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23 results on '"Erasmus M"'

5. TTV Load is Associated with SARS-CoV-2 Vaccination Response in Lung Transplant Recipients

Author

Verschuuren, E. A., Hoek, R., de Vries, R. D., van Baarle, D., van der Heiden, M., van Gemert, J., Gore, E., Niesters, H. G., Erasmus, M. E., Hellemons, M. E., Scherbeijn, S., van Kessel, C. H. Geurts, Buter, C. van Leer, Groningen Institute for Organ Transplantation (GIOT), Translational Immunology Groningen (TRIGR), Microbes in Health and Disease (MHD), and Cardiovascular Centre (CVC)

Subjects
Pulmonary and Respiratory Medicine, Transplantation, Surgery, Cardiology and Cardiovascular Medicine
Published
2022

8. A blood RNA signature for tuberculosis disease risk: a prospective cohort study

Author

Zak, D.E., Penn-Nicholson, A., Scriba, T.J., Thompson, E., Suliman, S., Amon, L.M., Mahomed, H., Erasmus, M., Whatney, W., Hussey, G.D., Abrahams, D., Kafaar, F., Hawkridge, T., Verver, S., Hughes, E.J., Ota, M., Sutherland, J., Howe, R., Dockrell, H.M., Boom, W.H., Thiel, B., Ottenhoff, T.H.M., Mayanja-Kizza, H., Crampin, A.C., Downing, K., Hatherill, M., Valvo, J., Shankar, S., Parida, S.K., Kaufmann, S.H.E., Walzl, G., Aderem, A., Hanekom, W.A., ACS Cohort Study Grp, and GC6-74 Cohort Study Grp

Subjects
Adult, 0301 basic medicine, medicine.medical_specialty, Tuberculosis, Adolescent, Gene Expression, Risk Assessment, Mycobacterium tuberculosis, Young Adult, 03 medical and health sciences, Tuberculosis diagnosis, Risk Factors, Internal medicine, Humans, Medicine, media_common.cataloged_instance, Prospective Studies, European union, Child, Prospective cohort study, media_common, Medicine(all), biology, Reverse Transcriptase Polymerase Chain Reaction, business.industry, General Medicine, Middle Aged, Gene signature, medicine.disease, biology.organism_classification, 3. Good health, RNA, Bacterial, 030104 developmental biology, Case-Control Studies, Immunology, Cohort, business, Cohort study
Abstract

Identification of blood biomarkers that prospectively predict progression of Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that combat the tuberculosis epidemic. We aimed to assess whether global gene expression measured in whole blood of healthy people allowed identification of prospective signatures of risk of active tuberculosis disease.In this prospective cohort study, we followed up healthy, South African adolescents aged 12-18 years from the adolescent cohort study (ACS) who were infected with M tuberculosis for 2 years. We collected blood samples from study participants every 6 months and monitored the adolescents for progression to tuberculosis disease. A prospective signature of risk was derived from whole blood RNA sequencing data by comparing participants who developed active tuberculosis disease (progressors) with those who remained healthy (matched controls). After adaptation to multiplex quantitative real-time PCR (qRT-PCR), the signature was used to predict tuberculosis disease in untouched adolescent samples and in samples from independent cohorts of South African and Gambian adult progressors and controls. Participants of the independent cohorts were household contacts of adults with active pulmonary tuberculosis disease.Between July 6, 2005, and April 23, 2007, we enrolled 6363 participants from the ACS study and 4466 from independent South African and Gambian cohorts. 46 progressors and 107 matched controls were identified in the ACS cohort. A 16 gene signature of risk was identified. The signature predicted tuberculosis progression with a sensitivity of 66·1% (95% CI 63·2-68·9) and a specificity of 80·6% (79·2-82·0) in the 12 months preceding tuberculosis diagnosis. The risk signature was validated in an untouched group of adolescents (p=0·018 for RNA sequencing and p=0·0095 for qRT-PCR) and in the independent South African and Gambian cohorts (p values0·0001 by qRT-PCR) with a sensitivity of 53·7% (42·6-64·3) and a specificity of 82·8% (76·7-86) in the 12 months preceding tuberculosis.The whole blood tuberculosis risk signature prospectively identified people at risk of developing active tuberculosis, opening the possibility for targeted intervention to prevent the disease.BillMelinda Gates Foundation, the National Institutes of Health, Aeras, the European Union, and the South African Medical Research Council.

Published
2016

9. Comparison of Long-Term Survival Outcomes in Recipients of Lungs from Donation After Circulatory Death (DCD) and Donation After Brain Death (DBD)

Author

Loor, G., primary, Camp, P., additional, D'Ovidio, F., additional, Edwards, L., additional, Erasmus, M., additional, Glanville, A., additional, Hertz, M., additional, Hopkins, P., additional, Keshavjee, S., additional, Levvey, B., additional, McCurry, K., additional, Musk, M., additional, Patterson, G., additional, Snell, G., additional, Stehlik, J., additional, Urban, R., additional, and Van Raemdonck, D., additional

Published
2017
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10. Extended Donation After Circulatory Death (DCD) Cat 3 Lung Donor Agonal and Post-Mortem Warm Ischemic Times (WIT) Do Not Affect Early Mortality

