Search

Your search keyword '"Elkrief, L."' showing total 29 results
Start Over Author "Elkrief, L." Publisher elsevier bv
29 results on '"Elkrief, L."'

2. Porto-sinusoidal vascular disease: proposal and description of a novel entity

Author

De Gottardi, A, Rautou, PE, Schouten, Joanne, Rubbia-Brandt, L, Leebeek, Frank, Trebicka, J, Darwish Murad, Sarwa, Vilgrain, V, Hernandez-Gea, V, Nery, F, Plessier, A, Berzigotti, A, Bioulac-Sage, P, Primignani, M, Seinela, D, Elkrief, L, Bedossa, P, Willa, D, Garcia-Pagan, JC, Jakob, B, Cazals-Hatem, D, Alonso, C, Erasmus MC other, Hematology, and Gastroenterology & Hepatology

Subjects
Pathology, medicine.medical_specialty, Cirrhosis, ddc:616.07, 03 medical and health sciences, Liver disease, 0302 clinical medicine, Incomplete septal cirrhosis, Venules, 600 Technology, Hypertension, Portal, medicine, Humans, Vascular Diseases, 610 Medicine & health, ddc:617, Hepatology, medicine.diagnostic_test, Portal Vein, Vascular disease, business.industry, Gastroenterology, medicine.disease, Capillaries, Portal vein thrombosis, Portal System, 030220 oncology & carcinogenesis, Liver biopsy, Portal hypertension, 030211 gastroenterology & hepatology, business, Nodular regenerative hyperplasia
Abstract

Portal hypertension in the absence of portal vein thrombosis and without cirrhosis, but with mild or moderate alterations of liver histology (eg, obliterative venopathy, nodular regenerative hyperplasia, or incomplete septal cirrhosis) is being increasingly recognised. Owing to the heterogeneity of causes and histological findings, a substantial number of terms have been used to describe such idiopathic non-cirrhotic portal hypertension. Patients with the same clinical and histological features exist, but without portal hypertension at the time of diagnosis. Therefore, improved criteria are needed to define this form of liver disease. Here, we propose the term porto-sinusoidal vascular disease, since all lesions found involve the portal venules or sinusoids. The definition of this entity is based on the characteristic absence of cirrhosis with or without signs of portal hypertension or histological lesions. The presence of known causes of liver disease does not rule out porto-sinusoidal vascular disease, but specific causes of vascular liver disease are excluded from its definition. The diagnosis of porto-sinusoidal vascular disease is based on liver biopsy and might include signs specific for portal hypertension with normal or mildly elevated liver stiffness values and no complete portal vein thrombosis. We provide simple diagnostic criteria, because agreement on a uniform nomenclature is an essential requirement for future collaborative studies.

Published
2019
Full Text
View/download PDF

3. COVID-19 in Liver Transplant Candidates: Pre- and Post-Transplant Outcome

Author

Giovanni P, Hann A, Invernzzi F, lesurtel m, G. Magini, François Faitot, C. Morelli, Stefano Fagiuoli, Karam, Damiano Patrono, Renato Romagnoli, Diaz-Fontenla F, Kounis I, C. Fondevila, zieniewicz k, Rita Facchetti, Paolo Cortesi, Paolo De Simone, Elkrief L, Mirza D, Iacob S, Caroline M. den Hoed, Gheorghe L, Sylvie Radenne, Bo Göran Ericzon, Marco Merli, Lluis Castells, Carmelo Loinaz, Christophe Duvoux, Roberto Fumagalli, Berlakovic G, Sara Conti, Christian Toso, Perera T, Luca S. Belli, Wojciech G. Polak, Massimo Puoti, Luciano Dc, Kollmann D, Detry O, Luisa Pasulo, and Audrey Coilly

Subjects
medicine.medical_specialty, education.field_of_study, Cirrhosis, business.industry, Proportional hazards model, medicine.medical_treatment, Population, Liver transplantation, medicine.disease, Vaccination, Respiratory failure, Internal medicine, medicine, media_common.cataloged_instance, European union, business, education, media_common, Cause of death
Abstract

