Connolly, Brian, additional, Cornut, Pierre Loic, additional, Csaky, Karl, additional, Danzig, Carl, additional, Das, Arup, additional, Daskalov, Vesselin, additional, Desco, Carmen, additional, Dessouki, Amr, additional, Dickinson, John, additional, Do, Brian, additional, Dollin, Michael, additional, Dugel, Pravin, additional, Dusova, Jaroslava, additional, Eichenbaum, David, additional, Eldem, Bora, additional, Engstrom, Robert, additional, Ernest, Jan, additional, Escobar, Joan Josep, additional, Esposti, Simona, additional, Eter, Nicole, additional, Falk, Naomi, additional, Farkas, Andrej, additional, Feiner, Leonard, additional, Feltgen, Nicolas, additional, Fernandez, Carlos, additional, Fernandez Vega, Alvaro, additional, Ferrone, Philip, additional, Figueira, Joao, additional, Figueroa, Marta, additional, Findl, .Oliver, additional, Fine, Howard, additional, Fortun, Jorge, additional, Fox, Gregory M, additional, Foxman, Scott, additional, Framme, Carsten, additional, Fraser-Bell, Samantha, additional, Fu, Arthur, additional, Fukutomi, Akira, additional, Fung, Nicholas, additional, Furno Sola, Federico, additional, Gallego-Pinazo, Roberto, additional, Garcia, Renata, additional, Garcia-Layana, Alfredo, additional, Gawecki, Maciej, additional, George, Sheen, additional, Ghanchi, Faruque, additional, Ghorayeb, Ghassan, additional, Goldberg, Roger, additional, Goldstein, Michaella, additional, Gomes, Nuno, additional, Gomez Ulla, Francisco, additional, Gonzalez, Victor, additional, Greven, Craig, additional, Gupta, Sunil, additional, Guzman, Miguel, additional, Harris, Martin, additional, Hatz, Katja, additional, Hau, Vivienne, additional, Hau, Vincent, additional, Hayashi, Ken, additional, Heier, Jeffrey, additional, Herba, Ewa, additional, Hershberger, Vrinda, additional, Higgins, Patrick, additional, Hirakata, Akito, additional, Ho, Allen, additional, Holekamp, Nancy, additional, Honda, Shigeru, additional, Hsu, Jason, additional, Hu, Allen, additional, Hurcikova, Maria, additional, Ikeda, Yasuhiro, additional, Isernhagen, Ricky, additional, Ito, Yasuki, additional, Jackson, Tim, additional, Jacoby, Rachael, additional, Jafree, Afsar, additional, Javey, Golnaz, additional, Javid, Cameron, additional, Jhaveri, Chirag, additional, Johnson, Mark, additional, Kacerík, Marek, additional, Kaluzny, Jakub, additional, Kampik, Daniel, additional, Kang, Se Woong, additional, Kapoor, Kapil, additional, Karabas, Levent, additional, Kawasaki, Tsutomu, additional, Kerenyi, Agnes, additional, Khanani, Arshad, additional, Khurana, Rahul, additional, Kim, Brian, additional, Kimura, Kazuhiro, additional, Kishino, Genichiro, additional, Kitano, Shigehiko, additional, Klein-Mascia, Kendra, additional, Kokame, Gregg, additional, Korobelnik, Jean Francois, additional, Kulikov, Alexey, additional, Kuriyan, Ajay, additional, Kwong, Henry, additional, Kwun, Robert, additional, Lai, Timothy, additional, Lai, Chi-Chun, additional, Laird, Philip, additional, Lalonde, Laurent, additional, Lanzetta, Paolo, additional, Larsen, Michael, additional, Laugesen, Caroline, additional, Lavinsky, Daniel, additional, Lebreton, Olivier, additional, Lee, Seong, additional, Levy, Jaime, additional, Lipkova, Blandina, additional, Liu, Mimi, additional, Liu, Judy, additional, Lohmann, Chris P, additional, London, Nikolas, additional, Lorenz, Katrin, additional, Lotery, Andrew, additional, Lozano Rechy, David, additional, Lujan, Silvio, additional, Ma, Patrick, additional, Maeno, Takatoshi, additional, Mahmood, Sajjad, additional, Makkouk, Fuad, additional, Malik, Khurram, additional, Marcus, Dennis, additional, Margherio, Alan, additional, Mastropasqua, Leonardo, additional, Maturi, Raj, additional, McCabe, Frank, additional, McKibbin, Martin, additional, Mehta, Hemal, additional, Menon, Geeta, additional, Mentes, Jale, additional, Michalska-Malecka, Katarzyna, additional, Misheva, Aneta, additional, Mitamura, Yoshinori, additional, Mitchell, Paul, additional, Modi, Yasha, additional, Mohamed, Quresh, additional, Montero, Javier, additional, Moore, Jeffrey, additional, Morales