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1. The Pan - COVID - AGICT Study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study.

Author

Dorma, Maria Pia Federica, primary, Giuliani, Giuseppe, additional, Guerra, Francesco, additional, Santelli, Francesco, additional, Esposito, Alessandro, additional, De Pastena, Matteo, additional, Turri, Giulia, additional, Pedrazzani, Corrado, additional, Kauffmann, Emanuele Federico, additional, Boggi, Ugo, additional, Solaini, Leonardo, additional, Ercolani, Giorgio, additional, Mastrangelo, Laura, additional, Jovine, Elio, additional, Di Franco, Gregorio, additional, Morelli, Luca, additional, Mazzola, Michele, additional, Ferrari, Giovanni, additional, Langella, Serena, additional, Ferrero, Alessandro, additional, La Mendola, Roberta, additional, Abu Hilal, Mohamnad, additional, Depalma, Norma, additional, D’Ugo, Stefano, additional, Spampinato, Marcello Giuseppe, additional, Frisini, Marco, additional, Brolese, Alberto, additional, Palaia, Raffaele, additional, Belli, Andrea, additional, Cillara, Nicola, additional, Deserra, Antonello, additional, Cannavera, Alessandro, additional, Sagnotta, Andrea, additional, Mancini, Stefano, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Coppola, Alessandro, additional, Di Benedetto, Fabrizio, additional, Coratti, Andrea, additional, Cova, Chiara, additional, Bianchi, Beatrice, additional, Nobile, Sara, additional, Maruccio, Martina, additional, Faustini, Federico, additional, Hilal, Mohamnad Abu, additional, Pecora, Irene, additional, Messinese, Simona, additional, Salvischiani, Lucia, additional, Esposito, Sofia, additional, Ferraro, Luca, additional, Rega, Daniela, additional, Delrio, Paolo, additional, La Raja, Carlotta, additional, Spinelli, Antonino, additional, Massaron, Simonetta, additional, De Nardi, Paola, additional, Deidda, Simona, additional, Restivo, Angelo, additional, Marano, Alessandra, additional, Borghi, Felice, additional, Piccoli, Micaela, additional, Cozzani, Federico, additional, Del Rio, Paolo, additional, Marcellinaro, Rosa, additional, Carlini, Massimo, additional, De Rosa, Raffaele, additional, Scabini, Stefano, additional, Maiello, Fabio, additional, Polastri, Roberto, additional, Zese, Monica, additional, Parini, Dario, additional, Casaril, Andrea, additional, Moretto, Gianluigi, additional, De Leo, Antonio, additional, Catarci, Marco, additional, Trapani, Renza, additional, Zonta, Sandro, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Caputo, Damiano, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, Mariani, Lorenzo, additional, Ceccarelli, Graziano, additional, Giuseppe, Rocco, additional, Bolzon, Stefano, additional, Grasso, Mariateresa, additional, Testa, Silvio, additional, Germani, Paola, additional, de Manzini, Nicolò, additional, Coletta, Diego, additional, De Franco, Lorenzo, additional, Benigni, Roberto, additional, Tribuzi, Angela, additional, Marra, Ubaldo, additional, Di Marino, Michele, additional, Zorcolo, Luigi, additional, Lisi, Giorgio, additional, Allisiardi, Fabrizio, additional, Grieco, Michele, additional, Righetti, Carolina, additional, Grassia, Michele, additional, Lucchi, Andrea, additional, Bagaglini, Giulia, additional, Sica, Giuseppe S., additional, Manara, Michele, additional, Turati, Luca, additional, Macone, Lorenzo, additional, Carminati, Roberta, additional, Mariani, Pierpaolo, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Pennella, Francesca Pennetti, additional, Rondelli, Fabio, additional, Romano, Lucia, additional, Giuliani, Antonio, additional, Albino, Vittorio, additional, Leongito, Maddalena, additional, David, Giulia, additional, Misitano, Pasquale, additional, Pasulo, Silvia, additional, Baiocchi, Gian Luca, additional, Baldari, Ludovica, additional, Cassinotti, Elisa, additional, Boni, Luigi, additional, Capolupo, Gabriella Teresa, additional, Caricato, Marco, additional, Bombardini, Cristina, additional, Anania, Gabriele, additional, Dibra, Rigers, additional, Martines, Gennaro, additional, Oliva, Renato, additional, Carati, Maria Vittoria, additional, Grazi, Gian Luca, additional, Marchegiani, Francesco, additional, Spolverato, Gaya, additional, Celotto, Francesco, additional, Pucciarelli, Salvatore, additional, La Torre, Filippo, additional, Iannone, Immacolata, additional, Krizzuk, Dimitri, additional, Sammartino, Francesco, additional, Catalano, Giorgia, additional, Strignano, Paolo, additional, Romagnoli, Renato, additional, Piccione, Domenico, additional, Nardo, Bruno, additional, Reddavid, Rossella, additional, Degiuli, Maurizio, additional, Gerosa, Martino, additional, Maggioni, Dario, additional, Zuolo, Michele, additional, Rigamonti, Marco, additional, Ghazouani, Omar, additional, Galleano, Raffaele, additional, Percivale, Andrea, additional, Tirloni, Luca, additional, Moraldi, Luca, additional, Fabbri, Nicolò, additional, Feo, Carlo Vittorio, additional, Colombo, Samuele, additional, Merlini, Ilenia, additional, Di Saverio, Salomone, additional, Barbato, Giuseppe, additional, Coratti, Francesco, additional, Formisano, Giampaolo, additional, Bianchi, Paolo Pietro, additional, and Bengala, Carmelo, additional

