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This article discusses the use of intraoperative computed tomography (CT) during neurosurgery. This intraoperative CT scanner is integrated with an image-guided surgery system. The authors' intent is to present information on how these technologies are implemented in the operating room and to describe the improvements in surgical accuracy. Two case studies demonstrate the workflow during spinal procedures and the advantages for the surgeons and patients.

Therapy of brain tumors has been limited by lack of effective methods of drug delivery. Systemic administration often fails to achieve therapeutic concentrations of drugs within intracranial tumors despite toxic systemic levels. This article discusses new methods for delivering therapeutic agents to brain tumors, including intra-arterial, intrathecal, intraventricular, and interstitial administration techniques.