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Your search keyword '"Fei-long, Zhang"' showing total 2 results
Start Over Author "Fei-long, Zhang" Publisher elsevier bv
2 results on '"Fei-long, Zhang"'

1. Preparation and characterization of injectable Mitoxantrone poly (lactic acid)/fullerene implants for in vivo chemo-photodynamic therapy

Author

Zhi Li, Li-li Pan, Xiali Zhu, Zhenzhong Zhang, and Fei-long Zhang

Subjects
Male, Drug, Polymers, Chemistry, Pharmaceutical, Phenylalanine, Polyesters, medicine.medical_treatment, media_common.quotation_subject, Biophysics, Antineoplastic Agents, Photodynamic therapy, Spleen, Pharmacology, Injections, Mice, chemistry.chemical_compound, In vivo, medicine, Animals, Radiology, Nuclear Medicine and imaging, Lactic Acid, Melanoma, media_common, Drug Carriers, Mitoxantrone, Kidney, Radiation, Radiological and Ultrasound Technology, Combined Modality Therapy, Xenograft Model Antitumor Assays, Microspheres, In vitro, Lactic acid, Drug Liberation, medicine.anatomical_structure, Photochemotherapy, chemistry, Fullerenes, medicine.drug
Abstract

Fullerene (C60) L-phenylalanine derivative attached with poly (lactic acid) (C60-phe-PLA) was developed to prepare injectable Mitoxantrone (MTX) multifunctional implants. C60-phe-PLA was self-assembled to form microspheres consisting of a hydrophilic antitumor drug (MTX) and a hydrophobic block (C60) by dispersion-solvent diffusion method. The self-assembled microspheres showed sustained release pattern almost 15days in vitro release experiments. According to the tissue distribution of C57BL mice after intratumoral administration of the microspheres, the MTX mainly distributed in tumors, and rarely in heart, liver, spleen, lung, and kidney. Photodynamic antitumor efficacy of blank microsphere was realized. Microspheres afforded high antitumor efficacy without obvious toxic effects to normal organs, owing to its significantly increased MTX tumor retention time, low MTX levels in normal organs and strong photodynamic activity of PLA-phe-C60. These C60-phe-PLA microspheres may be promising for the efficacy with minimal side effects in future treatment of solid tumors.

Published
2015
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2. Development of a new type lacquer based on Rhus vernicifera sap with chitosan

Author

Rong Lu, Fei-long Zhang, Naruhiko Ebata, and Tetsuo Miyakoshi

Subjects
Materials science, General Chemical Engineering, Organic Chemistry, engineering.material, Urushiol, Surfaces, Coatings and Films, Chitosan, chemistry.chemical_compound, Coating, chemistry, Drying time, visual_art, Particle-size distribution, Polymer chemistry, Materials Chemistry, visual_art.visual_art_medium, engineering, Molar mass distribution, Citric acid, Lacquer, Nuclear chemistry
Abstract

A new type lacquer coating was developed by adding certain molecular weight of chitosan to the Rhus vernicifera lacquer sap. The optimum range of chitosan molecular weight and adding quantity were investigated, and the blended lacquer coating was prepared based on these results. The properties, such as molecular weight distribution, particle size distribution, drying times, and gel fraction were examined. In addition, the reaction between urushiol and chitosan is discussed based on the results of nuclear magnetic resonance (NMR) and infrared (IR) measurements. A blended lacquer coating with 3% chitosan dissolve in 5% of citric acid showed almost the same drying time and film hardness as 100% R. vernicifera lacquer sap as examined in an automatic drying time recorder, but had lighter surface color. Furthermore, the UV resistance and viscoelastic property also were investigated in detail.

Published
2014
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