Published
2024
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3. The COVID - AGICT study: COVID–19 and advanced gastro-intestinal cancer surgical treatment. A multicentric Italian study on the SARS-CoV-2 pandemic impact on gastro-intestinal cancers surgical treatment during the 2020. Analysis of perioperative and short-term oncological outcomes

Author

Giuliani, Giuseppe, primary, Guerra, Francesco, additional, Messinese, Simona, additional, Santelli, Francesco, additional, Salvischiani, Lucia, additional, Esposito, Sofia, additional, Ferraro, Luca, additional, Esposito, Alessandro, additional, De Pastena, Matteo, additional, Rega, Daniela, additional, Delrio, Paolo, additional, La Raja, Carlotta, additional, Spinelli, Antonino, additional, Massaron, Simonetta, additional, De Nardi, Paola, additional, Kauffmann, Emanuele Federico, additional, Boggi, Ugo, additional, Deidda, Simona, additional, Restivo, Angelo, additional, Marano, Alessandra, additional, Borghi, Felice, additional, Piccoli, Micaela, additional, Depalma, Norma, additional, D'Ugo, Stefano, additional, Spampinato, Marcello, additional, Cozzani, Federico, additional, Del Rio, Paolo, additional, Marcellinaro, Rosa, additional, Carlini, Massimo, additional, De Rosa, Raffaele, additional, Scabini, Stefano, additional, Maiello, Fabio, additional, Polastri, Roberto, additional, Turri, Giulia, additional, Pedrazzani, Corrado, additional, Zese, Monica, additional, Parini, Dario, additional, Casaril, Andrea, additional, Moretto, Gianluigi, additional, De Leo, Antonio, additional, Catarci, Marco, additional, Trapani, Renza, additional, Zonta, Sandro, additional, Marsanic, Patrizia, additional, Muratore, Andrea, additional, Di Franco, Gregorio, additional, Morelli, Luca, additional, Coppola, Alessandro, additional, Caputo, Damiano, additional, Andreuccetti, Jacopo, additional, Pignata, Giusto, additional, Mastrangelo, Laura, additional, Jovine, Elio, additional, Mazzola, Michele, additional, Ferrari, Giovanni, additional, Mariani, Lorenzo, additional, Ceccarelli, Graziano, additional, Giuseppe, Rocco, additional, Bolzon, Stefano, additional, Grasso, Mariateresa, additional, Testa, Silvio, additional, Germani, Paola, additional, de Manzini, Nicolò, additional, Langella, Serena, additional, Ferrero, Alessandro, additional, Coletta, Diego, additional, Bianchi, Paolo Pietro, additional, Bengala, Carmelo, additional, Coratti, Andrea, additional, Franco, Lorenzo De, additional, Benigni, Roberto, additional, Tribuzi, Angela, additional, Marra, Ubaldo, additional, Di Marino, Michele, additional, Cova, Chiara, additional, Bianchi, Beatrice, additional, Nobile, Sara, additional, Zorcolo, Luigi, additional, Lisi, Giorgio, additional, Allisiardi, Fabrizio, additional, Grieco, Michele, additional, Righetti, Carolina, additional, Frisini, Marco, additional, Brolese, Alberto, additional, Grassia, Michele, additional, Lucchi, Andrea, additional, Bagaglini, Giulia, additional, Sica, Giuseppe