17 results on '"Evan Appelbaum"'
Search Results
2. Predictors of Major Atrial Fibrillation Endpoints in the National Heart, Lung, and Blood Institute HCMR
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Matthias G. Friedrich, Michelle Michels, Stefan K. Piechnik, Dana Dawson, Daniel Jacoby, Patrice Desvigne-Nickens, John P. DiMarco, William Bradlow, Christopher M. Kramer, Carolyn Y. Ho, Jeanette Schulz-Menger, Chiara Buccarelli-Ducci, Adam S. Helms, Michael Salerno, Hugh Watkins, Barbara Casadei, Lubna Choudhury, James A. White, Martin S. Maron, Jonathan W. Weinsaft, Paul Kolm, Amedeo Chiribiri, Anjali T. Owens, Sarahfaye Dolman, Evan Appelbaum, Hcmr Investigators, Raymond Y. Kwong, William S. Weintraub, Sherif F. Nagueh, Dong-Yun Kim, Milind Y. Desai, Stefan Neubauer, Michael Jerosch-Herold, Nancy L. Geller, Masliza Mahmod, and Colin Berry
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medicine.medical_specialty ,medicine.medical_treatment ,Catheter ablation ,030204 cardiovascular system & hematology ,Article ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Atrial Fibrillation ,medicine ,Humans ,Heart Atria ,Prospective Studies ,030212 general & internal medicine ,Risk factor ,Aged ,Framingham Risk Score ,Proportional hazards model ,business.industry ,Hypertrophic cardiomyopathy ,Atrial fibrillation ,Middle Aged ,medicine.disease ,United States ,Catheter Ablation ,Cardiology ,National Heart, Lung, and Blood Institute (U.S.) ,business ,Body mass index ,Natural history study - Abstract
Objectives This study sought to identify predictors of major clinically important atrial fibrillation endpoints in hypertrophic cardiomyopathy. Background Atrial fibrillation (AF) is a common morbidity associated with hypertrophic cardiomyopathy (HCM). The HCMR (Hypertrophic Cardiomyopathy Registry) trial is a prospective natural history study of 2,755 patients with HCM with comprehensive phenotyping. Methods All patients received yearly telephone follow-up. Major AF endpoints were defined as requiring electrical cardioversion, catheter ablation, hospitalization for >24 h, or clinical decisions to accept permanent AF. Penalized regression via elastic-net methodology identified the most important predictors of major AF endpoints from 46 variables. This was applied to 10 datasets, and the variables were ranked. Predictors that appeared in all 10 sets were then used in a Cox model for competing risks and analyzed as time to first event. Results Data from 2,631 (95.5%) patients were available for analysis after exclusions. A total of 127 major AF endpoints events occurred in 96 patients over 33.3 ± 12.4 months. In the final model, age, body mass index (BMI), left atrial (LA) volume index, LA contractile percent (active contraction), moderate or severe mitral regurgitation (MR), and history of arrhythmia the most important. BMI, LA volume index, and LA contractile percent were age-dependent. Obesity was a stronger risk factor in younger patients. Increased LA volume, reduced LA contractile percent, and moderate or severe MR put middle-aged and older adult patients at increased risk. Conclusions The major predictors of major AF endpoints in HCM include older age, high BMI, moderate or severe MR, history of arrhythmia, increased LA volume, and reduced LA contractile percent. Prospective testing of a risk score based on these parameters may be warranted.
