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6. Long-term outcomes of clinical complete responders after neoadjuvant treatment for rectal cancer in the International Watch & Wait Database (IWWD): an international multicentre registry study

Author

Cornelis J.H. van de Velde, Stephanie O. Breukink, Harm J. T. Rutten, Koen C.M.J. Peeters, Handan Tokmak, Hedwig van der Sluis, Carlos Carvalho, Henderik L Westreenen, Guilherme Pagin São Julião, Anna Martling, Angelita Habr-Gama, Elma Meershoek-Klein Kranenbarg, Jarno Melenhorst, Rodrigo Oliva Perez, Maria-Theresa Bär, Lee Malcomson, Melanie Langheinrich, Arthur Sun Myint, Daria K Wasowicz, Andrew G Renehan, Ane L Appelt, Amir Keshvari, Eric Belgers, Britt J. P. Hupkens, Zamam Z Mamedli, Anders Jakobsen, María L Morici, Soledad Iseas, Christiaan Hoff, Des C. Winter, Renaud Schiappa, Albert Wolthuis, Nigel Scott, Christopher M. Cunningham, Jan H.M.B. Stoot, Simon Gollins, A Koen Talsma, André D’Hoore, Maxime J M van der Valk, Robbert J I Bosker, Sietze A Koopal, Krysztof Bujko, Isadora Rosa, Jeroen W. A. Leijtens, Ben Creavin, Gustavo Rossi, Jean-Pierre Gerard, Mark P Saunders, Madeleine Ahlberg, Sarah T O'Dwyer, Sthela M. Murad-Regadas, David D. E. Zimmerman, Alexander L Vahrmeijer, Esther Bastiaannet, Nuno Figueiredo, Monique Maas, Marit E van der Sande, Carlos A. Vaccaro, Miranda Kusters, Regina G. H. Beets-Tan, Fabian A. Holman, Klaus E. Matzel, Denise E. Hilling, Oktar Asoglu, Rita Barroca, Fernando Sanchez Loria, Isabelle Terrasson, Geerard L. Beets, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, and Surgery

Subjects
Male, ORGAN PRESERVATION, SURGERY, Colorectal cancer, medicine.medical_treatment, computer.software_genre, Disease-Free Survival, CHEMORADIOTHERAPY, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Cumulative incidence, Registries, PATHOLOGICAL COMPLETE RESPONSE, TUMOR REGROWTH, PREDICTORS, Neoadjuvant therapy, Aged, Neoplasm Recurrence, Local/epidemiology, Manchester Cancer Research Centre, Database, Watchful Waiting/statistics & numerical data, business.industry, ResearchInstitutes_Networks_Beacons/mcrc, Incidence (epidemiology), Rectal Neoplasms/drug therapy, Cancer, General Medicine, Middle Aged, Outcome Assessment (Health Care)/methods, POLICY, medicine.disease, Total mesorectal excision, CHEMORADIATION THERAPY, 030220 oncology & carcinogenesis, Cohort, Female, 030211 gastroenterology & hepatology, Chemotherapy, Adjuvant/statistics & numerical data, business, computer, Chemoradiotherapy, MRI
Abstract

BACKGROUND: The strategy of watch and wait (W&W) in patients with rectal cancer who achieve a complete clinical response (cCR) after neoadjuvant therapy is new and offers an opportunity for patients to avoid major resection surgery. However, evidence is based on small-to-moderate sized series from specialist centres. The International Watch & Wait Database (IWWD) aims to describe the outcome of the W&W strategy in a large-scale registry of pooled individual patient data. We report the results of a descriptive analysis after inclusion of more than 1000 patients in the registry.METHODS: Participating centres entered data in the registry through an online, highly secured, and encrypted research data server. Data included baseline characteristics, neoadjuvant therapy, imaging protocols, incidence of local regrowth and distant metastasis, and survival status. All patients with rectal cancer in whom the standard of care (total mesorectal excision surgery) was omitted after neoadjuvant therapy were eligible to be included in the IWWD. For the present analysis, we only selected patients with no signs of residual tumour at reassessment (a cCR). We analysed the proportion of patients with local regrowth, proportion of patients with distant metastases, 5-year overall survival, and 5-year disease-specific survival.FINDINGS: Between April 14, 2015, and June 30, 2017, we identified 1009 patients who received neoadjuvant treatment and were managed by W&W in the database from 47 participating institutes (15 countries). We included 880 (87%) patients with a cCR. Median follow-up time was 3·3 years (95% CI 3·1-3·6). The 2-year cumulative incidence of local regrowth was 25·2% (95% CI 22·2-28·5%), 88% of all local regrowth was diagnosed in the first 2 years, and 97% of local regrowth was located in the bowel wall. Distant metastasis were diagnosed in 71 (8%) of 880 patients. 5-year overall survival was 85% (95% CI 80·9-87·7%), and 5-year disease-specific survival was 94% (91-96%).INTERPRETATION: This dataset has the largest series of patients with rectal cancer treated with a W&W approach, consisting of approximately 50% data from previous cohort series and 50% unpublished data. Local regrowth occurs mostly in the first 2 years and in the bowel wall, emphasising the importance of endoscopic surveillance to ensure the option of deferred curative surgery. Local unsalvageable disease after W&W was rare.FUNDING: European Registration of Cancer Care financed by European Society of Surgical Oncology, Champalimaud Foundation Lisbon, Bas Mulder Award granted by the Alpe d'Huzes Foundation and Dutch Cancer Society, and European Research Council Advanced Grant.

