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Objective To evaluate which early neurocognitive and behavioral precursors are associated with the development of attention-deficit/hyperactivity disorder (ADHD) and whether these are currently targeted in early interventions. Method We conducted 2 systematic reviews and meta-analyses of empirical studies to examine the following: (1) early-life (0−5 years) neurocognitive and behavioral precursors associated with familial likelihood for ADHD, an early ADHD diagnosis/elevated ADHD symptoms, and/or the presence of later-childhood ADHD; and (2) interventions delivered to children aged 0 to 5 years targeting the identified precursors or measuring these as outcomes. Standardized mean differences (Hedges’ g) and pre-post-treatment change scores (SMD) were computed. Results A total of 149 studies (165,095 participants) investigating 8 neurocognitive and behavioral domains met inclusion criteria for part 1. Multi-level random-effects meta-analyses on 136 studies revealed significant associations between ADHD and poorer cognitive (g = −0.46 [95% CIs: −0.59, −0.33]), motor (g = −0.35 [CIs: −0.48, −0.21]) and language (g = −0.43 [CIs: −0.66, −0.19]) development, social (g = 0.23 [CIs: 0.03, 0.43]) and emotional (g = 0.46 [CIs: 0.33, 0.58]) difficulties, early regulatory (g = 0.30 [CIs: 0.18, 0.43]) and sleep (g = 0.29 [CIs: 0.14, 0.44]) problems, sensory atypicalities (g = 0.52 [CIs: 0.16, 0.88]), elevated activity levels (g = 0.54 [CIs: 0.37, 0.72]), and executive function difficulties (g = 0.34 [CIs: 0.05, 0.64] to −0.87 [CIs: −1.35, −0.40]). A total of 32 trials (28 randomized, 4 nonrandomized, 3,848 participants) testing early interventions that targeted the identified precursors met inclusion criteria for part 2. Multi-level random-effects meta-analyses on 22 studies revealed significant intervention-related improvements in ADHD symptoms (SMD = 0.43 [CIs: 0.22, 0.64]) and working memory (SMD = 0.37 [CIs: 0.06, 0.69]). Conclusion Children aged 0 to 5 years with current or later-emerging ADHD are likely to experience difficulties in multiple neurocognitive/behavioral functions. Early interventions show some effectiveness in reducing ADHD symptoms, but their effects on neurocognitive/behavioral difficulties require further study.

This paper reports on the results of field surveys conducted at the approaching section of two bicycle crossroads in urban environment. The crossing roads are characterised by different cross-sections (one-lane and two-lane configurations) having a same marking scheme. The aim of the surveys was to evaluate the effectiveness of the specific marking scheme for the two different cross-sections and to provide relevant insight to improve the cyclist safety, based on the observed drivers’ behaviours. More specifically, the data analysis was aimed at: (i) studying the yielding behaviour of the drivers on the two bicycle configurations and evaluating the effects of the observed vehicle dynamics constraints in approaching phases; (ii) analysing drivers’ braking during the interaction with cyclist; (iii) defining a logistic regression model for predicting the drivers’ likelihood of yielding as a function of the variables describing his behaviour and the cross-section configurations. Results have stressed out a more critical driver yielding behaviour and braking performance when approaching the bicycle crossroad on the two-lane configuration. The logistic regression model have pointed out the cross-section variable to have the strongest effect on the logit of drivers yielding, determining a significant reduction of the likelihood of yielding if the interaction driver-cyclist occurs in the two-lane configuration. Overall, the obtained outcomes highlight a higher risk exposure of the cyclist crossing the two-lane configuration. The obtained outcomes imply that the same marking scheme on the two different cross-section configurations is inappropriate. It fails to induce proper driver behaviour when he/she approaches the bicycle crossing on the two-lane configuration in order to limit the cyclist's risk exposure to the values observed on the one-lane configuration. Eventually, several measures and recommendations have been defined to reduce the risk conditions identified in two-lane configuration.

In recent years, the Building Information Modeling (BIM) methodology has emerged as a pivotal approach for the design and management optimization of infrastructures. The need for fully integrated models has led to develop various tools to support the designers throughout the decision-making process of the entire life cycle of an infrastructure project. In particular, the design of transport infrastructures is a complex process that involves issues concerning all the different fields of civil engineering. In this framework, the BIM method can be efficiently applied to support the project of drainage systems capable of protecting railways and roadways from potential hydraulic risks. According to the above, this study presents an optimized BIM-based methodology for the integrated analysis of the flood risk and the design of the drainage system components. Specifically, the proposed method allows to implement hydraulics and hydrological numerical models as part of the different design phases. Such an approach holds two main advantages for the designer. On one hand, the computational modelling provides a decisive support in both defining water surface profiles over the designed area and identifying the spots exposed to major hydrological risks. On the other hand, the hydraulically guided modelling of each component of the drainage system allows for an increase of the overall productivity and efficiency of the project. A case study is presented to highlight the great potential of the proposed approach in ensuring both the integrity of datasets and the rapid clash detection of critical interferences between each system component. In conclusion, new perspectives about a fully integrated hydraulics analysis in the infrastructures design process are stressed out.

The two-photon absorption (TPA) properties of 4,4′-bis(para-di-n-butylaminostyryl)-2,2′-bipyridine (NBu2bipy) and related dipolar ([ZnY2(NBu2bipy)] (Y = Cl, CF3CO2), [Zn(2,2′-bipyridine)2(NBu2bipy)] [PF6]2) and octupolar ([Zn(NBu2bipy)3][PF6]2) complexes were investigated by the two-photon emission (TPE) technique in a femtosecond regime, working in the 730-930 nm spectral range. We found, in contrast with previous literature data, that the TPA enhancement upon coordination of a TPA active ligand to a metal center may be larger in the dipolar rather than the corresponding octupolar complex, the response being easily modulated by the choice of the ancillary ligands. © 2009 Elsevier B.V. All rights reserved.