Background: The impact of COVID-19 on patients on the waiting list for liver transplantation (LT) and on their post-LT course is presently unknown. Methods: Data from consecutive adult LT candidates with COVID-19 were collected across Europe in a dedicated registry and analyzed. Findings: From February 21st to November 20th, 2020, 136 adult cases with laboratory confirmed SARS-CoV-2 infection from 33 centers in 11 European countries were collected, with 113 having COVID-19. Thirty-seven (37/113, 32·7%) patients died after a median of 18 (10-30) days, respiratory failure being the major cause (33/37, 89·2%). The 60-day mortality risk did not significantly change between first (35·3%, 95% CI 23·9-50·0) and second wave (26·0%, 95% CI 16·2-40·2). Multivariable Cox regression analysis showed lab-MELD score ≥15 (MELD 15-19 HR 6·09, 95% CI 2·01-18·45; MELD ≥20 HR 5·21, 95% CI 1·76-15·45) and dyspnea on presentation (HR 4·10, 95% CI 2·09-8·06) being the two negative independent factors for mortality. The mortality risk reached 49·2% (31/63) in patients with decompensated cirrhosis and lab-MELD score ≥15. Twenty-six patient received a LT after a median time of 78.5 (IQR 44-102) days and 25 (96%) are alive after median follow-up of 118 days (IQR 31-170). Interpretation: Increased mortality in LT candidates with COVID-19 (32·7%), reaching 49·2% in those with decompensated cirrhosis and lab-MELD score ≥15, with no significant difference between first and second wave of the pandemic. Respiratory failure was the major cause of death. The dismal prognosis of patients with decompensated cirrhosis supports the adoption of strict preventative measures and the urgent testing of vaccination efficacy in this population. Prior SARS-CoV-2 symptomatic infection did not affect early post-transplant survival (96%). Funding: No funding source. Declaration of Interests: None to declare. Ethics Approval Statement: Data was collected in accordance with General Data Protection Regulation (GDPR), the European Union legislation and the ELTR privacy policy. Reg. HCB/2020/0479 released by CLINICAL RESEARCH ETHICS COMMITTEE from Hospital Clinic Barcelona

Published
2021
Full Text
View/download PDF

4. Traitement de l’ascite réfractaire par alfapump® avec cure de hernie durant la même intervention : une étude rétrospective, multicentrique, européenne chez des patients cirrhotiques

Author

Nguyen-Khac, E., primary, Sarba, R., additional, Spahr, L., additional, Staszewicz, W., additional, DeGottardi, A., additional, Storni, F., additional, Elkrief, L., additional, Dokmak, S., additional, Valla, D., additional, Pricope, D., additional, Sabbagh, C., additional, and Regimbeau, J.M., additional

Published
2021
Full Text
View/download PDF

5. Combined treatment of refractory ascites with an alfapump® plus hernia repair in the same surgical session: A retrospective, multicentre, European pilot study in cirrhotic patients

Author

Nguyen-Khac, E., primary, Sarba, R., additional, Spahr, L., additional, Staszewicz, W., additional, DeGottardi, A., additional, Storni, F., additional, Elkrief, L., additional, Dokmak, S., additional, Valla, D., additional, Pricope, D., additional, Sabbagh, C., additional, and Regimbeau, J.M., additional

Published
2021
Full Text
View/download PDF

6. Prognosis after abdominal surgery in patients with idiopathic non-cirrhotic portal hypertension: A multicenter retrospective study

Author

Elkrief, L., primary, Ferrusquia, J., additional, Audrey, P., additional, Moga, L., additional, Luis, T., additional, Praktiknjo, M., additional, Procopet, B., additional, Yuldashev, R., additional, Geovanni, H., additional, Hernandez-Gea, V., additional, Albillos, A., additional, Trebicka, J., additional, Spahr, L., additional, Plessier, A., additional, Valla, D., additional, Rubbia-Brandt, L., additional, Toso, C., additional, Bureau, C., additional, Carlos, G.P.J., additional, and Rautou, P.-E., additional

Published
2018
Full Text
View/download PDF

7. Regional variations in the development of acute-on-chronic liver failure (ACLF) in patients with cirrhosis and bacterial infections