- Published
- 2021
3. PREDICTORS OF CLINICALLY SIGNIFICANT ATRIAL FIBRILLATION IN THE NHLBI HYPERTROPHIC CARDIOMYOPATHY REGISTRY (HCMR)
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Milind Y. Desai, Patrice Desvigne-Nickens, Evan Appelbaum, Christopher M. Kramer, Hugh Watkins, Stefan Neubauer, William S. Weintraub, Dong-Yun Kim, Cheng Zhang, Carolyn Ho, Paul Kolm, Raymond Y. Kwong, Sarahfaye Dolman, Martin M. Maron, Stefan K. Piechnik, John P. DiMarco, Matthias M. Friedrich, Jeanette Schulz-Menger, Nancy Geller, and Michael Jerosch-Herold
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medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,Hypertrophic cardiomyopathy ,Atrial fibrillation ,Catheter ablation ,macromolecular substances ,medicine.disease ,Electrical cardioversion ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business - Abstract
Atrial fibrillation (AF) is a common morbidity associated with hypertrophic cardiomyopathy (HCM). Prior studies have focused on AF incidence. In HCMR, we have focused on predictors of clinically significant AF episodes defined as; 1) requiring electrical cardioversion or catheter ablation 2)
- Published
- 2020
4. Significance of False Negative Electrocardiograms in Preparticipation Screening of Athletes for Hypertrophic Cardiomyopathy
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C. Michael Gibson, John R. Lesser, Ethan J. Rowin, Mark S. Link, Evan Appelbaum, James E. Udelson, Barry J. Maron, Warren J. Manning, Martin S. Maron, and Tammy S. Haas
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Adult ,Male ,medicine.medical_specialty ,Heart disease ,Magnetic Resonance Imaging, Cine ,Disease ,Left ventricular hypertrophy ,Severity of Illness Index ,Asymptomatic ,Diagnosis, Differential ,Electrocardiography ,Young Adult ,Predictive Value of Tests ,Internal medicine ,medicine ,Humans ,Mass Screening ,cardiovascular diseases ,False Negative Reactions ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Incidence ,Hypertrophic cardiomyopathy ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,medicine.disease ,United States ,Survival Rate ,Death, Sudden, Cardiac ,Athletes ,Cohort ,Exercise Test ,Cardiology ,Female ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
Preparticipation screening of athletes with 12-lead electrocardiography has been promoted for the detection of asymptomatic cardiovascular disease, particularly hypertrophic cardiomyopathy (HC). Although false-positive electrocardiographic (ECG) results for HC are well recognized in athlete screening, expected false-negative rates are unknown. The aim of this study was to characterize the rate of false-negative ECG findings in a cohort of young asymptomatic patients with phenotypically expressed HC, defined by cardiovascular magnetic resonance, using the 2010 European Society of Cardiology recommended ECG criteria for the identification of suspected heart disease in trained athletes. Cardiac magnetic resonance studies and 12-lead electrocardiography were performed in 114 consecutive asymptomatic patients with HC aged ≤35 years (mean age 22 ± 8 years; 77% male patients). Electrocardiograms were analyzed to distinguish pathologic ECG patterns from alterations considered nonpathologic and physiologic consequences of athletic training. Among the 114 patients with HC, 103 (90%) demonstrated ≥1 pathologic ECG abnormality, while the remaining 11 patients (10%) had normal or nonpathologic ECG patterns and therefore defined a subgroup in whom ECG screening would not be expected to raise suspicion of heart disease (i.e., false-negative results). In this false-negative ECG results group, maximal left ventricular wall thickness was 17 ± 2 mm (range 15 to 21), compared to patients with pathologic ECG patterns, in whom maximal left ventricular wall thickness was 22 ± 5 mm (p = 0.003). In conclusion, a substantial minority of young asymptomatic patients with HC with phenotypically expressed left ventricular hypertrophy have nonpathologic ECG findings on the basis of the 2010 European Society of Cardiology guidelines. In principle, this high false-negative rate of 10% represents an important limitation in applying 12-lead electrocardiography to large, apparently healthy athletic populations for the detection of HC.