Published
2018
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7. Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial

Author

Palace, Jacqueline, primary, Wingerchuk, Dean M., additional, Fujihara, Kazuo, additional, Berthele, Achim, additional, Oreja-Guevara, Celia, additional, Kim, Ho Jin, additional, Nakashima, Ichiro, additional, Levy, Michael, additional, Terzi, Murat, additional, Totolyan, Natalia, additional, Viswanathan, Shanthi, additional, Wang, Kai-Chen, additional, Pace, Amy, additional, Yountz, Marcus, additional, Miller, Larisa, additional, Armstrong, Róisín, additional, Pittock, Sean, additional, Muñoz, Daniel Julio, additional, Amor, Jorge David, additional, Bocchiardo, Carolina, additional, Danielle, Julieta Iourno, additional, Laffue, Alfredo, additional, Obregon, Carolina Daniela Diaz, additional, Paez, Maria Fernanda, additional, Perez, Roberto Martin, additional, Rocchi, Viviana Ana Maria, additional, Teijeiro, Loreley Deborah, additional, Gómez, Jesica, additional, Villa, Andres Maria, additional, Aguirre, Florencia, additional, Fernández, Victoria Carla, additional, Goicoechea, Ramon F., additional, Melamud, Luciana, additional, Stillman, Ana, additional, de Virgiliis, Mariana, additional, Cassara, Fatima Pagani, additional, Cordoba, Marta, additional, Gutierrez, Maria Teresa, additional, Ingolotti, Mariana, additional, Larripa, Natalia, additional, Lupinacci, Anahi, additional, Arroyo, Josefina, additional, Romano, Alejandra, additional, Torres, Mariana Foa, additional, Ballario, Carlos Héctor, additional, Chiesa, Ana Elisa, additional, Gómez, Hernán Gustavo, additional, Lattini, Hernán Gabriel, additional, Mainella, Carolina Natalia, additional, Bolner, Gisel Edith, additional, Eschoyez, María Soledad, additional, Broadley, Simon Andrew, additional, Heshmat, Saman, additional, Sabet, Arman, additional, Swayne, Andrew, additional, Freeman, Susan, additional, Sanchez, Sofia Jimenez, additional, Shuey, Neil, additional, Dalic, Linda, additional, French, Ann, additional, Kuma, Guru, additional, Laing, Joshua, additional, Law, Lai Yin, additional, MacIntyre, Jennifer, additional, Neal, Andrew, additional, Plummer, Christopher, additional, Ramachandran, Prashanth, additional, Sedal, Leslie, additional, Wilson, Ian, additional, Winkel, Antony, additional, Zhang, Wenwen, additional, Chen, Tina, additional, Watts, Rani, additional, Barnett, Michael, additional, Barton, Joshua, additional, Beadnall, Heidi, additional, Garber, Justin, additional, Hardy, Todd Andrew, additional, Trewin, Benjamin, additional, Taha, Marinda, additional, Walters, Deleni, additional, Sieger, Federico Arturo Silva, additional, Alfonso, Nhora Patricia Ruiz, additional, Camacho, Anna Maria Pinzon, additional, Moreno, Alexander Pabón, additional, Prad, Jorge Armando Castellanos, additional, Rueda, Adriana Paola Duarte, additional, Castillo, Tatiana, additional, Gonzalez, Karol Melissa Castillo, additional, Pico, Martha Yolanda Moreno, additional, Castill, Judith, additional, Habek, Mario, additional, Adamec, Ivan, additional, Barun, Barbara, additional, Crnosija, Luka, additional, Gabelic, Tereza, additional, Nytrova, Petra, additional, Krasulova, Eva, additional, Pavlickova, Jana, additional, Tyblova, Michaela, additional, Zubkova, Jana, additional, Petersen, Thor, additional, Dale, Gro Helen, additional, Rasmussen, Peter Vestergaard, additional, Stilund, Morten, additional, Svendsen, Kristina Bacher, additional, Brandt, Vivi, additional, Collongues, Nicolas, additional, Fleury, Marie-Celine, additional, Kremer, Laurent, additional, Bendele, Sandrine, additional, Neff, Valérie, additional, Diem, Ricarda, additional, Platten, Michael, additional, Berberich, Anne, additional, Jansen, Jonabelle, additional, Jaschoneck, Hannah, additional, Wildemann, Brigitte, additional, Aures, Ursula, additional, Brandenburger, Tanja, additional, Haut, Tanja, additional, Fernández, Maria-Lourdes Treceno, additional, Aly, Lilian, additional, Brinkhoff, Kirsten, additional, Buck, Dorothea, additional, Golkowski, Daniel, additional, Hermisson, Mirjam, additional, Hoshi, Muna-Miriam, additional, Kaminski, Miriam, additional, Kowarik, Markus Christian, additional, Kronsbein, Helena, additional, Lehmann-Horn, Klaus, additional, Pongratz, Viola Maria, additional, Schweiker, Andreas, additional, Leddy, Lisa-Ann, additional, Mueller, Silvia, additional, Obergfell, Kim, additional, Wanka, Marion, additional, Zettl, Uwe Klaus, additional, Klinke, Jan, additional, Loebermann, Micha, additional, Meister, Stefanie, additional, Rimmele, Florian, additional, Winkelmann, Alexander, additional, Schroeder, Ina, additional, Lau, Alexander Yuk-Lun, additional, Au, Lisa Wing-Chi, additional, Fan, Florence Sin-Ying, additional, Ip, Vincent Hing-Lung, additional, Ma, Karen Ka-Yan, additional, Ma, Sze-Ho, additional, Mok, Vincent Chung-Tong, additional, Au, Cheryl Chung-Kwan, additional, Kwan, Pauline Wing-Lam, additional, Patti, Francesco, additional, Caramma, Andrea Salvatore, additional, Chisari, Clara Grazia, additional, Fermo, Salvatore Lo, additional, Messina, Silvia, additional, Projetto, Maria, additional, Caserta, Cinzia, additional, Filla, Alessandro, additional, Costabile, Teresa, additional, Pane, Chiara, additional, Sacca, Francesco, additional, Marsili, Angela, additional, Puorro, Giorgia, additional, Bergamaschi, Roberto, additional, Berra, Eliana, additional, Mallucci, Giulia, additional, Fattore, Cinzia, additional, Gasperini, Claudio, additional, Galgani, Simonetta, additional, Haggiag, Shalom, additional, Ruggieri, Serena, additional, Vento, Claudio, additional, Quartuccio, Esmeralda Maria, additional, Pozzilli, Carlo, additional, Barletta, Valeria Teresa, additional, Borriello, Giovanna, additional, De Giglio, Laura, additional, Marinelli, Fabiana, additional, Tasillo, Miriam, additional, Amadori, Alessandra, additional, Fischetti, Mariano, additional, Gurreri, Flavia, additional, Mori, Masahiro, additional, Masuda, Hiroki, additional, Ohtani, Ryohei, additional, Sekiguchi, Yukari, additional, Uchida, Tomohiko, additional, Uzawa, Akiyuki, additional, Ito, Hiromi, additional, Kabasawa, Emi, additional, Kaneko, Yoko, additional, Matsushita, Takuya, additional, Matsuse, Dai, additional, Murai, Hiroyuki, additional, Hayashi, Shintaro, additional, Masak, Katsuhisa, additional, Ogata, Hidenori, additional, Shinoda, Koji, additional, Uehara, Taira, additional, Watanabe, Mitsuru, additional, Yamaguchi, Hiroo, additional, Yamasaki, Ryo, additional, Yonekawa, Tomomi, additional, Jingu, Maki, additional, Nagano, Makiko, additional, Nakamura, Yumiko, additional, Sano, Yoshiko, additional, Araki, Manabu, additional, Lin, Youwei, additional, Mori, Madoka, additional, Mukai, Yohei, additional, Sano, Terunori, additional, Sato, Wakiro, additional, Gogun, Naoya, additional, Maeda, Yuriko, additional, Nishimoto, Asami, additional, Tsukamoto, Sachiko, additional, Yanagi, Ritsuko, additional, Saida, Takahiko, additional, Nakamura, Shinichi, additional, Nasu, Tetsuya, additional, Saida, Kyoko, additional, Shikata, Yuko, additional, Kodani, Yoshimi, additional, Saeki, Megumi, additional, Sawada, Yukako, additional, Yoshikawa, Hiroo, additional, Kimura, Takashi, additional, Nishi, Masamitsu, additional, Sakamoto, Shun, additional, Ukon, Shinichiro, additional, Watanabe, Shohei, additional, Ebisuya, Saori, additional, Kimura, Nami, additional, Matsuura, Manami, additional, Morisaki, Yukie, additional, Muroi, Yoshiko, additional, Onishi, Kuniko, additional, Oshima, Ikuko, additional, Washino, Yuki, additional, Yamashita, Tomomi, additional, Misu, Tatsuro, additional, Kaneko, Kimihiko, additional, Kato, Masaaki, additional, Kuroda, Hiroshi, additional, Kurosawa, Kazuhiro, additional, Nishiyama, Shuhei, additional, Ono, Hirohiko, additional, Takai, Yoshiki, additional, Abe, Keiko, additional, Hoshi, Hitomi, additional, Jinushi, Mari, additional, Oyama, Azusa, additional, Sakuma, Motonari, additional, Sawada, Yuko, additional, Ishibashi, Satoru, additional, Yokota, Takanori, additional, Nishida, Yoichiro, additional, Ozaki, Kokoro, additional, Sanjo, Nobuo, additional, Sato, Nozomu, additional, Denno, Fuki, additional, Hiraki, Haruko, additional, Matsubara, Yumi, additional, Kanda, Takashi, additional, Abe, Masaaki, additional, Honda, Masaya, additional, Kawai, Motoharu, additional, Koga, Michiaki, additional, Maeda, Toshihiko, additional, Ogasawara, Junichi, additional, Omoto, Masatoshi, additional, Sano, Yasuteru, additional, Sato, Ryota, additional, Shimizu, Fumitaka, additional, Arima, Hideki, additional, Fukui, Sachie, additional, Ishikawa, Yoshiko, additional, Koyama, Tomoko, additional, Shimose, Shigemi, additional, Shinozaki, Hirokazu, additional, Watanabe, Masanori, additional, Yasuda, Sachi, additional, Yoshiwaka, Chieko, additional, Adenan, Suffian, additional, Aris, Mohd Azman M, additional, Mawardi, Ahmad Shahir bin, additional, Adnan, Muhammad Al Hafiz, additional, Munusamy, Nanthini, additional, Razali, Siti Nur Omaira, additional, Somasundram, Punitha, additional, Hyun, Jae Won, additional, Jeong, In Hye, additional, Kim, Su-Hyun, additional, Shin, Hyun-June, additional, Yoo, Ji Sung, additional, Jang, HyunMin, additional, Joung, AeRan, additional, Kim, Byung-Jo, additional, Baek, Seol-Hee, additional, Kim, Jung Bin, additional, Kim, Yoo Hwan, additional, Koo, Yong Seo, additional, Lee, Chan Nyoung, additional, Seok, Hung Youl, additional, Hwang, Jinhee, additional, Kim, Sung Min, additional, Ahn, So Hyun, additional, Choi, Kyomin, additional, Choi, Seok-Jin, additional, Kim, Jun-Soon, additional, Kwon, Young Nam, additional, Shin, Je-Young, additional, Kwon, Hyeonju, additional, Kim, Byoung Joon, additional, Cho, Eun Bin, additional, Cho, Hye-Jin, additional, Choi, Misong, additional, Kim, DongSun, additional, Kim, Ju Hyeon, additional, Ki, SeungJu, additional, Lee, Hye Lim, additional, Lee, Kwang-Ho, additional, Min, Ju-Hong, additional, Park, Ji-Hyung, additional, Seok, Jinmyoung, additional, Choi, Eunhwa, additional, Park, Sang Ae, additional, Kim, Seung Min, additional, Jeong, Ha-Neul, additional, Jeongbin, Bong, additional, Jung, Jin Woo, additional, Kim, Seung Woo, additional, Kim, Yool-hee, additional, Lee, Hyung Seok, additional, Shin, Ha Young, additional, Jung, Yeon, additional, Kim, Min Jung, additional, Lee, Nou Ri, additional, Shin, MiJu, additional, Khabirov, Farit A, additional, Averyanova, Lyudmila, additional, Babicheva, Natalya, additional, Granatov, Eugenii, additional, Kazarov, Sergey, additional, Khaybullin, Timur, additional, Rogozhin, Alexander, additional, Pokhabov, Dmitry V, additional, Abramov, Vladislav, additional, Amelina, Anastasia, additional, Nesteroca, Yulia, additional, Bozhenkina, Tatyana, additional, Boyko, Aleksey N, additional, Demyan, Elena G, additional, Khoroshilova, Inessa, additional, Melnikov, Mikhail, additional, Popova, Ekaterina V, additional, Sharanova, Svetlana N, additional, Shchur, Sergey G, additional, Sazonov, Denis V, additional, Babenko, Larisa, additional, Bayandina, Elena, additional, Yarmoschuk, Asya, additional, Baliazin, Victor A, additional, Baliazina, Elena, additional, Budaeva, Elena, additional, Chernikova, Irina, additional, Goncharova, Zoya, additional, Krasnov, Vladimir, additional, Myatleva, Marina, additional, Rodionova, Olga V., additional, Samulyzhko, Iuliana, additional, Timofeeva, Alla A., additional, Duran, Sabas Boyero, additional, Bilbao, Maria Mar Mendibe, additional, Cuervo, Irene Diaz, additional, Domingo, Jose Maria Losada, additional, Eizaguirre, Amaia Gonzalez, additional, Llona, Jose Eulalio Barcena, additional, Moyano, Roberto Valverde, additional, Bahamonde, Carmen, additional, Lopez, Fernando Sanchez, additional, Morales, Raquel Pinar, additional, Morales, Eduardo Agüera, additional, Roman, Carmen Bahamonde, additional, Sepulveda, Juan Jose Ochoa, additional, Valero, Maria del Carmen Blanco, additional, Viña, Nazaret Pelaez, additional, Gavilan, Cristina Conde, additional, Sanchez, Ana Maria Jover, additional, Bedmar, Sara Vila, additional, Garcia, Nuria Gonzalez, additional, Garcia, Aida Orviz, additional, Gonzalez-Suarez, Ines, additional, Guillamon, Elena Miñano, additional, Kawiorski, Miguel, additional, Schulz, Elena Guerra, additional, Alonso, Alba Garcia, additional, Perez, Francisco Jesus Lopez, additional, Sarmiento, Marta Palacios, additional, Ayuso, Guillermo Izquierdo, additional, Mascarell, Guillermo Navarro, additional, Camino, Cristina Paramo, additional, Garcia, Asuncion Varas, additional, Mendoza, Yaiza Montserrat, additional, Muñoz, Veronica Ines Vargas, additional, Tonda, Patricia Torres, additional, Tsai, Ching-Piao, additional, Yin, Jiu-Haw, additional, Chen, Mei-Jung, additional, Li, Shan-Ni, additional, Wang, Fei-Ti, additional, Srisuwannanukorn, Suwat, additional, Boonmongkol, Thanatat, additional, Borisutbuathip, Duangporn, additional, Singwicha, Duangkamol, additional, Siritanan, Krittika, additional, Thearapati, Chidchanoke, additional, Sornda, Kwanmuang, additional, Apiwattanakul, Metha, additional, Aungsumart, Saharat, additional, Suanprasert, Narupat, additional, Suksuchano, Kaona, additional, Parkinsee, Nittaya, additional, Kulkantrakorn, Kongkiat, additional, Lolekha, Praween, additional, Potigumjon, Artit, additional, Sukphulloprat, Puchit, additional, Suksasunee, Dararat, additional, Komaratat, Chankawee, additional, Luangtong, Sunattana, additional, Arayawichanont, Arkhom, additional, Konpan, Phanpaphon, additional, Riablershirun, Nathapol, additional, Wiroteurairuang, Thaddao, additional, Jantaweesirirat, Panadda, additional, Kurne, Aslı, additional, Erkent, Irem, additional, Kurt, Ebru Bekircan, additional, Saylam, Ezgi, additional, Caliskan, Yagmur, additional, Orsel, Gulsah, additional, Celik, Yahya, additional, Celebi, Canan, additional, Tekatas, Aslan, additional, Banbal, Tugce, additional, Demir, Gulsen