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Your search keyword '"Fairen‐Jimenez, David"' showing total 18 results
Start Over Author "Fairen‐Jimenez, David" Publisher elsevier bv
18 results on '"Fairen‐Jimenez, David"'

2. Sol-gel processing of a covalent organic framework for the generation of hierarchically porous monolithic adsorbents

Author

Carrington, Mark E., primary, Rampal, Nakul, additional, Madden, David G., additional, O’Nolan, Daniel, additional, Casati, Nicola Pietro Maria, additional, Divitini, Giorgio, additional, Martín-Illán, Jesús Á., additional, Tricarico, Michele, additional, Cepitis, Ritums, additional, Çamur, Ceren, additional, Curtin, Teresa, additional, Silvestre-Albero, Joaquin, additional, Tan, Jin-Chong, additional, Zamora, Felix, additional, Taraskin, Sergei, additional, Chapman, Karena W., additional, and Fairen-Jimenez, David, additional

Published
2022
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3. Densified HKUST-1 Monoliths as a Route to High Volumetric and Gravimetric Hydrogen Storage Capacity

Author

Madden, David Gerard, primary, O’Nolan, Daniel, additional, Rampal, Nakul, additional, Babu, Robin, additional, Çamur, Ceren, additional, Al Shakhs, Ali N., additional, Zhang, Shi-Yuan, additional, Rance, Graham A., additional, Perez, Javier, additional, Casati, Nicola Pietro Maria, additional, Cuadrado-Collados, C., additional, O’Sullivan, Denis, additional, Rice, Nicholas P., additional, Gennett, Thomas, additional, Parilla, Philip, additional, Shulda, Sarah, additional, Hurst, Katherine E., additional, Stavila, Vitalie, additional, Allendorf, Mark D., additional, Silvestre-Albero, Joaquin, additional, Forse, Alexander C., additional, Champness, Neil R., additional, Chapman, Karena W., additional, and Fairen-Jimenez, David, additional

Published
2022
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9. A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown

Author

Teplensky, Michelle H., primary, Fantham, Marcus, additional, Poudel, Chetan, additional, Hockings, Colin, additional, Lu, Meng, additional, Guna, Alina, additional, Aragones-Anglada, Marta, additional, Moghadam, Peyman Z., additional, Li, Peng, additional, Farha, Omar K., additional, Bernaldo de Quirós Fernández, Sandra, additional, Richards, Frances M., additional, Jodrell, Duncan I., additional, Kaminski Schierle, Gabriele, additional, Kaminski, Clemens F., additional, and Fairen-Jimenez, David, additional

Published
2019
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15. Selective Surface PEGylation of UiO-66 Nanoparticles for Enhanced Stability, Cell Uptake, and pH-Responsive Drug Delivery

Author

Abánades Lázaro, Isabel, Haddad, Salame, Sacca, Sabrina, Orellana-Tavra, Claudia, Fairen-Jimenez, David, and Forgan, Ross S

Subjects
microporous materials, drug delivery, endocytosis, zirconium, SDG3: Good health and well-being, nanoparticles, metal-organic frameworks, surface modification, 3. Good health
Abstract

The high storage capacities and excellent biocompatibilities of metal-organic frameworks (MOFs) have made them emerging candidates as drug-delivery vectors. Incorporation of surface functionality is a route to enhanced properties, and here we report on a surface-modification procedure-click modulation-that controls their size and surface chemistry. The zirconium terephthalate MOF UiO-66 is (1) synthesized as ∼200 nm nanoparticles coated with functionalized modulators, (2) loaded with cargo, and (3) covalently surface modified with poly(ethylene glycol) (PEG) chains through mild bioconjugate reactions. At pH 7.4, the PEG chains endow the MOF with enhanced stability toward phosphates and overcome the "burst release" phenomenon by blocking interaction with the exterior of the nanoparticles, whereas at pH 5.5, stimuli-responsive drug release is achieved. The mode of cellular internalization is also tuned by nanoparticle surface chemistry, such that PEGylated UiO-66 potentially escapes lysosomal degradation through enhanced caveolae-mediated uptake. This makes it a highly promising vector, as demonstrated for dichloroacetic-acid-loaded materials, which exhibit enhanced cytotoxicity. The versatility of the click modulation protocol will allow a wide range of MOFs to be easily surface functionalized for a number of applications.