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- 2012
5. Relation Between Infarct Size in ST-Segment Elevation Myocardial Infarction Treated Successfully by Percutaneous Coronary Intervention and Left Ventricular Ejection Fraction Three Months After the Infarct
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Warren J. Manning, Evan Appelbaum, Jennifer L. Giuseffi, Satishkumar Mohanavelu, Caitlin J. Harrigan, Yuri B. Pride, and C. Michael Gibson
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Adult ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Myocardial Infarction ,Magnetic Resonance Imaging, Cine ,Atherectomy ,Electrocardiography ,Risk Factors ,Interquartile range ,Internal medicine ,Angioplasty ,medicine ,Humans ,ST segment ,cardiovascular diseases ,Myocardial infarction ,Angioplasty, Balloon, Coronary ,Aged ,Aged, 80 and over ,Ejection fraction ,business.industry ,ST elevation ,Percutaneous coronary intervention ,Stroke Volume ,Middle Aged ,medicine.disease ,Treatment Outcome ,cardiovascular system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies ,circulatory and respiratory physiology - Abstract
The goal of this analysis was to determine the relation between myocardial infarct size and left ventricular (LV) ejection fraction (EF) in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneous coronary intervention (pPCI) using cardiovascular magnetic resonance imaging (CMR). After STEMI, LVEF and infarct size correlate with prognosis, but the relation between infarct size and LVEF is incompletely known. Consecutive subjects presenting to a single center with STEMI treated with pPCI were enrolled, and cine functional and late gadolinium enhancement CMR was performed 3 months after presentation. From cine images, LVEF was calculated using volumetric summation of disks method. Infarct size was measured as percent LV myocardial volume with late gadolinium enhancement. In the 78 patients enrolled (mean age 54.5 years, range 42 to 82), median LVEF was 56% (interquartile range 49 to 62) and median infarct size was 11% (interquartile range 5 to 18). Of the 53 patients with infarct size15%, all had LVEF40%, and there was no significant relation between infarct size and LVEF (slope -0.43, R(2) = 0.045, p = 0.13). In patients with infarct sizeor =15%, there was a significant negative linear association between infarct size and LVEF (slope -1.21, R(2) = 0.66, p0.001), such that for every 5% increase in infarct size, there was a 6.1% decrease in LVEF. In conclusion, there is a negative linear relation between infarct size and LVEF for moderate to large infarcts. For small infarcts there is no significant relation between infarct size and LVEF. Up to 15% of LV myocardial volume may be infarcted before there is any appreciable decrease in LVEF.
- Published
- 2010
6. Spectrum and Clinical Significance of Systolic Function and Myocardial Fibrosis Assessed by Cardiovascular Magnetic Resonance in Hypertrophic Cardiomyopathy
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Evan Appelbaum, Carol J Salton, John R. Lesser, Caitlin J. Harrigan, C. Michael Gibson, Martin S. Maron, James E. Udelson, Christopher J. O'Donnell, Iacopo Olivotto, Barry J. Maron, and Warren J. Manning
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Adult ,Male ,medicine.medical_specialty ,Systole ,Cardiomyopathy ,Interquartile range ,Internal medicine ,Ventricular Dysfunction ,medicine ,Humans ,cardiovascular diseases ,Ventricular remodeling ,Ejection fraction ,Ventricular Remodeling ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Stroke Volume ,Magnetic resonance imaging ,Stroke volume ,Cardiomyopathy, Hypertrophic ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Female ,cardiovascular system ,Cardiology ,Cardiology and Cardiovascular Medicine ,business - Abstract
In hypertrophic cardiomyopathy (HCM), the clinical significance attributable to the broad range of left ventricular (LV) systolic function, assessed as the ejection fraction (EF), is incompletely resolved. We evaluated the EF using cardiovascular magnetic resonance (CMR) imaging in a large cohort of patients with HCM with respect to the clinical status and evidence of left ventricular remodeling with late gadolinium enhancement (LGE). CMR imaging was performed in 310 consecutive patients, aged 42 +/- 17 years. The EF in patients with HCM was 71 +/- 10% (range 28% to 89%), exceeding that of 606 healthy controls without cardiovascular disease (66 +/- 5%, p0.001). LGE reflecting LV remodeling showed an independent, inverse relation to the EF (B-0.69, 95% confidence interval -0.86 to -0.52; p0.001) and was greatest in patients with an EF50%, in whom it constituted a median value of 29% of the LV volume (interquartile range 16% to 40%). However, the substantial subgroup with low-normal EF values of 50% to 65% (n = 45; 15% of the whole cohort), who were mostly asymptomatic or mildly symptomatic (37 or 82% with New York Heart Association functional class I to II), showed substantial LGE (median 5% of LV volume, interquartile range 2% to 10%). This overlapped with the subgroup with systolic dysfunction and significantly exceeded that of patients with an EF of 66% to 75% and75% (median 2% of the LV volume, interquartile range 1.5% to 4%; p0.01). In conclusion, in a large cohort of patients with HCM, a subset of patients with low-normal EF values (50% to 65%) was identified by contrast-enhanced CMR imaging as having substantial degrees of LGE, suggesting a transition phase, potentially heralding advanced LV remodeling and systolic dysfunction, with implications for clinical surveillance and management.
