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15 results on '"Fabrizia Carli"'

1. Women Exposure to Di(2-Ethylhexyl)Phthalate (Dehp) and Bisphenol a (Bpa) from Different Residing Areas in Italy: Data from the Life Persuaded Project

Author

Fabrizia Carli, Sabrina Tait, Luca Busani, Demetrio Ciociaro, Veronica Della Latta, Anna Paola Pala, Annalisa Deodati, Andrea Raffaelli, Filippo Pratesi, Raffaele Conte, Francesca Maranghi, Roberta Tassinari, Enrica Fabbrizi, Giacomo Toffol, Stefano Cianfarani, Cinzia La Rocca, and amalia gastaldelli

Subjects
History, Polymers and Plastics, Business and International Management, Industrial and Manufacturing Engineering
Published
2022
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2. TM6SF2/PNPLA3/MBOAT7 loss-of-function genetic variants impact on NAFLD development and progression both in patients and in in vitro models

Author

Marica Meroni, Luca Miele, Veronica Erconi, Giorgio Soardo, S. Sabatini, Massimiliano Ruscica, A.L. Fracanzani, Giacomo P. Comi, Amalia Gastaldelli, E.R. De Caro, Miriam Longo, E. Paolini, Dario Ronchi, Chiara Macchi, A. Alisi, Fabrizia Carli, Luca Valenti, and Paola Dongiovanni

Subjects
Hepatology, business.industry, Gastroenterology, Genetic variants, Medicine, In patient, business, Bioinformatics, Loss function, In vitro, TM6SF2
Published
2020
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3. MBOAT7 Down-Regulation by Hyperinsulinemia Induces Fat Accumulation in Hepatocytes

Author

Raffaela Rametta, Luca Valenti, Anna Ludovica Fracanzani, Fabrizia Carli, Nicholas O. Davidson, Paola Dongiovanni, Serena Pelusi, Stefano Gatti, Marco Maggioni, Amalia Gastaldelli, Guido Baselli, Sara Badiali, Stefano Romeo, Miriam Longo, and Marica Meroni

Subjects
medicine.medical_specialty, business.industry, Insulin, medicine.medical_treatment, Fatty liver, Context (language use), medicine.disease, Endocrinology, Internal medicine, Lipogenesis, medicine, Hyperinsulinemia, media_common.cataloged_instance, European union, Steatosis, Steatohepatitis, business, media_common
Abstract

Background & Aims: Naturally occurring variation in Membrane-bound O-acyltransferase domain-containing 7 (MBOAT7), an enzyme involved in phospholipid acyl-chain remodeling, has been associated with steatosis and hepatic disorders. We examined the relationship between hepatic MBOAT7 down-regulation and fat accumulation. Methods: Hepatic MBOAT7 expression was surveyed in 119 obese individuals and in experimental models. MBOAT7 was acutely silenced by antisense oligonucleotides in C57Bl/6 mice, and by CRISPR/Cas9 in HepG2. Results: In obese individuals, hepatic MBOAT7 mRNA decreased from normal liver to steatohepatitis, independently of diabetes, inflammation and MBOAT7 genotype. Mboat7 levels were reduced in murine models of fatty liver, and by hyperinsulinemia. In wild-type mice, Mboat7 was down-regulated by refeeding and insulin, concomitantly with insulin signaling activation. Acute hepatic Mboat7 silencing promoted hepatic steatosis in vivo and enhanced expression of fatty acid transporter Fatp1. MBOAT7-/- HepG2 showed altered phospholipids remodeling consistent with decreased enzymatic activity, increased triglyceride accumulation, enhanced lipogenesis and FATP1 expression, while FATP1 deletion rescued the phenotype. Conclusions: These results suggest that MBOAT7 down-regulation by hyperinsulinemia contributes to hepatic fat accumulation, impairing phospholipids remodeling and up-regulating FATP1. Funding Statement: LV was supported by MyFirst Grant AIRC n.16888, Ricerca Finalizzata Ministero della Salute RF-2016-02364358, Ricerca corrente Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, LV and AG. received funding from the European Union (EU) Programme Horizon 2020 (under grant agreement No. 777377) for the project LITMUS-“ Liver Investigation: Testing Marker Utility in Steatohepatitis”. MM was supported by Fondazione Italiana per lo Studio del Fegato (AISF) ‘Prof. Mario Coppo’ fellowship. AG received funding from the European Union (EU) Programme Horizon 2020 under grant agreement no. 634413 for the project EPoS-“Elucidating Pathways of Steatohepatitis”. Declaration of Interests: The authors declare no conflict of interest relevant to the present manuscript. Ethics Approval Statement: Informed written consent was obtained from each patient and the study protocol was approved by the Ethical Committee of the Fondazione IRCCS Ca’ Granda of Milan and conforms to the ethical guidelines of the 1975 Declaration of Helsinki. We received an approval from an Animal Use Committee for the animal work from the University of Milan and the Italian Ministry of Health Review Boards, in the context of the protocol 8/14, as indicated in the material and methods section in the manuscript. The authorization number of this protocol is 295/2012–A, received on 12/20/2012.