Akman, additional, Altunrende, Burcu, additional, Matur, Zeliha, additional, Topcular, Baris, additional, Elmas, Tules, additional, Gulo, Aysenur, additional, Ozdemir, Selin, additional, Ozkoklesen, Cansu, additional, Ozturk, Mahinur, additional, Yanik, Mertkan, additional, Yildirim, Elif, additional, Tutuncu, Melih, additional, Altintas, Ayse, additional, Cam, Abdulsamet, additional, Elmali, Ayse Deniz, additional, Saip, Sabahattin, additional, Siva, Aksel, additional, Tanrıverdi, Uygur, additional, Uygunoglu, Ugur, additional, Caliskan, Sinem, additional, Gulo, Pinar, additional, Kozig, Esra, additional, Sakiz, Sakine, additional, Sengun, Ihsan Sukru, additional, Idiman, Egemen, additional, Ala, Rahmi Tumay, additional, Arslan, Duygu, additional, Bulut, Utku, additional, Karakaptan, Yasemin, additional, Kaya, Derya, additional, Mehdiyev, Zaur, additional, Balkan, Bengu, additional, Kuku, Berfu, additional, Ozhun, Mujgan, additional, Tuga, Celal, additional, Ugur, Muzeyyen, additional, Efendi, Husnu, additional, Bunul, Sena Destan, additional, Cavus, Hakan, additional, Gorke, Yunus Emre, additional, Kutlu, Ayse, additional, Ozturk, Seda, additional, Sarikaya, Cansu Egilmez, additional, Becerikli, Gulsah, additional, Semiz, Cansu, additional, Tun, Ozlem, additional, Ayer, Sehriban, additional, Onar, Musa Kazim, additional, Ozberk, Mehlika Berra, additional, Sen, Sedat, additional, Cavdar, Tugce Kirbas, additional, Veske, Adife, additional, Boz, Cavit, additional, Altiparmak, Didem, additional, Aydin, Cigdem Ozen, additional, Gazioglu, Sibel, additional, Bekircan, Duygu, additional, Jacob, Anu, additional, Arndt, Heike, additional, Elsone, Liene, additional, Hamid, Shahd Hassan Mahmoud, additional, Whittam, Daniel Hugh, additional, Wilson, Martin, additional, O'Brien, Imelda, additional, Leite, Maria Isabel da Silva, additional, Cruz, Pedro Maria Rodriguez, additional, Jenkins, Damian Robert, additional, Tackley, George, additional, Cavey, Ana, additional, Everett, Rosie, additional, Hodder, Joy, additional, Koelewyn, Abigail, additional, Mowry, Ellen, additional, Royal, Walter, additional, Shin, Robert, additional, Bever, Christopher, additional, Harrison, Daniel, additional, Rus, Horea, additional, Zheng, Wei, additional, Callison, Karen, additional, Naunton, Kerry, additional, Frishberg, Benjamin M, additional, Blumenfeld, Andrew M, additional, Inocelda, Andrew, additional, Korabathina, Kalyani, additional, Lobatz, Michael, additional, Mortin, Melissa M, additional, Oh, Irene J, additional, Rosenberg, Jay H, additional, Sadoff, Mark, additional, Sahagian, Gregory A, additional, Wang, Anchi, additional, Camberos, Yasmin, additional, Sanchez, Guadalupe, additional, Soto, Estela, additional, Nicholas, Jacqueline A, additional, Boster, Aaron, additional, Eubank, Geoffrey, additional, Groezinger, Katy, additional, Lauf, Meghan, additional, Okai, Annette F, additional, Hasan, Rashedul, additional, Khoury, Chaouki, additional, Stokes, Victoria, additional, Clardy, Stacey, additional, Cortez, Melissa, additional, Greenlee, John, additional, Rose, John, additional, Soldan, Mateo Paz, additional, Emett, Amanda, additional, Esquibel, Lawanda, additional, Fagatele, Lilly, additional, Wong, Ka-Ho, additional, Stevens, James C, additional, Banas, Thomas M, additional, Bultemeyer, Marlene C, additional, Haller, Andrea, additional, Manalo, Natalie, additional, Aeschliman, Keri, additional, Kocks, Debi, additional, Racke, Michael, additional, Boster, Aaron Lee, additional, Bowman, Michelle, additional, Imitola, Jaime, additional, Kisanuki, Yasushi, additional, Green, Misty, additional, Scarberry, Stephanie, additional, Lynch, Sharon G, additional, Anderson, Heather S, additional, Gronseth, Gary S, additional, Hammond, Nancy E, additional, Jassam, Yasir N, additional, Mittal, Manoj K, additional, Nashatizadeh, Muhammed M, additional, Levine, Nicholas, additional, Schmidt, Lisa, additional, Sibley, Jill, additional, Whitley, Vonda, additional, Winkley, James, additional, Coleman, Timothy, additional, Cooper, Gregory, additional, Sheffield, Stephanie, additional, Turner, Keri, additional, Galloway, Dana, additional, Tillett, Robert S, additional, Ganesh, Geeta A, additional, Plato, Brian M, additional, Seifert, Tad D, additional, Godwin, Diana, additional, Lockridge, Deborah, additional, Rammohan, Kottil W, additional, Sheremata, William A, additional, Delgado, Silvia, additional, Gonzalez, Jose, additional, Lizarraga, Alexis, additional, Maldonado, Janice, additional, Ortega, Melissa, additional, Tornes, Leticia, additional, Babcock, Yanet, additional, Cailam, Osmara, additional, Campos, Yesica, additional, Couvertier, Irlisse, additional, Daneri, Bettina, additional, Deni, Jeremy, additional, Hernandez, Jeffrey, additional, Jaramillo, Tatiana, additional, Morris, Tenita, additional, Nobel, Daniel, additional, Oliveira, Anjelis, additional, Richardson, Reshma, additional, Rodriguez, Gloria, additional, Romero, Ana, additional, Sandova, Carlos, additional, Sawant, Ruta, additional, Tueros, Lissett, additional, Zetka, Eric S, additional, Zheng, Chao, additional, Jacobs, Daniel H, additional, Easterling, Constance, additional, Fairbank, Jennifer, additional, Iyengar, Revathi, additional, Klafter, Mark, additional, Lindquist, Justin, additional, Sadek, Ahmed H, additional, Toro, Elizabeth Carmona, additional, Verma, Navin, additional, Castro, Brigith Patino, additional, Sukhraj-Singh, Nadia, additional, Berger, Joseph, additional, Williamson, Eric, additional, Chahin, Salim, additional, Jacobs, Dina, additional, Markowitz, Clyde, additional, Dobbins, Jessica, additional, Mace, Lauren, additional, Martin, Maria, additional, Pinckney, Ashley, additional, Roberts, Amber, additional, Zaydan, Islam, additional, Mitchell, Galen W, additional, Heyman, Rock A, additional, Orie, Ryan L, additional, Suski, Valerie R, additional, Oddis, Kerry, additional, Punjack, Darlene, additional, Flanagan, Eoin, additional, Gadoth, Avi, additional, McKeon, Andrew, additional, Tobin, W Oliver, additional, Zekeridou, Anastasia, additional, Dunlay, Katie, additional, Sagen, Jessica, additional, Carter, Jonathan L, additional, Estephan, Bachir, additional, Goodman, Brent P, additional, Snyder, Charlene R Hoffman, additional, Francone, Andrea, additional, Galasky, Irene, additional, Thomas, Martha, additional, Repovic, Pavle, additional, Bowen, James, additional, Mayadev, Angeli, additional, Qian, Peiqing, additional, Courtney, Yuriko, additional, Lennox, Lauren, additional, Naismith, Robert Thomas, additional, Cross, Anne Haney, additional, Evans, Emily, additional, Longbrake, Erin E, additional, Orchard, Megan E, additional, Wu, Gregory F, additional, Heinrich, Linda, additional, Sommers, Susan, additional, Amjad, Faria, additional, Mitchell, Erika, additional, Mora, Carlos, additional, Schreiber, Bethany, additional, Tornatore, Carlo, additional, Carlson, Alexis, additional, McCarthy, Sacha, additional, and Oliver, Alexandria, additional