S., additional, Manara, Michele, additional, Turati, Luca, additional, Macone, Lorenzo, additional, Carminati, Roberta, additional, Mariani, Pierpaolo, additional, Rizzo, Gianluca, additional, Coco, Claudio, additional, Pennella, Francesca Pennetti, additional, Rondelli, Fabio, additional, Romano, Lucia, additional, Giuliani, Antonio, additional, Palaia, Raffaele, additional, Belli, Andrea, additional, Albino, Vittorio, additional, Leongito, Maddalena, additional, David, Giulia, additional, Misitano, Pasquale, additional, Pasulo, Silvia, additional, Baiocchi, Gian Luca, additional, La Mendola, Roberta, additional, Hilal, Mohamnad Abu, additional, Baldari, Ludovica, additional, Cassinotti, Elisa, additional, Boni, Luigi, additional, Capolupo, Gabriella Teresa, additional, Caricato, Marco, additional, Pinotti, Enrico, additional, Montuori, Mauro, additional, Bombardini, Cristina, additional, Anania, Gabriele, additional, Dibra, Rigers, additional, Martines, Gennaro, additional, Solaini, Leonardo, additional, Ercolani, Giorgio, additional, Oliva, Renato, additional, Carati, Maria Vittoria, additional, Grazi, Gian Luca, additional, Ghio, Giacomo, additional, Marchegiani, Francesco, additional, Pucciarelli, Salvatore, additional, La Torre, Filippo, additional, Iannone, Immacolata, additional, Krizzuk, Dimitri, additional, Sammartino, Francesco, additional, Catalano, Giorgia, additional, Strignano, Paolo, additional, Romagnoli, Renato, additional, Piccione, Domenico, additional, Nardo, Bruno, additional, Reddavid, Rossella, additional, Degiuli, Maurizio, additional, Gerosa, Martino, additional, Maggioni, Dario, additional, Zuolo, Michele, additional, Rigamonti, Marco, additional, Ghazouani, Omar, additional, Galleano, Raffaele, additional, Percivale, Andrea, additional, Tirloni, Luca, additional, Moraldi, Luca, additional, Fabbri, Nicolò, additional, Feo, Carlo Vittorio, additional, Colombo, Samuele, additional, Di Saverio, Salomone, additional, Barbato, Giuseppe, additional, Coratti, Francesco, additional, Sagnotta, Andrea, additional, Mancini, Stefano, additional, and Formisano, Giampaolo, additional

Published
2023
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4. P293. Disentangling the Effects of Depression and Perceived Stress on Cortisol Levels in Individuals With Obesity

Author

Mariani, Nicole, primary, McLaughlin, Anna, additional, Lambert, Ellen, additional, Kose, Melisa, additional, Patsalos, Olivia, additional, Bogdanova, Anna, additional, Ferraro, Luca, additional, Chamseddine, Ghassan, additional, Panagiotopoulos, Spyros, additional, Chang, Avril, additional, Ramar, Sasindran, additional, Patel, Ameet, additional, Rubino, Francesco, additional, and Mondelli, Valeria, additional

