1. Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia
- Author
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Agnieszka Wierzbowska, Hagop M. Kantarjian, Grzegorz Mazur, Erhan Berrak, Jacques Delaunay, Mark M. Jones, and Mark D. Minden
- Subjects
Adult ,medicine.medical_specialty ,ECOG PS, Eastern Cooperative Oncology Group Performance Status ,BUN, blood urea nitrogen ,Decitabine ,AST, aspartate aminotransferase ,Gastroenterology ,lcsh:RC254-282 ,Article ,CRi, complete response with incomplete blood count recovery ,hemic and lymphatic diseases ,Internal medicine ,White blood cell ,ALT, alanine aminotransferase ,Post-hoc analysis ,medicine ,Blood urea nitrogen ,AML, acute myeloid leukemia ,Acute myeloid leukemia ,Leukemia ,SC, supportive care ,business.industry ,PR, partial remission ,Myeloid leukemia ,Hematology ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,medicine.anatomical_structure ,Oncology ,Immunology ,CR, complete response ,Cytarabine ,business ,medicine.drug ,French–American–British classification ,FAB, French–American–British classification ,WBC, white blood cell - Abstract
Background: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. Methods: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. Results: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. Conclusions: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant.
- Published
- 2014
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