Published
2021
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8. Chemical compatibility study between ceramic breeder and EUROFER97 steel for HCPB-DEMO blanket

Author

Fernando Sanchez, Regina Knitter, and Keisuke Mukai

Subjects
010302 applied physics, Nuclear and High Energy Physics, Materials science, Diffusion, Metallurgy, Pellets, Blanket, Atmospheric temperature range, Thermal diffusivity, 01 natural sciences, 010305 fluids & plasmas, Corrosion, Breeder (animal), Nuclear Energy and Engineering, visual_art, 0103 physical sciences, visual_art.visual_art_medium, General Materials Science, Ceramic
Abstract

Chemical compatibility between ceramic breeder (Li 4 SiO 4 + 20 mol% addition of Li 2 TiO 3 ) and EUROFER97 steel was examined in this study. These materials were contacted and heated at 623, 823 and 1073 K under He + 0.1 vol.% H 2 atmosphere for up to 12 weeks. Limited influence was found in the breeder specimens, although losses of the constituent elements appeared near the surface of the breeder pellets heated at 1073 K. For the EUROFER specimens with formation of a corrosion layer, element diffusivity was estimated based on diffusion kinetics. In the temperature range, effective diffusion coefficients of oxygen into EUROFER steel were in the range from 3.5 × 10 −14 to 2.5 × 10 −12 cm 2 /s and found to be faster than that of Li. The coefficients yielded an activation energy of 0.93 eV for oxygen diffusion into EUROFER steel and predicted the possible thickness of the corrosion layer after operational periods.