Published
2019
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4. FRI-283-Impact on NAFLD of long-term weight loss after bariatric surgery

Author

Virna Zampa, Fabrizia Carli, Marianna Palumbo, Stefania Camastra, Bárbara Patrício, Ele Ferrannini, Amalia Gastaldelli, Melania Gaggini, Brenno Astiarraga, and Chiara Barbieri

Subjects
medicine.medical_specialty, Hepatology, business.industry, Weight loss, Medicine, medicine.symptom, business, Term (time), Surgery
Published
2019
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5. PS-006-MBOAT7 downregulation induces hepatic lipid accumulation

Author

Stefano Gatti, Fabrizia Carli, Raffaela Rametta, Marica Meroni, Guido Baselli, Stefano Romeo, Sara Badiali, Marco Maggioni, Paola Dongiovanni, Anna Ludovica Fracanzani, Miriam Longo, Amalia Gastaldelli, Luca Valenti, and Serena Pelusi

Subjects
Hepatology, Downregulation and upregulation, Chemistry, Hepatic lipid, Cell biology
Published
2019
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6. Metabolomic profile of morbidly obese NAFLD: effect of weight loss by exenatide or diet

Author

Brenno Astiarraga, Fabrizia Carli, Bárbara Patrício, Stefania Camastra, Melania Gaggini, Eleuterio Ferrannini, Amalia Gastaldelli, Chiara Rosso, and Elisabetta Bugianesi

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Morbidly obese, Metabolomics, Weight loss, Internal medicine, Medicine, medicine.symptom, business, Exenatide, medicine.drug
Published
2019
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7. Impact of short term weight loss (very low calorie diet vs bariatric surgery) on hepatic insulin resistance and plasma lipidomic profile

Author

Francesco Rubino, Amerigo Iaconelli, Fabrizia Carli, Melania Gaggini, Amalia Gastaldelli, Chiara Barbieri, Geltrude Mingrone, and Augusto Veneziani

Subjects
medicine.medical_specialty, Hepatology, business.industry, food.diet, medicine.disease, Term (time), Very low calorie diet, Insulin resistance, Endocrinology, food, Weight loss, Internal medicine, medicine, medicine.symptom, business
Published
2018
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8. Bile acid composition modulate insulin resistance in non-diabetic patients with NAFLD

Author

M.L. Abate, Monica Cucco, Fabrizia Carli, Jacob George, Mohammed Eslam, Chiara Rosso, Amalia Gastaldelli, Chiara Barbieri, Melania Gaggini, Giorgio Maria Saracco, Ramy Younes, Sally Coulter, V. Della Latta, Elisabetta Bugianesi, and F.W. Chen

Subjects
0301 basic medicine, medicine.medical_specialty, Hepatology, Bile acid, medicine.drug_class, Chemistry, medicine.disease, 03 medical and health sciences, 030104 developmental biology, Endocrinology, Insulin resistance, Internal medicine, medicine, Composition (visual arts), Non diabetic
Published
2018
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9. Increased hepatic glucose production and insulin resistance are associated to increased plasma concentrations of glucogenic amino acids in subjects with NAFLD

Author

Amalia Gastaldelli, Emma Buzzigoli, V. Della Latta, Melania Gaggini, Maurizio Cassader, A. Smedile, Chiara Rosso, Fabrizia Carli, Elisabetta Bugianesi, Roberto Gambino, M.L. Abate, Demetrio Ciociaro, and Milena Marietti

Subjects
0301 basic medicine, chemistry.chemical_classification, medicine.medical_specialty, 030109 nutrition & dietetics, Hepatic glucose, Hepatology, business.industry, Gastroenterology, medicine.disease, Amino acid, 03 medical and health sciences, Endocrinology, Insulin resistance, chemistry, Internal medicine, Plasma concentration, Medicine, business
Published
2017
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10. Increased hepatic glucose production and insulin resistance in subjects with non-alcoholic fatty liver disease is associated to increased plasma concentrations of glucogenic amino acids

