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Your search keyword '"F. M. Van Der Zant"' showing total 3 results
Start Over Author "F. M. Van Der Zant" Publisher elsevier bv
3 results on '"F. M. Van Der Zant"'

2. Radiation synovectomy of the upper extremity joints: Does leakage from the joint to non-target organs impair its therapeutic effect?

Author

Z. N. Jahangier, J. D. Moolenburgh, G.G.M. Gommans, F. M. van der Zant, and Johannes W G Jacobs

Subjects
Adult, medicine.medical_specialty, Clinical variables, medicine.medical_treatment, Brachytherapy, Urology, Spleen, Synovectomy, Non target, Rheumatic Diseases, medicine, Humans, Radiation Injuries, Aged, Leakage (electronics), Aged, 80 and over, Synovitis, Radiation, business.industry, Therapeutic effect, Radiotherapy Dosage, Middle Aged, Surgery, Rhenium, medicine.anatomical_structure, Baseline characteristics, Arm, Lymph, business, Erbium, Extravasation of Diagnostic and Therapeutic Materials
Abstract

Does leakage impair the therapeutic effect of radiosynoviorthesis (RSO)? Are there differences in leakage between (169)Erbium and (186)Rhenium? At baseline and at 6 and 12 months after RSO, six clinical parameters were scored. Changes in clinical variables over time were summed to a change composite index (CCI), ranging from 0 (no effect) to 12 (maximal effect). CCIor= 6 was considered successful treatment. Differences in leakage between responders and non-responders, and between (169)Erbium and (186)Rhenium were examined. Regression analyses were performed to explore whether baseline variables predicted leakage. Both at 6 and 12 months response rates were 25 of 36 (69%). Five of 11 (45%) non-responders showed leakage versus 20 of 25 (80%) responders (P=0.06). Mean leakage to lymph nodes was 0.4+/-0.7% versus 2.4+/-0.8% (P=0.04). Median leakage to liver/spleen was 0% versus 0.3% (P=0.4). Only age at the time of injection correlated significantly with leakage to lymph nodes. The (169)Erbium group showed leakage in 1 of 7 (14%) versus 24 of 30 (80%) for the (186)Rhenium group (P=0.002). Mean leakage to lymph nodes was 0.11+/-0.3% versus 2.1+/-2.8% (P=0.001). Median leakage to liver/spleen was 0% versus 0.5% (P=0.006). Leakage to non-target organs does not impair the clinical effect of RSO. Only age predicted leakage to lymph nodes significantly. Other baseline characteristics did not predict leakage. (169)Erbium shows significantly lower leakage to non-target organs than (186)Rhenium in RSO.

Published
2007

3. SPECT in the diagnosis of Alzheimer's disease and multi-infarct-dementia

Author

F. M. van der Zant, M. J. P. G. van Kroonenburgh, R.J.W. Dunnewold, O. J. S. Buruma, Ernest K. J. Pauwels, A. Hijdra, Henry C. Weinstein, Mayke M. A. Derix, E.O. van Royen, E. A. van der Velde, J.B.K. Lanser, and Joost Haan

Subjects
Male, Disease, Technetium Tc 99m Exametazime, Alzheimer Disease, Oximes, Healthy volunteers, Humans, Medicine, Dementia, Aged, Aged, 80 and over, Tomography, Emission-Computed, Single-Photon, Analysis of Variance, medicine.diagnostic_test, business.industry, Brain, Organotechnetium Compounds, General Medicine, SPECT Brain, medicine.disease, Dementia, Multi-Infarct, Positron emission tomography, Clinical diagnosis, Tracer uptake, Female, Surgery, Neurology (clinical), Alzheimer's disease, business, Nuclear medicine
Abstract

SPECT with Tc-99m HM-PAO as a radiopharmaceutical was performed in 17 patients meeting research criteria for Alzheimer's disease (AD), in 10 patients with a clinical diagnosis of multi-infarct-dementia (MID) and in 12 healthy volunteers. Regional tracer uptake was measured in frontal, parietal, and temporoparietal regions. A statistically significant decrease of tracer uptake in the temporoparietal region was found in AD-patients compared with controls. AD-patients showed less activity in this region than MID-patients, but this difference did not reach statistical significance. In both AD- and MID-patients decrease of tracer uptake was not correlated with dementia severity. We conclude that SPECT brain imaging is not yet ready for routine use in the distinction between AD and MID.

Published
1991

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