Published
2017
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9. Assessing the effects of temporal ambivalence on defining palaeosystem interrelations, and applicability to the analysis of archaeological survey data

Author

Marta Navazo, Antoni Canals, Alfonso Benito-Calvo, and Fernando Sanchez-Trigueros

Subjects
010506 paleontology, Pleistocene, Context (archaeology), 010502 geochemistry & geophysics, Ambivalence, 01 natural sciences, Archaeology, Data set, Sequence (geology), Principal component analysis, Survey data collection, Scale (map), Geology, 0105 earth and related environmental sciences, Earth-Surface Processes
Abstract

We present a possibility-based method with applications to the analysis of archaeological survey data under constraints of temporal ambivalence. The method is a generalizable heuristic for automated learning and data mining that estimates the set of possible responses associated with ambivalent numerical data, by (i) assessing the degree of epistemic ambivalence that is carried in a data set with ambivalent information, and by (ii) monitoring the effects of this degree on data analysis, enabling the adaptation of classical data analysis to the treatment of both crisp and fuzzy information. Owing to the strong methodological foundations of the application, a detailed introduction of the ambivalent paradigm is presented first so its adaptability to archaeological survey data can be followed later. The approach is demonstrated in selecting informative features of uncertain palaeosystems by ambivalent Principal Component Analysis (PCA), and exemplified with archaeological survey data collected in the Sierra de Atapuerca and the Arlanzon valley (Burgos, Spain), focusing on the effects of temporal ambivalence on the analysis of associations between lithological palaeoenvironments and Middle Palaeolithic technologies in an open-air context. Although survey data in this region is affected by varying degrees of temporal ambivalence that, on occasion, span several isotopic stages of the late Pleistocene sequence, its effects on feature selection, regarding PCA, are not significant enough to produce contradictory reprojections of palaeolithological data onto the principal space, thanks to a gradual stabilization of the relief in the Middle Arlanzon valley, on a regional scale, during the late Pleistocene. By applying correlation-based dissimilarity distances and cluster analysis to the grouping of ambivalent score patterns, ambivalent features that describe the palaeolithological context of the Middle Palaeolithic scatters can be grouped on the PC1 × PC2 principal plane into four contexts with a similar palaeolithological evolution among group members: the Mesozoic crest of the Sierra de Atapuerca (Group 1), the Neogene levels of the Villalval-Rubena platform (Group 2), lithologically mixed areas between fluvial valleys and Neogene hills (Group 3), and the valleys of the Arlanzon, Pico and Vena rivers (Group 4). In none of these groups the evolution of the local palaeolandscape is notable enough, once again on a regional scale, to produce conflicting descriptions of the palaeolithological signatures where the archaeological scatters occur, although Group 3 (a geographical interface between different lithological palaeoenvironments) has been more dynamic than the rest of environments over the time range the lithic scatters would have formed.

Published
2017
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10. Non-surgical management of rectal cancer. Series of 68 cases, long follow up in two leading centres in Argentina

Author

Guillermo Mendez, J. O’Connor, Mariana Coraglio, M. Chacon, Alejandro Pairola, Eduardo Huertas, Enrique Roca, Adriana Dieguez, Soledad Iseas, Fernando Sanchez Loria, and Javier Mariani

Subjects
Adult, Male, medicine.medical_specialty, Organoplatinum Compounds, Colorectal cancer, medicine.medical_treatment, Argentina, Kaplan-Meier Estimate, Disease-Free Survival, Metastasis, Capecitabine, 03 medical and health sciences, 0302 clinical medicine, Median follow-up, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Stage (cooking), Aged, Retrospective Studies, Hepatology, Rectal Neoplasms, business.industry, Gastroenterology, Cancer, Chemoradiotherapy, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Neoadjuvant Therapy, Oxaliplatin, Surgery, Radiation therapy, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Fluorouracil, Neoplasm Recurrence, Local, business, Follow-Up Studies, medicine.drug
Abstract

Background The non-surgical management in a selected group of rectal cancer patients has shown promising results with adequate follow up. Aims describing the results of the non-surgical management in patients with complete clinical response, with a close follow up. Methods Between 2006 and 2015, patients with rectal cancer, stages I-III, without metastasis, treated with neoadjuvant CRT/CT, who had clinical complete response were included. CCR was defined through digital palpation, endoscopy-based criteria and MRI. Follow up was set according to institutional guidelines. Results 68 patients were included. Initial stage was assessed with MRI in 55/68 pts and EUS 11/68. Considering the recurrence risk factors 57.6% (29/68) were T2-3ab N0, 3.3% (2/68) were T4N0, 29% (20/68) were T3-4 N1-2, with 39.7% with positive MRC. Mean distance to the anal margin was 3 cm. Chemoradiation included radiotherapy at 50.4 cGy, and concurrent capecitabine. In 22% a fluoropirimidine and oxaliplatin-based schema was used as induction therapy. Median follow up was 37.5 months and response assessment time 9 weeks (5–19). Eleven patients recurred, 6 endoluminally, 3 developed mesorectal recurrence, and two distant failure. Five years DFS and OS were 76.3% and 93.8%. Conclusions conservative management was feasible with close follow up in leading cancer centres. In this series, DFS and OS were comparable to the data already reported in the literature.

Published
2016
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11. GINGIVAL GLANDULAR ODONTOGENIC CYSTS OR GINGIVAL SALIVARY GLAND CHORISTOMA? AN UNUSUAL CASE

Author

Dolly Aristizábal García and Diego Fernando Sanchez Henao

Subjects
Cuboidal Cell, medicine.medical_specialty, Pathology, Choristoma, medicine.diagnostic_test, business.industry, H&E stain, medicine.disease, Pathology and Forensic Medicine, Eosinophilic, Biopsy, Glandular odontogenic cyst, medicine, Alveolar ridge, Radiology, Nuclear Medicine and imaging, Dentistry (miscellaneous), Surgery, Histopathology, Oral Surgery, business
Abstract

The gingival injures have a multifactorial etiology as hormonal influences, trauma, bacterial plaque, and rests derived from odontogenic epithelium that can cause different developmental or odontogenic anomalies. Objective: To show an unusual case with presence of ectopic glandular tissue in gingiva. Medical description: A 72-year-old woman with a medical history of mastectomy 6 years ago, presents with a swelling above the alveolar ridge at the level of the right lower premolar, translucent, fluctuating, asymptomatic, of 2 months’ duration. Radiography description: Root tip with endodontic treatment; diffuse radiolucent cervical area extending 3 mm on each side. Histopathology description: Cuts of 5 µm, from excisional biopsy, stained with hematoxylin and eosin (H & E) observed in magnitude 10 x and 40 x; a bilayer epithelium, eosinophilic cuboidal cells with a sometimes-ciliated glandular appearance, band of fibrous tissue and chronic inflammatory infiltrate. Other histochemical stains: The Alcian blue–stained epithelial structures with mucinous content, and the periodic acid-Schiff (PAS) was not observed. Conclusion: Ectopic glandular tissue in the gingiva is rare and might be related to glandular odontogenic cyst (found more often intraosseous, this case is in the alveolar ridge) or gingival salivary gland choristoma, a mature tissue in ectopic location. Therefore, pluripotential embryonic epithelial cells can develop into glandular tissue. Collaboration: Pathology Institute Mejia Jimenez (Cali, Colombia).