- Published
- 2010
7. Significance of Papillary Muscle Abnormalities Identified by Cardiovascular Magnetic Resonance in Hypertrophic Cardiomyopathy
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Warren J. Manning, Caitlin J. Harrigan, James E. Udelson, Barry J. Maron, John R. Lesser, Jacqueline L. Buros, Evan Appelbaum, C. Michael Gibson, and Martin S. Maron
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Adult ,Male ,medicine.medical_specialty ,Heart disease ,Heart Ventricles ,Population ,Cardiomyopathy ,Magnetic Resonance Imaging, Cine ,Ventricular Outflow Obstruction ,Internal medicine ,medicine ,Humans ,Mass index ,Prospective Studies ,education ,Papillary muscle ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Reproducibility of Results ,Magnetic resonance imaging ,Cardiomyopathy, Hypertrophic ,Middle Aged ,Papillary Muscles ,medicine.disease ,medicine.anatomical_structure ,Case-Control Studies ,Circulatory system ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business - Abstract
Increased thickness of the left ventricular (LV) wall is the predominant feature of the hypertrophic cardiomyopathy (HC) phenotype. The structural characteristics of the LV papillary muscles (PMs) have received little attention. In this study, cardiovascular magnetic resonance (CMR) was used to characterize PM morphology in a large HC population. Cine and delayed enhancement (DE) CMR images were obtained in 201 patients with HC and 43 control subjects. PM number and mass index were greater in patients with HC compared with controls (2.5 vs 2.1, p0.001, and 6 +/- 2 vs 3 +/- 2 g/m(2), p0.001, respectively), including 109 (54%) with PM massor =7 g/m(2) (or =2 SDs above the mean for controls). Greater LV wall mass index was associated with more substantial PM mass (r = 0.09, p0.001). Furthermore, 12 patients with HC (19%) had normal LV mass with localized wall thickness but increased PM mass. In patients with HC with LV outflow obstruction at rest, PMs were positioned closer to the ventricular septum (displaced anteriorly: 58% vs 42% for subjects without obstruction, p = 0.02), with more marked hypertrophy (9 +/- 5 vs 6 +/- 4 g/m(2), p0.001). Preoperative CMR identified 3 patients with accessory, anteriorly displaced PMs judged to contribute to outflow obstruction, which were resected during septal myectomy. DE of the PMs was identified in 13 patients with HC (6%), including 3 with DE confined to PMs. In conclusion, CMR demonstrates LV PMs to be part of the cardiomyopathic process in HC, with increases in number and mass, and not uncommonly associated with remodeling with DE. The identification of accessory PMs may be useful in planning preoperative strategy.
