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Background Results on the relationship between coffee and tea drinking and the risk of oral cavity cancer are contrasted. The aim of this study was to evaluate the relation between coffee and tea drinking and the risk of oral cavity cancer in France, a high incidence area. Material and methods We conducted a population based case–control study with face-to-face interviews and standardized questionnaires (the ICARE study, Investigation of occupational and environmental causes of respiratory cancers). We used data from 689 cases of oral cavity squamous cell carcinoma and 3481 controls. Odds-ratios (ORs) and 95% confidence intervals (95% CI) associated with tea and coffee consumption (quantity, duration, cumulative consumption) were estimated by unconditional logistic regression with adjustment for age, gender, area of residence, education, body mass index, tobacco smoking and alcohol drinking. Results We observed inverse associations between oral cavity cancer and tea or coffee consumption (odds ratio, 0.39; 95% CI 0.21–0.70, for the highest quartile of tea consumption, and 0.60, 95% CI 0.34–1.05, for the highest quartile of coffee consumption). Exclusive tea or coffee consumption was associated with a reduced risk of oral cavity cancer and their joint effect was multiplicative. No differences in risk between men and women or between consumers of tobacco and alcohol and non-consumers were observed. The odds ratios related to the subsites usually included in the oropharynx (soft palate and base of the tongue) did not differ significantly from that observed for the other subsites of the oral cavity. Conclusions Tea and coffee drinking may decrease the risk of oral cavity cancer through antioxidant components which play a role in the repair of cellular damages. These findings need further investigation in prospective studies and the underlying mechanisms in humans remain to be clarified.

Introduction Renal cell carcinoma (RCC) contributes significantly to the global cancer burden, annually accounting for over 140,000 deaths worldwide. Several lifestyle risk factors have been strongly implicated in RCC aetiology, most notably obesity and hypertension, as well as other factors associated with the metabolic syndrome (MetS). While these factors appear to be implicated in RCC aetiology from an epidemiological point of view, the underlying causal pathways remain to be elucidated. Our aim was to identify metabolites associated with RCC risk in pre-diagnostic blood samples. Methods A targeted metabolomic platform based on liquid chromatography tandem mass spectrometry (LC-MS; AbsoluteIDQ™ p180 kit from BIOCRATES), was used to quantify 145 metabolites in pre-diagnostic blood samples from 634 RCC case-control pairs from the European Prospective Investigation into Cancer and Nutrition (EPIC), and 140 case-control pairs from the Melbourne Collaborative Cohort study (MCCS). After excluding metabolites with more than 20% samples below the limit of detection or quantification, 127 metabolites were analysed in relation to RCC risk using conditional logistic regression. Metabolites associated with the risk of RCC in EPIC, after correction for multiple testing, were evaluated in MCCS. Further adjustment for body mass index (BMI), waist-to-hip ratio, alcohol and smoking was performed. Results After multiple testing correction (P-value Conclusions Our study is the first to evaluate the association between metabolites measured in pre-diagnostic blood samples and risk of RCC. The results highlight glycerophospholipids as a group of metabolites that may be important in RCC aetiology, but their causal relevance remains to be confirmed.

Introduction Le cancer broncho-pulmonaire (CBP) est la premiere cause de cancer professionnel. L’etude ICARE, etude cas-temoins en population generale ayant inclus tous les cas de CBP incidents, primitifs, histologiquement confirmes a pour objectif ici d’investiguer la relation entre activite professionnelle de soudage et risque de CBP. Methode Un questionnaire specifique « fumees de soudage » a permis d’obtenir une probabilite d’exposition et des donnees techniques professionnelles. Les analyses ont porte sur la population masculine et les regressions logistiques ont ete ajustees sur l’âge, le departement, le nombre total d’emplois occupes, un index de consommation tabagique et un index d’exposition cumulee a l’amiante obtenu a partir d’une matrice emploi-exposition specifique. Resultats Apres ajustement, le risque de CBP associe au metier de soudeur (code BIT 8.72) atteint 1,7 [1,1–2,5]. Il augmente plus la duree d’exposition augmente ( 10 ans : 2 [1–3,9]) et lorsque le delai par rapport a cette premiere activite depasse 35 ans. Un type precis de soudage n’a pas pu etre isole. Le risque atteint 2 [1,1–3,4] quand les pieces a souder sont recouvertes de peinture ou de graisse. Si le nettoyage s’effectue avec du trichloroethylene, il passe a 5,6 [1,3–23,6]. Conclusion Des moyens mecaniques plutot que chimiques devraient etre privilegies pour nettoyer les surfaces avant de les souder. En cas d’impossibilite, des moyens de prevention pour cette activite doivent etre renforces. Cette etude contribue a l’argumentaire de causalite entre CBP et exposition aux fumees de soudage en cas de demande de reconnaissance en maladie professionnelle.

Introduction Les expositions professionnelles constituent des facteurs de risque importants du cancer du poumon, peu etudiees dans les metiers principalement feminins. L’objectif de cette analyse etait d’etudier les associations entre les professions relatives au menage et le risque de cancer du poumon. Methodes Les donnees sont issues de l’etude cas-temoins en population generale ICARE. L’histoire professionnelle detaillee a ete recueillie par un questionnaire standardise. Les odds ratios (ORs) et leurs intervalles de confiance a 95 % (IC 95 %) ont ete estimes par regression logistique non conditionnelle, chez les femmes (619 cas, 760 temoins) et les hommes (2265 cas, 2780 temoins), en detaillant l’exposition par profession et par secteur d’activite, et selon la duree d’emploi. Les analyses ont ete ajustees sur l’âge, le departement, le nombre d’emplois, la consommation de cigarettes vie entiere, et specifiquement pour les hommes, les expositions professionnelles cancerogenes pour le poumon. Resultats Des associations positives ont ete mises en evidence entre le menage et le cancer du poumon pour des durees d’exposition superieures a 7 ans, notamment pour les femmes employees chez des particuliers (OR = 2,28, IC 95 % = 1,30–3,99). Nous avons egalement observe un risque accru de cancer du poumon pour les femmes, comme pour les hommes, associe au menage dans le secteur de l’education, et une association positive avec le cancer du poumon, non significative, chez les hommes gardiens d’immeubles (OR = 2,03, IC 95 % = 0,71–5,79). Discussion La poursuite de l’etude des liens entre menage et cancer du poumon pourrait permettre de confirmer ces resultats et d’identifier les agents potentiellement en cause.