Author

Fabrizia Carli, Milena Marietti, Amalia Gastaldelli, Roberto Gambino, Elisabetta Bugianesi, Veronica Della Latta, Maurizio Cassader, Chiara Rosso, Melania Gaggini, Maria Lorena Abate, Demetrio Ciociaro, Antonina Smedile, and Emma Buzzigoli

Subjects
chemistry.chemical_classification, 0303 health sciences, medicine.medical_specialty, Hepatic glucose, Hepatology, Chemistry, Fatty liver, Non alcoholic, Disease, medicine.disease, Amino acid, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Internal medicine, Plasma concentration, medicine, 030211 gastroenterology & hepatology, 030304 developmental biology
Published
2017
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11. Angiopoietin-like4 is associated with lipid metabolism and severe fibrosis in non-diabetic patients with non-alcoholic fatty liver disease

Author

Emma Buzzigoli, C. Saponaro, Gian Paolo Caviglia, Amalia Gastaldelli, Maria Lorena Abate, Antonina Smedile, Giorgio Maria Saracco, Milena Marietti, Fabrizia Carli, Melania Gaggini, Elisabetta Bugianesi, and Chiara Rosso

Subjects
medicine.medical_specialty, Hepatology, business.industry, Fatty liver, Gastroenterology, Non alcoholic, Lipid metabolism, Disease, Severe fibrosis, medicine.disease, Angiopoietin, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, 030220 oncology & carcinogenesis, Internal medicine, Medicine, 030211 gastroenterology & hepatology, business, Non diabetic
Published
2016
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12. P857 A NEW INDEX OF GLUTATHIONE TURNOVER (GSH_TI) AND ITS ASSOCIATION WITH SEVERITY OF NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Author

Lavinia Mezzabotta, Fabrizia Carli, Emma Buzzigoli, Roberto Gambino, M.L. Abate, C. Saponaro, Chiara Rosso, Elisabetta Bugianesi, Ester Vanni, Maurizio Cassader, Amalia Gastaldelli, Demetrio Ciociaro, and Melania Gaggini

Subjects
medicine.medical_specialty, Pathology, Index (economics), Hepatology, business.industry, Fatty liver, Non alcoholic, Disease, Glutathione, medicine.disease, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, medicine, business
Published
2014
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13. P849 QUANTITATIVE AND QUALITATIVE ANALYSIS OF PLASMA FREE FATTY ACIDS AND THEIR IMPACT ON LIVER DAMAGE IN NAFLD PATIENTS

Author

Gian Paolo Caviglia, M.L. Abate, Roberto Gambino, M. Rizzetto, Francesca Saba, Elisabetta Bugianesi, Emma Buzzigoli, Fabrizia Carli, Lavinia Mezzabotta, A. Smedile, Amalia Gastaldelli, Chiara Rosso, Melania Gaggini, C. Saponaro, Ester Vanni, Maurizio Cassader, and Federico Salomone

Subjects
Qualitative analysis, Hepatology, Biochemistry, Chemistry, Liver damage, Plasma free fatty acid
Published
2014
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14. P0519 : Lipidomics reveals that low plasma unsaturated to saturated fat ratios are biomarkers of NAFLD and liver damage

Author

Fabrizia Carli, Emma Buzzigoli, Maurizio Cassader, Amalia Gastaldelli, C. Saponaro, Gian Paolo Caviglia, Demetrio Ciociaro, S. Carenzi, Roberto Gambino, M.L. Abate, Melania Gaggini, Francesca Saba, Ester Vanni, Lavinia Mezzabotta, A. Smedile, Chiara Rosso, Elisabetta Bugianesi, and Mario Rizzetto

Subjects
Hepatology, Biochemistry, Chemistry, Saturated fat, Lipidomics, Liver damage
Published
2015
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15. P845 IMPACT OF FAT VERSUS GLUCOSE LOAD ON OXIDATIVE STRESS IN NON-ALCOHOLIC FATTY LIVER DISEASE

Author

C. Saponaro, Francesca Saba, Antonina Smedile, Mario Rizzetto, Fabrizia Carli, Lavinia Mezzabotta, Maurizio Cassader, Maria Lorena Abate, Ester Vanni, Amalia Gastaldelli, Chiara Rosso, Elisabetta Bugianesi, Melania Gaggini, Federico Salomone, Gian Paolo Caviglia, Roberto Gambino, S. Carenzi, and Emma Buzzigoli

Subjects
medicine.medical_specialty, Hepatology, business.industry, Fatty liver, Non alcoholic, Disease, medicine.disease_cause, medicine.disease, Endocrinology, Biochemistry, Internal medicine, medicine, business, Oxidative stress
Published
2014
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