Author

Wong, F., primary, Singh, V., additional, Caraceni, P., additional, Maiwall, R., additional, Piano, S., additional, Marciano, S., additional, Fernandez, J., additional, Alessandria, C., additional, Soares, E., additional, Kim, D.J., additional, Kim, S.E., additional, Marino, M., additional, Vorobioff, J., additional, de Cassia Ribeiro Barea, R., additional, Merli, M., additional, Elkrief, L., additional, Manuel, V., additional, Blasco, V., additional, Krag, A., additional, Singh, S., additional, Lesmana, L.A., additional, Toledo, C., additional, Xavier, V., additional, Intagliata, N., additional, Rabinowich, L., additional, Bruns, T., additional, Yoon, E.L., additional, Girala, M., additional, Pyrsopoulos, N.T., additional, Kim, T.H., additional, Yim, S.Y., additional, Durand, F., additional, Gadano, A., additional, and Angeli, P., additional

Published
2018
Full Text
View/download PDF

8. Epidemiology, predictors and outcomes of multi drug resistant bacterial infections in patients with cirrhosis across the world. Final results of the “Global study”

Author

Piano, S., primary, Singh, V., additional, Caraceni, P., additional, Maiwall, R., additional, Alessandria, C., additional, Fernandez, J., additional, Soares, E., additional, Kim, D.J., additional, Kim, S.E., additional, Marino, M., additional, Vorobioff, J., additional, de Cassia Ribeiro Barea, R., additional, Merli, M., additional, Elkrief, L., additional, Blasco, V.M.V., additional, Krag, A., additional, Singh, S., additional, Lesmana, L.A., additional, Toledo, C., additional, Marciano, S., additional, Xavier, V., additional, Wong, F., additional, Intagliata, N., additional, Rabinowich, L., additional, Colombato, L.A., additional, Kim, S.G., additional, Gerbes, A., additional, Durand, F., additional, Roblero, J.P., additional, Bhamidimarri, K., additional, Boyer, T.D., additional, Maevskaya, M., additional, Fassio, E.L., additional, Kim, H.S., additional, Hwang, J.-S., additional, Gadano, A., additional, Sarin, S.K., additional, and Angeli, P., additional

Published
2018
Full Text
View/download PDF

9. Determinants of clinical efficacy of empirical antibiotic treatment in patients with cirrhosis and bacterial infections: Results from the ICA global study

Author

Maiwall, R., primary, Piano, S., additional, Singh, V., additional, Caraceni, P., additional, Alessandria, C., additional, Fernandez, J., additional, Soares, E., additional, Kim, D.J., additional, Kim, S.E., additional, Marino, M., additional, Vorobioff, J., additional, de Cassia Ribeiro Barea, R., additional, Merli, M., additional, Elkrief, L., additional, Blasco, V.M.V., additional, Krag, A., additional, Singh, S., additional, Lesmana, L.A., additional, Toledo, C., additional, Marciano, S., additional, Xavier, V., additional, Wong, F., additional, Intagliata, N., additional, Rabinowich, L., additional, Colombato, L.A., additional, Kim, S.G., additional, Gerbes, A., additional, Durand, F., additional, Roblero, J.P., additional, Kim, J.H., additional, Man, R.D., additional, Song, D.S., additional, Brodersen, C.E., additional, Gadano, A., additional, Sarin, S.K., additional, and Angeli, P., additional

Published
2018
Full Text
View/download PDF

10. Adherence to EASL antibiotic treatment recommendations improves the outcomes of patients with cirrhosis and bacterial infections. Results from the ICA Global Study

Author

Piano, S., primary, Singh, V., additional, Caraceni, P., additional, Maiwall, R., additional, Alessandria, C., additional, Fernandez, J., additional, Soares, E., additional, Kim, D.J., additional, Kim, S.E., additional, Marino, M., additional, Vorobioff, J., additional, de Cassia Ribeiro Barea, R., additional, Merli, M., additional, Elkrief, L., additional, Blasco, V.M.V., additional, Krag, A., additional, Singh, S., additional, Lesmana, L.A., additional, Toledo, C., additional, Marciano, S., additional, Xavier, V., additional, Wong, F., additional, Intagliata, N., additional, Rabinowich, L., additional, Colombato, L.A., additional, Kim, S.G., additional, Gerbes, A., additional, Durand, F., additional, Roblero, J.P., additional, Bhamidimarri, K., additional, Boyer, T.D., additional, Maevskaya, M., additional, Fassio, E.L., additional, Kim, H.S., additional, Hwang, J.-S., additional, Gadano, A., additional, Sarin, S.K., additional, and Angeli, P., additional

