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11 results on '"Ferry, G."'

2. Clinical Challenges and Images in GI

Author

Ferry G, Ajay Jain, Guillerman Rp, Richard Kellermayer, and Deguzman Mm

Subjects
medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, General surgery, Gastroenterology, medicine, Complication, medicine.disease, business, Aortitis, Surgery
Published
2008

3. Immunohistochemical detection of platinated DNA in the cochlea of cisplatin-treated guinea pigs

Author

John C.M.J. de Groot, Marjolein van Ruijven, Ferry G. J. Hendriksen, and Guido F. Smoorenburg

Subjects
Pathology, medicine.medical_specialty, Kidney Cortex, Guinea Pigs, Biology, DNA Adducts, Ototoxicity, otorhinolaryngologic diseases, medicine, Animals, Tissue Distribution, Inner ear, Organ of Corti, Spiral ganglion, Cochlea, Cell Nucleus, Cisplatin, Staining and Labeling, Anatomy, medicine.disease, Immunohistochemistry, Sensory Systems, Hair Cells, Auditory, Outer, medicine.anatomical_structure, Spiral ligament, Female, sense organs, Immunostaining, medicine.drug
Abstract

Cisplatin-induced ototoxicity is correlated with functional and morphological changes in the organ of Corti, the stria vascularis and the spiral ganglion. However, the cochlear sites of cisplatin uptake and accumulation have not been properly identified. Therefore, we have developed an immunohistochemical method to, indirectly, detect cisplatin in semithin cryosections of the guinea pig cochlea (basal turn) using an antiserum containing antibodies against cisplatin-DNA adducts. Platinated DNA was present in the nuclei of most cells in the organ of Corti and the lateral wall after cisplatin administration. Nuclear immunostaining was most pronounced in the outer hair cells, the marginal cells and the spiral ligament fibrocytes. This study is the first to demonstrate the presence of cisplatin in histological sections of the cochlea.

Published
2005

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