Canton, Virgilio, additional, Morori-Katz, Haia, additional, Morugova, Tatiana, additional, Murakami, Tomoaki, additional, Muzyka-Wozniak, Maria, additional, Nardi, Marco, additional, Nemcansky, Jan, additional, Nester-Ostrowska, Kamila, additional, Neto, Julio, additional, Newell, Charles, additional, Nicolo, Massimo, additional, Nielsen, Jared, additional, Noda, Kousuke, additional, Obana, Akira, additional, Ogata, Nahoko, additional, Oh, Hideyasu, additional, Oh, Kean, additional, Ohr, Matthew, additional, Oleksy, Piotr, additional, Oliver, Scott, additional, Olivier, Sebastien, additional, Osher, James, additional, Ozcalişkan, Sehnaz, additional, Ozturk, Banu, additional, Papp, Andras, additional, Park, Kyu Hyung, additional, Parke, D Wilkin, additional, Parravano, Maria Cristina, additional, Patel, Sugat, additional, Patel, Sunil, additional, Pearce, Ian, additional, Pearlman, Joel, additional, Penha, Fernando, additional, Perente, Irfan, additional, Perkins, Stephen, additional, Pertile, Grazia, additional, Petkova, Iva, additional, Peto, Tunde, additional, Pieramici, Dante, additional, Pollreisz, Andreas, additional, Pongsachareonnont, Pear, additional, Pozdeyeva, Nadezhda, additional, Priglinger, Siegfried, additional, Qureshi, Jawad, additional, Raczynska, Dorota, additional, Rajagopalan, Rajesh, additional, Ramirez Estudillo, Juan, additional, Raskauskas, Paul, additional, Rathod, Rajiv, additional, Razavi, Hessam, additional, Regillo, Carl, additional, Ricci, Federico, additional, Rofagha, Soraya, additional, Romanczak, Dominika, additional, Romanowska-Dixon, Bożena, additional, Rosberger, Daniel, additional, Rosenblatt, Irit, additional, Rosenblatt, Brett, additional, Ross, Adam, additional, Ruamviboonsuk, Paisan, additional, Ruiz Moreno, Jose Maria, additional, Salomão, Gustavo, additional, Sandhu, Sukhpal, additional, Sandner, Dirk, additional, Sararols, Laura, additional, Sawada, Osamu, additional, Schadlu, Ramin, additional, Schlottmann, Patricio, additional, Schuart, Claudia, additional, Seitz, Berthold, additional, Seres, András, additional, Sermet, Figen, additional, Shah, Sandeep, additional, Shah, Ankur, additional, Shah, Rohan, additional, Sharma, Sumit, additional, Sheidow, Thomas, additional, Sheth, Veeral, additional, Shimouchi, Akito, additional, Shimura, Masahiko, additional, Sikorski, Bartosz, additional, Silva, Rufino, additional, Singer, Michael, additional, Singerman, Lawrence, additional, Singh, Rishi, additional, Souied, Eric, additional, Spinak, David J, additional, Spital, Georg, additional, Steinle, Nathan, additional, Stern, Jeffrey, additional, Stoller, Glenn, additional, Stoltz, Robert, additional, Stone, Cameron, additional, Stone, Amy, additional, Suan, Eric, additional, Sugimoto, Masahiko, additional, Sugita, Iichiro, additional, Sun, Jennifer, additional, Sun, Xiaodong, additional, Suner, Ivan, additional, Szalczer, Lajos, additional, Szecsko, Timea, additional, Tabassian, Ali, additional, Takagi, Hitoshi, additional, Takayama, Kei, additional, Taleb, Alexandre, additional, Talks, James, additional, Tan, Gavin, additional, Tanabe, Teruyo, additional, Taylor, Stanford, additional, Thach, Allen, additional, Thompson, John, additional, Tlucek, Paul, additional, Torti, Robert, additional, Tosheva Guneva, Daniela, additional, Toth-Molnar, Edit, additional, Uchiyama, Eduardo, additional, Vajas, Attila, additional, Varma, Deepali, additional, Varsanyi, Balazs, additional, Vassileva, Petja, additional, Vaz-Pereira, Sara, additional, Veith, Miroslav, additional, Vela, Jose Ignacio, additional, Viola, Francesco, additional, Virgili, Gianni, additional, Vogt, Gábor, additional, Vorum, Henrik, additional, Weber, Pamela, additional, Wecke, Thoalf, additional, Wee, Raymond, additional, Weger, Martin, additional, Weishaar, Paul, additional, Wickremasinghe, Sanjeewa, additional, Williams, Thomas Reginald, additional, Williams, Thomas, additional, Williams, Geoff, additional, Wolf, Armin, additional, Wolfe, Jeremy, additional, Wong, James, additional, Wong, David, additional, Wong, Ian, additional, Wong, Robert, additional, Wowra, Bogumil, additional, Wykoff, Charles C, additional, Wylęgała, Edward, additional, Yang, Chang-Hao, additional, Yasukawa, Tsutomu, additional, Yates, Paul, additional, Yilmaz, Gursel, additional, Yiu, Glenn, additional, Yoon, Young Hee, additional, Yoreh, Barak, additional, Yoshida, Shigeo, additional, Yu, Hyeong Gon, additional, Yu, Seung Young, additional, Yurieva, Tatiana, additional, Zacharias, Leandro, additional, Zaczek Zakrzewska, Karolina, additional, Zambrano, Alberto, additional, Zatorska, Barbara, additional, Zeolite, Carlos, additional, and Zheutlin, Jeffrey, additional

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2022
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