Author

Levvey, B., primary, Edwards, L., additional, Robinson, A., additional, Keshavjee, S., additional, Erasmus, M., additional, Glanville, A., additional, Hopkins, P., additional, Musk, M., additional, Patterson, A., additional, Hertz, M., additional, D'Ovidio, F., additional, McCurry, K., additional, Camp, P., additional, Carrico, B., additional, Stehlik, J., additional, Van Raemdonck, D., additional, and Snell, G., additional

Published
2017
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11. The palladium-catalysed arylation and vinylation of alkenes—enantioselective fashion

Author

Erasmus M. Vogl and Masakatsu Shibasaki

Subjects
chemistry.chemical_classification, Alkene, Organic Chemistry, Enantioselective synthesis, chemistry.chemical_element, Regioselectivity, Biochemistry, Inorganic Chemistry, chemistry, Asymmetric carbon, Heck reaction, Materials Chemistry, Organic chemistry, Physical and Theoretical Chemistry, Enantiomer, Palladium
Abstract

The enantioselective Heck reaction is a powerful method for the synthesis of both tertiary and quaternary chiral carbon centres, with enantiomeric excesses (ees) often around 80% and in some cases much higher. A variety of carbocyclic and heterocyclic systems can be constructed or modified including spirocyclic systems. Although problems of regioselectivity with respect to the product alkene continue to limit the scope of the reaction somewhat, there are indications that these may be surmountable and that a new generation of ligands and a refined methodology, may improve both enantio- and regiocontrol. All the relevant literature is discussed.

Published
1999

12. Linking BINOL: C2-symmetric ligands for investigations on asymmetric catalysis

Author

Shigeki Matsunaga, Erasmus M. Vogl, Masakatsu Shibasaki, Motomu Kanai, and Takehiko Iida

Subjects
chemistry.chemical_compound, Chemistry, Stereochemistry, Organic Chemistry, Drug Discovery, Enantioselective synthesis, Ring (chemistry), Biochemistry, Cyclohexene oxide, Catalysis
Abstract

The synthesis of new C 2 -symmetric chiral ligands consisting of two binaphthol units linked by a short bridge is described. These ligands can be used for investigating catalytic asymmetric reactions which utilize BINOL or related ligands as was demonstrated for the ring opening reaction of cyclohexene oxide with 4-methoxyphenol.

Published
1998

13. Characteristics of Various Categories of Controlled Donors after Circulatory Death Do Not Affect Outcome after Lung Transplantation; an Analysis of ISHLT DCD Registry Data

Author

Raemdonck, D. Van, primary, Levvey, B., additional, Edwards, L., additional, Stehlik, J., additional, Erasmus, M., additional, Glanville, A., additional, Hertz, M., additional, Hopkins, P., additional, Chambers, D., additional, Musk, M., additional, Budev, M., additional, Mason, D., additional, Puri, V., additional, Yusen, R., additional, D’Ovidio, F., additional, Keshavjee, S., additional, Cypel, M., additional, and Snell, G., additional

Published
2016
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14. Donation After Circulatory Death (DCD) versus Donation After Brain Death (DBD): Contrasting Donor and Recipient Characteristics in the ISHLT DCD Lung Transplant (LTx) Registry

Author

Levvey, B., primary, Snell, G., additional, Edwards, L., additional, Stehlik, J., additional, Erasmus, M., additional, Glanville, A., additional, Hertz, M., additional, Hopkins, P., additional, Chambers, D., additional, Musk, M., additional, Budev, M., additional, Mason, D., additional, Puri, V., additional, Yusen, R., additional, D’Ovidio, F., additional, Keshavjee, S., additional, Cypel, M., additional, and Raemdonck, D. Van, additional

Published
2016
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15. Bidentate phosphines of heteroarenes: effective stabilization of the Co2(CO)6 fragment by 4,6-bis(diphenylphosphino) dibenzofuran

Author

Joachim Bruckmann, Erasmus M. Vogl, Matthias W. Haenel, and Carl Krüger

Subjects
Denticity, Fragment (computer graphics), Stereochemistry, Organic Chemistry, Solid-state, chemistry.chemical_element, Biochemistry, Medicinal chemistry, Inorganic Chemistry, Dibenzofuran, chemistry.chemical_compound, chemistry, Materials Chemistry, Physical and Theoretical Chemistry, Spectroscopy, Cobalt
Abstract

Reaction of Co2(CO)8 with 4,6-bis(diphenylphosphino)dibenzofuran (1) in diethylether gives the dinuclear complex 4,6-bis(diphenylphosphino)dibenzofurandicobalthexacarbonyl (2). The solid state structures of 1 and 2 have been established by X-ray crystallography. Low temperature 13C-NMR spectroscopy was used to analyse 2 in solution.

Published
1996

17. Favorable Outcomes of Donation after Cardiac Death in Lung Transplantation: A Multicenter Study

Author

Cypel, M., primary, Levvey, B., additional, Van Raemdonck, D., additional, Erasmus, M., additional, Love, R., additional, Mason, D., additional, Glanville, A., additional, Stehlik, J., additional, Herz, M., additional, Whitson, B., additional, Puri, V., additional, Dark, J., additional, Hopkins, P., additional, Snell, G., additional, and Keshavjee, S., additional

Published
2013
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