Published
2020
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14. Video-Assisted Thoracic Surgical Repair of the Airway

Author

José M. Galbis-Caravajal, Néstor J. Martínez-Hernández, Fernando Sanchez-Garcia, and Alejandro Váquez-Sánchez

Subjects
Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Intubation, Intratracheal, medicine, Humans, Intubation, Video assisted, Fibrous joint, Surgical repair, Thoracic Surgery, Video-Assisted, business.industry, Middle Aged, Surgery, Trachea, medicine.anatomical_structure, 030228 respiratory system, Cardiothoracic surgery, Cardiology and Cardiovascular Medicine, Complication, business, Airway
Abstract

We communicate the first reported application of video-assisted thoracic surgery for early repair of a postintubation tracheal laceration. The patient was a 60-year-old man. After an initial unsuccessful approach with conservative measures, surgical repair was indicated. The patient underwent 2-port video-assisted thoracic surgery for direct tracheal repair using a 3-0 resorbable monofilament running suture and two reinforcing X-stitches. Bronchoscopic control after 2 and 4 weeks showed complete restoration of the airway, with no complication.

Published
2019
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15. EFFECT OF SCLEROTHERAPY USING COPPER WIRES ASSOCIATED WITH CORTICOSTEROIDS IN THE TREATMENT OF VASCULAR LESIONS

Author

Alejandro Ángel Ortiz, Diego Fernando Sanchez Henao, Ruberh Andres Mera Vergara, Daniela Bernal Rojas, and Dolly Aristizábal García

Subjects
medicine.medical_specialty, business.industry, medicine.medical_treatment, Fibrous tissue, Oral cavity, medicine.disease, Pathology and Forensic Medicine, Resection, Surgery, Lesion, Fibrosis, Anesthetic, medicine, Sclerotherapy, Radiology, Nuclear Medicine and imaging, Dentistry (miscellaneous), Oral Surgery, medicine.symptom, business, Hyaline, medicine.drug
Abstract

Vascular injuries in the oral cavity cause anesthetic and functional problems, and a high risk of severe hemorrhages in simple surgical treatments; therapy with copper wires and corticosteroids generates local coagulation and fibrosis and are effective for an uncomplicated resection. Through a series of cases, clinical and anatomopathologic characteristics of the combined sclerotherapy effects are described, as an alternative for the treatment of vascular malformations performed on 7 patients, using intralesional corticoid (0.2 mL/cm2) for 2 or 3 weeks, followed by a cerclage with copper wires, for 1 week, until color change from red or purple to lighter color and a fibrous consistency was observed. Continued resection of the lesion occurred in the absence of bleeding. Histologic studies were performed, which revealed neoformation of fibrous tissue, hyalinization of blood vessels, and loss of endothelial continuity. The result was favorable in 100% of the cases.

Published
2020
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16. 50 Years Ago in

Author

Luis Fernando Sanchez Espino

Subjects
medicine.medical_specialty, medicine.anatomical_structure, business.industry, Pediatrics, Perinatology and Child Health, medicine, MEDLINE, Sinus thrombosis, medicine.disease, business, Thrombosis, Sinus (anatomy), Surgery
Published
2019
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18. Rapid cost estimation of metallic components for the aerospace industry

Author

Vicente Rodríguez Montequín, Fernando Sanchez, Francisco Ortega, and Javier de Cos

Subjects
Economics and Econometrics, Polynomial, Artificial neural network, Cost estimate, Computer science, business.industry, Management Science and Operations Research, Machine learning, computer.software_genre, General Business, Management and Accounting, Turbine, Industrial and Manufacturing Engineering, Probabilistic neural network, Projection pursuit, Artificial intelligence, business, Aerospace, computer
Abstract

This paper illustrates and compares the results of the application of two different approaches—non-parametric and artificial neural network techniques—for the rapid cost estimation of turbine components. This technique is a simple and automatic way for the estimation of the cost of a piece with no expert intervention. Three methods of estimation are compared: the projection pursuit method (PPR), the local polynomial approach (LOESS) and adaptive neural networks (ANNs). This comparative analysis serves to enhance current work that seeks to choose the optimum predictor model. The results confirm the validity of the neural network theory in this field of application, but not a clear superiority as compared with the non-parametric approach. The present research provides a new tool to avoid inadequate piece budgeting strategies. The use of these methods contributes to the minimisation of errors in the budgeting of new items.

Published
2008
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19. Análisis clínico y funcional de los resultados de la uvulopalatofaringoplastia a largo plazo

Author

F.J. García Callejo, E.N. Fernández Julián, A. Morant Ventura, M.H. Orts Alborch, L. De la Fuente, Fernando Sanchez, M. Esparcia Navarro, and J. Marco Algarra

Subjects
Müller's maneuver, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Uvulopalatopharyngoplasty, Sleep apnea, medicine.disease, nervous system diseases, respiratory tract diseases, Surgery, Endoscopy, Obstructive sleep apnea, stomatognathic system, Otorhinolaryngology, Anesthesia, Severity of illness, medicine, Health questionnaire, business, Body mass index
Abstract

In order to evaluate the clinical and functional effectiveness of uvulopalatopharyngoplasty (UPPP) in chronic roncopathy, we studied the subjective improvement of operated patients and compared to pulsioximetry findings before and after surgery. A follow-up was made on 72 patients entitled of chronic roncopathy--51 with obstructive sleep apnea syndrome (OSAS) and 21 with simple snoring-, for a mean period of time of 41 months. Preoperatory study included on ENT exploration, fibre optic endoscopy, Muller maneuver, pharyngeal CT, value of daytime sleepiness with Epworth's scale, espirometry and pulsioximetry, and the postoperatory study included of pulsioximetry and a health questionnaire over snoring and daytime sleepiness. Snoring improved or disappeared in 13 of 21 patients (61.8%), and daytime sleepiness did it in 26 of 39 (66.6%). Therapeutic failure in snoring was mainly due to an increase in the body mass index. After UPPP in OSAS, only 21 patients (41.1%) showed all positive response criteria (decrease into ODI > or = 50% or in absolute values or = 85%). UPPP failed in long term evaluation in the rest of individuals. Patient selection is mandatory to optimize clinical response of UPPP for snoring, without OSAS success depends on body mass index, respiratory disturbances ratios and the eventual presence of another upper airways collapses below velopharyngeal segment.