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- 2008
8. Coronary Magnetic Resonance Imaging
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Reza Nezafat, Evan Appelbaum, Susan B. Yeon, Peter G. Danias, Warren J. Manning, and Thomas H. Hauser
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Coronary angiography ,medicine.medical_specialty ,Coronary Disease ,Multidetector ct ,Coronary disease ,Coronary Angiography ,X ray computed ,Internal medicine ,Image Processing, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,cardiovascular diseases ,Coronary Artery Bypass ,medicine.diagnostic_test ,business.industry ,Respiration ,Magnetic resonance imaging ,General Medicine ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Tomography x ray computed ,cardiovascular system ,Cardiology ,Stents ,Radiology ,Tomography ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Artery - Abstract
This article highlights the technical challenges and general imaging strategies for coronary MRI. This is followed by a review of the clinical results for the assessment of anomalous CAD, coronary artery aneurysms, native vessel integrity, and coronary artery bypass graft disease using the more commonly applied MRI methods. It concludes with a brief discussion of the advantages/disadvantages and clinical results comparing coronary MRI with multidetector CT (MDCT) coronary angiography.
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- 2007
9. EFFECT OF PURIFIED OMEGA-3 FATTY ACIDS ON REDUCING LEFT VENTRICULAR REMODELING AFTER ACUTE MYOCARDIAL INFARCTION (OMEGA-REMODEL STUDY: A DOUBLE-BLIND RANDOMIZED CLINICAL TRIAL)
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Siddique Abbasi, William S. Harris, Raymond Y. Kwong, Joseph P. McConnell, Shuaib M Abdullah, Michael L. Steigner, Michael Jerosch-Herold, Udo Hoffmann, Evan Appelbaum, Jiazuo H. Feng, Bobby Heydari, Ravi V. Shah, and Ron Blankstein
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chemistry.chemical_classification ,medicine.medical_specialty ,business.industry ,Placebo-controlled study ,Fatty acid ,food and beverages ,medicine.disease ,eye diseases ,law.invention ,Double blind ,Randomized controlled trial ,chemistry ,law ,Internal medicine ,medicine ,Cardiology ,lipids (amino acids, peptides, and proteins) ,Myocardial infarction ,sense organs ,Ventricular remodeling ,business ,Acute mi ,Cardiology and Cardiovascular Medicine ,human activities ,Polyunsaturated fatty acid - Abstract
Omega-3 fatty acid (PUFAs) may have a number of beneficial pleiotropic effects. One randomized trial demonstrated significant survival benefit for PUFAs following acute MI. We conducted a randomized, double-blinded, placebo controlled trial of PUFA supplementation post acute MI. 358 patients were
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- 2015
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10. FEMALE GENDER IS ASSOCIATED WITH MAJOR ADVERSE CARDIOVASCULAR EVENTS IN PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY
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Elena Biagini, I Olivotto, Susie N. Hong-Zohlman, Christiane Gruner, James E. Udelson, Tammy S. Haas, Gabriele Egidy Assenza, Harry Rakowski, Raymond H. Chan, Martin S. Maron, Thomas H. Hauser, Barry Maron, Camillo Autore, John Lesser, Carlo Nicola De Cecco, Francesco Formisano, Andrew M. Crean, Paolo Spirito, Warren J. Manning, Benedetta Tomberli, Evan Appelbaum, Ethan Rowin, C. Michael Gibson, Claudio Rapezzi, and E. Francis Cook
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medicine.medical_specialty ,business.industry ,Hypertrophic cardiomyopathy ,macromolecular substances ,medicine.disease ,Sudden cardiac death ,Internal medicine ,Cardiovascular Disorder ,cardiovascular system ,Cardiology ,medicine ,In patient ,cardiovascular diseases ,Young adult ,business ,Cardiology and Cardiovascular Medicine - Abstract
Hypertrophic cardiomyopathy (HCM) is the most common, heritable cardiovascular disorder and the most frequent cause of sudden cardiac death (SCD) in young adults. Gender disparities with regards to clinical outcomes among HCM patients are not well-defined. We investigated the relationship between
- Published
- 2012
- Full Text
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11. Reply
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A. Selcuk Adabag, Barry J. Maron, Evan Appelbaum, Caitlin J. Harrigan, Jacqueline L. Buros, C. Michael Gibson, John R. Lesser, Constance A. Hanna, James E. Udelson, Warren J. Manning, and Martin S. Maron
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Cardiology and Cardiovascular Medicine - Published
- 2008
12. DOES FOCAL LATE GADOLINIUM ENHANCEMENT AT THE RIGHT VENTRICULAR INSERTION POINTS MATTER IN RISK STRATIFICATION FOR SUDDEN DEATH IN HYPERTROPHIC CARDIOMYOPATHY?
