1. Cell-penetrating peptoids: Introduction of novel cationic side chains
- Author
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Franziska Rönicke, Dominik K. Kölmel, Martin Nieger, Anna Hörner, Stefan Bräse, and Ute Schepers
- Subjects
Models, Molecular ,Pharmacology ,Aza Compounds ,Molecular Structure ,Chemistry ,Stereochemistry ,Organic Chemistry ,Cationic polymerization ,Peptoid ,Cell-Penetrating Peptides ,General Medicine ,Crystallography, X-Ray ,chemistry.chemical_compound ,Organophosphorus Compounds ,Cations ,Crown Ethers ,Drug Discovery ,Polyamines ,Tumor Cells, Cultured ,Side chain ,Humans ,HeLa Cells ,Enzymatic degradation - Abstract
During the last decade peptoid-based molecular transporters have been broadly applied. They are highly valued for their easy synthesis and their superior stability against enzymatic degradation. The special structure of peptoids generally allows introducing a variety of different side chains. Yet, the cationic side chains of cell-penetrating peptoids displayed solely lysine- or arginine-like structures. Thus this report is intended to extend the spectrum of cationic peptoid side chains. Herein, we present novel functional groups, like polyamines, aza-crown ethers, or triphenylphosphonium ions that are introduced into peptoids for the first time. In addition, the obtained peptoids were tested for their cell-penetrating properties.
- Published
- 2014
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