Published
2018
Full Text
View/download PDF

11. Epidemiology, predictors and outcomes of multi drug resistant (MDR) bacterial infections in patients with cirrhosis across the world. Final results of the “Global study”

Author

Piano, S., primary, Singh, V., additional, Caraceni, P., additional, Maiwall, R., additional, Alessandria, C., additional, Fernandez, J., additional, Soares, E.C., additional, Kim, D.J., additional, Kim, S.E., additional, Marino, M., additional, Vorobioff, J., additional, Barea, R. Ribeiro, additional, Merli, M., additional, Elkrief, L., additional, Vargas, V., additional, Krag, A., additional, Singh, S.P., additional, Lesmana, L.A., additional, Toledo, C., additional, Marciano, S., additional, Verhelst, X., additional, Wong, F., additional, Intagliata, N., additional, Rabinowich, L., additional, Colombato, L.A., additional, Kim, S.G., additional, Gerbes, A., additional, Durand, F., additional, Roblero, J.P., additional, Bhamidimarri, K.R., additional, Boyer, T.D., additional, Maevskaya, M., additional, Fassio, E., additional, Kim, H.S., additional, Hwang, J.S., additional, Gadano, A., additional, Sarin, S.K., additional, and Angeli, P., additional

Published
2018
Full Text
View/download PDF

12. Non-invasive evaluation of clinically significant portal hypertension: validation of two novel algorithms combining liver and spleen stiffness using shear-wave elastography in a large independent cohort of patients with cirrhosis

Author

Elkrief, L., primary, Rautou, P.-E., additional, Ronot, M., additional, Zappa, M., additional, Burgio, M.Di., additional, Roux, O., additional, Bissonnette, J., additional, Payancé, A., additional, Lebrec, D., additional, Francoz, C., additional, Soubrane, O., additional, Valla, D., additional, Durand, F., additional, Vilgrain, V., additional, and Castéra, L., additional

Published
2017
Full Text
View/download PDF

13. A randomized trial of 6-month norfloxacin therapy in patients with Child-Pugh class C cirrhosis

Author

Moreau, R., primary, Elkrief, L., additional, Bureau, C., additional, Pérarnau, J.-M., additional, Thévenot, T., additional, Saliba, F., additional, Louvet, A., additional, Nahon, P., additional, Oberti, F., additional, Anty, R., additional, Hillaire, S., additional, Pasquet, B., additional, Ozenne, V., additional, Rudler, M., additional, Ollivier-Hourmand, I., additional, Robic, M.-A., additional, D’Alteroche, L., additional, Di Martino, V., additional, Rautou, P.-E., additional, Gault, N., additional, and Lebrec, D., additional

Published
2017
Full Text
View/download PDF

14. HIV-Positive-to-HIV-Positive Liver Transplantation

Author

Calmy, A., primary, van Delden, C., additional, Giostra, E., additional, Junet, C., additional, Rubbia Brandt, L., additional, Yerly, S., additional, Chave, J.-P., additional, Samer, C., additional, Elkrief, L., additional, Vionnet, J., additional, and Berney, T., additional

Published
2016
Full Text
View/download PDF

17. Alfapump® System versus Large Volume Paracentesis in the Treatment of Refractory Ascites; Results from a Multicenter Randomised Controlled Study (Rct)

Author

Adebayo, D., primary, Bureau, C., additional, de Rieu, M.C., additional, Valla, D., additional, Elkrief, L., additional, Peck-Radosavljevic, M., additional, Bota, S., additional, McCune, A., additional, Abbadi, R., additional, Vargas, V., additional, Simon-Talero, M., additional, Cordoba, J., additional, Angeli, P., additional, Rosi, S., additional, Macdonald, S., additional, Whittaker, S., additional, Trepte, C., additional, and Jalan, R., additional