Published
2022
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5. Disentangling the effects of depression and perceived stress on cortisol levels in individuals with obesity

Author

Mariani, N., primary, McLaughlin, Anna, additional, Lambert, Ellen, additional, Kose, Melisa, additional, Patsalos, Olivia, additional, Bogdanova, Anna, additional, Ferraro, Luca, additional, Chamseddine, Ghassan, additional, Panagiotopoulos, Spyros, additional, Chang, Avril, additional, Ramar, Sasindran, additional, Patel, Ameet, additional, Rubino, Francesco, additional, and Mondelli, Valeria, additional

Published
2021
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6. COR758, a negative allosteric modulator of GABAB receptors

Author

Porcu, Alessandra, primary, Mostallino, Rafaela, additional, Serra, Valeria, additional, Melis, Miriam, additional, Sogos, Valeria, additional, Beggiato, Sarah, additional, Ferraro, Luca, additional, Manetti, Fabrizio, additional, Gianibbi, Beatrice, additional, Bettler, Bernhard, additional, Corelli, Federico, additional, Mugnaini, Claudia, additional, and Castelli, M. Paola, additional

Published
2021
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11. Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease

Author

de Oliveira Junior, Edilson Ribeiro, primary, Truzzi, Eleonora, additional, Ferraro, Luca, additional, Fogagnolo, Marco, additional, Pavan, Barbara, additional, Beggiato, Sarah, additional, Rustichelli, Cecilia, additional, Maretti, Eleonora, additional, Lima, Eliana Martins, additional, Leo, Eliana, additional, and Dalpiaz, Alessandro, additional

Published
2020
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15. Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents

Author

Musumeci, Teresa, primary, Serapide, Maria Francesca, additional, Pellitteri, Rosalia, additional, Dalpiaz, Alessandro, additional, Ferraro, Luca, additional, Dal Magro, Roberta, additional, Bonaccorso, Angela, additional, Carbone, Claudia, additional, Veiga, Francisco, additional, Sancini, Giulio, additional, and Puglisi, Giovanni, additional

Published
2018
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17. Oxcarbazepine free or loaded PLGA nanoparticles as effective intranasal approach to control epileptic seizures in rodents

Author

Musumeci, T, Serapide, M, Pellitteri, R, Dalpiaz, A, Ferraro, L, Dal Magro, R, Bonaccorso, A, Carbone, C, Veiga, F, Sancini, G, Puglisi, G, Musumeci, Teresa, Serapide, Maria Francesca, Pellitteri, Rosalia, Dalpiaz, Alessandro, Ferraro, Luca, Dal Magro, Roberta, Bonaccorso, Angela, Carbone, Claudia, Veiga, Francisco, Sancini, Giulio, Puglisi, Giovanni, Musumeci, T, Serapide, M, Pellitteri, R, Dalpiaz, A, Ferraro, L, Dal Magro, R, Bonaccorso, A, Carbone, C, Veiga, F, Sancini, G, Puglisi, G, Musumeci, Teresa, Serapide, Maria Francesca, Pellitteri, Rosalia, Dalpiaz, Alessandro, Ferraro, Luca, Dal Magro, Roberta, Bonaccorso, Angela, Carbone, Claudia, Veiga, Francisco, Sancini, Giulio, and Puglisi, Giovanni

