1. Association of the forced oscillation technique with negative expiratory pressure in COPD
- Author
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Kazuhiro Asada, Satoru Morita, Takafumi Suda, Ichiro Hayashi, Shogo Sakurai, Eisuke Mochizuki, Yuichiro Shishido, Taisuke Akamatsu, Takahito Suzuki, Yukiko Shimoda, Toshihiro Shirai, Takefumi Akita, Mika Saigusa, Akito Yamamoto, Kazutaka Mori, and Rie Noguchi
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,Vital capacity ,Multivariate analysis ,Physiology ,Logistic regression ,Sensitivity and Specificity ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Forced Oscillation Technique ,Forced Expiratory Volume ,Internal medicine ,medicine ,Humans ,030212 general & internal medicine ,Dynamic hyperinflation ,Aged ,Aged, 80 and over ,Emphysema ,COPD ,Receiver operating characteristic ,medicine.diagnostic_test ,business.industry ,General Neuroscience ,medicine.disease ,Surgery ,Logistic Models ,ROC Curve ,030228 respiratory system ,Multivariate Analysis ,Cardiology ,Female ,Tomography, X-Ray Computed ,business - Abstract
Expiratory flow limitation (EFL) during tidal breathing is common in patients with severe COPD, and a major determinant of dynamic hyperinflation and exercise limitation. The negative expiratory pressure (NEP) technique has been the gold standard to detect EFL, while the forced oscillation technique (FOT) has also been reported to detect it. However, the association of FOT with NEP is not fully understood. We assessed whether broadband frequency FOT would predict the presence of EFL measured by NEP. FOT, NEP, and spirometry were performed in 51 patients with COPD. The extent of emphysema was measured by high-resolution computed tomography and scored. Fifteen patients were classified into the EFL-positive group and 36 into the EFL-negative group. In multivariate logistic regression analysis, EFL was independently predicted by emphysema score, forced vital capacity, and whole-breath respiratory system reactance at 5Hz (X5). The receiver operator characteristic curve analysis revealed that inspiratory X5 best predicted EFL-positivity. X5-related forced oscillatory parameters are useful for detecting EFL in the management of COPD.
- Published
- 2016
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