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Earl Francis Cook, I Olivotto, James E. Udelson, Elena Biagini, Raymond H. Chan, C. Michael Gibson, Warren J. Manning, John Lesser, Susie Hong, Gabriele Egidy Assenza, Ethan Rowin, Paolo Spirito, Martin S. Maron, Claudio Rapezzi, Benedetta Tomberli, Andrew Creane, Francesco Formisano, Tammy S. Haas, Camillo Autore, Evan Appelbaum, Carlo Nicola De Cecco, Harry Rakowski, Barry Maron, and Christiane Gruner
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Hypertrophic cardiomyopathy ,Magnetic resonance imaging ,medicine.disease ,Sudden death ,Increased risk ,Fibrosis ,Internal medicine ,embryonic structures ,Risk stratification ,cardiovascular system ,medicine ,Cardiology ,Late gadolinium enhancement ,In patient ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,business - Abstract
Cardiovascular magnetic resonance (CMR) with extensive late gadolinium enhancement (LGE) is a novel marker for increased risk for sudden death in patients with hypertrophic cardiomyopathy (HCM) presumably due to ventricular tachyarrhythmias emanating from areas of replacement fibrosis. Of particular
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- 2013
13. Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
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Ajay Pachika, David K. Packham, Bhupinder Singh, Scott D. Solomon, Dennis L. Andress, Evan Appelbaum, Amil M. Shah, Donald M. Lloyd-Jones, Daniel Zehnder, Ishir Bhan, Julia Wenger, J.B. Cannata, Hector Tamez, Christoph Wanner, Wuyan Zhang, Yili Pritchett, B. Taylor Thompson, Rajiv Agarwal, Ravi Thadhani, Warren J. Manning, Carmine Zoccali, and Yuchiao Chang
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Paricalcitol ,medicine.medical_specialty ,education.field_of_study ,Ejection fraction ,business.industry ,Population ,medicine.disease ,Brain natriuretic peptide ,Left ventricular hypertrophy ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Left atrial enlargement ,Cardiology and Cardiovascular Medicine ,business ,education ,medicine.drug ,Kidney disease - Abstract
Background Left atrial enlargement, a sensitive integrator of left ventricular diastolic function, is associated with increased cardiovascular morbidity and mortality. Vitamin D is linked to lower cardiovascular morbidity, possibly modifying cardiac structure and function; however, firm evidence is lacking. We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146). Methods and results One hundred ninety-six patients with chronic kidney disease (estimated glomerular filtration rate 15-60 mL/min per 1.73m 2 ), mild to moderate left ventricular hypertrophy, and preserved ejection fraction were randomly assigned to 2 μg of oral paricalcitol or matching placebo for 48 weeks. Two-dimensional echocardiography was obtained at baseline and at 24 and 48 weeks after initiation of therapy. Over the study period, there was a significant decrease in LAVi (−2.79 mL/m 2 , 95% CI −4.00 to −1.59 mL/m 2 ) in the paricalcitol group compared with the placebo group (−0.70 mL/m 2 [95% CI −1.93 to 0.53 mL/m 2 ], P = .002). Paricalcitol also attenuated the rise in levels of brain natriuretic peptide (10.8% in paricalcitol vs 21.3% in placebo, P = .02). For the entire population, the change in brain natriuretic peptide correlated with change in LAVi ( r = 0.17, P = .03). Conclusions Forty-eight weeks of therapy with an active vitamin D analog reduces LAVi and attenuates the rise of BNP. In a population where only few therapies alter cardiovascular related morbidity and mortality, these post hoc results warrant further confirmation.