16. Structure-Mechanical Stability Relations of Metal-Organic Frameworks via Machine Learning

Author

Chun-Man Chow, Jelle Wieme, David Fairen-Jimenez, N. Moharrami, Sven Rogge, Diego A. Gómez-Gualdrón, Gareth Conduit, Marta Aragones-Anglada, Aurelia Li, Veronique Van Speybroeck, Peyman Z. Moghadam, Li, Aurelia [0000-0001-8298-3992], Conduit, Gareth [0000-0003-3807-6361], Fairen Jimenez, David [0000-0002-5013-1194], and Apollo - University of Cambridge Repository

Subjects
Technology and Engineering, ADSORPTION, Computer science, Bioengineering, 02 engineering and technology, 010402 general chemistry, Translation (geometry), Network topology, 01 natural sciences, MOFS, Computational science, ENERGY, DELIVERY, Molecular dynamics, DESIGN, UIO-66, General Materials Science, Sensitivity (control systems), Topology (chemistry), 40 Engineering, Structure (mathematical logic), 3403 Macromolecular and Materials Chemistry, 34 Chemical Sciences, Artificial neural network, Mechanical screening, CARRIERS, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 0210 nano-technology, STORAGE, QUICKFF
Abstract

Summary Assessing the mechanical stability of metal-organic frameworks (MOFs) is critical to bring these materials to any application. Here, we derive the first interactive map of the structure-mechanical landscape of MOFs by performing a multi-level computational analysis. First, we used high-throughput molecular simulations for 3,385 MOFs containing 41 distinct network topologies. Second, we developed a freely available machine-learning algorithm to automatically predict the mechanical properties of MOFs. For distinct regions of the high-throughput space, in-depth analysis based on in operando molecular dynamics simulations reveals the loss-of-crystallinity pressure within a given topology. The overarching mechanical screening approach presented here reveals the sensitivity on structural parameters such as topology, coordination characteristics and the nature of the building blocks, and paves the way for computational as well as experimental researchers to assess and design MOFs with enhanced mechanical stability to accelerate the translation of MOFs to industrial applications.

Published
2019

17. The launch of a freely accessible MOF CIF collection from the CSD

Author

Suzanna C. Ward, David Fairen-Jimenez, Seth B. Wiggin, Peter A. Wood, Aurelia Li, Rocio Bueno Perez, Li, Aurelia [0000-0001-8298-3992], Fairen Jimenez, David [0000-0002-5013-1194], and Apollo - University of Cambridge Repository

Subjects
3402 Inorganic Chemistry, Database, 34 Chemical Sciences, Computer science, General Materials Science, computer.software_genre, computer
Abstract

The computational study of metal-organic frameworks (MOFs) relies heavily on the availability, quality, and simulation-readiness of MOF structural data. We announce here the release of the freely accessible and regularly updated “CSD MOF Collection,” a dataset of >10,000 3D porous computation-ready MOFs, derived from our automatically updated CSD MOF subset.

Published
2021

18. A Highly Porous Metal-Organic Framework System to Deliver Payloads for Gene Knockdown

Author

Meng Lu, Peyman Z. Moghadam, Michelle H. Teplensky, David Fairen-Jimenez, Omar K. Farha, Chetan Poudel, Marcus Fantham, Clemens F. Kaminski, Sandra Bernaldo de Quirós Fernández, Alina Guna, Colin Hockings, Duncan I. Jodrell, Marta Aragones-Anglada, Frances M. Richards, Gabriele Kaminski Schierle, Peng Li, Poudel, Chetan [0000-0002-8512-9238], Hockings, Colin [0000-0002-0248-0517], Richards, Fran [0000-0001-7947-7853], Jodrell, Duncan [0000-0001-9360-1670], Kaminski Schierle, Gabriele [0000-0002-1843-2202], Kaminski, Clemens [0000-0002-5194-0962], Fairen Jimenez, David [0000-0002-5013-1194], and Apollo - University of Cambridge Repository

Subjects
Small interfering RNA, Endosome, General Chemical Engineering, Endocytic cycle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, RNA interference, Materials Chemistry, Genetics, Environmental Chemistry, Gene, Gene knockdown, 34 Chemical Sciences, Chemistry, fungi, Biochemistry (medical), RNA, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Cell biology, FOS: Biological sciences, Drug delivery, 0210 nano-technology, Biotechnology
Abstract

Summary Since first reported, RNA interference (RNAi) has become a widely used tool for cellular genetic knockdown. However, RNA instability and susceptibility to enzymatic degradation have prevented its widespread clinical use. Thus, research efforts are seeking methods to protect the fragile RNA payload during delivery. Here, we report the use of a metal-organic framework (MOF) to load, protect, and deliver small interfering ribonucleic acids (siRNAs). We confirmed the protection of MOF-internalized siRNA from enzymatic degradation. Furthermore, through combined encapsulation of siRNA in the MOF with various cofactors (proton sponge, KALA peptide, and NH4Cl), we show that endosomal retention can be evaded and ensure that gene knockdown is efficacious. In vitro studies after siRNA-MOF complexation demonstrated up to 27% consistent knockdown. We use structured illumination microscopy (SIM) to study the complex’s endocytic uptake. Overall, we demonstrate the potential of these highly porous and biodegradable materials to improve the efficacy and efficiency of future gene therapies.

Published
2019
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