Abstract

The brain as a target for drug delivery is a challenge in pharmaceutical research. Among the several proposed strategies, the intranasal route represents a good strategy to deliver drugs to the brain. The goal of this study was to investigate the potential use of oxcarbazepine (OXC) to enhance brain targeting efficiency after intranasal (IN) administration. As well as attempting to use as low a dose as possible to obtain therapeutic effect. Our results showed that, after IN administrations, the dose of OXC that was effective in controlling epileptic seizures was 0.5 mg/kg (1 dose, every 20 min for 1 h) in rodents, confirmed by Cerebral Spinal Fluid (CSF) bioavailability. With the aim of reducing the number of administrations, sustaining drug release and increasing brain targeting, OXC was loaded into poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs). The selected nanoformulation for in vivo studies was obtained re-suspending the freeze-dried and cryo-protected OXC loaded PLGA NPs. The translocation of 1-1′-Dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine Iodide loaded PLGA NPs, from nose to the brain, was confirmed by Fluorescence Molecular Tomography, which also evidenced an accumulation of NPs in the brain after repeated IN administrations. IN administrations of OXC loaded PLGA NPs reduced the number of administrations to 1 over 24 h compared to the free drug thus controlling seizures in rats. Immunohistochemical evaluations (anti-neurofilament, anti-beta tubulin, and anti-caspase3) demonstrated a neuroprotective effect of OXC PLGA NPs after 16 days of treatment. These encouraging results confirmed the possibility of developing a novel non-invasive nose to brain delivery system of OXC for the treatment of epilepsy.

Published
2018

23. Solid microparticles based on chitosan or methyl-β-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

Author

Rassu, Giovanna, primary, Soddu, Elena, additional, Cossu, Massimo, additional, Brundu, Antonio, additional, Cerri, Guido, additional, Marchetti, Nicola, additional, Ferraro, Luca, additional, Regan, Raymond F., additional, Giunchedi, Paolo, additional, Gavini, Elisabetta, additional, and Dalpiaz, Alessandro, additional

Published
2015
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27. Understanding the balance and integration of volume and synaptic transmission. Relevance for psychiatry

Author

Fuxe, Kjell, primary, Borroto-Escuela, Dasiel O., additional, Tarakanov, Alexander, additional, Fernandez, Wilber Romero, additional, Manger, Paul, additional, Rivera, Alicia, additional, van Craenenbroeck, Kathleen, additional, Skieterska, Kamila, additional, Diaz-Cabiale, Zaida, additional, Filip, Malgorzata, additional, Ferraro, Luca, additional, Tanganelli, Sergio, additional, Guidolin, Diego, additional, Cullheim, Staffan, additional, de la Mora, Miguel Perez, additional, and Agnati, Luigi F., additional

Published
2013
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36. Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease

Author

Chiodi, Valentina, primary, Uchigashima, Motokazu, additional, Beggiato, Sarah, additional, Ferrante, Antonella, additional, Armida, Monica, additional, Martire, Alberto, additional, Potenza, Rosa Luisa, additional, Ferraro, Luca, additional, Tanganelli, Sergio, additional, Watanabe, Masahiko, additional, Domenici, Maria Rosaria, additional, and Popoli, Patrizia, additional

Published
2012
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39. Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Δ9-THC

Author

Castaldo, Pasqualina, primary, Magi, Simona, additional, Cataldi, Mauro, additional, Arcangeli, Sara, additional, Lariccia, Vincenzo, additional, Nasti, Annamaria Assunta, additional, Ferraro, Luca, additional, Tomasini, Maria Cristina, additional, Antonelli, Tiziana, additional, Cassano, Tommaso, additional, Cuomo, Vincenzo, additional, and Amoroso, Salvatore, additional

Published
2010
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50. Ascorbic and 6-Br-ascorbic acid conjugates as a tool to increase the therapeutic effects of potentially central active drugs

Author

Dalpiaz, Alessandro, primary, Pavan, Barbara, additional, Vertuani, Silvia, additional, Vitali, Federica, additional, Scaglianti, Martina, additional, Bortolotti, Fabrizio, additional, Biondi, Carla, additional, Scatturin, Angelo, additional, Tanganelli, Sergio, additional, Ferraro, Luca, additional, Marzola, Giuliano, additional, Prasad, Puttur, additional, and Manfredini, Stefano, additional

Published
2005
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