Published
2002
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23. Pneumothorax—Guidelines of Action

Author

Soledad López-Martín, Nuria Manes, Fernando Sanchez-Gascon, and Helena Hernandez-Rodriguez

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Pneumothorax, Action (philosophy), business.industry, Medicine, Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, business, Intensive care medicine, medicine.disease
Published
2002
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24. Neisseriaceae isolated from unusual sites

Author

Fernando Sanchez, Guillermo Prats, Ferran Navarro, and Pere Coll

Subjects
Microbiology (medical), Infectious Diseases, biology, business.industry, Medicine, Neisseriaceae, biology.organism_classification, business, Microbiology
Published
1993
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26. Reversible morphological alterations of cortical neurons in juvenile and adult hypothyroidism in the rat

Author

Francisco Escobar, Dey Rey, Fernando Sanchez-Toscano, Gabriella Morreale de Escobar, and Antonio Ruiz-Marcos

Subjects
Thyroid Hormones, medicine.medical_specialty, Thyrotropin, Biology, Hypothyroidism, Cortex (anatomy), Internal medicine, medicine, Animals, Distribution (pharmacology), Juvenile, Molecular Biology, Visual Cortex, Neurons, General Neuroscience, Thyroid, Age Factors, Dendrites, Cortical neurons, Rats, Adult hypothyroidism, Thyroxine, medicine.anatomical_structure, Visual cortex, Endocrinology, Growth Hormone, Female, Neurology (clinical), Developmental Biology, Hormone
Abstract

We have studied: (i) whether or not hypothyroidism induced experimentally in the adult rat affects the number and distribution of spines along the apical shaft of pyramidal cells from the visual cortex; and (ii) whether treatment with thyroid hormone would reverse such changes. Two experiments were performed. Experiment A involved the study of rats which were thyroidectomized (T¯) at 40 or at 120 days of age, killed at 120 and 220 days of age, respectively, data being compared to those of adequate sex and age-paired controls. Experiment B involved rats which were T¯ at 40 days of age; they were subdivided into two groups, one of which was left untreated and theother received 0.2 μg of thyroxine/100 g body weight/day for 25 days. Both groups were killed at 90 days of age. We found that: (i) T¯ at 40 and at 120 days of age resulted in a decrease of the number of spines and a deragement of their distribution along the shaft, the observed changes being qualitatively comparable to those previously described 24,25 for rats T¯ at 10 days of age; and (ii) preliminary results from experiment B indicate that the observed changes in neuronal morphology might be reversible. It is suggested that age-independent and reversible alterations of learning capacity and electrocortical activity of hypothyroid rats 7,8 might have age-independent and reversible morphological correlates at the level of the cortex.

Published
1980
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27. Interaction of paramyxoviruses with human basophils and their effect on histamine release

Author

Fernando Sanchez-Legrand and Thomas F. Smith

Subjects
Adult, Cell Membrane Permeability, viruses, Immunology, Con A, Concanavalin A, RS, Respiratory syncytial virus, chemistry.chemical_element, In Vitro Techniques, Calcium, Pharmacology, Immunoglobulin E, Histamine Release, Article, Virus, chemistry.chemical_compound, HA, HEPES buffered saline, pH 7.4, containing 0.3 mg/ml of human serum albumin, Cell surface receptor, Extracellular, Humans, Immunology and Allergy, Receptor, MEM, Minimum essential medium, Calcimycin, UV, Ultraviolet, HSA, Human serum albumin, L-Lactate Dehydrogenase, biology, PI-3, Parainfluenza type 3 virus, 2-DG, 2-Deoxyglucose, biology.organism_classification, Sendai virus, Basophils, HACM, HEPES buffered saline, pH 7.4, containing 0.3 mg/ml of human serum albumin, 2 mmol/L of Ca++ and 1 mmol/L of Mg++, HEPES, N-2-hydroxyethylpiperazine-N′ -2-ethanesulfonic acid, chemistry, Biochemistry, Paramyxoviridae, FBS, Fetal bovine serum, biology.protein, LDH, Lactic dehydrogenase, Histamine
Abstract

We have demonstrated that human peripheral blood basophils released histamine on direct incubation with paramyxoviruses in vitro . Most histamine release occurred during the first 15 to 30 minutes after challenge, depending on the dose of virus used; release initiated by virus was complete by 1 hour. At a virus/cell ratio of 1:1, Sendai virus caused 41 ± 9% histamine release, whereas parainfluenza type 3 (PI-3) virus caused 25 ± 5% release and respiratory syncytial (RS) virus caused 19 ± 5% release. Sendai, but not PI-3 or RS, also caused a decrease in cell number and release of lactic dehydrogenase; however, this apparent cell lysis did not account for all the histamine released. Incubation of cells with virus desensitized them to subsequent triggering by viruses but did not affect response of cells to other stimuli. Histamine release was dependent on the virus/cell ratio, temperature, and metabolic energy, but it was not strictly dependent on the presence of calcium in the extracellular medium. Histamine release was not affected by preincubation of cells with colchicine, suggesting that microtubules were not involved in the release process. Basophils desensitized by anti-IgE in the absence of calcium or treated with lactic acid to dissociate IgE molecules from membrane receptors released amounts of histamine similar to that of control basophils; thus, release was not initiated through Fc ϵ receptors. It was found, however, that histamine release by these viruses was greatly reduced when concanavalin A was used for desensitization. These data demonstrate that the respiratory viruses studied can cause direct nonimmunologic release of histamine from human basophils. Our findings provide evidence for another mechanism by which respiratory viruses can initiate inflammation.

Published
1989
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28. Renal changes in hydatidiform mole with toxemia

Author

Hernando Rocha, Jesus A. Gomez, Fernando Sanchez-Torres, and Armando Santamaria

Subjects
medicine.medical_specialty, Pregnancy, business.industry, Obstetrics, Pregnancy toxemias, Mole, Obstetrics and Gynecology, Medicine, business, medicine.disease
Published
1965
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