Published
2016
Full Text
View/download PDF

19. P1266 : Human albumin use in cirrhotic patients in France: Results of the national “Albu-live” survey

Author

Garioud, A., primary, Cadranel, J.-F., additional, Pauwels, A., additional, Thévenot, T., additional, Louvet, A., additional, Dao, T., additional, Sogni, P., additional, Talbodec, N., additional, Bureau, C., additional, Thabut, D., additional, Elkrief, L., additional, Jouannaud, V., additional, Macaigne, G., additional, Bernard-Chabert, B., additional, Lison, H., additional, Alric, L., additional, Carbonnel, N., additional, Pageaux, G.-P., additional, Bettan, L., additional, Labadie, H., additional, Nahon, P., additional, Bader, R., additional, Zarski, J.-P., additional, Abergel, A., additional, Pol, S., additional, Pariente, A., additional, Amiot, X., additional, Mathurin, P., additional, Ollivier-Hourmand, I., additional, Bismuth, M., additional, Dupont, K., additional, Rosa-Hézode, I., additional, Lesgourgues, B., additional, Leroy, V., additional, Poynard, T., additional, Causse, X., additional, Chazouillères, O., additional, Valla, D., additional, Zanditenas, D., additional, Renou, C., additional, Trinchet, J.-C., additional, Paupard, T., additional, Ouzan, D., additional, Guyader, D., additional, Fontanges, T., additional, Hanslik, B., additional, De Lédinghen, V., additional, and Denis, J., additional

Published
2015
Full Text
View/download PDF

21. Survie à long terme et résection intestinale après ischémie mésentérique aiguë : étude observationnelle rétrospective de cohorte évaluant les facteurs pronostiques sur 164 survivants

Author

Nuzzo, A., primary, Bouhnik, Y., additional, Ronot, M., additional, Stefanescu, C., additional, Boudaoud, L., additional, Plessier, A., additional, Cazals-Hatem, D., additional, De Raucourt, E., additional, Elkrief, L., additional, Pasquet, B., additional, Castier, Y., additional, Paugam-Burtz, C., additional, Panis, Y., additional, Joly, F., additional, and Corcos, O., additional

Published
2014
Full Text
View/download PDF

22. P476 SHORT-TERM (28-DAY) CLINICAL COURSE AND TRANSPLANT-FREE MORTALITY IN ACUTE ON CHRONIC LIVER FAILURE (ACLF); EVIDENCE FOR REVERSIBILITY OF ACLF (A STUDY FROM THE CANONIC DATABASE)

Author

Gustot, T., primary, Fernandez, J., additional, Garcia, E., additional, Ginès, P., additional, Moreau, R., additional, Jalan, R., additional, Pavesi, M., additional, Durand, F., additional, Angeli, P., additional, Caraceni, P., additional, Markwardt, D., additional, Alessandria, C., additional, Solis Muñoz, P., additional, Laleman, W., additional, Trebicka, J., additional, Saliba, F., additional, Zeuzem, S., additional, Albillos, A., additional, Elkrief, L., additional, Benten, D., additional, Montero, J.L., additional, Chiva, M.T., additional, Concepcion, M., additional, Cordoba, J., additional, McCormick, A., additional, Stauber, R.E., additional, Vogel, W., additional, de Gottardi, A., additional, Morando, F., additional, Domenicali, M., additional, Gerbes, A., additional, Risso, A., additional, Deulofeu, C., additional, Bernardi, M., additional, and Arroyo, V., additional

Published
2014
Full Text
View/download PDF

23. P497 DIRECT SEQUENCING OF PROTEIN-C AND -S GENES IN PATIENTS WITH BUDD–CHIARI SYNDROME (BCS), PORTAL-VEIN THROMBOSIS (PVT) AND OBLITERATIVE-PORTAL-VENOPATHY (OPV) AND SUSPICION OF INHERITED PROTEIN-C OR -S DEFICIENCY

Author

Plessier, A., primary, Elkrief, L., additional, Rautou, P.E., additional, Deraucourt, E., additional, Goria, O., additional, Zekrini, K., additional, Boudaoud, L., additional, Valla, D., additional, and Alhenc Gelas, M., additional

Published
2014
Full Text
View/download PDF

24. O78 PROSPECTIVE COMPARISON OF LIVER AND SPLEEN STIFFNESS AND COMPOSITE SCORES, USING SUPERSONIC-SHEAR-IMAGING OR TRANSIENT ELASTOGRAPHY, FOR DETECTING CLINICALLY SIGNIFICANT PORTAL HYPERTENSION IN PATIENTS WITH CIRRHOSIS

