1. Modulation of chromatin modifying complexes by noncoding RNAs in trans
- Author
-
Ezequiel Nazer and Elissa P. Lei
- Subjects
Genetics ,CCCTC-Binding Factor ,RNA, Untranslated ,Dosage compensation ,Transcription, Genetic ,fungi ,Gene Dosage ,Insulator (genetics) ,Biology ,Non-coding RNA ,Chromatin ,Article ,Chromatin remodeling ,Cell biology ,DEAD-box RNA Helicases ,Repressor Proteins ,Animals ,Humans ,Trans-acting ,Gene ,ChIA-PET ,Developmental Biology - Abstract
Increasing evidence supports a central role for ncRNA in numerous aspects of chromatin function. For instance, ncRNAs can act as a scaffold for the recruitment of certain chromatin modifying complexes to specific sites within the genome. It is easily imaginable how this can occur in cis, but examples also exist whereby targeting of complexes by ncRNA occurs in trans to the site of transcription. Moreover, association of an ncRNA with a particular locus can trigger localization of the gene to a subnuclear structure harboring a specialized transcriptional environment. In this review, we discuss new insights into the mechanisms by which ncRNAs function in trans with respect to Polycomb Group, chromatin insulator, and dosage compensation complexes in mammals and/or Drosophila.
- Published
- 2014