- Published
- 2012
14. 286 Serial Quantification of Myocardial Infarction Tissue Heterogeneity During Infarct Healing By Cardiac MRI Provides Strong Characterization of Left Ventricular Remodeling (the NHLBI Prospect-CMR Study)
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Ron Blankstein, Raymond Y. Kwong, Bobby Heydari, Udo Hoffmann, Evan Appelbaum, Damien Mandry, Otavio R. Coelho-Filho, R. van der Geest, C. Yucheng, Michael Jerosch-Herold, Shuaib M Abdullah, and François-Pierre Mongeon
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Infarct healing ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Functional recovery ,medicine.disease ,Tissue heterogeneity ,Cardiac magnetic resonance imaging ,Internal medicine ,cardiovascular system ,medicine ,Cardiology ,Myocyte ,Myocardial fibrosis ,cardiovascular diseases ,Myocardial infarction ,Cardiology and Cardiovascular Medicine ,Ventricular remodeling ,business - Abstract
Background Late gadolinium enhancement (LGE) with infarct tissue heterogeneity characterized by cardiac magnetic resonance imaging (CMR) has been shown to be associated with arrhythmogenic substrates and increased mortality. Preliminary data suggests that areas of heterogeneous signal intensity (SI) within an infarct may represent an admixture of myocardial fibrosis, ischemic cellular apoptosis and viable myocytes potentially capable of functional recovery.
- Published
- 2012
15. PREVALENCE AND CLINICAL PROFILE OF MYOCARDIAL CRYPTS IN HYPERTROPHIC CARDIOMYOPATHY
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C. Michael Gibson, John R. Lesser, Ethan J. Rowin, Evan Appelbaum, David Lin, Tammy S. Haas, James E. Udelson, Jana Lindberg, Warren J. Manning, Barry J. Maron, and Martin S. Maron
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medicine.medical_specialty ,business.industry ,Internal medicine ,cardiovascular system ,Hypertrophic cardiomyopathy ,medicine ,Cardiology ,cardiovascular diseases ,Cardiology and Cardiovascular Medicine ,medicine.disease ,business - Published
- 2011
16. INFLUENCE OF DIABETES ON LEFT VENTRICULAR MASS REGRESSION WITH ALISKIREN, LOSARTAN OR BOTH
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Anil Verma, Anne-Catherine Pouleur, Margaret F. Prescott, Evan Appelbaum, Orly Vardeny, Scott D. Solomon, and Björn Dahlöf
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medicine.medical_specialty ,business.industry ,Aliskiren ,medicine.disease ,Left ventricular mass ,chemistry.chemical_compound ,Losartan ,chemistry ,Internal medicine ,Diabetes mellitus ,medicine ,Cardiology ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Published
- 2011
17. Large Hiatal Hernia Mimicking Left Atrial Mass
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Jonathan Chan, Kenneth Rice, Philip Smith, Warren J. Manning, and Evan Appelbaum
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medicine.medical_specialty ,Left atrial mass ,business.industry ,education ,Diagnostico diferencial ,Left atrium ,medicine.anatomical_structure ,Internal medicine ,medicine ,Cardiology ,Radiology ,Cardiology and Cardiovascular Medicine ,business ,psychological phenomena and processes ,Large hiatal hernia ,Diastolic flow - Abstract
[Figure][1] [![Graphic][3] ][3][![Graphic][4] ][4] A large well-circumscribed ovoid-shaped left atrial mass was noted on multiple echocardiographic views (A) . Moderate eccentric mitral regurgitant jet and abnormal high-velocity diastolic flow respected the contours of the mass
- Published
- 2009
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