Author

Elkrief, L., primary, Rautou, P.-E., additional, Ronot, M., additional, Lambert, S., additional, Dioguardi Burgio, M., additional, Francoz, C., additional, Plessier, A., additional, Durand, F., additional, Valla, D., additional, Lebrec, D., additional, Vilgrain, V., additional, and Castéra, L., additional

Published
2014
Full Text
View/download PDF

25. 1414 THE CLIF-CONSORTIUM SCORE PREDICTS MORTALITY MORE ACCURATELY THAN THE MELD AND MELD-SODIUM SCORES IN PATIENTS HOSPITALIZED WITH DECOMPENSATED CIRRHOSIS WITH AND WITHOUT ACUTE-ON-CHRONIC-LIVER FAILURE (ACLF).

Author

Pavesi, M., primary, Jalan, R., additional, Amoros, A., additional, Moreau, R., additional, Ginès, P., additional, Durand, F., additional, Angeli, P., additional, Caraceni, P., additional, Rodriguez, E., additional, Agarwarl, B., additional, Hopf, C., additional, Alessandria, C., additional, Solis-Muñoz, P., additional, Laleman, W., additional, Trebicka, J., additional, Saliba, F., additional, Zeuzem, S., additional, Albillos, A., additional, Gustot, T., additional, Mookerjee, R., additional, Elkrief, L., additional, Benten, D., additional, Montero, J.L., additional, Catalina, M.V., additional, Concepción, M., additional, Cordoba, J., additional, McCormick, A., additional, Stauber, R., additional, Vogel, W., additional, De Gottardi, A., additional, Peck-Radosavljevic, M., additional, van Vlierberghe, H., additional, Sperl, J., additional, Groenbaek, H., additional, Mortensen, C., additional, Coenraad, M.J., additional, Morando, F., additional, Domenicali, M., additional, Gerbes, A., additional, Risso, A., additional, Garcia, E., additional, Deulofeu, C., additional, Bernardi, M., additional, and Arroyo, V., additional

Published
2013
Full Text
View/download PDF

28. 1404 DIAGNOSIS, PREVALENCE, AND PROGNOSIS OF ACUTE-ON- CHRONIC LIVER FAILURE (ACLF): RESULTS OF THE EASL-CHRONIC LIVER FAILURE (CLIF) CONSORTIUM CANONIC STUDY

Author

Moreau, R., primary, Gines, P., additional, Jalan, R., additional, Pavesi, M., additional, Durand, F., additional, Angeli, P., additional, Caraceni, P., additional, Pereira, G., additional, Hopf, C., additional, Alessandria, C., additional, Solis, P., additional, Laleman, W., additional, Trebicka, J., additional, Saliba, F., additional, Zeuzem, S., additional, Albillos, A., additional, Gustot, T., additional, Yago, M., additional, Elkrief, L., additional, Benten, D., additional, Montero, J.-L., additional, Chiva, T., additional, Concepción, M., additional, Cordoba, J., additional, McCormick, A., additional, Stauber, R.-E., additional, Vogel, W., additional, De Gottardi, A., additional, Morando, F., additional, Domenicali, M., additional, Gerbes, A.-L., additional, Risso, A., additional, García, E., additional, Deulofeu, C., additional, Bernardi, M., additional, and Arroyo, V., additional

Published
2012
Full Text
View/download PDF

29. Clinical features and evolution of bacterial infection-related acute-on-chronic liver failure

Author

Carlo Alessandria, Carmine Gambino, Javier Fernández, Hans Van Vlierberghe, Sophie Restellini, Marcos Girala, Luis Colombato, Tae Hee Lee, Nikolaos Pyrsopoulos, Eduardo Fassio, Sang Gyune Kim, Gisela Pinero, Paolo Caraceni, Shivaram Prasad Singh, Do Seon Song, Ji Won Park, Julio Vorobioff, Dong Joon Kim, C. Toledo, Aleksander Krag, Liane Rabinowich, Preetam Nath, Robert A. de Man, Elza Cotrim Soares, Xavier Verhelst, Tiago Sevá Pereira, Gustavo Romero, Macarena Simón-Talero, Sung Eun Kim, Michele Bartoletti, Alexander L. Gerbes, Sebastián Marciano, Tony Bruns, Hyoung Su Kim, Ki Tae Suk, Nicolas M. Intagliata, Annette Dam Fialla, Adrià Juanola, Manuela Merli, Rita de Cassia Ribeiro Barea, Laure Elkrief, Rakhi Maiwall, Laurentius A Lesmana, Pere Ginès, Vikas Gautam, E.L. Yoon, M. Marino, Paolo Angeli, Kalyan Ram Bhamidimarri, Victor Vargas, Virendra Singh, Juan Pablo Roblero, François Durand, Cosmas A. Rinaldi Lesmana, M. V. Maevskaya, Gustavo Navarro, Adrian Gadano, Florence Wong, Pramod Kumar, Tae Hun Kim, Daniela Campion, Salvatore Piano, Giacomo Zaccherini, Barbara Lattanz, Jae Seok Hwang, Sun Young Yim, Thomas D. Boyer, Jeong Han Kim, Carlos Brodersen, Wong F., Piano S., Singh V., Bartoletti M., Maiwall R., Alessandria C., Fernandez J., Soares E.C., Kim D.J., Kim S.E., Marino M., Vorobioff J., Barea R.D.C.R., Merli M., Elkrief L., Vargas V., Krag A., Singh S.P., Lesmana L.A., Toledo C., Marciano S., Verhelst X., Intagliata N., Rabinowich L., Colombato L., Kim S.G., Gerbes A., Durand F., Roblero J.P., Bruns T., Yoon E.L., Girala M., Pyrsopoulos N.T., Kim T.H., Yim S.Y., Juanola A., Gadano A., Angeli P., Bhamidimarri K., Boyer T.D., Brodersen C., Campion D., Caraceni P., de Man R.A., Fassio E., Fialla A.D., Gambino C., Gautam V., Gines P., Hwang J.S., Kim H.S., Kim J.H., Kumar P., Lattanz B., Lee T.H., Rinaldi Lesmana C.A., Maevskaya M., Nath P., Navarro G., Park J.-W., Pinero G., Restellini S., Romero G., Seva -Pereira T., Simon-Talero M., Song D.S., Suk K.T., Van Vlierberghe H., and Zaccherini G.

Subjects
Male, 0301 basic medicine, Cirrhosis, Organ Dysfunction Scores, Antibiotic resistance, medicine.medical_treatment, Liver transplantation, Severity of Illness Index, 0302 clinical medicine, ACLF, MDR, Epidemiology, Cross Infection, Mortality rate, Age Factors, Bacterial Infections, Middle Aged, Prognosis, Community-Acquired Infections, Europe, Hospitalization, Female, 030211 gastroenterology & hepatology, Alcohol-Related Disorders, medicine.medical_specialty, Sepsi, India, Risk Assessment, Sepsis, 03 medical and health sciences, Sex Factors, Spontaneous bacterial peritonitis, Internal medicine, medicine, Humans, XDR, Cirrhosi, Hepatology, business.industry, Acute-On-Chronic Liver Failure, medicine.disease, Pneumonia, 030104 developmental biology, antibiotic resistance, liver transplantation, sepsis, business
Abstract

Background & Aims: Bacterial infections can trigger the development of organ failure(s) and acute-on-chronic liver failure (ACLF). Geographic variations in bacteriology and clinical practice could lead to worldwide differences in ACLF epidemiology, phenotypes and associated outcomes. Herein, we aimed to evaluate regional differences in bacterial infection-related ACLF in patients with cirrhosis admitted to hospital. Methods: This post hoc analysis included 1,175 patients with decompensated cirrhosis (with bacterial infection on admission or nosocomial infection) from 6 geographic regions worldwide. Clinical, laboratory and microbiological data were collected from the diagnosis of infection. Patients were followed-up for organ failure(s) and ACLF development according to the EASL-CLIF criteria from enrolment to discharge/death. Results: A total of 333 patients (28%) had ACLF at diagnosis of infection, while 230 patients developed ACLF after diagnosis of infection, resulting in an overall rate of bacterial infection related-ACLF of 48%, with rates differing amongst different geographic regions (38% in Southern Europe vs. 75% in the Indian subcontinent). Bacterial infection related-ACLF more frequently developed in younger patients (55 ± 13 vs. 58 ± 14 years), males (73% vs. 62%), patients with alcohol-related cirrhosis (59% vs. 45%) and those with a higher baseline MELD score (25 ± 11 vs. 16 ± 5) (all p

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results